query: which substance increases the production of rbc 's

pos: Erythropoiesis Erythropoiesis Erythropoiesis (from Greek 'erythro' meaning "red" and 'poiesis' meaning "to make") is the process which produces red blood cells (erythrocytes). It is stimulated by decreased O in circulation, which is detected by the kidneys, which then secrete the hormone erythropoietin. This hormone stimulates proliferation and differentiation of red cell precursors, which activates increased erythropoiesis in the hemopoietic tissues, ultimately producing red blood cells (erythrocytes). In postnatal birds and mammals (including humans), this usually occurs within the red bone marrow. In the early fetus, erythropoiesis takes place in the mesodermal cells of the yolk sac. By the third or fourth

pos: Gene doping in 2009, scientists administered follistatin via gene therapy to the quadriceps of non-human primates, resulting in local muscle growth similar to the mice. Erythropoietin is a glycoprotein that acts as a hormone, controlling red blood cell production. Athletes have injected the EPO protein as a performance-enhancing substance for many years (blood doping). When the additional EPO increases the production of red blood cells in circulation, this increases the amount of oxygen available to muscle, enhancing an athlete's endurance. Recent studies suggest it may be possible to introduce another EPO gene into an animal in order to increase EPO production endogenously.

pos: Placental insufficiency glycogen stores. Fetal hypoxemia triggers erythropoietin release. This stimulates RBC production from medullary and extramedullary sites and eventually results in polycythemia. Oxygen carrying capacity of blood is thus increased. Prolonged tissue hypoxemia may cause early release of erythrocytes from maturation sites and thus count of nucleated RBCs in blood increases. These factors, increase in blood viscosity, decrease in cell membrane fluidity and platelet aggregation are important precurosrs in accelerating placental vascular occlusion. There is decrease in immunoglobulin, absolute B-cell counts and total WBC count. T-helper and cytotoxic T-cells are suppressed in proportion of degree of acidemia. These conditions lead to

pos: Normocytic anemia except after 12 to 24 hrs where polychromasia appears. For reduced production of RBCs, like with low erythropoietin, the RBC morphology is unremarkable. Patients with disordered RBC production, e.g. myelodysplastic syndrome, may have a dual population of elliptocytes, teardrop cells, or other poikilocytes as well as a nucleated RBCs. Hemolysis will often demonstrate poikilocytes specific to a cause or mechanism. E.g. Bite cells and/or blistor cells for oxidative hemolysis, Acanthocytes for pyruvate kinase deficiency or McLeod phenotype, Sickle cells for sickle cell anemia, Spherocytes for immune-mediated hemolysis or hereditary spherocytosis, Elliptocytosis for iron deficiency or hereditary elliptocytosis and schistocytes for

neg: Anthony S. Fell Anthony S. Fell Anthony S. Fell, OC is a Canadian businessman who was formerly Chairman and CEO of RBC Dominion Securities (RBC DS), the corporate and investment banking subsidiary of the Royal Bank of Canada (RBC). From 1980 to 2000, he was the Chief Executive Officer of Dominion Securities, which RBC purchased a majority stake in 1988 and completely acquired in 1996; thereafter Fell assumed the title of Deputy Chairman of RBC from 1998 to 2000, making him the number two executive after John Cleghorn, the Chairman and CEO of the bank holding company RBC. In 2000, Fell relinquished his

neg: Blood doping benefits to athletes than those provided by the equivalent hemoglobin in traditional RBC infusion. Recent developments have shown that HBOCs are not only simple RBC substitutes, but highly effective O donors in terms of tissue oxygenation. Additional effects include increases in blood serum iron, ferritin, and Epo; up to 20% increased diffusion of oxygen and improved exercise capacity; increased CO production; and lower lactic acid generation in anaerobic activity. HBOCs have been shown in trials to be extremely dangerous in humans. Because Haemoglobin-based oxygen carriers increase both the risk of death and risk of myocardial infarction clinical trials were ended.

neg: Anthony S. Fell Deputy Chair title and was succeeded as CEO of RBC Capital Markets by Gord Nixon (who would succeed Cleghorn as CEO of RBC in 2001), and that year RBC DS was also rebranded to RBC Capital Markets (RBC CM). Fell remained Chairman of RBC CM until he retired in 2007. After retiring from RBC, Fell remains a corporate director. He sits on the board of directors of multiple corporations, including BCE Inc., CAE Inc., and Loblaw Companies In 2001, he was made an Officer of the Order of Canada. Anthony S. Fell Anthony S. Fell, OC is a Canadian businessman

neg: Azolla feeding azolla to dairy cattle, pigs, ducks, and chickens, with reported increases in milk production, weight of broiler chickens and egg production of layers, as compared to conventional feed. One FAO study describes how azolla integrates into a tropical biomass agricultural system, reducing the need for inputs. "Azolla" has also been suggested as a food stuff for human consumption. However, no long term studies of the healthiness of eating "Azolla" have been made on humans and "Azolla" may contain BMAA, a substance that is a possible cause of neurodegenerative diseases. However, "Azolla"'s cyanobacteria belongs to the genus "Anabaena" and species

neg: Hypoxia in fish The net influx of ions and the compensatory activation of -ATPase to maintain ionic equilibrium within the RBC results in a steady decline in cellular ATP, also serving to increase Hb-O affinity. As a further result of inward movement, the osmolarity of the RBC increases causing osmotic influx of water and cell swelling. The dilution of the cell contents causes further spatial separation of hemoglobin from the inorganic phosphates and again serves to increase Hb-O affinity. Nearly all animals have more than one kind of Hb present in the RBC. Multiple Hb isoforms (see isoforms) are particularly common in ectotherms,

neg: Acid a substance that, when added to water, increases the concentration of H ions in the water. Note that chemists often write H("aq") and refer to the hydrogen ion when describing acid-base reactions but the free hydrogen nucleus, a proton, does not exist alone in water, it exists as the hydronium ion, HO. Thus, an Arrhenius acid can also be described as a substance that increases the concentration of hydronium ions when added to water. Examples include molecular substances such as HCl and acetic acid. An Arrhenius base, on the other hand, is a substance which increases the concentration of hydroxide

neg: Sleep onset during daytime, this glycogen is converted into fuel for neurons; thus, prolonged wakefulness causes a decrease in the level of glycogen in the brain. A fall in the level of glycogen causes an increase in the level of extracellular adenosine, which has an inhibitory effect in neural activity. This accumulation of adenosine serves as a sleep-promoting substance. Additionally, the production of the neurotransmitter acetylcholine increases in the hippocampus as sleep continues, and also increases in the cortex until REM sleep is reached. The majority of sleep neurons are located in the ventrolateral preoptic area (vlPOA). These sleep neurons are silent

neg: Regulatory Barriers Clearinghouse to overcoming regulatory barriers. RBC also staffs a toll-free phone line, Monday through Friday, from 8:30 a.m. to 5:15 p.m, Eastern Time, along with email support. The Clearinghouse publishes a free bimonthly e-newsletter, Breakthroughs, which contains successful strategies for overcoming regulatory barriers to affordable housing. Breakthroughs articles are submitted by the public, or are the result of interesting developments throughout the housing industry. Regulatory Barriers Clearinghouse The Regulatory Barriers Clearinghouse (RBC) collects, processes, assembles, and disseminates information on existing barriers that inhibit the production and conservation of affordable housing. RBC is part of the U.S. Department of Housing and Urban

neg: Anemia performance in children of school age. Restless legs syndrome is more common in those with iron-deficiency anemia. The causes of anemia may be classified as impaired red blood cell (RBC) production, increased RBC destruction (hemolytic anemias), blood loss and fluid overload (hypervolemia). Several of these may interplay to cause anemia eventually. Indeed, the most common cause of anemia is blood loss, but this usually does not cause any lasting symptoms unless a relatively impaired RBC production develops, in turn most commonly by iron deficiency. (See Iron deficiency anemia) Anemias of increased red blood cell destruction are generally classified as hemolytic

neg: Italian crested newt to be catalase. These extra proteins were produced in high concentrations in early RBC, but decrease quickly as the cell matures. Casale et al. also found that although hemoglobin production decreases as the RBC matures, the cell creates more protein to aid in hemoglobin production. "T. carnifex" is likely to develop in areas of varying temperatures and changing oxygen availability. This is an important piece of knowledge about the typical environment of "T. carnifex": from a very early age, the species is exposed to situations in which they will need to be able to regulate their oxygen levels. Continuing with

neg: Phase diagram the solid and liquid phases have the same symmetry group. For most substances, the solid–liquid phase boundary (or fusion curve) in the phase diagram has a positive slope so that the melting point increases with pressure. This is true whenever the solid phase is denser than the liquid phase. The greater the pressure on a given substance, the closer together the molecules of the substance are brought to each other, which increases the effect of the substance's intermolecular forces. Thus, the substance requires a higher temperature for its molecules to have enough energy to break out of the fixed pattern

neg: Cam follower but decreases the load capacity. The cage also increases internal space so it can hold more lubrication, which increases the time between relubrications. Depending on the exact design sometimes two rollers are put in each pocket of the cage, using a cage design originated by RBC Bearings in 1971. For heavy-duty applications a "roller" design can be used. This employs two rows of rollers of larger diameter than used in needle roller cam followers to increase the dynamic load capacity and provide some thrust capabilities. This design can support higher speeds than the full complement design. For light-duty applications a

neg: Mean corpuscular hemoglobin concentration or PCV) and falsely decrease the calculated haemoglobin (fewer intact RBC) Other: Heinz bodies (many, particularly if large) may falsely increase the MCHC but not the MCH. Agglutination: Falsely increases the MCHC (measured haemoglobin is proportionally higher than HCT). The MCH is more accurate in this setting. Excess EDTA: Dehydrates RBC, falsely increasing MCHC and MCH. Mean corpuscular hemoglobin concentration The Mean corpuscular hemoglobin concentration, a measure of the concentration of haemoglobin in a given volume of packed blood. It is calculated by dividing the haemoglobin by the haematocrit. Reference ranges for blood tests are 32 to 36 g/dL (320

neg: Milieu intérieur to up to 10–5 seconds) tunnels through the ground substance. Major ordering energy structures in the body are created by the ground substance, such as collagen, which not only conducts energy but generates it, due to its piezoelectric properties. This is what occurs in the adaptation response described by Hans Selye. When the ground regulation is out of balance, the probability of chronic illness increases. Research by Heine indicates that unresolved emotional traumas release a neurotransmitter substance P which causes the collagen to take on a hexagonal structure that is more ordered than their usual structure, putting the ground substance

neg: High-content screening but involves assays of more complex cellular phenotypes as outputs. Phenotypic changes may include increases or decreases in the production of cellular products such as proteins and/or changes in the morphology (visual appearance) of the cell. Hence HCA typically involves automated microscopy and image analysis. Unlike high-content analysis, high-content screening implies a level of throughput which is why the term "screening" differentiates HCS from HCA, which may be high in content but low in throughput. In high content screening, cells are first incubated with the substance and after a period of time, structures and molecular components of the cells are

neg: Phagocyte (intracellular killing) or outside of the phagocyte (extracellular killing). When a phagocyte ingests bacteria (or any material), its oxygen consumption increases. The increase in oxygen consumption, called a respiratory burst, produces reactive oxygen-containing molecules that are anti-microbial. The oxygen compounds are toxic to both the invader and the cell itself, so they are kept in compartments inside the cell. This method of killing invading microbes by using the reactive oxygen-containing molecules is referred to as oxygen-dependent intracellular killing, of which there are two types. The first type is the oxygen-dependent production of a superoxide, which is an oxygen-rich bacteria-killing substance.

neg: Percy Lavon Julian (by common molds of the order Mucorales). Their fermentation process could produce 11α-hydroxyprogesterone or 11α-hydroxycortisone from progesterone or Compound S, respectively, which could then by further chemical steps be converted to cortisone or 11β-hydroxycortisone (cortisol). After two years, Glidden abandoned production of cortisone to concentrate on Substance S. Julian developed a multistep process for conversion of pregnenolone, available in abundance from soybean oil sterols, to cortexolone. In 1952, Glidden, which had been producing progesterone and other steroids from soybean oil, shut down its own production and began importing them from Mexico through an arrangement with Diosynth (a small Mexican company

neg: RBC Bank Investing remained subsidiaries of RBC. RBC later returned to offering retail banking services to American customers with its acquisition of Los Angeles-based City National Bank in 2015. RBC Bank RBC Bank is the trading name of RBC Bank (Georgia), N.A., the United States-based retail banking division of the Royal Bank of Canada (RBC) which is targeted toward Canadian snowbirds, expatriates, and frequent tourists. The brand name was originally used by (formerly RBC Centura), formed in 2001 when RBC acquired the Raleigh, North Carolina-based Centura Bank. In 2012, RBC Bank USA's banking division for American clients was sold to PNC Financial

neg: Triple-alpha process and process gave very significant support to Hoyle's hypothesis of stellar nucleosynthesis, which posited that all chemical elements had originally been formed from hydrogen, the true primordial substance. The anthropic principle has been cited to explain the fact that nuclear resonances are sensitively arranged to create large amounts of carbon and oxygen in the universe. With further increases of temperature and density, fusion processes produce nuclides only up to nickel-56 (which decays later to iron); heavier elements (those beyond Ni) are created mainly by neutron capture. The slow capture of neutrons, the s-process, produces about half of elements beyond iron.

neg: Clandestine chemistry Known as a "club drug", the National Institute on Drug Abuse tracks its incidence of use in children as young as twelve, and the prevalence of users increases with age. In the 1980s and early 1990s, most methamphetamine production in the United States occurred in small independent laboratories. Phenylacetone, one precursor of methamphetamine, became a Schedule II controlled immediate precursor in 1979. Underground chemists searched for alternative methods for producing methamphetamine. The two predominant methods which appeared both involve the reduction of ephedrine or pseudoephedrine to methamphetamine. At the time, neither was a watched chemical, and pills containing the substance

neg: Hypothermia is often associated with paradoxical undressing. Researchers in Germany claim this is "obviously an autonomous process of the brain stem, which is triggered in the final state of hypothermia and produces a primitive and burrowing-like behavior of protection, as seen in hibernating animals". This happens mostly in cases where temperature drops slowly. Hypothermia usually occurs from exposure to low temperatures, and is frequently complicated by alcohol consumption. Any condition that decreases heat production, increases heat loss, or impairs thermoregulation, however, may contribute. Thus, hypothermia risk factors include: substance abuse (including alcohol abuse), homelessness, any condition that affects judgment (such as

neg: Acipimox plasma and their inflow into the liver. Consequently, VLDL cholesterol production in the liver is reduced, which leads indirectly to a reduction in LDL and increase in HDL cholesterol. Acipimox is completely absorbed from the gut. It is not bound to blood plasma proteins and not metabolized. Elimination occurs in two phases, the first having a half-life of two hours, the second of 12 to 14 hours. The substance is eliminated via the kidney. Acipimox Acipimox (trade name Olbetam in Europe) is a niacin derivative used as a lipid-lowering agent. It reduces triglyceride levels and increases HDL cholesterol. It may

neg: RBC Bank RBC Bank RBC Bank is the trading name of RBC Bank (Georgia), N.A., the United States-based retail banking division of the Royal Bank of Canada (RBC) which is targeted toward Canadian snowbirds, expatriates, and frequent tourists. The brand name was originally used by (formerly RBC Centura), formed in 2001 when RBC acquired the Raleigh, North Carolina-based Centura Bank. In 2012, RBC Bank USA's banking division for American clients was sold to PNC Financial Services while RBC's cross-border banking services for Canadians were transferred to the newly incorporated RBC Bank (Georgia), N.A. subsidiary. On November 2, 1990, Peoples Bancorp and Planters

neg: Royal Brunei Catering It also provides ad hoc outside catering services, and industrial catering services to the Raja Istri Pengiran Anak Saleha (RIPAS) Hospital. There is also a small goods manufacturing operation which includes the production of the Alfresco brand Ice Cream, bread, pastries and cakes for RBC Bakery & Pastry and a range of RBC Delicatessen products such as retail burgers and sausages. Most of these activities are based at the Aircraft Catering Centre. In addition, Royal Brunei Catering also provides laundry and dry cleaning services via its chain of laundry shops. Royal Brunei Trading is a subsidiary of Royal Brunei Airlines.

neg: Pulpitis mastocyte degranulation. SP is highly expressed in dental pulp and dentin. When pain, thermal, and/or chemical stimulation is present, SP production and release increases. Current studies focus on whether controlling Substance P expression may control tooth pain. In addition, dental caries is more likely to develop pulpitis due to less time for the dental pulp to react and protect itself by occluding the dentinal tubules. Based on the tooth injury, sensory nerve fibers react to pulpitis by growing terminal branches into the adjacent surviving pulp, which also changes the cytochemical phenotype. This neural growth typically lasts few a few days

neg: Regulatory Barriers Clearinghouse Regulatory Barriers Clearinghouse The Regulatory Barriers Clearinghouse (RBC) collects, processes, assembles, and disseminates information on existing barriers that inhibit the production and conservation of affordable housing. RBC is part of the U.S. Department of Housing and Urban Development's (HUD's) Office of Policy Development and Research (PD&R) overall effort to help create cohesive, economically viable, and healthy communities. It was created in response to the American Homeownership and Economic Opportunity Act of 2000 and in recognition that as much as a third of the cost of a new home is driven by state and local regulations. RBC maintains a searchable online

neg: The Rubberbodies Collective dance performer, Athansia Kanellopoulou, on the production of, "Penelope: Dust of our awakened dreams" (MITP, Valletta). On the 23rd of March rbc member Mario Sammut (Cygna) performed Malta's first “silent concert”, held in a circa 5600-year-old temple, in collaboration with the French composer Vincent Villuis. Hagar Qim temples. In 2012, the rbc ran the performance Old Salt, a theatre work for Malta's National Art Festival that was made in collaboration with Liam Gauci of the National Maritime Museum. The Rubberbodies Collective The Rubberbodies Collective (RBC), stylised the rubberbodies collective, is a dance and theatre group that was founded on the

neg: Dual diagnosis more likely that an individual will initiate substance misuse at a younger age than their peers. They are also more likely to have a poorer outcome, such as longer time to remission, and increased psychiatric complications from substance misuse. While generally stimulant medications do not seem to worsen substance misuse, they are known to be abused in some cases. Psychosocial therapy and/or nonstimulant medications and extended release stimulants are ADHD treatment options that reduce these risks. Unlike ADHD, which significantly increases the risk of substance use disorder, autism spectrum disorder has the opposite effect of significantly reducing the risk of

neg: Beer in Italy and produced small amounts, but the systems of production were destroyed in various barbarian invasions. The first medical school, the Schola Medica Salernitana, praised the substance stating that it "supports old age, flows through the veins, increases well-being, and strengthens the blood." On the occasion of his wedding, Ludovico Sforza distributed beer freely to the Milanese. At this time, it was referred to in Florence as "barley wine". The first brewery in Italy, according to Hermes Zampollo, was "Spluga" in Chiavenna, which opened in 1840. However, the company Wührer stated that its brewing commenced in Brescia in 1829. The first

neg: Yelizaveta Osetinskaya connections to Vladimir Putin. Earlier that year, she was named a 2016-17 International John S. Knight Journalism Fellow at Stanford University. Yelizaveta Osetinskaya Yelizaveta Nikolayevna Osetinskaya (; born 3 May 1977, Moscow) is a Russian journalist and media manager. She is notable as a former editor-in-chief of the Russian edition of "Forbes" (2011-2013) and of RBC (2014-2016). Her reforms at RBC helped make it one of the most-cited Russian media holdings. Under her editorship, RBC emphasized investigative journalism, with highlights including the participation of Russian troops in the War in Donbass and the business connections of president Vladimir Putin's family.

neg: Hematopoietic stem cell niche (30 days post-conception) in humans. As the embryo requires rapid oxygenation due to its high mitotic activity, these islands are the main source of red blood cell (RBC) production via fusing endothelial cells (ECs) with the developing embryonic circulation. The hemangioblast theory, which posits that the RBCs and ECs derive from a common progenitor cell, was developed as researchers observed that receptor knockout mice, such as flk1-/-, exhibited defective RBC formation and vessel growth. A year later, Choi showed that blast cells derived from embryonic stem (ES) cells displayed common gene expression of both hematopoietic and endothelial precursors. However, Ueno

neg: Afrodisiac (song) pop and dance-pop influences, "Afrodisiac" was built along on a flute and a synthesised old-school drum machine groove. Critics also noted an “orchestra band feel with a definite Caribbean influence and some 1980s electro sound”, which incorporates a baby-cry sample, that bears resemblance to fellow Timbaland production "Are You That Somebody?", a recorded by Aaliyah in 1998. Backing vocals were inspired by Irish singer Enya. Lyrically, Norwood, as the female protagonist, expresses her addictive passion for a special person, whom she declares her very own aphrodisiac, a substance that increases her sexual desire. Speaking of what motivated her to record

neg: Rotating biological contactor RBC was installed in West Germany in 1959, later it was introduced in the United States and Canada. In the United States, rotating biological contactors are used for industries producing wastewaters high in biochemical oxygen demand (BOD) (e.g., petroleum industry and dairy industry). A properly designed RBC produced a very high quality final effluent. However both the organic and hydraulic loading had to be addressed. In the 1980's problems were encountered in the USA prompting the Environmental Agency to commission a number of reports. These reports identified a number of issues and criticized the RBC process. One author suggested that

neg: Altitude training Over the past thirty years, EPO has become frequently abused by competitive athletes through blood doping and injections in order to gain advantages in endurance events. Abuse of EPO, however, increases RBC counts beyond normal levels (polycythemia) and increases the viscosity of blood, possibly leading to hypertension and increasing the likelihood of a blood clot, heart attack or stroke. The natural secretion of EPO by the human kidneys can be increased by altitude training, but the body has limits on the amount of natural EPO that it will secrete, thus avoiding the harmful side effects of the illegal doping procedures.

neg: Royal Bank of Canada in English and "RBC Banque Royale" in French and serves approximately ten million clients through its network of 1,209 branches. "RBC Bank" is the U.S. banking subsidiary which formerly operated 439 branches across six states in the Southeastern United States, but now only offers cross-border banking services to Canadian travellers and expats. RBC also has 127 branches across seventeen countries in the Caribbean, which serve more than 16 million clients. RBC Capital Markets is RBC's worldwide investment and corporate banking subsidiary, while the investment brokerage firm is known as RBC Dominion Securities. Investment banking services are also provided through RBC

neg: Vapor pressure the temperature of a liquid increases, the kinetic energy of its molecules also increases. As the kinetic energy of the molecules increases, the number of molecules transitioning into a vapor also increases, thereby increasing the vapor pressure. The vapor pressure of any substance increases non-linearly with temperature according to the Clausius–Clapeyron relation. The atmospheric pressure boiling point of a liquid (also known as the normal boiling point) is the temperature at which the vapor pressure equals the ambient atmospheric pressure. With any incremental increase in that temperature, the vapor pressure becomes sufficient to overcome atmospheric pressure and lift the liquid

neg: Induced stem cells clinical requirements. Red blood cells (RBC)s generated in vitro from mobilized CD34 positive cells have normal survival when transfused into an autologous recipient. RBC produced in vitro contained exclusively fetal hemoglobin (HbF), which rescues the functionality of these RBCs. In vivo the switch of fetal to adult hemoglobin was observed after infusion of nucleated erythroid precursors derived from iPSCs. Although RBCs do not have nuclei and therefore can not form a tumor, their immediate erythroblasts precursors have nuclei. The terminal maturation of erythroblasts into functional RBCs requires a complex remodeling process that ends with extrusion of the nucleus and the

neg: Mean corpuscular hemoglobin concentration RBC density of 1g/mL and negligible haemoglobin in plasma. A low MCHC can be interpreted as identifying decreased production of hemoglobin. MCHC can be normal even when hemoglobin production is decreased (such as in iron deficiency) due to a calculation artifact. MCHC can be elevated ("polychromatic") in hereditary spherocytosis, sickle cell disease and homozygous haemoglobin C disease, depending upon the hemocytometer. MCHC can be elevated in some megaloblastic anemias. MCHC can be falsely elevated when there is agglutination of red cells (falsely lowering the measured RBC) or when there is opacifaction of the plasma (falsely increasing the measured hemoglobin). Causes

neg: Thermodynamic databases for pure substances slope of a plot of temperature vs. isobaric heat content (or the derivative of a temperature/heat content equation). The SI units for heat capacity are J/(mol·K). When heat is added to a condensed-phase substance, its temperature increases until a phase change temperature is reached. With further addition of heat, the temperature remains constant while the phase transition takes place. The amount of substance that transforms is a function of the amount of heat added. After the transition is complete, adding more heat increases the temperature. In other words, the enthalpy of a substance changes isothermally as it undergoes a physical

neg: Polypill pharmacy (governed at the state-level in the US). Technologies are under development to facilitate production of customized polypills, such as for example by the use of ink-jet printing mechanisms to precisely deposit selected drug substance(s) onto sheets which can then be inserted into capsules (enabling "individualized dosing and automated fabrication of medicines containing multiple drugs," in addition to custom single-drug products). Similar technology can also be used to print tablets, more directly. Ink-jet or fluid-jet approaches do require each drug substance to be dissolved in a liquid solvent, but they can be particularly conducive to custom formulation with various possible

neg: 13-Hydroxyoctadecadienoic acid These 15-LOX 1 effects appear due to the enzyme's production of 13("S")-HODE. The 15-LOX 1/13(S)-HODE axis also promotes the growth of prostate cancer in various animal models. In one animal model the pro-growth effects of 15-LOX 1 were altered by dietary targeting: increases in dietary linoleic acid, an omega-6 fatty acid, promoted while increases in dietary stearidonic acid, an omega-3 fatty acid reduced the growth of human prostate cancer explants. These effects could be due the ability of the linoleic acid diet to increase the production of the 15-Lox 1 metabolite, 13-HODE, and the ability of the stearidonic acid to

neg: Thermodynamic temperature wavelength increases (the photons' energy decreases). When the particles of a substance are as close as possible to complete rest and retain only ZPE-induced quantum mechanical motion, the substance is at the temperature of absolute zero ("T"=0). Note that whereas absolute zero is the point of zero thermodynamic temperature and is also the point at which the particle constituents of matter have minimal motion, absolute zero is not necessarily the point at which a substance contains zero thermal energy; one must be very precise with what one means by "internal energy". Often, all the phase changes that "can" occur in

neg: Anti-inflammatory Although many such foods contain the anti-inflammatory Omega-3 as well, low doses of Omega-6 interfere with Omega-3's ability to reduce inflammation, while higher doses are capable of completely inhibiting the effects of most currently-used anti-inflammatory agents (cyclooxygenase 1 inhibitors, cyclooxygenase 2 inhibitors, and antileukotrienes). The concomitant use of NSAIDs with alcohol and/or tobacco products significantly increases the already elevated risk of peptic ulcers during NSAID therapy. NSAID painkillers may interfere with and reduce the efficacy of SSRI antidepressants through inhibiting TNFα and IFNγ, both of which are cytokine derivatives. Anti-inflammatory Anti-inflammatory, or antiinflammatory, is the property of a substance or

neg: Percy Lavon Julian Illinois. On December 2, 1953, Pfizer acquired exclusive licenses of Glidden patents for the synthesis of Substance S. Pfizer had developed a fermentation process for microbial 11β-oxygenation of steroids in a single step that could convert Substance S directly to 11β-hydrocortisone (cortisol), with Syntex undertaking large-scale production of cortexolone at very low cost. Circa 1950, Julian moved his family to the Chicago suburb of Oak Park, becoming the first African-American family to reside there. Although some residents welcomed them into the community, there was also opposition. Before they even moved in, on Thanksgiving Day, 1950, their home was fire-bombed. Later,

neg: RBC (football club) season in the Vierde Klasse. One week after winning promotion, they won the championship in their division. After the end of the 2012–13 season it was announced that RBC would return to their old ground, the RBC Stadion for the 2013–14 season. After finishing second two years in a row, RBC won the Vierde Klasse in 2017 and it currently plays in the Derde Klasse which is after a reorganisation now the eighth tier in Dutch football (and the sixth tier in amateur football). RBC (football club) Roosendaal Boys Combinatie, commonly abbreviated to RBC (), is a Dutch football club

neg: Sickle cell disease in 2003. This is achieved, in part, by reactivating fetal haemoglobin production in place of the haemoglobin S that causes sickle cell anaemia. Hydroxyurea had previously been used as a chemotherapy agent, and there is some concern that long-term use may be harmful, but this risk has been shown to be either absent or very small and it is likely that the benefits outweigh the risks. Blood transfusions are often used in the management of sickle cell disease in acute cases and to prevent complications by decreasing the number of red blood cells (RBC) that can sickle by adding normal

neg: Bryan Pedersen program in order to compensate for projected future funding shortfalls. The plan drew the opposition of a fellow Republican legislator, Steve Harshman of Casper, who believes that Pedersen's proposal is beyond what is required to make sure the retirement system is solvent. Members of the Wyoming Senate Appropriations Committee are considering another plan which would remove cost-of-living allowances for certain retirement plans, limiting future benefit increases, and authorizing a study to recommend additional adjustments. Bryan Pedersen Bryan K. Pedersen (born January 27, 1975) is a financial consultant with RBC Wealth Management in the capital city of Cheyenne, Wyoming, who is

neg: Melting Melting Melting, or fusion, is a physical process that results in the phase transition of a substance from a solid to a liquid. This occurs when the internal energy of the solid increases, typically by the application of heat or pressure, which increases the substance's temperature to the melting point. At the melting point, the ordering of ions or molecules in the solid breaks down to a less ordered state, and the solid melts to become a liquid. Substances in the molten state generally have reduced viscosity as the temperature increases. An exception to this principle is the element sulfur,

neg: RBC (football club) became known as "Roosendaal Boys Combinatie" (RBC) because of the merger with "Roosendaalsche Boys". In 1955 the club turned professional and won the Tweede Divisie B in 1957. With the leagues restructured by the KNVB the club left professional football in 1971. Between the return to professional status in 1983 RBC was a successful amateur club. In 2000 the club reached the Eredivisie for the first time just for one season. Before 2001, RBC played its league games in stadium De Luiten, which had a capacity of 2,000 seats and 5,000 standing places. In 2001, RBC moved into its new

neg: Microbial drug delivery inflammation. The administration of IL-10 topically avoids systemic effects, such as immunosuppression in non-target tissues. When using LL-Thy12, IL-10 secretion is dependent on the quantity of live LL-Thy12 in the GI tract. As the presence of dietary thymidine increases the quantity of LL-Thy12, the drug production increases proportionately. Reductions in dietary thymidine kill LL-Thy12, decreasing the production of IL-10. There is a delay of approximately 72-hours between a change in thymidine dosage and the production of IL-10. Due to LL-Thy12’s dependence on thymidine, they will die upon exiting the body through defecation. "B. ovatus" has been used in animal studies

neg: RBC Bank Security First Network Bank which had only one office. The bank merged with Flag Bank, increasing its presence in Georgia. RBC continued to grow in the Southeast after acquiring 39 branches of Birmingham, Alabama-based AmSouth Bank on March 9, 2007. Previously, RBC Centura had no locations in Alabama. RBC's footprint in Alabama, Georgia, and Florida expanded significantly after its acquisition of Alabama National BanCorporation (ANB). RBC received U.S. approval February 5, 2008, and on April 14, 51 branches re-opened as RBC Bank. The remaining branches re-opened by June 2008. ANB operated in three states through eleven different subsidiaries. Construction of

neg: Value-form of "Capital, Volume III", good profits can be made by trading large quantities of goods quite fast below their value (the classical principle of competition). According to Ian Paul Wright, "Mirowski unfortunately misreads Marx's concept of substance." As the accumulation of capital grows, more and more durable and financial assets exist "external" to the sphere of production. When society becomes wealthier, the total value of the personally owned properties of individuals (assets owned by households) and public property increases, even if some people own little and others own a lot. Marx was primarily concerned with the value of newly produced

neg: RBC Bank those projects. But the company says the value of a Fresno project is less than the outstanding loan balance. Nine major lenders, including RBC, are owed a combined total of $196 million on Dunmore Homes' 26 new-home communities, according to the builder. On June 19, 2011, PNC Financial Services agreed to buy RBC Bank USA from Royal Bank of Canada for $3.45 billion. The sale of RBC Bank closed in March 2012. Upon acquisition, all RBC Bank branches were rebranded as PNC branches and the RBC Bank brand became dormant for US customers. RBC Insurance, RBC Wealth Management and RBC

neg: Tofu solution is a solution in which a material is evenly suspended in a liquid, more specifically, a non homogeneous mixture, in which one substance of microscopically dispersed insoluble particles is suspended throughout another substance. Tofu structure is related to soymilk components, particularly colloid components such as protein particles and oil globules. Protein particles content increases with the increase of the globulin ratio in the soybeans. Tofu varieties ensue from adding coagulants at various concentrations. The two main components of the soybean important in tofu making are the 11S component, containing glycinin and the 7S subunit, containing hemagglutinins, lipoxygenases, b-amylase, and

neg: Royal Bank of Canada largest sponsors of amateur sports and is the longest-running Canadian sponsor of the Olympic Games. It employ dozens of top-tier amateur athletes as part-time spokespeople through the RBC Olympians program. RBC is also a major sponsor of Hockey Canada and owns the naming rights to the Canadian national junior 'A' ice hockey championship, the Royal Bank Cup. In addition, it supports Canadian hockey at the grassroots level through the RBC Play Hockey program. RBC owns naming rights to the RBC Centre, RBC Convention Centre Winnipeg, RBC Canadian Open, and RBC Heritage (formerly the Heritage Classic). From 2002 to 2012, RBC

neg: Volumetric flow rate area through which the volume passes through, , and a unit vector normal to the area, . The relation is . The reason for the dot product is as follows. The only volume flowing "through" the cross-section is the amount normal to the area, that is, parallel to the unit normal. This amount is: where is the angle between the unit normal and the velocity vector of the substance elements. The amount passing through the cross-section is reduced by the factor . As increases less volume passes through. Substance which passes tangential to the area, that is perpendicular to the

neg: Anemia will remain an important element of classification and diagnosis. Limitations of MCV include cases where the underlying cause is due to a combination of factors – such as iron deficiency (a cause of microcytosis) and vitamin B12 deficiency (a cause of macrocytosis) where the net result can be normocytic cells. The "kinetic" approach to anemia yields arguably the most clinically relevant classification of anemia. This classification depends on evaluation of several hematological parameters, particularly the blood reticulocyte (precursor of mature RBCs) count. This then yields the classification of defects by decreased RBC production versus increased RBC destruction or loss. Clinical

neg: Hemolytic anemia circulation. In healthy individuals, the breakdown and removal of RBCs from the circulation is matched by the production of new RBCs in the bone marrow. In conditions where the rate of RBC breakdown is increased, the body initially compensates by producing more RBCs; however, breakdown of RBCs can exceed the rate that the body can make RBCs, and so anemia can develop. Bilirubin, a breakdown product of hemoglobin, can accumulate in the blood, causing jaundice. In general, hemolytic anemia occurs as a modification of the RBC life cycle. That is, instead of being collected at the end of its useful

neg: The Rubberbodies Collective The Rubberbodies Collective The Rubberbodies Collective (RBC), stylised the rubberbodies collective, is a dance and theatre group that was founded on the Mediterranean island of Malta in 2009 following a series of improvisational workshops and the subsequent production of Grace u Rofflu. Since 2010, The Rubberbodies Collective have been recognised as one of Malta's national creative groups and images of their work were included in the Maltese cultural policy. In 2012 The Rubberbodies Collective produced an interactive installation entitled -hEx: inverting geometry. This installation formed a part of Malta's, 2012 Science in the City, festival. The rbc also collaborated with

neg: Fearless (Jazmine Sullivan album) there is just as much depth". "Vibe"s Erika Ramirez praised Sullivan's singing and lyrical substance, writing "Sullivan's vocal perfection pilots her debut album... and boasts her self-penned lyrics which are filled with struggle and heartache, embodying every inch of the soul star she is". In his consumer guide for MSN Music, critic Robert Christgau gave "Fearless" a rating of honorable mention (), indicating "an enjoyable effort consumers attuned to its overriding aesthetic or individual vision may well treasure." "NOW"s Benjamin Boles commended Sullivan for her "strong voice" and the album's production, stating "she’s pulling from a pleasingly wide range of

neg: Linenizing Linenizing Linenizing is the process of impressing a linen-like pattern onto the surface of paper, cloth or other malleable substance. Linenizing is most frequently done on paper products and its use on paper products goes back to the early part of the 20th century. A paper roll is threaded between two hard rollers, usually made from steel. One or both of the steel rollers has a linen pattern engraved on it. As the nip pressure between the two hard rollers increases, the pattern from the engraved roller(s) is pressed into the paper. The end result is a pattern that looks

neg: Mitsubishi S-AWC compared to the Lancer Evolution IX. The prototype system also featured two additional components controlling suspensions and steering, which failed to make the production version of S-AWC system: Active Steering System realizes handling with more linear response by adaptively controlling front wheel turn angle according to steering input and vehicle speed. At slower vehicle speeds the system improves response by shifting to a quicker steering gear ratio, while at higher speeds it substantially improves stability by moving to a slower gear ratio. For rapid steering inputs, S-AWC momentarily increases front wheel turn angle and Super AYC control to realize sharper

neg: Chairman layer of management), while other vice chairs have more responsibilities but are otherwise on an equal tier with EVPs. Executives with the title vice chair and deputy chair are usually "not" members of the board of directors. The Royal Bank of Canada previously used "deputy chair" (i.e. Anthony S. Fell, Deputy Chairman of RBC, who was also Chairman and CEO of RBC Dominion Securities) and "vice chair" (i.e. Peter Currie, Vice Chairman and Chief Financial Officer) in their inner management circle until 2004. Chairman The chairman (also chair) is the highest officer of an organized group such as a board,

neg: Personality theories of addiction affect increases the likelihood of initiation of substance use, the negative affective states produced by withdrawal are the most commonly reported factors for continued use. Key to this concept is the Hedonic Hypothesis, which states that individuals initiate use of the substance or behaviour for their pleasurable effects, but then take it compulsively to avoid withdrawal symptoms, resulting in dependence. Based on this hypothesis, some researchers believe that individuals engaging in risky use of substances or behaviours may be over-responsing to negative stimuli, which leads to addiction. Negative affect has also been a powerful predictor in terms of vulnerability to

neg: Myo-inositol trispyrophosphate The substance has also been examined in the context of other illnesses involving hypoxia, such as cardiovascular disease and dementia Myo-inositol trispyrophosphate Myo-inositol trispyrophosphate (ITPP) is an inositol phosphate, a pyrophosphate, a drug candidate, and a putative performance-enhancing substance, which exerts its biological effects by increasing tissue oxygenation. ITPP is a pyrophosphate derivative of phytic acid with the molecular formula CHOP. ITPP is a membrane-permeant allosteric regulator of hemoglobin that mildly reduces its oxygen-binding affinity, which shifts the oxygen-hemoglobin dissociation curve to the right and thereby increases oxygen release from the blood into tissue. Phytic acid, in contrast, is not

neg: Pith and substance circumscribed. Cases relating to Pith and Substance.- Citation in the matter of M/s. Sky Gourmet Catering Private Limited V/s Tax Authorities (Commercial Tax and Service Tax) in the matter of Writ Appeal No. 671 to 726 of 2011 (T-Res) decided on 18th day of April, 2011 by Hon'ble High Court of Karnataka at Bangalore may also be seen. Pith and substance Pith and substance is a legal doctrine in Canadian constitutional interpretation used to determine under which head of power a given piece of legislation falls. The doctrine is primarily used when a law is challenged on the basis that

neg: Magnetohydrodynamic generator up the small losses for the non-supercritical connections. Because of the high temperatures, the non-conducting walls of the channel must be constructed from an exceedingly heat-resistant substance such as yttrium oxide or zirconium dioxide to retard oxidation. Similarly, the electrodes must be both conductive and heat-resistant at high temperatures. The AVCO coal-fueled MHD generator at the CDIF was tested with water-cooled copper electrodes capped with platinum, tungsten, stainless steel, and electrically conducting ceramics. MHD reduces overall production of hazardous fossil fuel wastes because it increases plant efficiency. In MHD coal plants, the patented commercial "Econoseed" process developed by the U.S.

neg: Economic production quantity can notice from the equations above that the total ordering cost decreases as the production quantity increases. Inversely, the total holding cost increases as the production quantity increases. Therefore, in order to get the optimal production quantity we need to set holding cost per year equal to ordering cost per year and solve for quantity (Q), which is the EPQ formula mentioned below. Ordering this quantity will result in the lowest total inventory cost per year. Economic production quantity The economic production quantity model (also known as the EPQ model) determines the quantity a company or retailer should order to

neg: Hylomorphism possesses at least one substantial form. It may also possess a variety of accidental forms. For Aristotle, a "substance" ("ousia") is an individual thing—for example, an individual man or an individual horse. The substantial form of substance S consists of S's essential properties, the properties that S's matter needs in order to be the kind of substance that S is. In contrast, S's accidental forms are S's non-essential properties, properties that S can lose or gain without changing into a different kind of substance. In some cases, a substance's matter will itself be a substance. If substance A is made

neg: Biopharmaceutical Medicines Agency in February 2006. This decision was reversed in June 2006 and approval was given August 2006. In the European Union, a biological medicinal product is one of the active substance(s) produced from or extracted from a biological (living) system, and requires, in addition to physico-chemical testing, biological testing for full characterisation. The characterisation of a biological medicinal product is a combination of testing the active substance and the final medicinal product together with the production process and its control. For example: In the United States, biologics are licensed through the biologics license application (BLA), then submitted to and

neg: Epigenetics of diabetes Type 2 re-methylated to form methionine, be taken into the cysteine biosynthetic pathway, or be freed into the extracellular medium. When a person lacks sulfur in their diet, it prompts the body to use methionine and form cysteine. This in turn increases the risk of a person contracting type 2 diabetes later in life. The reason behind this turns out to be rather simple. Methionine directly affects S-adenosyl methionine (SAM) levels. SAM is the substance that provides the methyl groups for DNA methylation. A shortage of SAM leads to an inability to develop proper methylation patterns, and is thought to be an

neg: Alcohol packaging warning messages of alcoholic beverages "reflect[s] a growing evidence base relating to the relationship between alcohol consumption and a range of health problems including cancer, diabetes, cardiovascular disease, overweight and obesity, liver disease, fetal abnormalities, cognitive impairment, mental health problems, and accidental injury". Even light and moderate alcohol consumption increases cancer risk in individuals. As of 2014, alcohol warning labels are required in many countries, including Brazil, Colombia, Costa Rica, France, Guatemala, Mexico, Russia, South Africa, Taiwan, Thailand, and the United States. Modern alcohol advertising promotes alcoholic beverages heavily “as though it was not a toxic substance”. The alcohol industry has tried

neg: Earl Jones (investment advisor) exposed a trail of professional and financial negligence, which directly assisted in the criminal prosecution and legal proceedings in the Quebec Superior Court against those professional and financial liaisons Jones leveraged to perpetrate his fraud. On July 15, 2010, some of Jones' victims were authorized by a Quebec Superior Court judge to launch a class action suit against his banker, Royal Bank of Canada (RBC). They allege that RBC knew or should have known that Jones was misusing his RBC account and failed to take corrective measures. RBC claims not to know that Jones was misrepresenting its role in his

neg: Suzanne Labarge Institutions. During her time with RBC, she served as the chief risk officer of RBC Capital Markets Corporation and RBC Capital Markets. Labarge served as the chief risk officer of Royal Bank of Canada until September 2004 and its executive vice president and corporate treasurer from 1995 to 1998. Labarge had served as the chief risk officer at RBC Financial Group and the vice chairman at RBC Capital Markets Corporation and RBC Capital Markets. She served as the vice chairman at RBC Financial Group. Labarge served as vice chairman of Royal Bank of Canada until September 2004. Labarge has been

neg: Myo-inositol trispyrophosphate Myo-inositol trispyrophosphate Myo-inositol trispyrophosphate (ITPP) is an inositol phosphate, a pyrophosphate, a drug candidate, and a putative performance-enhancing substance, which exerts its biological effects by increasing tissue oxygenation. ITPP is a pyrophosphate derivative of phytic acid with the molecular formula CHOP. ITPP is a membrane-permeant allosteric regulator of hemoglobin that mildly reduces its oxygen-binding affinity, which shifts the oxygen-hemoglobin dissociation curve to the right and thereby increases oxygen release from the blood into tissue. Phytic acid, in contrast, is not membrane-permeant due to its charge distribution. Rodent studies "in vivo" demonstrated increased tissue oxygenation and dose-dependent increases in endurance during

neg: RBC Centre named the RBC Centre and the neighbouring Ritz-Carlton Toronto as the two most beautiful buildings completed in the 21st century in Toronto. He praised their integration into the community, and how they have revived Wellington Street. RBC Centre RBC Centre, also known as the RBC Dexia Building, is an office tower in Toronto, Ontario, Canada. Unlike the corporate offices of other Canadian financial institutions, the RBC Centre is outside of Toronto's Financial District. It has been owned and managed by Cadillac Fairview Corporation jointly with the Ontario Pension Board since 2012. The building is connected to the PATH. RBC Centre's

neg: Heat capacity possible degrees of freedom, and thus the larger the number of degrees of freedom available to the particles of a substance "other" than translational kinetic energy, the larger will be the specific heat capacity for the substance. For example, rotational kinetic energy of gas molecules stores heat energy in a way that increases heat capacity, since this energy does not contribute to temperature. In addition, quantum effects require that whenever energy be stored in any mechanism associated with a bound system which confers a degree of freedom, it must be stored in certain minimal-sized deposits (quanta) of energy, or else

neg: Transport maximum Transport maximum In physiology, transport maximum (alternatively Tm or T) refers to the point at which increases in concentration of a substance do not result in an increase in movement of a substance across a cell membrane. In renal physiology, the concept of transport maximum is often discussed in the context of glucose and PAH. For both substances (as with all substances), the quantity "excreted" can be determined with the following equation: The proximal convoluted tubule of the nephron has protein channels that reabsorb glucose, and others that secrete para-aminohippuric acid (PAH). However, its ability to do so is proportionate

neg: Reaction inhibitor Reaction inhibitor A reaction inhibitor is a substance that decreases the rate of, or prevents, a chemical reaction. A catalyst, in contrast, is a substance that increases the rate of a chemical reaction. 2 → 2 + , which is catalyzed by heat, light, and impurities. An inhibitor can reduce the effectiveness of a catalyst in a catalysed reaction (either a non-biological catalyst or an enzyme). E.g., if a compound is so similar to (one of) the reactants that it can bind to the active site of a catalyst but does not undergo a catalytic reaction then that catalyst molecule

neg: Sirtuin 1 reproductive lifespan in yeast even in the absence of Sir2. In organisms more complicated than yeast, it appears that Sir2 acts by deacetylation of several other proteins besides histones. Resveratrol is a substance that has been shown through experiment to have a number of life-extending and health benefits in various species; it also increases the activity of Sir2, which is the postulated reason for its beneficial effects. Resveratrol is produced by plants when they are stressed, and it is possible that plants use the substance to increase their own Sir2 activity in order to survive periods of stress. Although there

neg: Thermal expansion Thermal expansion Thermal expansion is the tendency of matter to change in shape, area, and volume in response to a change in temperature. Temperature is a monotonic function of the average molecular kinetic energy of a substance. When a substance is heated, the kinetic energy of its molecules increases. Thus, the molecules begin vibrating/moving more and usually maintain a greater average separation. Materials which contract with increasing temperature are unusual; this effect is limited in size, and only occurs within limited temperature ranges (see examples below). The relative expansion (also called strain) divided by the change in temperature is called

neg: Quinaldine red since its binding increases the fluorescence without extra tags being needed. The dye's ability to bind to proteins makes it a great tag. Once bound to a protein, fluorescent signals are emitted which allow the strength of QR binding to the protein to be determined. Using this technique allows for many dynamic interactions to be understood. Another variation to detecting the QR probes is by measuring the fluorescence via a spectrofluorometer. This allows the concentration of the QR-substance (could be a protein or nucleic acids) to be measured. This also indirectly allows the binding ability of QR to the substance

neg: Clearance (pharmacology) of these equations can be found in e.g Rang and Dale's Pharmacology For substances that exhibit substantial plasma protein binding, clearance is generally dependent on the total concentration (free + protein-bound) and not the free concentration. Most plasma substances have primarily their free concentrations regulated, which thus remains the same, so extensive protein binding increases total plasma concentration (free + protein-bound). This decreases clearance compared to what would have been the case if the substance did not bind to protein. However, the mass removal rate is the same, because it depends only on concentration of free substance, and is independent

neg: Royal Bank of Canada & Trust Co. RBC installed its first computer in 1961, the first in Canadian banking. In the 1960s, RBC Insurance was created. In 1968, it merged with Ontario Loan and Debenture Company (formerly Ontario Savings and Investment Society). In 1993, RBC merged with Royal Trust. In 1998, RBC acquired Security First Network Bank in Atlanta—the first pure Internet bank. In 2000, RBC merged merchant credit/debit card acquiring business with BMO Bank of Montreal's to form Moneris Solutions. In 2013, RBC completed the acquisition of the Canadian subsidiary of Ally Financial. RBC Insurance is the largest Canadian bank-owned insurance organization, with

neg: RBC Capital Markets RBC Capital Markets RBC Capital Markets is a global investment bank providing services in banking, finance and capital markets to corporations, institutional investors, asset managers and governments globally. Locations span 70 offices in 15 countries across North America, the UK, Europe and the Asia-Pacific region. Employment estimates for RBC professionals are roughly 7,200 per company reports. Services provided include insights required to raise capital, access markets, mitigate risk and acquire or dispose of assets for clients worldwide. RBC Capital Markets is part of Royal Bank of Canada (RBC). Operating since 1869, RBC is the fifth largest in North America and

neg: Morphine-N-oxide the semi-synthetics such as heroin, dihydrocodeine, dihydromorphine, hydromorphone, and hydrocodone also have equivalent amine oxide derivatives. Morphine-"N"-Oxide has a DEA ACSCN of 9307 and annual production quota of 655 grammes in 2013. It is a Schedule I controlled substance in the US. Morphine-N-oxide Morphine-"N"-oxide (genomorphine) is an active opioid metabolite of morphine. Morphine itself, in trials with rats, acts 11–22 times more potent than morphine-"N"-oxide subcutaneously and 39–89 times more potent intraperitoneally. However, pretreatment with amiphenazole or tacrine increases the potency of morphine-"N"-oxide in relation to morphine (intraperitoneally more so than in subcutaneous administration). A possible explanation is that morphine-"N"-oxide

neg: Coalbed methane a compressor station and into natural gas pipelines. The produced water is either reinjected into isolated formations, released into streams, used for irrigation, or sent to evaporation ponds. The water typically contains dissolved solids such as sodium bicarbonate and chloride but varies depending on the formation geology. Coalbed methane wells often produce at lower gas rates than conventional reservoirs, typically peaking at near per day (about 0.100 m³/s), and can have large initial costs. The production profiles of CBM wells are typically characterized by a "negative decline" in which the gas production rate initially increases as the water is pumped

neg: Zimbabwe Broadcasting Corporation the government, with the RBC initially acquired a 51 per cent stake in the service, which became part of the RBC in 1976. RBC TV was funded by advertising and a television licence fee. Television reception was confined mainly to the large cities, and most viewers were whites. Umtali (now Mutare) only received television in 1972, by which time it was estimated that more than 90 per cent of the white population had access to the service. In 1965, the white minority government of Ian Smith issued a Unilateral Declaration of Independence, under which censorship of broadcasting and the press

neg: Urobilinogen obstructive jaundice or treatment with broad-spectrum antibiotics, which destroy the intestinal bacterial flora. (Obstruction of bilirubin passage into the gut or failure of urobilinogen production in the gut.) Low urine urobilinogen levels may result from congenital enzymatic jaundice (hyperbilirubinemia syndromes) or from treatment with drugs that acidify urine, such as ammonium chloride or ascorbic acid. Elevated levels may indicate hemolytic anaemia (excessive breakdown of red blood cells RBC), overburdening of the liver, increased urobilinogen production, re-absorption – a large hematoma, restricted liver function, hepatic infection, poisoning or liver cirrhosis. Urobilinogen ( D-urobilinogen) is closely related to two other compounds: mesobilirubinogen

neg: Drug policy of Virginia to prescribe nor dispense marijuana for any purpose. Drug policy of Virginia The U.S. state of Virginia has various policies restricting the production, sale, and use of several defined controlled substance. § 18.2-251.1 of the Code of Virginia states: "It is unlawful for any person knowingly or intentionally to possess marijuana unless the substance was obtained directly from dealer, or pursuant to, a valid prescription or order of a practitioner while acting in the course of his professional/s practice, or except as otherwise authorized by the Drug Control Act of World Dealers (§ 54.1-3400 et seq.)." Currently, the Code of

neg: Drug policy of Virginia Drug policy of Virginia The U.S. state of Virginia has various policies restricting the production, sale, and use of several defined controlled substance. § 18.2-251.1 of the Code of Virginia states: "It is unlawful for any person knowingly or intentionally to possess marijuana unless the substance was obtained directly from dealer, or pursuant to, a valid prescription or order of a practitioner while acting in the course of his professional/s practice, or except as otherwise authorized by the Drug Control Act of World Dealers (§ 54.1-3400 et seq.)." Currently, the Code of Virginia does not authorize medical providers nor pharmacies

neg: Silly Love Songs Street". "Silly Love Songs" has generally received positive reviews from critics, despite the common criticism of the song lacking substance. "AllMusic"'s Stephen Thomas Erlewine described the song, as well as its follow-up single, "Let 'Em In", as "so lightweight that their lack of substance seems nearly defiant." Music critic Robert Christgau called the two tracks "charming if lightweight singles", while "Rolling Stone" critic Stephen Holden said "Silly Love Songs" was "a clever retort whose point is well taken." John Bergstrom of "PopMatters" called the song "an exemplary piece of mid-‘70s pop production and a pure pleasure." In 1999, New Zealand

neg: Flubber (film) his wife, which he declares directly to Philip, though Philip takes it as a joke. Before he can make it to the wedding, his latest experiment shows fast development, forcing him to miss another wedding. The resulting substance created from the experiment is a living green goo that increases in speed as it bounces and proves to be difficult to control, wreaking havoc on the neighborhood before the professor finally manages to capture it. Weebo (voiced by Jodi Benson), Philip's hovering robot assistant, classifies the substance as "flying rubber", leading Philip to christen it as "Flubber". Philip continues to work

neg: Zenos E10 delivering @ 7,000 rpm and @ 2,500 rpm. Production began at the same time as for the E10. The E10 S accelerates from 0 to 60 mph (0–97 km/h) in 4.0 seconds, and can reach 145 mph (233 km/h). In September 2016, an upgrade kit was made available for the E10 S, which increases power to and torque to . The upgrade kit can be fitted to new or used cars and includes new air intake, modified intercooler and remapped ECU. This car with a higher-powered 2.3 L Ford EcoBoost engine, delivering @ 6,000 rpm and @ 4,000 rpm, was

neg: Stronger Futures policy funds Mobile Child Protection teams, the employment of twelve remote Aboriginal family and community workers, and the Youth in Communities Program, which help keep youth connected to school and away from substance abuse. Advocates of the Stronger Futures policy discuss how it encourages the livelihood of indigenous community members and increases the amount of services for Aboriginal families in the Northern Territory. Proponents of the Stronger Futures policy claim that it increases safety within Aboriginal communities of the Northern Territory. Members of the Australian Government, such as Jenny Macklin, Trish Crossin, Nicola Roxon, and Warren Snowden, say the policy will

neg: Personality theories of addiction addiction in adolescents. High-risk adolescents have been found to be highly reactive to negative stimuli, which increases their motivation to engage in substance use following a negative emotion-arousing situation. Moreover, it has been established that adolescents high in negative affect are at increased risk for moving from recreational use to problematic use despite a family history of addiction. Furthermore, the trait negative urgency, the propensity to engage in risky behaviour in response to distress, is highly predictive of certain aspects of substance abuse in adolescents. Early individual differences in emotional differences in reactivity and regulation underlie the later emergence of

neg: Behavioral epigenetics of rodents, via DNA methylation and histone modification. Epigenetic modifications have been observed in studies on rodents involving ethanol, nicotine, cocaine, amphetamine, methamphetamine and opiates. Specifically, these epigenetic changes modify gene expression, which in turn increases the vulnerability of an individual to engage in repeated substance overdose in the future. In turn, increased substance abuse results in even greater epigenetic changes in various components of a rodent's reward system (e.g., in the nucleus accumbens). Hence, a cycle emerges whereby changes in the pleasure-reward areas contribute to the long-lasting neural and behavioural changes associated with the increased likelihood of addiction, the