query: who was the first person to use penicillin

pos: History of penicillin and subsequently concentrated what he later named "penicillin". During the next twelve years, Fleming grew and distributed the original mold, which was eventually identified as "Penicillium notatum" (now known as "Penicillium chrysogenum"). He was unsuccessful in making a stable form of it for mass production. Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to treat sycosis (eruptions in beard follicles) with penicillin but was unsuccessful, probably because the drug did not penetrate deep enough. Moving on to ophthalmia neonatorum, a gonococcal infection in babies, he achieved the first cure on 25 November 1930. He cured four

pos: Penicillin November 19, 1999. In 1930, Cecil George Paine, a pathologist at the Royal Infirmary in Sheffield, attempted to use penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, and failed to cure a fifth. In 1939, Australian scientist Howard Florey (later Baron Florey) and a team of researchers (Ernst Boris Chain, Edward Abraham, Arthur Duncan Gardner, Norman Heatley, M. Jennings, J.

pos: Roaring Twenties Alexander Fleming discovered a substance that killed a number of disease-causing bacteria. In 1929, he named the new substance "penicillin". His publications were largely ignored at first, but it became a significant antibiotic in the 1930s. In 1930, Cecil George Paine, a pathologist at Sheffield Royal Infirmary, used penicillin to treat sycosis barbae, eruptions in beard follicles, but was unsuccessful. Moving on to ophthalmia neonatorum, a gonococcal infection in infants, he achieved the first recorded cure with penicillin, on November 25, 1930. He then cured four additional patients (one adult and three infants) of eye infections, but failed to cure

neg: Alexander Fleming period. Almroth Wright had predicted antibiotic resistance even before it was noticed during experiments. Fleming cautioned about the use of penicillin in his many speeches around the world. On 26 June 1945, he made the following cautionary statements: "the microbes are educated to resist penicillin and a host of penicillin-fast organisms is bred out ... In such cases the thoughtless person playing with penicillin is morally responsible for the death of the man who finally succumbs to infection with the penicillin-resistant organism. I hope this evil can be averted." He cautioned not to use penicillin unless there was a properly

neg: Martin Henry Dawson prepare it and use it in human disease. This included the successful treatment of bacterial endocarditis with penicillin, and the use of gold salts in the treatment of rheumatoid arthritis. Dawson became the first person in history to stick a needle full of an antibiotic (penicillin) into a patient, on October 16, 1940. After he had graduated Dalhousie University in Halifax with a BA in 1916 he started serving in the Canadian forces in the First World War. Pte. M. Henry Dawson was with No. 7 Stationary Hospital at La Harve, France. He became a Capt. in the Nova Scotia

neg: Penicillin Penicillin Penicillin (PCN or pen) is a group of antibiotics which include penicillin G (intravenous use), penicillin V (use by mouth), procaine penicillin, and benzathine penicillin (intramuscular use). Penicillin antibiotics were among the first medications to be effective against many bacterial infections caused by staphylococci and streptococci. They are still widely used today, though many types of bacteria have developed resistance following extensive use. About 10% of people report that they are allergic to penicillin; however, up to 90% of this group may not actually be allergic. Serious allergies only occur in about 0.03%. All penicillins are β-lactam antibiotics. Penicillin

neg: Mary Percy Jackson was as good as everyone said it was, and whether it was safe. She decided she would give some of it to the next person who was so sick that she was sure that person would die, having no more she could do for that person. This proved to be a little native girl with pneumonia, whom Jackson believed would not live through the night. She mixed the penicillin and gave a small amount to the girl her every three hours until she was better. The child markedly improved with every hour after beginning the injections of penicillin, and went

neg: Syphilis to penicillin; due to the risk of birth defects, these are not recommended for pregnant women. Resistance to macrolides, rifampicin, and clindamycin is often present. Ceftriaxone, a third-generation cephalosporin antibiotic, may be as effective as penicillin-based treatment. It is recommended that a treated person avoid sex until the sores are healed. For neurosyphilis, due to the poor penetration of benzathine penicillin into the central nervous system, those affected are given large doses of intravenous penicillin for a minimum of 10 days. If a person is allergic to penicillin, ceftriaxone may be used or penicillin desensitization attempted. Other late presentations may

neg: Alvin Ingram in 1944, it housed 3,286 GI–patients. The U.S. Army designated Bushnell Hospital as the military’s first center for the study of penicillin’s possible use. On April 1, 1943, the first shipment of penicillin arrived at Bushnell, and during the War, it administered penicillin more than any other institution in the United States. In addition to administering some of the first doses of penicillin, Ingram promoted its use to the surrounding Brigham community. In speech by then-Captain Alvin Ingram to the Rotary Club of Brigham City, he explained how penicillin was discovered in 1928 by Alexander Fleming, and extolled recent successes

neg: Penicillin competitively inhibits the excretion of penicillin, increasing penicillin's concentration and prolonging its activity. Eventually, the advent of mass-production techniques and semi-synthetic penicillins resolved the supply issues, so this use of probenecid declined. Probenecid is still useful, however, for certain infections requiring particularly high concentrations of penicillins. After World War II, Australia was the first country to make the drug available for civilian use. In the U.S., penicillin was made available to the general public on March 15, 1945. The chemical structure of penicillin was first proposed by Edward Abraham in 1942 and was later confirmed in 1945 using X-ray crystallography

neg: Scarlet fever reason for prompt treatment with antibiotics is the ability to prevent transmission of the infection between children. An infected individual is most likely to pass on the infection to another person during the first 2 weeks. A child is no longer contagious (able to pass the infection to another child) after 24 hours of antibiotics. The antibiotic of choice is penicillin V which is taken by mouth in pill form. Children who are not able to take pills can be given amoxicillin which comes in a liquid form and is equally effective. Duration of treatment is 10 days. Benzathine Penicillin

neg: Penicillin lactose does not. The pH and the levels of nitrogen, lysine, phosphate, and oxygen of the batches must also be carefully controlled. The biotechnological method of directed evolution has been applied to produce by mutation a large number of "Penicillium" strains. These techniques include error-prone PCR, DNA shuffling, , and strand-overlap PCR. Semisynthetic penicillins are prepared starting from the penicillin nucleus 6-APA. Overall, there are three main and important steps to the biosynthesis of penicillin G (benzylpenicillin). Penicillin Penicillin (PCN or pen) is a group of antibiotics which include penicillin G (intravenous use), penicillin V (use by mouth), procaine penicillin,

neg: Antistaphylococcal penicillins and the reasons for this are historical. Antistaphylococcal penicillins Antistaphylococcal penicillins are a class of Beta lactam antibiotics used to treat infections caused by bacteria. Penicillin resistance in "Staphylococcus aureus" appeared very soon after penicillin entered general clinical use in 1943, and the mechanism of resistance was the production of β-lactamase. Modification of the penicillin molecule so that it was resistant to being broken down by β-lactamase was able to temporarily overcome this problem. These compounds became known as antistaphylococcal penicillins. The first of these compounds was methicillin, which is no longer in general use. The range of these penicillins

neg: Antistaphylococcal penicillins Antistaphylococcal penicillins Antistaphylococcal penicillins are a class of Beta lactam antibiotics used to treat infections caused by bacteria. Penicillin resistance in "Staphylococcus aureus" appeared very soon after penicillin entered general clinical use in 1943, and the mechanism of resistance was the production of β-lactamase. Modification of the penicillin molecule so that it was resistant to being broken down by β-lactamase was able to temporarily overcome this problem. These compounds became known as antistaphylococcal penicillins. The first of these compounds was methicillin, which is no longer in general use. The range of these penicillins available in each country is very different,

neg: Lyme disease in various types of skin lesions, including EM. Although his conclusions were later shown to be erroneous, interest in the study of spirochetes was sparked. In 1949, Nils Thyresson, who also worked at the Karolinska Institute, was the first to treat ACA with penicillin. In the 1950s, the relationship among tick bite, lymphocytoma, EM and Bannwarth's syndrome was recognized throughout Europe leading to the widespread use of penicillin for treatment in Europe. In 1970, a dermatologist in Wisconsin named Rudolph Scrimenti recognized an EM lesion in a patient after recalling a paper by Hellerström that had been reprinted in an

neg: Blake Colburn Wilbur portion of the population between Atherton and Mountain View. Wilbur's practice extended beyond. "Patients would come from Eureka to Fresno to see Dr. Wilbur". (Dr. Lawrence Basso, Interview, May 2011.) During the World War II war years Wilbur was the first to use penicillin on a patient at the Clinic. In an interview about the early years of PAMC, Lee explained that the founding partners divided up their profits informally. Each person was asked to suggest the amount that he or she deserved for the year, "It had this effect: They were modest about what they put down" Lee added,

neg: Penicillamine of penicillin but has no antibiotic properties itself. A variety of penicillamine–copper complex structures are known. John Walshe first described the use of penicillamine in Wilson's disease in 1956. He had discovered the compound in the urine of patients (including himself) who had taken penicillin, and experimentally confirmed that it increased urinary copper excretion by chelation. He had initial difficulty convincing several world experts of the time (Denny Brown and Cumings) of its efficacy, as they held that Wilson's disease was not primarily a problem of copper homeostasis but of amino acid metabolism, and that dimercaprol should be used as

neg: Penicillin amidase Penicillin amidase Also called penicillin acylase. In enzymology, a penicillin amidase () is an enzyme that catalyzes the chemical reaction Thus, the two substrates of this enzyme are penicillin and HO, whereas its two products are carboxylate and 6-aminopenicillanate. This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is penicillin amidohydrolase. Other names in common use include penicillin acylase, benzylpenicillin acylase, novozym 217, semacylase, alpha-acylamino-beta-lactam acylhydrolase, and ampicillin acylase. This enzyme participates in penicillin and cephalosporin biosynthesis. As of late 2007,

neg: Howard Florey Howard Florey Howard Walter Florey, Baron Florey, (24 September 189821 February 1968) was an Australian pharmacologist and pathologist who shared the Nobel Prize in Physiology or Medicine in 1945 with Sir Ernst Chain and Sir Alexander Fleming for his role in the development of penicillin. Although Fleming received most of the credit for the discovery of penicillin, it was Florey who carried out the first ever clinical trials in 1941 of penicillin at the Radcliffe Infirmary in Oxford on the first patient, a constable from Oxford. The patient started to recover but subsequently died because Florey was unable, at that

neg: Production of antibiotics of said antibiotic determines what one is attempting to produce. An example of semi-synthetic production involves the drug ampicillin. A beta lactam antibiotic just like penicillin, ampicillin was developed by adding an addition amino group (NH) to the R group of penicillin. This additional amino group gives ampicillin a broader spectrum of use than penicillin. Methicillin is another derivative of penicillin and was discovered in the late 1950s, the key difference between penicillin and methicillin being the addition of two methoxy groups to the phenyl group. These methoxy groups allow methicillin to be used against penicillinase producing bacteria that would

neg: Cloxacillin Cloxacillin Cloxacillin is an antibiotic useful for the treatment of a number of bacterial infections. This includes impetigo, cellulitis, pneumonia, septic arthritis, and otitis externa. It is not effective for methicillin-resistant "Staphylococcus aureus" (MRSA). It is used by mouth and by injection. Side effects include nausea, diarrhea, and allergic reactions including anaphylaxis. "Clostridium difficile" diarrhea may also occur. It is not recommended in people who have previously had a penicillin allergy. Use during pregnancy appears to be relatively safe. Cloxacillin is in the penicillin family of medications. Cloxacillin was patented in 1960 and approved for medical use in 1965. It

neg: History of penicillin (now Sandoz) developed the first acid-stable penicillin for oral administration, Penicillin V. American chemist John C. Sheehan of the Massachusetts Institute of Technology (MIT) subsequently completed the first chemical synthesis of penicillin in 1957. The second-generation semi-synthetic β-lactam antibiotic methicillin, designed to counter first-generation-resistant penicillinases, was introduced in the United Kingdom in 1959. Methicillin-resistant forms of "Staphylococcus aureus" likely already existed at the time. History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about

neg: Side effects of penicillin test is typically performed by an allergist who uses a skin-prick and intradermal injection of penicilloyl-polylysine, a negative control (normal saline), and a positive control (histamine). There is a common side effect that can develop when other medications are used. This is the development of cross sensitivities to other antibiotics. If someone has developed side effects when taking penicillin, these side effects may develop with a new medication even though the person has not taken the new medication before. Those medications that may cause a cross sensitivity reaction are: carbapenems, ampicillin, cefazolin, cephalosporins and cloxacillin. Common adverse drug reactions (≥

neg: Penicillin found in the broth filtrate. Despite this, he remained interested in the potential use of penicillin and presented a paper entitled "A Medium for the Isolation of Pfeiffer's Bacillus" to the Medical Research Club of London, which was met with little interest and even less enthusiasm by his peers. Had Fleming been more successful at making other scientists interested in his work, penicillin for medicinal use would possibly have been developed years earlier. Despite the lack of interest of his fellow scientists, he did conduct several experiments on the antibiotic substance he discovered. The most important result proved it was

neg: Antibiotic use in dentistry associated with a higher incidence of drug rashes than penicillin and thus, should not be prescribed to patients suffering from Infectious mononucleosis or lymphocytic leukaemia as there is a higher risk of developing a drug rash. Erythromycin: This is a wide spectrum antibiotic that has a similar range on the antibacterial spectrum to penicillin, making it the ideal first choice if patients are allergic to penicillin. It is also useful for treatment against B-lactamase-producing bacteria although it is not particularly as effective against oral and dental infections, due to such infections usually being caused by obligate anaerobes. Cephalosporin: This is

neg: Penicillium chrysogenum in the fungus that would lead to an increase in penicillin yield. The effort was successful, and a mutant strain that yielded more than a thousand times the penicillin of Fleming's original culture was produced and cultured. This discovery, in combination with vastly improved methods of culturing the fungus based on the principle of aerating the culture medium, resulted in the ability to mass-produce penicillin in quantities great enough for distribution and mass use in the United States Army, and also in the British army during the World War II. The ability to produce penicillin appears to have evolved over

neg: Penicillin active against gram-negative bacteria than benzylpenicillin. Benzylpenicillin, procaine penicillin and benzathine penicillin can only be given by intravenous or intramuscular injections, but phenoxymethylpenicillin can be given by mouth because of its acidic stability. While the number of penicillin-resistant bacteria is increasing, penicillin can still be used to treat a wide range of infections caused by certain susceptible bacteria, including Streptococci, Staphylococci, Clostridium, Neisseria, and Listeria genera. The following list illustrates minimum inhibitory concentration susceptibility data for a few medically significant bacteria: Common (≥ 1% of people) adverse drug reactions associated with use of the penicillins include diarrhoea, hypersensitivity, nausea, rash,

neg: Erythromycin reactions. It is generally safe in those who are allergic to penicillin. Erythromycin also appears to be safe to use during pregnancy. While generally regarded as safe during breastfeeding its use by the mother during the first two weeks of life may increase the risk of pyloric stenosis in the baby. This risk also applies if taken directly by the baby during this age. It is in the macrolide family and works by decreasing bacterial protein production. Erythromycin was first isolated in 1952 from the bacteria "Saccharopolyspora erythraea". It is on the World Health Organization's List of Essential Medicines, the

neg: Antibiotic use in dentistry of bacteria from advanced caries. The first line of treatment is the removal of the source of inflammation or infection by local operative measures. Generally, the abscess can be eradicated through surgical drainage alone; however this is sometimes inadequate. Therefore, systemic antibiotic treatment may be required, but only if there is evidence of spreading infection. As the bacteria involved are known, antibiotic therapy selection can be specific, based on published susceptibilities. Penicillin in the form of amoxicillin is the most common antibiotic to use. However, 3% of the patient population is allergic to penicillin, so erythromycin is often used in

neg: Side effects of penicillin 1% of people) associated with use of the penicillins include diarrhoea, hypersensitivity, nausea, rash, neurotoxicity, urticaria, and superinfection (including candidiasis). Infrequent adverse effects (0.1–1% of people) include fever, vomiting, erythema, dermatitis, angioedema, seizures (especially in people with epilepsy), and pseudomembranous colitis. When penicillin is used at high doses hypokalemia, metabolic acidosis, and hyperkalemia can occur. Developing hypernatremia after administering high doses of penicillin can be a serious side effect. The side effects of penicillin can be altered by taking other medications at the same time. Taking oral contraceptives along with penicillin may lower the effects of the contraceptive. When probenecid

neg: History of penicillin long periods in their hearth lofts before embarking on military campaigns in order to make a poultice of the cakes to treat wounds. In 17th-century Poland, wet bread was mixed with spider webs (which often contained fungal spores) to treat wounds. The technique was mentioned by Henryk Sienkiewicz in his 1884 book "With Fire and Sword". In England in 1640, the idea of using mold as a form of medical treatment was recorded by apothecaries such as John Parkinson, King's Herbarian, who advocated the use of mold in his book on pharmacology. The modern history of penicillin research begins in

neg: John Charles Cutler killed syphilis bacterium, would protect prisoners against infection when he later exposed them to the bacterium. Those infected were later treated with penicillin. Cutler became assistant surgeon general in 1958. In the 1960s, Cutler was involved in the ongoing Tuskegee syphilis experiment, during which several hundred African-American men who had contracted syphilis were observed, but left untreated. In “The Deadly Deception”, the 1993 "Nova" documentary about the Tuskegee experiments, Cutler states, “It was important that they were supposedly untreated, and it would be undesirable to go ahead and use large amounts of penicillin to treat the disease, because you’d interfere

neg: Phenoxymethylpenicillin Phenoxymethylpenicillin Phenoxymethylpenicillin, also known as penicillin V and penicillin VK, is an antibiotic useful for the treatment of a number of bacterial infections. Specifically it is used for the treatment of strep throat, otitis media, and cellulitis. It is also used to prevent rheumatic fever and to prevent infections following removal of the spleen. It is given by mouth. Side effects include diarrhea, nausea, and allergic reactions including anaphylaxis. It is not recommended in those with a history of penicillin allergy. It is relatively safe for use during pregnancy. It is in the penicillin and beta lactam family of medications.

neg: History of penicillin History of penicillin The history of penicillin follows a number of observations and discoveries of apparent evidence of antibiotic activity in molds before the modern isolation of the chemical penicillin in 1928. There are anecdotes about ancient societies using molds to treat infections, and in the following centuries many people observed the inhibition of bacterial growth by various molds. However, it is unknown if the species involved were "Penicillium" species or if the antimicrobial substances produced were penicillin. The Scottish physician Alexander Fleming was the first to suggest that a "Penicillium" mold must secrete an antibacterial substance, and the first

neg: Ceftriaxone reported. It has also been reported to cause post renal failure in children. Like other antibiotics, ceftriaxone use can result in "Clostridium difficile"-associated diarrhea ranging from mild diarrhea to fatal colitis. Ceftriaxone should not be used in those with an allergy to ceftriaxone or any component of the formulation. Although there is negligible cross-reactivity between penicillins and third-generation cephalosporins, caution should still be used when using ceftriaxone in penicillin-sensitive patients. Caution should be used in people who have had previous severe penicillin allergies. It should not be used in hyperbilirubinemic neonates, particularly those who are premature because ceftriaxone is reported

neg: History of syphilis was supported by the U.S. Public Health Service (PHS) in partnership with the Tuskegee Institute. The study began in 1932, when syphilis was a widespread problem and there was no safe and effective treatment. The study was designed to measure the progression of untreated syphilis. By 1947, penicillin had been shown to be an effective cure for early syphilis and was becoming widely used to treat the disease. Its use in later syphilis, however, was still unclear. Study directors continued the study and did not offer the participants treatment with penicillin. This is debated, and some have found that penicillin

neg: History of penicillin to concentrate the active substance involved, which he named penicillin, in 1928. Penicillin was the first modern antibiotic. During the next twelve years Fleming grew, distributed, and studied the original mold, which was determined to be a rare variant of "Penicillium notatum" (now "Penicillium chrysogenum"). Many later scientists were involved in the stabilization and mass production of penicillin and in the search for more productive strains of "Penicillium". Important contributors include Ernst Chain, Howard Florey, Norman Heatley, and Edward Abraham. Shortly after the discovery of penicillin, scientists found that some disease-causing pathogens display antibiotic resistance to penicillin. Research that aims

neg: Penicillin synthesis was 6-aminopenicillanic acid (6-APA), the nucleus of penicillin. Attaching different groups to the 6-APA 'nucleus' of penicillin allowed the creation of new forms of penicillin. The narrow range of treatable diseases or "spectrum of activity" of the penicillins, along with the poor activity of the orally active phenoxymethylpenicillin, led to the search for derivatives of penicillin that could treat a wider range of infections. The isolation of 6-APA, the nucleus of penicillin, allowed for the preparation of semisynthetic penicillins, with various improvements over benzylpenicillin (bioavailability, spectrum, stability, tolerance). The first major development was ampicillin in 1961. It offered a

neg: Penicillin (band) Penicillin (band) Penicillin (stylized as PENICILLIN) is a Japanese visual kei alternative rock band, formed in Tokyo in 1992. Formed by friends at Tokai University in Tokyo, Japan on February 14, 1992. Penicillin began with Chisato on vocals, Gisho on bass, O-Jiro on drums and both Yuuji and Shaisuke on guitar. Before anything was recorded however the band's line-up changed to Hakuei on vocals, Gisho on bass, O-Jiro on drums and both Shaisuke and Chisato on guitar. Their name was taken from the punk rock group "Penicillin Shock" in the manga series "To-y" and they titled their first album, which

neg: Antibiotic Edward Abraham succeeded in purifying the first penicillin, penicillin G, in 1942, but it did not become widely available outside the Allied military before 1945. Later, Norman Heatley developed the back extraction technique for efficiently purifying penicillin in bulk. The chemical structure of penicillin was first proposed by Abraham in 1942 and then later confirmed by Dorothy Crowfoot Hodgkin in 1945. Purified penicillin displayed potent antibacterial activity against a wide range of bacteria and had low toxicity in humans. Furthermore, its activity was not inhibited by biological constituents such as pus, unlike the synthetic sulfonamides. (see below) The development of

neg: Penicillin by Dorothy Crowfoot Hodgkin, who was also working at Oxford. She later received the Nobel prize for this and other structure determinations. Chemist John C. Sheehan at the Massachusetts Institute of Technology (MIT) completed the first chemical synthesis of penicillin in 1957. Sheehan had started his studies into penicillin synthesis in 1948, and during these investigations developed new methods for the synthesis of peptides, as well as new protecting groups—groups that mask the reactivity of certain functional groups. Although the initial synthesis developed by Sheehan was not appropriate for mass production of penicillins, one of the intermediate compounds in Sheehan's

neg: Albert Alexander (police officer) were fearful of the side effects large doses of penicillin might have. For a human volunteer, they needed a patient who was in a terminal condition; Constable Alexander suited this requirement. On 12 February 1941, Constable Alexander was given an intravenous infusion of 160 mg (200 units) of penicillin. Within 24 hours, Alexander's temperature had dropped, his appetite had returned and the infection had begun to heal. However, due to the instability of penicillin and the war-time restrictions placed on Florey's laboratory, only a small quantity of penicillin had been extracted and, although Florey and colleagues extracted any remaining penicillin

neg: Gonorrhea him/her. The United States' Centers for Disease Control and Prevention (CDC) currently recommend that individuals who have been diagnosed and treated for gonorrhea avoid sexual contact with others until at least one week past the final day of treatment in order to prevent the spread of the bacterium. Many antibiotics that were once effective including penicillin, tetracycline, and fluoroquinolones are no longer recommended because of high rates of resistance. Resistance to cefixime has reached a level such that it is no longer recommended as a first-line agent in the United States, and if it is used a person should be

neg: History of biotechnology society could be met by fermenting agricultural waste was an important ingredient of the "chemurgic movement." Fermentation-based processes generated products of ever-growing utility. In the 1940s, penicillin was the most dramatic. While it was discovered in England, it was produced industrially in the U.S. using a deep fermentation process originally developed in Peoria, Illinois. The enormous profits and the public expectations penicillin engendered caused a radical shift in the standing of the pharmaceutical industry. Doctors used the phrase "miracle drug", and the historian of its wartime use, David Adams, has suggested that to the public penicillin represented the perfect health

neg: Animal bite for dog and cat bites of the hand, and human bites if they are more than superficial. They are also recommended in those who have poor immune function. Evidence for antibiotics to prevent infection in bites in other areas is not clear. The first choice is amoxicillin with clavulanic acid, and if the person is penicillin-allergic, doxycycline and metronidazole. The antistaphylococcal penicillins (e.g., cloxacillin, nafcillin, flucloxacillin) and the macrolides (e.g., erythromycin, clarithromycin) are not used for empirical therapy, because they do not cover "Pasteurella" species. Rabies prevention is generally available in North America and the Northern European states. Tetanus toxoid

neg: Cefalexin effective against infections caused by methicillin-resistant "Staphylococcus aureus" (MRSA), "Enterococcus", or "Pseudomonas". Like other antibiotics, cefalexin cannot treat viral infections, such as the flu, common cold or acute bronchitis. Cefalexin can be used in those who have mild or moderate allergies to penicillin. However, it is not recommended in those with severe penicillin allergies. Common side effects include stomach upset and diarrhea. Allergic reactions or infections with "Clostridium difficile", a cause of diarrhea, are also possible. Use during pregnancy or breast feeding does not appear to be harmful to the baby. It can be used in children and those over

neg: World War II U.S. Military Sex Education Isles (USAFBI) received special attention from the Medical Department. The units were directed, in cooperation with local authorities, to establish the first off-base Prophylactic Stations and trace the contacts of servicemen who became infected. American units were warned to keep everything as tactful as possible, and to use general terms such as U.S. Army Aid Station, instead of Prophylactic Station. Despite the measures taken, v.d. spread among the troops, and even with rapid and effective treatment, including the use of sulfa drugs and penicillin, the cost to the Army was heavy due to lost time from duty, diversion of medical

neg: William Frankland (allergist) edited by Fleming. Although largely content with the initial draft, Fleming is reported to have replaced Frankland's closing comment that "due to increased use, allergy to penicillin is expected to increase" with "due to increased purity [of production], allergy to penicillin is likely to decrease." Frankland has since acknowledged that Fleming may have been "partly right" because the quality of penicillin production at the time was poor. In 1954, Frankland published "Prophylaxis of summer Hay-fever and Asthma". The article reported the results of a trial involving 200 patients with previous histories of grass pollen sensitivity half treated with active vaccines,

neg: Norman Heatley to a PhD in 1936, and he then moved to Oxford where he became a fellow of Lincoln College at the University of Oxford and joined a team working under Howard Florey, which also included Ernst Chain. Alexander Fleming had first discovered penicillin by accident in 1928, but at that time believed it had little application. When Florey and his team recognised the potential of the discovery for combating bacterial infection, they faced the problem of how to manufacture penicillin in sufficient quantities to be of use. Heatley, although the junior member of the team, possessed a natural gift for

neg: Streptococcal pharyngitis for people with severe penicillin allergies. First-generation cephalosporins may be used in those with less severe allergies and some evidence supports cephalosporins as superior to penicillin. Streptococcal infections may also lead to acute glomerulonephritis; however, the incidence of this side effect is not reduced by the use of antibiotics. The symptoms of strep throat usually improve within three to five days, irrespective of treatment. Treatment with antibiotics reduces the risk of complications and transmission; children may return to school 24 hours after antibiotics are administered. The risk of complications in adults is low. In children, acute rheumatic fever is rare

neg: Cefazolin are involved. It is indicated for use in the following infections: It can also be used peri-operatively to prevent infections post-surgery, and is often the preferred drug for surgical prophylaxis. There is no penetration into the central nervous system and therefore cefazolin is not effective in treating meningitis. Cefazolin has been shown to be effective in treating methicillin-susceptible "Staphylococcus aureus" (MSSA) but does not work in cases of methicillin-resistant "Staphylococcus aureus" (MRSA). In many instances of staphylococcal infections, such as bacteremia, cefazolin is an alternative to penicillin in patients who are allergic to penicillin. However, there is still potential for

neg: Iroquois Iroquois take a compound decoction of the Carex oligosperma as an emetic before running or playing lacrosse. They also use Waldsteinia fragarioides taking a compound decoction of the plants as a blood remedy, and applying a poultice of the smashed plants to snakebites. The Iroquois also used quinine, chamomile, ipecac, and a form of penicillin. The Iroquois have historically followed a matriarchal system. No person is entitled to 'own' land, but it is believed that the Creator appointed women as stewards of the land. Traditionally, the Clan Mothers appoint leaders, as they have raised children and are therefore held to

neg: Procaine benzylpenicillin benzylpenicillin is in the penicillin and beta lactam family of medications. It works via benzylpenicillin and results in bacterial death. Procaine makes the combination long acting. Procaine benzylpenicillin was introduced for medical use in 1948. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.09–0.18 per day. In the United States a course of treatment costs $100–200. Specific indications for procaine penicillin include: At high doses procaine penicillin can cause seizures and CNS abnormalities due to procaine present

neg: Lake Norconian Club occurred at the hospital; first use of penicillin for tubercular patients, first air transportation of Naval patients across the United States with final destination in Norco, first uses of polio vaccine outside of Pittsburgh, first hand-held X-ray machines, as well as advances in prosthetic devices and occupational therapy. Actress Kay Francis was in charge of hospital morale, and she saw to it that many of the stars who frequented the resort now entertained the patients; including The Three Stooges, the Marx Brothers, Abbott and Costello, Jack Benny, Harry James, Marlene Dietrich, Gary Cooper, Kay Kyser, James Cagney, Clark Gable and

neg: Rationing in the United States panics, such as flashlights and batteries after Pearl Harbor. Scarce medicines such as penicillin were rationed by triage officers in the US military during World War II. Civilian hospitals received only small amounts of penicillin during the war, because it was not mass-produced for civilian use until after the war. A triage panel at each hospital decided which patients would receive the penicillin. The work of issuing ration books and exchanging used stamps for certificates was handled by some 5,500 local ration boards of mostly volunteer workers selected by local officials. Many levels of rationing went into effect. Some items,

neg: Atlantic slave trade treated with simple antibiotics such as penicillin and other medications that can inhibit and rid the body of harmful bacteria. The trade of enslaved Africans in the Atlantic has its origins in the explorations of Portuguese mariners down the coast of West Africa in the 15th century. Before that, contact with African slave markets was made to ransom Portuguese who had been captured by the intense North African Barbary pirate attacks on Portuguese ships and coastal villages, frequently leaving them depopulated. The first Europeans to use enslaved Africans in the New World were the Spaniards, who sought auxiliaries for their

neg: Metrical phonology The tree in (1) represents the metrical structure for the sentence "Doctors use penicillin". when the sentence is providing all new information. This is called broad focus, and might be used in response to a question like "What did you learn at the hospital today?" The same metrical structure would be used when the sentence has narrow focus on the word 'penicillin'; for example, if it was used in response to a question like "What do doctors use to treat that disease?". However, we need a new metrical structure to put narrow focus on the word 'doctors', for example, if

neg: Staphylococcus aureus can no longer catalyze the formation of the cross-links. As a result, cell wall formation and degradation are imbalanced, thus resulting in cell death. In most countries, however, penicillin resistance is extremely common, and first-line therapy is most commonly a penicillinase-resistant β-lactam antibiotic (for example, oxacillin or flucloxacillin, both of which have the same mechanism of action as penicillin). Combination therapy with gentamicin may be used to treat serious infections, such as endocarditis, but its use is controversial because of the high risk of damage to the kidneys. The duration of treatment depends on the site of infection and on

neg: Orismology for "paintbrush", which is "penicillus". "Methicillin", a type of penicillin, gained its name by attaching the stem "-cillin" (from the United States Adopted Names Council's list of stems) to a prefix "meth" which has no inherent meaning. The study of penicillin and methicillin individually would be an etymological study of terminology. However, the study of methicillin as its name derived from penicillin historically might best be described, according to Elk, as "orismologic". Elk's use of the words "orismology" and "terminology" echo the historical notions of Kirby and Spence rather than modern disciplinary senses of these words. Orismology does not entail

neg: Orvan Hess Orvan Hess Orvan Walter Hess (June 18, 1906 – September 6, 2002) was an American physician noted for his early use of penicillin and the development of the fetal heart monitor. Hess was born in Baoba, Pennsylvania. At the age of two, after his mother's death, the family moved to Margaretville, New York where he grew up. Hess was inspired by Doctor Gordon Bostwick Maurer—who started Margaretville's first hospital in 1925— to study medicine. He married Dr. Maurer's sister, Carol Maurer, in 1928. Hess went to Lafayette College and was graduated in 1927, and received his MD from the University

neg: Penicillin was discovered in 1928 by Scottish scientist Alexander Fleming. People began using it to treat infections in 1942. There are several enhanced penicillin families which are effective against additional bacteria; these include the antistaphylococcal penicillins, aminopenicillins and the antipseudomonal penicillins. They are derived from "Penicillium" fungi. The term "penicillin" is often used generically to refer to benzylpenicillin (penicillin G, the original penicillin found in 1928), procaine benzylpenicillin (procaine penicillin), benzathine benzylpenicillin (benzathine penicillin), and phenoxymethylpenicillin (penicillin V). Procaine penicillin and benzathine penicillin have the same antibacterial activity as benzylpenicillin but act for a longer period of time. Phenoxymethylpenicillin is less

neg: History of penicillin patients (one adult, the others infants) of eye infections, although a fifth patient was not so lucky. At Oxford, Howard Walter Florey organized a large and very skilled biochemical research team, notable among them Ernst Boris Chain and Norman Heatley, to undertake clinical trials and produce a stable penicillin in quantity. In 1940, Chain and Edward Abraham reported the first indication of antibiotic resistance to penicillin, an "E. coli" strain that produced the penicillinase enzyme, which was capable of breaking down penicillin and completely negating its antibacterial effect. Between 1941 and 1943, Moyer, Coghill and Raper at the USDA Northern

neg: Antibiotic use in dentistry cases of hypersensitivity. Studies conducted to investigate the effects of antibiotics on patients with acute periapical periodontitis and acute apical abscess showed that patients receiving antibiotics in addition to root canal treatment did not have a reduced level of inflammation as compared to the patients not receiving antibiotics. However the available research on this topic is not of optimal quality therefore the results are not entirely reliable. Phenoxymethyl Penicillin: Penicillin-based antibiotics are used commonly against a broad range of bacterial infections within the body, primarily due to non-toxic effects and minor side effects. In dentistry, phenoxymethyl penicillin is used as

neg: Rheumatic fever use of antibiotics will not alter cardiac involvement in the development of rheumatic fever. Some suggest the use of benzathine benzylpenicillin. Monthly injections of long-acting penicillin must be given for a period of five years in patients having one attack of rheumatic fever. If there is evidence of carditis, the length of therapy may be up to 40 years. Another important cornerstone in treating rheumatic fever includes the continual use of low-dose antibiotics (such as penicillin, sulfadiazine, or erythromycin) to prevent recurrence. While corticosteroids are often used, evidence to support this is poor. Salicylates are useful for pain. Steroids are

neg: Acute infectious thyroiditis a combination of a penicillin and a beta-lactamase inhibitor. However, in patients with a penicillin allergy, clindamycin or a macrolide can be prescribed. The majority of anaerobic organisms involved with AIT are susceptible to penicillin. Certain Gram-negative bacilli (ex: "Prevotella", "Fusobacteria", and "Porphyromonas") are exhibiting an increased resistance based on the production of beta-lactamase. Patients who have undergone recent penicillin therapy have demonstrated an increase in beta-lactamase-producing (anaerobic and aerobic) bacteria. Clindamycin, or a combination of metronidazole and a macrolide, or a penicillin combined with a beta-lactamase inhibitor is recommended in these cases. Fungal thyroiditis can be treated with amphotericin

neg: Cardiobacterium hominis penicillin and penicillin derivatives such as ampicillin. However, penicillin-resistant strains, including those that produce beta-lactamases, have been described with increasing frequency. Clinical guidelines thus recommend that "C. hominis" and other HACEK organisms be presumed to harbor ampicillin resistance and therefore be treated with a third-generation cephalosporin. "C. hominis" and other HACEK organisms also exhibit "in vitro" susceptibility to trimethoprim-sulfamethoxazole, fluoroquinolones, and aztreonam. "C. hominis" is often resistant to erythromycin. Since cefotaxime use may be not appropriate for "C. hominis" endocarditis, an alternative regimen might include association of co-amoxiclav and gentamicin. Cardiobacterium hominis Cardiobacterium hominis is a Gram-negative bacillus (rod-shaped) bacterium

neg: Orvan Hess most-used tests in obstetrics. The original machine still resides today in the basement of a building just outside the city of Hartford called the "Hartford Medical Society." Orvan Hess Orvan Walter Hess (June 18, 1906 – September 6, 2002) was an American physician noted for his early use of penicillin and the development of the fetal heart monitor. Hess was born in Baoba, Pennsylvania. At the age of two, after his mother's death, the family moved to Margaretville, New York where he grew up. Hess was inspired by Doctor Gordon Bostwick Maurer—who started Margaretville's first hospital in 1925— to study

neg: Pen-Strep Pen-Strep Pen-Strep (syn. Penicillin-Streptomycin) is a mixture of penicillin and streptomycin widely used in mammalian cell culture media to prevent bacterial contamination. The solution contains 5,000 Units of Penicillin G (sodium salt) which acts as the active base, and 5,000 micrograms of Streptomycin (sulfate) (base per milliliter), formulated in 0.85% saline. In general, 50-100 Units of Pen-Strep per milliliter of media is used to avoid contamination in cell culture. Thus, the retail product is generally 100 X more concentrated. It is recommended for use in cell culture applications at a concentration of 10 ml per Liter. It is the most

neg: Meningeal syphilis syphilis uses penicillin, which has been an effective treatment used since the 1940s. Other forms also include Benzathine penicillin, which is usually used for primary and secondary syphilis (it has no resistance to penicillin however). Benzathine penicillin is used for long acting form, and if conditions worsen, penicillin G is used for late syphilis. The Jarisch-Herxheimer reaction, which is the response to the body after endotoxins are released by the death of harmful organisms in the human body, starts usually during the first day of antibiotic treatment. The reaction increases the person's body temperature, decreases the overall blood pressure (both

neg: Gladys Lounsbury Hobby to the war effort. Hobby died of a heart attack in 1993 at her home in a Pennsylvania retirement community. Hobby is recognized for her work in creating a form of penicillin that was effective on human hosts. In 1940, Hobby and her colleagues, Dr. Karl Meyer and Dr. Martin Henry Dawson, wrote to Howard Florey and Ernst Chain to procure a sample of penicillin. They naively decided to make some penicillin and soon became experts in the fermentation process, and began refining it into a drug. Hobby, Meyer, and Dawson performed the first tests of penicillin on humans in

neg: Benzylpenicillin of penicillin allergy. Use during pregnancy is generally safe. It is in the penicillin and β-lactam class of medications. Benzylpenicillin was discovered in 1929 by Alexander Fleming and came into commercial use in 1942. It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system. The wholesale cost in the developing world is about US$0.24–2.72 per day. In the United States a course of treatment costs $100–200. As an antibiotic, benzylpenicillin is noted to possess effectiveness mainly against Gram-positive organisms. Some Gram-negative organisms such as "Neisseria gonorrhoeae" and "Leptospira

neg: Deacetoxycephalosporin-C synthase Deacetoxycephalosporin-C synthase In enzymology, a deacetoxycephalosporin-C synthase () is an enzyme that catalyzes the chemical reaction The 3 substrates of this enzyme are penicillin N, 2-oxoglutarate, and O, whereas its 4 products are deacetoxycephalosporin C, succinate, CO, and HO. This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with 2-oxoglutarate as one donor, and the other dehydrogenated. The systematic name of this enzyme class is penicillin-N,2-oxoglutarate:oxygen oxidoreductase (ring-expanding). Other names in common use include DAOCS, penicillin

neg: Penicillin Orr-Ewing and G. Sanders) at the Sir William Dunn School of Pathology, University of Oxford made progress in showing the "in vivo" bactericidal action of penicillin. In 1940, they showed that penicillin effectively cured bacterial infection in mice. In 1941, they treated a policeman, Albert Alexander, with a severe face infection; his condition improved, but then supplies of penicillin ran out and he died. Subsequently, several other patients were treated successfully. In December 1942, survivors of the Cocoanut Grove fire in Boston were the first burn patients to be successfully treated with penicillin. By late 1940, the Oxford team under

neg: Lincosamides found to accumulate in highest concentrations in the kidneys when compared to other tissues, while clindamycin was found in highest concentrations within the lungs. Clindamycin accumulates in macrophages and other white blood cells, which can result in concentrations 50 times higher than plasma levels. Lincosamides are often used clinically as an alternative antibiotic for patients who are allergic to penicillin. Of the lincosamides, clindamycin is most commonly used within the clinic due to its higher bioavailability, higher oral absorption and efficacy within the target organism spectrum. Lincosamides are generally the first-choice use antibiotic class in veterinary microbiology, most commonly used

neg: Antibiotic resistance in gonorrhea Antibiotic resistance in gonorrhea The Gonorrhea bacterium Neisseria gonorrhoeae has developed antibiotic resistance to many antibiotics. The bacteria was first identified in 1879, although some Biblical scholars believe that references to the disease can be found as early as Parshat Metzora of the Old Testament. In the 1940s effective treatment with penicillin became available, but by the 1970s resistant strains predominated. Resistance to penicillin has developed through two mechanisms: chromasomally mediated resistance (CMRNG) and penicillinase-mediated resistance (PPNG). CMRNG involves step wise mutation of penA, which codes for the penicillin-binding protein (PBP-2); mtr, which encodes an efflux pump that removes penicillin

neg: John C. Sheehan John C. Sheehan John Clark Sheehan (23 September 1915 – 21 March 1992) was an American organic chemist whose work on synthetic penicillin led to tailor-made forms of the drug. After nine years of hard work at the Massachusetts Institute of Technology (M.I.T.), he became the first to discover a practical method for synthesizing penicillin V. While achieving total synthesis, Sheehan also produced an intermediate compound, 6-aminopenicillanic acid, which turned out to be the foundation of hundreds of kinds of synthetic penicillin. Dr. Sheehan's research on synthetic penicillin paved the way for the development of customized forms of the lifesaving

neg: History of penicillin Regional Research Laboratory (NRRL) in Peoria, Illinois, United States, developed methods for industrialized penicillin production and isolated higher-yielding strains of the "Penicillium" fungus. In December 1942, survivors of the Cocoanut Grove fire in Boston were the first burn patients to be successfully treated with penicillin. Simultaneous research by Jasper H. Kane and other Pfizer scientists in Brooklyn developed the practical, deep-tank fermentation method for production of large quantities of pharmaceutical-grade penicillin. Dorothy Hodgkin determined the correct chemical structure of penicillin using X-ray crystallography at Oxford in 1945. In Kundl, Tyrol, Austria, in 1952, Hans Margreiter and Ernst Brandl of Biochemie

neg: Josep Trueta use of a new plaster cast method for the treatment of open wounds and fractures helped save a great number of lives during several wars. Trueta formed part of a group of Catalans exiled in the United Kingdom who denounced the situation of Catalonia under Franco's regime. He wrote "The Spirit of Catalonia", a book aimed at explaining Catalan history to English-speaking society. He joined the team run by Florey and Chain that developed penicillin in Oxford, and held the first live animal to be injected with the revolutionary antibiotic. from 1949 to 1966 he was the third Nuffield Professor

neg: Jenapharm Although the institute had been founded in 1944 with just 9 employees, Hans Knöll produced there the first batch of penicillin made in Germany, right before the end of the war. In 1948 the institute was producing 10 billion IUs of penicillin per month. In the late 1940s rickets was rampant amongst the children in the Soviet-occupied zone. In 1949 Alfred Schubert, who first developed a method of synthesis of vitamin D at the Friedrich-Schiller University, set up and industrial process that produced about 10 kg/year of Vitamin D. (Vitamin D was superseded by vitamin D 10 years later). In

neg: Margaret Jennings (scientist) Margaret Jennings (scientist) Margaret Augusta Jennings (2 December 1904, Swanbourne – 14 November 1994), née Margaret Augusta Fremantle, was a British scientist who was part of the group at the University of Oxford under Howard Florey who worked on the clinical application of penicillin. Margaret Jennings joined the University of Oxford's Sir William Dunn School of Pathology under Howard Florey in 1936. By 1938, she was part of the team led by Florey investigating the production and applications of penicillin. Jennings undertook animal work as well as research on bacteriology. As part of testing, Jennings assayed the toxicity of penicillin

neg: Percival Bazeley Christmas of 1943, the first Australian penicillin had arrived in New Guinea to save countless lives. In the months to follow, enormous quantities of penicillin were produced in the primitive CSL plant, and Australia can boast of being the first country in the world to have had penicillin available for its civilian population, having met not only the needs of its own defence forces, but also those of the American allies in the southwest Pacific. It was during this period that Captain Bazeley's promotion as Major occurred, and the familiar black beret of the Armoured Corps was replaced by the

neg: Alexander Fleming developed a method of purifying penicillin to an effective first stable form in 1940, several clinical trials ensued, and their amazing success inspired the team to develop methods for mass production and mass distribution in 1945. Fleming was modest about his part in the development of penicillin, describing his fame as the "Fleming Myth" and he praised Florey and Chain for transforming the laboratory curiosity into a practical drug. Fleming was the first to discover the properties of the active substance, giving him the privilege of naming it: penicillin. He also kept, grew, and distributed the original mould for twelve

neg: Norman Heatley Heatley who realised that the most effective vessel for this purpose was something like the porcelain bedpans in use at the Radcliffe Infirmary. These were in short supply because of wartime, so Heatley designed a modified version which was manufactured in the Potteries. With the help of these, the Oxford laboratory became the first penicillin factory, and subsequent tests on human beings proved the efficacy of the new treatment. Even so, it was very difficult to produce enough for sustained treatment. In December 1940, a 43-year-old Police Constable, Albert Alexander, was accidentally scratched by a rose thorn on his mouth,

neg: Oxacillin using vancomycin. The use of oxacillin is contraindicated in individuals that have experienced a hypersensitivity reaction to any medication in the penicillin family of antibiotics. Cross-allergenicity has been documented in individuals taking oxacillin that experienced a previous hypersensitivity reaction when given cephalosporins and cephamycins. Commonly reported adverse effects associated with the use of oxacillin include skin rash, diarrhea, nausea, vomiting, hematuria, agranulocytosis, eosinophilia, leukopenia, neutropenia, thrombocytopenia, hepatotoxicity, acute interstitial nephritis, and fever. High doses of oxacillin have been reported to cause renal, hepatic, and nervous system toxicity. Common to all members of the penicillin class of drugs, oxacillin may cause

neg: Howard Florey be treated with smaller quantities. Florey's research team investigated the large-scale production of the mould and efficient extraction of the active ingredient, succeeding to the point where, by 1945, penicillin production was an industrial process for the Allies in World War II. However, Florey said that the project was originally driven by scientific interests, and that the medicinal discovery was a bonus: Florey shared the Nobel Prize in Physiology or Medicine in 1945 with Ernst Boris Chain and Alexander Fleming. Fleming first observed the antibiotic properties of the mould that makes penicillin, but it was Chain and Florey who developed

neg: Oriol Mitjà He conducted a randomized trial and published in 'The Lancet' that revealed that a single-dose oral azithromycin is effective to cure yaws and is easier and safer to administer as compared to the standard treatment with injectable penicillin. Accordingly, the World Health Organization (WHO) changed the treatment policies to recommend the use of azithromycin as the first-line treatment for yaws. Mitjà is currently Assistant Professor at the Institute of Global Health of Barcelona, Special Adviser in Neglected Tropical Diseases to the WHO, and Honorary Senior Lecturer in Public Health at the School of Medicine and Health Sciences of the University

neg: Side effects of penicillin some are uncommon and serious and others are rare. The route of administration of penicillin can have an effect on the development of side effects. An example of this is irritation and inflammation that develops at a peripheral infusion site when penicillin is administered intravenously. In addition, penicillin is available in different forms. There are different penicillin medications (penicillin G benzathine, penicillin G potassium, Penicillin G sodium, penicillin G procaine, and penicillin V) as well as a number of β-lactam antibiotics derived from penicillin (e.g. amoxicillin) generally also referred to as "penicillin". Side effects may only last for a short

neg: Tonsillitis however, symptoms may last for up to two weeks. If the tonsillitis is caused by group A streptococcus, then antibiotics are useful, with penicillin or amoxicillin being primary choices. Cephalosporins and macrolides are considered good alternatives to penicillin in the acute setting. A macrolide such as erythromycin is used for people allergic to penicillin. Individuals who fail penicillin therapy may respond to treatment effective against beta-lactamase producing bacteria such as clindamycin or amoxicillin-clavulanate. Aerobic and anaerobic beta lactamase producing bacteria that reside in the tonsillar tissues can "shield" group A streptococcus from penicillins. Chronic cases can be treated with tonsillectomy

neg: Cefazolin susceptible: Cefazolin is pregnancy category B, indicating general safety for use in pregnancy. Caution should be used in breastfeeding as a small amount of cefazolin enters the breast milk. Cefazolin can be used prophylactically against perinatal Group B streptococcal infection (GBS). Although penicillin and ampicillin are the standard of care for GBS prophylaxis, penicillin-allergic women with no history of anaphylaxis can be given cefazolin instead. These patients should be closely monitored as there is a small chance of an allergic reaction due to the similar structure of the antibiotics. There has been no established safety and effectiveness for use in

neg: Kay's Tutor v Ayrshire & Arran Health Board the effect that penicillin was the cause of the boy's deafness came from Mr Williams, a neuro-surgeon. His theory that penicillin injected intrathecally would itself have a destructive effect on the auditory nerve was rejected by the Lord Ordinary. The Lord Ordinary, however, developed his own theory, which was not put to any of the expert medical witnesses who gave evidence for the respondents nor was it canvassed at all at the hearing. The First Division of the Court of Session held that the appellant was not entitled to succeed on the basis of this theory and this decision has

neg: Catalytic triad secondary hydroxyl of threonine in a manner analogous to the use of the serine primary hydroxyl. However, due to the steric interference of the extra methyl group of threonine, the base member of the triad is the "N"-terminal amide which polarises an ordered water which, in turn, deprotonates the catalytic hydroxyl to increase its reactivity. Similarly, there exist equivalent 'serine only' and 'cysteine only' configurations such as penicillin acylase G and penicillin acylase V which are evolutionarily related to the proteasome proteases. Again, these use their "N"-terminal amide as a base. This unusual triad occurs only in one superfamily of

neg: Aztreonam if the patient is allergic to a certain cephalosporin known as ceftazidime. Aztreonam exhibits cross-reactivity with this cephalosporin due to a similar side chain. Physicians should evaluate prior allergy history when prescribing this medicine. Special caution is warranted in patients who are allergic to ceftazidime and are subsequently placed on aztreonam therapy. Aztreonam is similar in action to penicillin. It inhibits muropeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking. It has a very high affinity for penicillin-binding protein-3 and mild affinity for penicillin-binding protein-1a. Aztreonam binds the penicillin-binding proteins of Gram-positive and anaerobic bacteria very poorly and

neg: Oxacillin Oxacillin Oxacillin sodium (trade name Bactocill) is a narrow-spectrum beta-lactam antibiotic of the penicillin class developed by Beecham. Oxacillin is a penicillinase-resistant β-lactam. It is similar to methicillin, and has replaced methicillin in clinical use. Other related compounds are nafcillin, cloxacillin, dicloxacillin, and flucloxacillin. Since it is resistant to penicillinase enzymes, such as that produced by "Staphylococcus aureus", it is widely used clinically in the US to treat penicillin-resistant "Staphylococcus aureus". However, with the introduction and widespread use of both oxacillin and methicillin, antibiotic-resistant strains called methicillin-resistant and oxacillin-resistant "Staphylococcus aureus" (MRSA/ORSA) have become increasingly prevalent worldwide. MRSA/ORSA is treated

neg: Manfred Bayer Manfred Bayer Dr. Manfred E Bayer (22 September 1928 – 27 February 2015) was a medical doctor and a microscopist, best known for his research in bacterial and viral infrastructure using electron microscopy. He was the first person to visualize yellow fever virus in cultured cells and to obtain ultra-thin sections of the cell wall of "E. coli" by penicillin. Bayer was born in Görlitz, Prussia. He joined the University of Kiel, Germany for higher studies in biology and obtained his degree in 1949. He studied medicine at the University of Hamburg, Germany. He completed his clinical training in 1953.

neg: Manfred Bayer Disease Association Inc. for his research on "Effects of Low Frequency Magnetic Fields on Borrelia burgdorferi." List of German scientists Manfred Bayer Dr. Manfred E Bayer (22 September 1928 – 27 February 2015) was a medical doctor and a microscopist, best known for his research in bacterial and viral infrastructure using electron microscopy. He was the first person to visualize yellow fever virus in cultured cells and to obtain ultra-thin sections of the cell wall of "E. coli" by penicillin. Bayer was born in Görlitz, Prussia. He joined the University of Kiel, Germany for higher studies in biology and obtained

neg: Antibiotic use in dentistry an example of a wide spectrum antibiotic that is relatively stable to staphylococcal penicillinase although this stability varies with different cephalosporins. Certain cephalosporins in dentistry can be administered orally while others can be given by injections. In the case of an allergy to penicillin, cephalosporins may be a suitable alternative. Metronidazole: This is an antimicrobial effective against some protozoa and strict anaerobes. In the UK, it has effective use in dentistry as it is the primary drug prescribed for acute ulcerative gingivitis. It is also sometimes used either alongside penicillin or alone against dentoalveolar infections with the advantage of having

neg: Nobel Prize controversies various infectious diseases". Fleming accidentally stumbled upon the then-unidentified fungal mold. However, some critics pointed out that Fleming did not in fact discover penicillin, that it was technically a rediscovery; decades before Fleming, Sir John Scott Burdon-Sanderson, William Roberts (physician), John Tyndall and Ernest Duchesne had already done studies and research on its useful properties and medicinal characteristics. Moreover, according to Fleming himself, the first known reference to penicillin was from Psalm 51: "Purge me with hyssop and I shall be clean". Meanwhile, he had learned from mycologist Charles Thom (the same who helped Fleming establish the identity of the

neg: Paddington isolated penicillin, earning the award of a Nobel Prize. The hospital has an Alexander Fleming Laboratory Museum where visitors can see Fleming's laboratory, restored to its 1928 condition, and explore the story of Fleming and the discovery and development of penicillin through displays and video. Edward Wilson, physician, naturalist and ornithologist, who died in 1912 on Captain Robert Scott's ill-fated British Antarctic expedition, had earlier practised as a doctor in Paddington. The former Senior Street primary school was renamed the Edward Wilson School after him in 1951. British painter Lucian Freud had his studio in Paddington, first at Delamere Terrace

neg: Andrew J. Moyer Andrew J. Moyer Andrew J. Moyer (November 30, 1899 – February 17, 1959) was an American microbiologist. He was a researcher at the USDA Northern Regional Research Laboratory in Peoria, Illinois. His group was responsible for the development of techniques for the mass production of penicillin. This led to the wide scale use of penicillin in World War II. Moyer was inducted into the National Inventors Hall of Fame in 1987. A scholarship fund was created in his name at the University of Maryland in 1977. Moyer was born in Star City, Indiana. He graduated from Wabash College with an

neg: Norman Heatley ingenuity and invention. It was he who suggested transferring the active ingredient of penicillin back into water by changing its acidity, this would purify the penicillin. Heatley recorded these trials, carried out on eight mice in May 1940, in his diary: On returning home, he realised that in haste and darkness, he had put his underpants on back to front, and noted this in his diary too, adding "It really looks as if penicillin may be of practical importance." In order to conduct tests on human patients, even more of the drug had to be produced, and again it was

neg: Penicillin caused by infected wounds among Allied forces, saving an estimated 12%–15% of lives. Availability was severely limited, however, by the difficulty of manufacturing large quantities of penicillin and by the rapid renal clearance of the drug, necessitating frequent dosing. Methods for mass production of penicillin were patented by Andrew Jackson Moyer in 1945. Florey had not patented penicillin, having been advised by Sir Henry Dale that doing so would be unethical. Penicillin is actively excreted, and about 80% of a penicillin dose is cleared from the body within three to four hours of administration. Indeed, during the early penicillin era,