The U.S. Air Force is a military service organized within the Department of the Air Force, one of the three military departments of the Department of Defense. The Air Force is headed by the civilian Secretary of the Air Force, who reports to the Secretary of Defense, and is appointed by the President with Senate confirmation. The highest-ranking military officer in the Department of the Air Force is the Chief of Staff of the Air Force, who exercises supervision over Air Force units, and serves as a member of the Joint Chiefs of Staff. Air Force combat and mobility forces are assigned, as directed by the Secretary of Defense, to the Combatant Commanders, and neither the Secretary of the Air Force nor the Chief of Staff have operational command authority over them.
Who assigns combat missions to the Air Force? 
Secretary of Defense