query: placenta develops from the outer cells of the

pos: Placenta other organs and tissues are PEG10 and the cancer testis antigen PAGE4 expressed in cytotrophoblasts, CSH1and KISS1 expressed in syncytiotrophoblasts, and PAPPA2 and PRG2 expressed in extravillous trophoblasts. The placenta begins to develop upon implantation of the blastocyst into the maternal endometrium. The outer layer of the blastocyst becomes the trophoblast, which forms the outer layer of the placenta. This outer layer is divided into two further layers: the underlying cytotrophoblast layer and the overlying syncytiotrophoblast layer. The syncytiotrophoblast is a multinucleated continuous cell layer that covers the surface of the placenta. It forms as a result of differentiation and

pos: Human embryogenesis trophoblast then differentiates into an inner layer, the cytotrophoblast, and an outer layer, the syncytiotrophoblast. The cytotrophoblast contains cuboidal epithelial cells and is the source of dividing cells, and the syncytiotrophoblast is a syncytial layer without cell boundaries. The syncytiotrophoblast implants the blastocyst in the decidual epithelium by projections of chorionic villi, forming the embryonic part of the placenta. The placenta develops once the blastocyst is implanted, connecting the embryo to the uterine wall. The decidua here is termed the decidua basalis; it lies between the blastocyst and the myometrium and forms the maternal part of the placenta. The implantation

pos: Bilaminar blastocyst an outer and inner group of cells: the peripheral outer cell layer, the trophoblast, and the central inner cell mass, the embryoblast. The trophoblast goes on to become the fetal portion of the placenta and related extraembryonic membranes. The epiblast and hypoblast arise from the embryoblast and later give rise to the embryo proper and its affiliated extraembryonic membranes. Once the zygote has differentiated into 30 cells, it starts to form a fluid-filled central cavity called the blastocyst cavity (blastocoele). This cavity is essential because as the embryo continues to divide, the outer layer of cells grows very crowded and

pos: Cleavage (embryo) and used for genetic testing. Most of the blastomeres in this stage become polarized and develop tight junctions with the other blastomeres. This process leads to the development of two different populations of cells: Polar cells on the outside and apolar cells on the inside. The outer cells, called the trophoblast cells, pump sodium in from the outside, which automatically brings water in with it to the basal (inner) surface to form a blastocoel cavity in a process called compaction. The trophoblast cells will eventually give rise to the embryonic contribution to the placenta called the chorion. The inner cells

pos: Blastocyst end of the germinal stage of embryogenesis. The zygote develops by mitosis, and when it has developed into 16 cells becomes known as the morula. In many animals, though not in humans, the morula then develops by cavitation to become the blastula. Cellular differentiation then develops the blastula's cells into two types: trophoblast cells that surround the blastocoel and an inner mass of cells (the embryoblast). The conceptus is then known as the blastocyst. The side of the blastocyst where the inner cellular mass forms is called the animal pole, and the opposite side is the vegetal pole. The outer

pos: Pre-eclampsia pre-eclampsia while subsequent pregnancies by a different paternal donor had a higher risk of developing pre-eclampsia. In normal early embryonic development, the outer epithelial layer contains cytotrophoblast cells, a stem cell type found in the trophoblast that later differentiates into the fetal placenta. These cells differentiate into many placental cells types, including extravillous trophoblast cells. Extravillous trophoblast cells are an invasive cell type which remodel the maternal spiral arteries by replacing the maternal epithelium and smooth muscle lining the spiral arteries causing artery dilation. This prevents maternal vasoconstriction in the spiral arteries and allows for continued blood and nutrient supply

pos: Trophoblast Trophoblast Trophoblasts (from Greek "trephein": to feed, and "blastos": germinator) are cells forming the outer layer of a blastocyst, which provide nutrients to the embryo and develop into a large part of the placenta. They are formed during the first stage of pregnancy and are the first cells to differentiate from the fertilized egg. This layer of trophoblasts is also collectively referred to as "the trophoblast", or, after gastrulation, the trophectoderm, as it is then contiguous with the ectoderm of the embryo. The trophoblast proliferates and differentiates into 2 cell layers at approximately 6 days after fertilization for humans: Trophoblasts

pos: Blastocyst Blastocyst The blastocyst is a structure formed in the early development of mammals. It possesses an inner cell mass (ICM) which subsequently forms the embryo. The outer layer of the blastocyst consists of cells collectively called the trophoblast. This layer surrounds the inner cell mass and a fluid-filled cavity known as the blastocoele. The trophoblast gives rise to the placenta. The name "blastocyst" arises from the Greek βλαστός "blastos" ("a sprout") and κύστις "kystis" ("bladder, capsule"). In humans, blastocyst formation begins about 5 days after fertilization, when a fluid-filled cavity opens up in the morula, a ball of cells. The

pos: C19MC miRNA cluster C19MC miRNA cluster The C19MC miRNA cluster is a microRNA cluster consisting of 46 genes. These 46 genes encode 59 mature miRNAs. The C19MC miRNA cluster is only found in primate (including human) genomes and expresses miRNAs almost exclusively in the placenta, but also in testis, embryonic stem cells, and some tumors. They are also expressed highly in trophoblast-derived vesicles, including exosomes. C19MC miRNAs have been shown to be among the most expressed miRNAs in the human placenta and are also found in the serum of pregnant women. Trophoblast cells, found in the human placenta, produce many different types of

pos: Trophoblast are specialized cells of the placenta that play an important role in embryo implantation and interaction with the decidualised maternal uterus. The core of placental villi contain mesenchymal cells and placental blood vessels that are directly connected to the fetal circulation via the umbilical cord. This core is surrounded by two layers of trophoblast; a single layer of mononuclear cytotrophoblast that fuse together to form the overlying multinucleated syncytiotrophoblast layer that covers the entire surface of the placenta. It is this syncytiotrophoblast that is in direct contact with the maternal blood that reaches the placental surface, and thus facilitates the

pos: Gestational hypertension such as rodents and primates, the vascular resistance in the placenta was low, leading scientists to the conclusion that the greatest resistance to maternal blood flow is found elsewhere in the maternal vascular system. The high vascular resistance outside of the placenta leads to higher maternal blood pressure throughout the body. The fetal cells that implant into the uterine wall are known as the trophoblast. The hemochorial placenta bathes the fetal trophoblast in maternal blood by forming lacunae, or lakes, of the mother's blood that surround fetal tissue. The lacunae are filled by the spiral arteries, which means that the

pos: Antepartum bleeding decidua basalis. In the absence of a decidua basalis, trophoblast cells on the developing blastocyst form an abnormally deep attachment to the uterine wall, this is known as abnormal placentation. Abnormal placentation can categorised into 3 types, depending on the depth of infiltration of the chorionic villi into the uterine wall: In placenta percreta, the chorionic villi have grow entirely through the myometrium and invade into the perimetrium. Placenta percreta results in the most intense haemorrhaging that can be expected caused by abnormal placentation. In the event of placental detachment from the uterine wall, the depth of chorionic villi attachment

pos: Trophoblast exchange of nutrients, wastes and gases between the maternal and fetal systems. In addition, cytotrophoblast in the tips of villi can differentiate into another type of trophoblast called the extravillous trophoblast. Extravillous trophoblast grow out from the placenta and penetrate into the decidualised uterus. This process is essential not only for physically attaching the placenta to the mother, but also for altering the vasculature in the uterus to allow it to provide an adequate blood supply to the growing fetus as pregnancy progresses. Some of these trophoblast even replace the endothelial cells in the uterine spiral arteries as they remodel

neg: Human embryogenesis develops into the umbilical cord to attach the placenta to the embryo. Arteries in the decidua are remodelled to increase the maternal blood flow into the intervillous spaces of the placenta, allowing gas exchange and the transfer of nutrients to the embryo. Waste products from the embryo will diffuse across the placenta. As the syncytiotrophoblast starts to penetrate the uterine wall, the inner cell mass (embryoblast) also develops. The inner cell mass is the source of embryonic stem cells, which are pluripotent and can develop into any one of the three germ layer cells,and which have the potency to give

neg: Pregnancy (mammals) mass of the blastocyst divides rapidly, forming two layers. The top layer becomes the embryo, and cells from there occupy the amniotic cavity. At the same time, the bottom layer forms a small sac (if the cells begin developing in an abnormal position, an ectopic gestation may also occur at this point). Several days later, chorionic villi in the forming placenta anchor the implantation site to the uterus. A system of blood and blood vessels now develops at the point of the newly forming placenta, growing near the implantation site. The small sac inside the blastocyst begins producing red blood

neg: Pregnancy (mammals) cells. For the next 24 hours, connective tissue develops between the developing placenta and the growing embryo. This later develops into the umbilical cord. Following this, a narrow line of cells appears on the surface on the embryo. Its growth makes the embryo undergo gastrulation, in which the three primary tissue layers of the fetus, the ectoderm, mesoderm, and endoderm, develop. The narrow line of cells begin to form the endoderm and mesoderm. The ectoderm begins to grow rapidly as a result of chemicals being produced by the mesoderm. These three layers give rise to all the various types of

neg: Villitis of unknown etiology the villous trophoblastic barrier via the anchoring villi. The anchoring villi lose their layer of continuous epithelial syncytiotrophoblast as the villi mature into invasive intermediate trophoblasts through the developmental course of the placenta. A trophic factor, IL-15, for CD8+ memory T-cells is expressed by decidual stromal cells. The trafficking of maternal lymphocytes responding to an antigen in the chronic deciduitis could activate and enter via the decidua. VUE is a T-cell mediated, CD8+ dominating inflammatory reaction. VUE develops in the foetal fibrovasculature stroma of the placenta villi usually towards the end of pregnancy (term placentas). The lymphocytes in VUE are

neg: Endometrial cup that invade the placenta have been described in humans. The purpose of these cells In both humans and horses is believed to be to interact with the mother’s immune system and increase maternal immunological tolerance of the developing fetus. Mature endometrial cup cells appear rounded and secrete eCG; all but a few cells have two nuclei. As the mare's immune system begins to react to the presence of the pregnancy, histological changes are visible. First, as the endometrial cup grows and develops, maternal white blood cells, including T cells, B cells, and macrophages, mass in the uterine stroma. They begin

neg: Hemolytic disease of the newborn Hemolytic disease of the newborn Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN, or erythroblastosis fetalis, is an alloimmune condition that develops in a peripartum fetus, when the IgG molecules (one of the five main types of antibodies) produced by the mother pass through the placenta. Among these antibodies are some which attack antigens on the red blood cells in the fetal circulation, breaking down and destroying the cells (hemolysis). The fetus can develop reticulocytosis and anemia. This fetal disease ranges from mild to very severe, and fetal death from heart

neg: Umbilical cord diameter. This diameter decreases rapidly within the placenta. The fully patent umbilical artery has two main layers: an outer layer consisting of circularly arranged smooth muscle cells and an inner layer which shows rather irregularly and loosely arranged cells embedded in abundant ground substance staining metachromatic. The smooth muscle cells of the layer are rather poorly differentiated, contain only a few tiny myofilaments and are thereby unlikely to contribute actively to the process of post-natal closure. The umbilical cord contains Wharton's jelly, a gelatinous substance made largely from mucopolysaccharides which protects the blood vessels inside. It contains one vein, which

neg: Hemolytic disease of the newborn been reported in puppies. Hemolytic disease of the newborn Hemolytic disease of the newborn, also known as hemolytic disease of the fetus and newborn, HDN, HDFN, or erythroblastosis fetalis, is an alloimmune condition that develops in a peripartum fetus, when the IgG molecules (one of the five main types of antibodies) produced by the mother pass through the placenta. Among these antibodies are some which attack antigens on the red blood cells in the fetal circulation, breaking down and destroying the cells (hemolysis). The fetus can develop reticulocytosis and anemia. This fetal disease ranges from mild to very severe, and

neg: Amniotic sac Amniotic sac The amniotic sac, commonly called the bag of waters, sometimes the membranes, is the sac in which the fetus develops in amniotes. It is a thin but tough transparent pair of membranes that hold a developing embryo (and later fetus) until shortly before birth. The inner of these fetal membranes, the amnion, encloses the amniotic cavity, containing the amniotic fluid and the fetus. The outer membrane, the chorion, contains the amnion and is part of the placenta. On the outer side, the amniotic sac is connected to the yolk sac, the allantois and, via the umbilical cord, to

neg: Sphaerotheca castagnei the outer cell walls become flattened and darker in color. Like other species in "Sphaerotheca", "S. castagnei" contains only a single ascus. The cell in which the egg nucleus develops and is fertilized (the "carpogonium") elongates, divides and a curved row of 5 or 6 cells is formed. The penultimate cell of this row contains two large nuclei; while the other cells of the row have one nucleus each. The young ascus develops from this penultimate cell in which the two nuclei fuse following a rapid increase in the size of the ascus; which presses against the inner wall cells

neg: Pregnancy specific biological substances Pregnancy specific biological substances Pregnancy-specific biological substances, which include the placenta, umbilical cord, amniotic fluid, and amniotic membrane are being studied for a number of health uses. For example, Placental-derived stem cells are being studied so they can serve as a potential treatment method for cell therapy. Hepatocyte-like cells (HLC) are generated from differentiated human amniotic epithelial cells (hAEC) that are abundant in the placenta. HLC may replace hepatocytes for hepatocyte transplantation to treat acute or chronic liver damage. Recent research has shown that the placenta and placenta derivatives are being regenerative cell therapies and also includes immunological features.Placenta structures

neg: Prenatal nutrition based on physiological fetal development, which include blastogenesis, embryonic stage and fetal stage. Blastogenesis is the stage from fertilization to about 2 weeks. The fertilized egg or the zygote becomes a blastocyst where the outer layer and the inner cell mass differentiate to form placenta and the fetus respectively. Implantation occurs at this stage where the blastocyst becomes buried in the endometrium. Embryonic stage is approximately from 2 weeks to 8 weeks. It is also in this stage where the blastocyst develops into an embryo, where all major features of human are present and operational by the end of this

neg: Placenta and food. Placenta The placenta is a temporary organ that connects the developing fetus via the umbilical cord to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy. Placentas are a defining characteristic of placental mammals, but are also found in marsupials and some non-mammals with varying levels of development. The placenta functions as a fetomaternal organ with two components: the fetal placenta (Chorion frondosum), which develops from the same blastocyst that forms the fetus, and the maternal placenta

neg: Placenta Placenta The placenta is a temporary organ that connects the developing fetus via the umbilical cord to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy. Placentas are a defining characteristic of placental mammals, but are also found in marsupials and some non-mammals with varying levels of development. The placenta functions as a fetomaternal organ with two components: the fetal placenta (Chorion frondosum), which develops from the same blastocyst that forms the fetus, and the maternal placenta (Decidua basalis),

neg: Human reproduction Another method of assisted reproductive technology is in vitro fertilization, where one or more egg cells are retrieved from a woman's ovaries and co-incubated with sperm outside the body. The resulting embryo can then be reinserted into the woman's womb. Pregnancy is the period of time during which the fetus develops, dividing via mitosis inside the female. During this time, the fetus receives all of its nutrition and oxygenated blood from the female, filtered through the placenta, which is attached to the fetus' abdomen via an umbilical cord. This drain of nutrients can be quite taxing on the female, who

neg: Germ layer into kidneys and gonads. The paraxial mesoderm develops into cartilage, skeletal muscle, and dermis. The lateral plate mesoderm develops into the circulatory system (including the heart and spleen), the wall of the gut, and wall of the human body. Through cell signaling cascades and interactions with the ectodermal and endodermal cells, the mesodermal cells begin the process of differentiation. The mesoderm forms: muscle (smooth and striated), bone, cartilage, connective tissue, adipose tissue, circulatory system, lymphatic system, dermis, genitourinary system, serous membranes, and notochord. The ectoderm generates the outer layer of the embryo, and it forms from the embryo's epiblast. The

neg: PSG1 (gene) to characterize these separate types of PSGs, samples of the human placenta can be extracted and analyzed or they can be collected from blood. Though PSGs are abundant in the bloodstream a larger concentration is also found in the placenta, because PSGs are synthesized in the syncytiotrophoblast cells located in the placenta. Rodents also produce PSGs within their placenta but these cells are called spongiotrophoblasts. The presence of the PSGs can be recognized as early as 14 days after the initial fertilization of the egg. Throughout the course of the pregnancy the levels of PCGs within the bloodstream will continue

neg: Entoprocta their lives. Individuals have one or two pairs of gonads, placed between the atrium and stomach, and opening into a single gonopore in the atrium. The eggs are thought to be fertilized in the ovaries. Most species release eggs that hatch into planktonic larvae, but a few brood their eggs in the gonopore. Those that brood small eggs nourish them by a placenta-like organ, while larvae of species with larger eggs live on stored yolk. The development of the fertilized egg into a larva follows a typical spiralian pattern: the cells divide by spiral cleavage, and mesoderm develops from a

neg: Rubella each year. The disease is caused by rubella virus, a togavirus that is enveloped and has a single-stranded RNA genome. The virus is transmitted by the respiratory route and replicates in the nasopharynx and lymph nodes. The virus is found in the blood 5 to 7 days after infection and spreads throughout the body. The virus has teratogenic properties and is capable of crossing the placenta and infecting the fetus where it stops cells from developing or destroys them. During this incubation period, the patient is contagious typically for about one week before he/she develops a rash and for about

neg: Placenta which develops from the maternal uterine tissue. It metabolizes a number of substances and can release metabolic products into maternal or fetal circulations. The placenta is expelled from the body upon birth of the fetus. The word "placenta" comes from the Latin word for a type of cake, from Greek πλακόεντα/πλακοῦντα "plakóenta/plakoúnta", accusative of πλακόεις/πλακούς "plakóeis/plakoús", "flat, slab-like", in reference to its round, flat appearance in humans. The classical plural is "placentae", but the form "placentas" is common in modern English and probably has the wider currency at present. Placental mammals, such as humans, have a chorioallantoic placenta that forms

neg: Amniotic epithelial cell the inhibition of angiogenesis, which is the basic conversion of a tumor into malignant cancer. In harvesting embryonic stem cells, a human embryo is destroyed. Many pro-life individuals associate this act with abortion and consider it immoral. Amniotic epithelial cells are harvested from the placenta, which is commonly discarded after birth. The cells are very easily obtainable without the use of intrusive procedures. Thus their use averts the controversy about embryonic stem cells. There are also large amounts of amniotic epithelial cells found in the placenta and can be found in upwards of 50-100 million cells from one extraction. However,

neg: Development of the human body that sits within the pelvis of the mother. The process the mother experiences whilst carrying the fetus or embryo is referred to as pregnancy. The placenta connects the developing fetus to the uterine wall to allow nutrient uptake, thermo-regulation, waste elimination, and gas exchange via the mother's blood supply; to fight against internal infection; and to produce hormones which support pregnancy. The placenta provides oxygen and nutrients to growing fetuses and removes waste products from the fetus's blood. The placenta attaches to the wall of the uterus, and the fetus's umbilical cord develops from the placenta. These organs connect the

neg: Singapore Cord Blood Bank services, but retain ownership over the use of their cord blood. Cord blood is the blood that circulates through the umbilical cord from the foetus to the placenta. After delivery, the placenta is almost always thrown away. Yet this humble umbilical cord has become a life saving and precious commodity, because cord blood is rich in blood stem cells. Blood stem cells are young or immature cells that can transform into other forms of essential blood cell types (pluripotent), such as red blood cells, white blood cells and platelets. The use of blood stem cells has emerged as a potentially

neg: Immune tolerance in pregnancy uses several mechanisms: Still, the placenta does allow maternal IgG antibodies to pass to the fetus to protect it against infections. However, these antibodies do not target fetal cells, unless any fetal material has escaped across the placenta where it can come in contact with maternal B cells and make those B cells start to produce antibodies against fetal targets. The mother does produce antibodies against foreign ABO blood types, where the fetal blood cells are possible targets, but these preformed antibodies are usually of the IgM type, and therefore usually do not cross the placenta. Still, rarely, ABO incompatibility

neg: Microchimerism to draw resources from the placenta, while the maternal system tries to limit it. Microchimerism Microchimerism is the presence of a small number of cells that originate from another individual and are therefore genetically distinct from the cells of the host individual. This phenomenon may be related to certain types of autoimmune diseases; however, the mechanisms responsible for this relationship are unclear. In humans (and perhaps in all placentals), the most common form is fetomaternal microchimerism (also known as "fetal cell microchimerism" or "fetal chimerism") whereby cells from a fetus pass through the placenta and establish cell lineages within the

neg: Amniotic epithelial cell placenta associated with a particular person's birth would not be rejected by that person; such organs would have the same genotype as that person and thus be fully compatible with that person's immune system. Because there is not a sufficient amount of amniotic epithelial cells extracted from a single term placenta to be use in cellular therapies, the cells must be expanded in a lab. However, some studies have shown that once these cells are duplicated in the lab, some of the pluripotentency is lost. Also, these lab grown cells have shown altered gene expression causing a differing phenotype as

neg: Endometrial arteries blood to the endometrium but are also beneficial during pregnancy. When a female is pregnant a placenta develops. The baby receives blood, nutrients and oxygen via the umbilical cord which is attached to the placenta. Between the placenta and the myometrium are intervillous spaces where the endometrial arteries supply blood to. The placenta has villous trees which allow for blood to circulate and then be transported to the baby via the placenta. Endometrial arteries are divided into the common ones and the arteriovenous anastomosis. The common ones are arteries that are homologous to the arteries of the rest of the

neg: Relaxin granular and theca cells in the follicles will express relaxin in increasing levels depending on their size. During early pregnancy, the preimplantation conceptus will express relaxin, which will promote angiogenesis in the endometrium by up-regulating VEGF . This will allow the endometrium to prepare for implantation. In horses alone, the embryo in the uterus will express relaxin mRNA at least 8 days after ovulation. Then as the conceptus develops expression will increase, which is likely to promote embryo development. In addition to relaxin production by the horse embryo, the maternal placenta is the main source of relaxin production, whereas in

neg: Cord blood bank within ten minutes of giving birth. Additional stem cells may be collected from the placenta. After the health care provider draws the cord blood from the placental end of the umbilical cord, the placenta is couriered to the stem cell laboratory, where it is processed for additional stem cells. An adequate cord blood collection requires at least 75mL in order to ensure that there will be enough cells to be used for a transplantation. Before the cord blood is stored for later use, it undergoes viral testing, including tests for HIV and Hepatitis B and C, and tissue typing to

neg: Soluble fms-like tyrosine kinase-1 sFlt-1 treatment to a pattern of vasoconstriction and endothelial dysfunction identical to the syndrome produced when cells are incubated with serum from preeclamptic patients. Additionally, adenoviral transfer of the sFlt-1 gene to pregnant rats has been shown to produce a syndrome similar to preeclampsia. Though sFlt-1 is produced in small amounts by endothelial cells and monocytes, the placenta is theorized to be the major source of sFlt-1 during pregnancy. sFlt-1 mRNA shows strong expression in the placenta, and serum concentration of sFlt-1 falls significantly in patients after delivery of the placenta. Expression of sFlt-1 is stimulated by hypoxic conditions. In

neg: Polyploidy present. There are also two distinct phenotypes in triploid placentas and fetuses that are dependent on the origin of the extra haploid set. In digyny, there is typically an asymmetric poorly grown fetus, with marked adrenal hypoplasia and a very small placenta. In diandry, a partial hydatidiform mole develops. These parent-of-origin effects reflect the effects of genomic imprinting. Complete tetraploidy is more rarely diagnosed than triploidy, but is observed in 1–2% of early miscarriages. However, some tetraploid cells are commonly found in chromosome analysis at prenatal diagnosis and these are generally considered 'harmless'. It is not clear whether these tetraploid

neg: Cord lining Cord lining Cord lining, cord tissue, or umbilical cord lining membrane, is the outermost layer of the umbilical cord. As the umbilical cord itself is an extension of the placenta, the umbilical cord lining membrane is an extension of the amniotic membrane covering the placenta. The umbilical cord lining membrane comprises two layers: the amniotic (or epithelial) layer and the sub-amniotic (or mesenchymal) layer. The umbilical cord lining membrane is a rich source of two strains of stem cells: epithelial stem cells (from the amniotic layer) and mesenchymal stem cells (from the sub-amniotic layer). Discovered by Singapore based CellResearch Corp

neg: Pregnancy specific biological substances consist of unique physiognomies. Placenta's structure not only regulates its function but also gives the probability of efficient use in clinics and in biotechnology. Pregnancy specific biological substances Pregnancy-specific biological substances, which include the placenta, umbilical cord, amniotic fluid, and amniotic membrane are being studied for a number of health uses. For example, Placental-derived stem cells are being studied so they can serve as a potential treatment method for cell therapy. Hepatocyte-like cells (HLC) are generated from differentiated human amniotic epithelial cells (hAEC) that are abundant in the placenta. HLC may replace hepatocytes for hepatocyte transplantation to treat acute or

neg: Umbilical cord Umbilical cord In placental mammals, the umbilical cord (also called the navel string, birth cord or funiculus umbilicalis) is a conduit between the developing embryo or fetus and the placenta. During prenatal development, the umbilical cord is physiologically and genetically part of the fetus and (in humans) normally contains two arteries (the umbilical arteries) and one vein (the umbilical vein), buried within Wharton's jelly. The umbilical vein supplies the fetus with oxygenated, nutrient-rich blood from the placenta. Conversely, the fetal heart pumps low oxygen containing blood, nutrient-depleted blood through the umbilical arteries back to the placenta. The umbilical cord develops

neg: Confined placental mosaicism Confined placental mosaicism Confined placental mosaicism (CPM) represents a discrepancy between the chromosomal makeup of the cells in the placenta and the cells in the fetus. CPM was first described by Kalousek and Dill in 1983. CPM is diagnosed when some trisomic cells are detected on chorionic villus sampling and only normal cells are found on a subsequent prenatal test, such as amniocentesis or fetal blood sampling. In theory, CPM is when the trisomic cells are found only in the placenta. CPM is detected in approximately 1-2% of ongoing pregnancies that are studied by chorionic villus sampling (CVS) at 10

neg: Placenta mother-to-child transmission of infectious diseases. The placenta and fetus may be regarded as a foreign allograft inside the mother, and thus must evade from attack by the mother's immune system. For this purpose, the placenta uses several mechanisms: However, the Placental barrier is not the sole means to evade the immune system, as foreign fetal cells also persist in the maternal circulation, on the other side of the placental barrier. The placenta also provides a reservoir of blood for the fetus, delivering blood to it in case of hypotension and vice versa, comparable to a capacitor. Numerous pathologies can affect

neg: Placenta and auxiliary lobe, the latter is called a succenturiate placenta. Sometimes the blood vessels connecting the lobes get in the way of fetal presentation during labor, which is called vasa previa. About 20,000 protein coding genes are expressed in human cells and 70% of these genes are expressed in the normal mature placenta. Some 350 of these genes are more specifically expressed in the placenta and fewer than 100 genes are highly placenta specific. The corresponding specific proteins are mainly expressed in trophoblasts and have functions related to female pregnancy. Examples of proteins with elevated expression in placenta compared to

neg: Ceragenix Pharmaceuticals methicillin-resistant "Staphylococcus aureus" (MRSA), vancomycin-resistant "Staphylococcus aureus" (VRSA), tobramycin-resistant "Pseudomonas aeruginosa" (PATR), "Escherichia coli", vaccinia virus, HIV, and "Bacillus anthracis" (anthrax) among others. The compounds work by breaching the outer membranes of their targets. The compounds are positively charged and are electrostatically attracted to the negatively charged phospholipids that tend to distinguish prokaryotic from eukaryotic cells. Ceragenix Pharmaceuticals Ceragenix Pharmaceuticals, Inc. is a biopharmaceutical company headquartered in Denver, Colorado that develops prescription therapies based on a platform of proprietary surface active technologies—skin Barrier Repair Technology (BRT) and Cerageninis, a new class of broad spectrum anti-infectives. The company discovers, develops and

neg: PTPRK resulted in a reduction in cell proliferation, migration and invasion. Expression of the variants of PTPkappa with mutations in the phosphatase domains, however, increased cell proliferation, migration and invasion, supporting a role for the involvement of the mutated variants of PTPkappa in tumorigenicity. In situ hybridization localized PTPkappa mRNA to the brain, lung, skeletal muscle, heart, placenta, liver, kidney and intestines during development. PTPkappa was also found to be expressed in the developing retina, in nestin-positive radial progenitor cells and later in development, in the ganglion cell layer, inner plexiform layer and outer segments of photoreceptors. PTPkappa protein is observed

neg: MFN2 mitochondria and facilitates the mixing of the membranes and the exchange of DNA between mitochondria. MFN1 and MFN2 mediate outer membrane fusion while OPA1 is involved in inner membrane fusion. Mitochondrial fusion is essential for embryonic development. knockout mice for either MFN1 or MFN2 have fusion deficits and die midgestation. MFN2 knockout mice die at embryonic day 11.5 due to a defect in the giant cell layer of the placenta. Fusion is also important for mitochondrial transport and localization in neuronal processes. Conditional MFN2 knockout mice show degeneration in the Purkinje cells of the cerebellum, as well as improperly localized

neg: Echinococcosis develops a "hydatid cyst", which grows to about 5–10 cm within the first year and is able to survive within organs for years. Cysts sometimes grow to be so large that by the end of several years or even decades, they can contain several liters of fluid. Once a cyst has reached a diameter of 1 cm, its wall differentiates into a thick outer, non-cellular membrane, which covers the thin germinal epithelium. From this epithelium, cells begin to grow within the cyst. These cells then become vacuolated, and are known as brood capsules, which are the parts of the parasite

neg: Hemolytic disease of the newborn (i.e., produces IgG antibodies against) a particular antigen are hemorrhage, blood transfusion, and ABO incompatibility. Fetal-maternal hemorrhage, which is the movement of fetal blood cells across the placenta, can occur during abortion, ectopic pregnancy, childbirth, ruptures in the placenta during pregnancy (often caused by trauma), or medical procedures carried out during pregnancy that breach the uterine wall. In subsequent pregnancies, if there is a similar incompatibility in the fetus, these antibodies are then able to cross the placenta into the fetal bloodstream to attach to the red blood cells and cause their destruction (hemolysis). This is a major cause of

neg: Neurula NIMZ begins in the second half of gastrulation and continues into the late neurula stage. Eventually, deep tissue of the IMZ forms the central notochord and the surrounding paraxial mesoderm. By the early neurula stage, the notochord is clearly distinguished. Notochordal cells become arranged in a formation representing a stack of coins in a process termed circumferential intercalation. The superficial layer of the IMZ develops into the roof of the archenteron, or the primitive gut, while the underlying endoderm forms the archenteron floor. The NIMZ develops into a structure resembling the early neural tube. The outer ectodermal layer of the

neg: Alien (creature in Alien franchise) order to develop a placenta as it grows, attaching itself to several major organs in the process. The placenta has cancerous qualities, such that even if the embryo were removed surgically, the placenta would simply cause the affected organs to shut down, resulting in death. Over the course of one to 24 hours—indeterminable in some cases, and sometimes up to a week, in the case of some queens—the embryo develops into a chestburster, at which point, it emerges, violently and fatally ripping open the chest of the host. There is no on-screen explanation of the reasons for the different incubation

neg: Prenatal development give rise to extra-embryonic structures, such as the placenta and the membranes. The embryo becomes embedded in the endometrium in a process called implantation. In most successful pregnancies, the embryo implants 8 to 10 days after ovulation. The embryo, the extra-embryonic membranes, and the placenta are collectively referred to as a conceptus, or the "products of conception". Rapid growth occurs and the embryo's main features begin to take form. This process is called differentiation, which produces the varied cell types (such as blood cells, kidney cells, and nerve cells). A spontaneous abortion, or miscarriage, in the first trimester of pregnancy

neg: Placenta fusion of the underlying cytotrophoblast cells, a process that continues throughout placental development. The syncytiotrophoblast (otherwise known as syncytium), thereby contributes to the barrier function of the placenta. The placenta grows throughout pregnancy. Development of the maternal blood supply to the placenta is complete by the end of the first trimester of pregnancy week 14 (DM). In preparation for implantation of the blastocyst, the uterine endometrium undergoes "decidualisation". Spiral arteries in decidua are remodeled so that they become less convoluted and their diameter is increased. The increased diameter and straighter flow path both act to increase maternal blood flow to

neg: Marie Angélique de Scorailles she lost her baby, a fragment of the placenta lodged in her uterus. An alternative suggestion is that she was killed by a rare form of cancer, which occasionally develops after a cyst on the placenta is expelled during pregnancy. On the whole, the overwhelming probability is that she died from complications arising from her earlier miscarriage. At court, some courtiers wrote about the duchess's death. According to Ernest Lavisse and Bernard Christmas, "Two miscarriages caused her to lose favor with the king." Princess Palatine reported that it was certain that the duchess was poisoned by Madame de Montespan. She

neg: Chorioangioma Chorioangioma Chorioangioma (Placental hemangioma) is a benign tumor of placenta. It is seen in approximately 0.5 to 1% pregnancies. It is mostly diagnosed ultrasonically in the second trimester of pregnancy. Large chorioangiomas are known to cause complications in pregnancy, while the smaller ones are asymptomatic. Large or multiple chorioangiomas may lead to complications. The complications are polyhydramnios, preterm labour, hemolytic anemia, fetal cardiomegaly, fetal thrombocytopenia, intrauterine growth retardation, preeclampsia, abruption of placenta and congenital anomalies. The origin of chorioangioma is from primitive chorionic mesenchyme. It develops when the blood vessels and stroma undergo rapid proliferation independent of the surrounding tissue.

neg: Reptile Most reptiles are oviparous, although several species of squamates are viviparous, as were some extinct aquatic clades — the fetus develops within the mother, contained in a placenta rather than an eggshell. As amniotes, reptile eggs are surrounded by membranes for protection and transport, which adapt them to reproduction on dry land. Many of the viviparous species feed their fetuses through various forms of placenta analogous to those of mammals, with some providing initial care for their hatchlings. Extant reptiles range in size from a tiny gecko, "Sphaerodactylus ariasae", which can grow up to to the saltwater crocodile, "Crocodylus porosus",

neg: Chorion this is also named the non-placental part of the chorion. As the chorion grows, the chorion laeve comes in contact with the decidua parietalis and these layers fuse. The villi at the embryonic pole, which is in contact with the decidua basalis, increase greatly in size and complexity, and hence this part is named the chorion frondosum. Thus the placenta develops from the chorion frondosum and the decidua basalis. "Monochorionic twins" are twins that share the same placenta. This occurs in 0.3% of all pregnancies, and in 75% of monozygotic (identical) twins, when the split takes place on or after

neg: Organ of Corti on the membrane of OHCs it then pulls on the basilar membrane and increasing how much the membrane is deflected, creating a more intense effect on the inner hair cells (IHCs). When the cell hyperpolarizes prestin lengthens and eases tension on the IHCs, which decreases the neural impulses to the brain. In this way, the hair cell itself is able to modify the auditory signal before it even reaches the brain. The organ of Corti, in between the scala tympani and the scala media, develops after the formation and growth of the cochlear duct. The inner and outer hair cells

neg: Top (comics) atomic top that would destroy half the world when it slowed down and imprisoned the Flash inside it, but the Flash vibrated out of it and sent it into space. His unique gimmick and moderate success in crime soon makes him a respected member of the Flash's Rogues Gallery. He dates Golden Glider, Captain Cold's sister, while coaching her on ice skating. Eventually, Top develops immense psionic powers, as years of spinning moves dormant brain cells to the outer areas of his brain, endowing him with mental powers. Unfortunately, the newly activated brain cells are destroyed by close proximity to

neg: Reticular membrane Reticular membrane The reticular membrane (RM, also called reticular lamina or apical cuticular plate) is a thin, stiff lamina that extends from the outer hair cells to the Hensen's cells. The RM is composed of "minute-fiddle-shaped cuticular structures" called the phalangeal extensions of the outer hair cells, interspaced with extensions coming from the outer phalangeal cells. The RM separates endolymph in the cochlear duct from underlying corticolymph and perilymph of the scala tympani. The hair processes of the outer hair cells emerge through and above the RM, thus immobilizing the apical pole of the outer hair cells. At the opposite

neg: Migration inducting gene 7 pathway while likely sparing normal cells. Mig-7 expression is found on, as well as in, epithelial tumor cells at the primary site, secondary (metastatic) sites, and blood from cancer patients. It is not produced by cells of normal human tissues or by cells from patients with inflammation but is expressed by epithelial precancerous and malignant cells. It is also expressed in fetal/embryonic cytotrophoblast cells of early placenta. Mig-7 expression increases in malignant cancers. There is a high sensitivity and specificity of Mig-7 detection in breast (98% n=48 of 49), uterine (100% n=49), gastric (94.5% n=104 of 110) and lung (100%

neg: Peter Dallos the basis of much of our current concepts of cochlear function, notably 50-60 dB amplification by outer hair cells [2.7] First intracellular recordings from outer hair cells in vivo; first intracellular recordings from hair cells in the low-frequency regions of the cochlea [2.8] First recordings from auditory nerve terminals in vivo [2.9] Experimental series establishing many properties of electromotility of isolated outer hair cells, including the proof that stereocilia displacement produces outer hair cell motility [2.10] Invention and development of the hemicochlea technique and intracellular recordings from hair cells in the hemicochlea under basilar membrane stimulation [2.11] Discovery that outer

neg: Enzyme replacement therapy initially manufactured by isolating the therapeutic enzyme from human placenta. The FDA has now approved ERTs that are derived from other human cells, animal cells (i.e. Chinese hamster ovary cells, or CHO cells), and plant cells. Lysosomal storage diseases are fatal group of diseases and a main application of ERT. Lysosomes are cellular organelles that are responsible for the metabolism of many different macromolecules and proteins. They use enzymes to break down macromolecules, which are recycled or disposed. As of 2012, there are 50 lysosomal storage diseases, and more are still being discovered. These disorders arise because of genetic mutations

neg: Outer plexiform layer Outer plexiform layer The outer plexiform layer (external plexiform layer) is a layer of neuronal synapses in the retina of the eye. It consists of a dense network of synapses between dendrites of horizontal cells from the inner nuclear layer, and photoreceptor cell inner segments from the outer nuclear layer. It is much thinner than the inner plexiform layer, where amacrine cells synapse with retinal ganglion cells. The synapses in the outer plexiform layer are between the rod cell endings or cone cell branched foot plates and horizontal cells. Unlike in most systems, rod and cone cells release neurotransmitters when

neg: Epithelial–mesenchymal transition However, on the other hand, p53, a well-known tumor suppressor, represses EMT by activating the expression of various microRNAs – miR-200 and miR-34 that inhibit the production of protein ZEB and SNAIL, and thus maintain the epithelial phenotype. After the initial stage of embryogenesis, the implantation of the embryo and the initiation of placenta formation are associated with EMT. The trophoectoderm cells undergo EMT to facilitate the invasion of endometrium and appropriate placenta placement, thus enabling nutrient and gas exchange to the embryo. Later in embryogenesis, during gastrulation, EMT allows the cells to ingress in a specific area of the

neg: Microchimerism Microchimerism Microchimerism is the presence of a small number of cells that originate from another individual and are therefore genetically distinct from the cells of the host individual. This phenomenon may be related to certain types of autoimmune diseases; however, the mechanisms responsible for this relationship are unclear. In humans (and perhaps in all placentals), the most common form is fetomaternal microchimerism (also known as "fetal cell microchimerism" or "fetal chimerism") whereby cells from a fetus pass through the placenta and establish cell lineages within the mother. Fetal cells have been documented to persist and multiply in the mother for

neg: Mouse embryonic fibroblast mouse, researcher should incise the stomach of female mouse and then detach the embryo from the placenta in a biohazard hood. Then the liver and head should be taken out. Finally digest the remains by enzymes to obtain single isolated cells and culture the cells in a tissue culture dishes. MEF cells can be cultured "in vitro" in DMEM medium with 10% FBS. To transmit MEFs, researches should use trypsin to digest the cells (making them detach from the surface) and transmit 1/5 cells digested into a new dish. In 1962, George Todaro and Howard Green, two researchers in New

neg: Syncytium because it allows rapid coordinated contraction of muscles along their entire length. Action potentials propagate along the surface of the muscle fiber from the point of synaptic contact, through intercalated discs. Although a syncytium, cardiac muscle differs because the cells are not long and multinucleated. Cardiac tissue is therefore described as a functional syncytium, as opposed to the true syncytium of skeletal muscle. Certain animal immune-derived cells may form aggregate cells also, for example the osteoclast cells responsible for bone resorption. Another important vertebrate syncytium is in the placenta of placental mammals. Embryo-derived cells that form the interface with the

neg: Progestogen the placenta (see below). In the human, the fetal adrenals produce dehydroepiandrosterone (DHEA) via the pregnenolone pathway. Progesterone is the major progestogen produced by the corpus luteum of the ovary in all mammalian species. Luteal cells possess the necessary enzymes to convert cholesterol to pregnenolone, which is subsequently converted into progesterone. Progesterone is highest in the diestrus phase of the estrous cycle. The role of the placenta in progestogen production varies by species. In the sheep, horse, and human, the placenta takes over the majority of progestogen production, whereas in other species the corpus luteum remains the primary source of

neg: Outer plexiform layer not receiving a light signal. Outer plexiform layer The outer plexiform layer (external plexiform layer) is a layer of neuronal synapses in the retina of the eye. It consists of a dense network of synapses between dendrites of horizontal cells from the inner nuclear layer, and photoreceptor cell inner segments from the outer nuclear layer. It is much thinner than the inner plexiform layer, where amacrine cells synapse with retinal ganglion cells. The synapses in the outer plexiform layer are between the rod cell endings or cone cell branched foot plates and horizontal cells. Unlike in most systems, rod and

neg: Bark (botany) with the outside atmosphere. As the bark develops, new lenticels are formed within the cracks of the cork layers. The rhytidome is the most familiar part of bark, being the outer layer that covers the trunks of trees. It is composed mostly of dead cells and is produced by the formation of multiple layers of suberized periderm, cortical and phloem tissue. The rhytidome is especially well developed in older stems and roots of trees. In shrubs, older bark is quickly exfoliated and thick rhytidome accumulates. It is generally thickest and most distinctive at the trunk or bole (the area from

neg: Acrosome Acrosome The acrosome is an organelle that develops over the anterior half of the head in the spermatozoa (sperm cells) of many animals including humans. It is a cap-like structure derived from the Golgi apparatus. Acrosome formation is fully completed 5–10 years after testicular maturation. In Eutherian mammals the acrosome contains digestive enzymes (including hyaluronidase and acrosin). These enzymes break down the outer membrane of the ovum, called the zona pellucida, allowing the haploid nucleus in the sperm cell to join with the haploid nucleus in the ovum. This shedding of the acrosome, or acrosome reaction, can be stimulated "in

neg: Connective tissue Connective tissue Connective tissue (CT) is one of the four basic types of animal tissue, along with epithelial tissue, muscle tissue, and nervous tissue. It develops from the mesoderm. Connective tissue is found in between other tissues everywhere in the body, including the nervous system. In the central nervous system, the three outer membranes (the meninges) that envelop the brain and spinal cord are composed of connective tissue. They support and protect the body. All connective tissue consists of three main components: fibers (elastic and collagenous fibers), ground substance and cells. Not all authorities include blood or lymph as connective

neg: Chorion Chorion The chorion is the outermost fetal membrane around the embryo in mammals, birds and reptiles. It develops from an outer fold on the surface of the yolk sac, which lies outside the zona pellucida (in mammals), known as the vitelline membrane in other animals. In insects it is developed by the follicle cells while the egg is in the ovary. In humans and other mammals (excluding monotremes), the chorion is one of the fetal membranes that exist during pregnancy between the developing fetus and mother. The chorion and the amnion together form the amniotic sac. It is formed by

neg: Choriogenesis identical twins as they are once again implicating environmental intercession. Choriogenesis In developmental biology, choriogenesis is the formation of the chorion, an outer membrane of the placenta that eventually forms chorionic villi that allow the transfer of blood and nutrients from mother to fetus. Identical twins have identical genomes in the immediate aftermath of twinning. Two-thirds of monozygotic twins share the same placenta, arising by cleavage before the fourth day of development; the other third have separate placentas because cleavage has taken place after the fourth day after choriogenesis has begun. Placentas vary with respect to the transport of nutrients

neg: Choriogenesis Choriogenesis In developmental biology, choriogenesis is the formation of the chorion, an outer membrane of the placenta that eventually forms chorionic villi that allow the transfer of blood and nutrients from mother to fetus. Identical twins have identical genomes in the immediate aftermath of twinning. Two-thirds of monozygotic twins share the same placenta, arising by cleavage before the fourth day of development; the other third have separate placentas because cleavage has taken place after the fourth day after choriogenesis has begun. Placentas vary with respect to the transport of nutrients and hormones, a variance that may influence epigenesis. For example,

neg: Immune tolerance in pregnancy can give rise to IgG antibodies that cross the placenta, and are caused by sensitization of mothers (usually of blood type 0) to antigens in foods or bacteria. Still, the placental barrier is not the sole means to evade the immune system, as foreign fetal cells also persist in the maternal circulation, on the other side of the placental barrier. The placenta does not block maternal IgG antibodies, which thereby may pass through the human placenta, providing immune protection to the fetus against infectious diseases. One model for the induction of tolerance during the very early stages of pregnancy is

neg: Cytotrophoblastic shell spread out are called cytotrophoblastic columns. Once formation is complete, the cytotrophoblast layer from the anchoring villi disappears, leaving behind a mesoderm core surrounded by syncytial cells. Cytotrophoblastic shell The cytotrophoblastic shell is the external layer of cytotrophoblasts from the fetus that is found on the maternal surface of the placenta. The cytotrophoblastic shell firmly secures the placenta to the mother's endometrium called the decidua basalis. Gaps in the cytotrophoblastic shell allow endometrial arteries and veins to reach the intervillous space. A cytotrophoblast cap penetrates through the fetus' syncytiotrophoblasts and reaches the maternal decidua, forming the anchoring villus. The cytotrophoblast

neg: Amniotic epithelial cell Amniotic epithelial cell An amniotic epithelial cell is a form of stem cell extracted from the lining of the inner membrane of the placenta. Amniotic epithelial cells start to develop around 8 days post fertilization. These cells are known to have some of the same markers as embryonic stem cells, more specifically, Oct-4 and nanog. These transcription factors are the basis of the pluripotency of stem cells. Amniotic epithelial cells have the ability to develop into any of the three germ layers: endoderm, mesoderm, and ectoderm. They can develop into several organ tissues specific to these germ layers including heart,

neg: Amniotic epithelial cell into mucosal-like cells and remained on the mucosal defect and therefore could be a possible mechanism for treating those defects. Scientists have recently discovered that human amniotic epithelial cells are able to produce and release the plasma protein albumin. Amniotic epithelial cell An amniotic epithelial cell is a form of stem cell extracted from the lining of the inner membrane of the placenta. Amniotic epithelial cells start to develop around 8 days post fertilization. These cells are known to have some of the same markers as embryonic stem cells, more specifically, Oct-4 and nanog. These transcription factors are the basis

neg: Osteopontin been observed to express splice variants of OPN. The cancer-specific splice variants are osteopontin-a, osteopontin-b, and osteopontin-c. Exon 5 is lacking from osteopontin-b, whereas osteopontin-c lacks exon 4. Osteopontin-c has been suggested to facilitate the anchorage-independent phenotype of some human breast cancer cells due to its inability to associate with the extracellular matrix. Osteopontin is biosynthesized by a variety of tissue types including cardiac fibroblasts, preosteoblasts, osteoblasts, osteocytes, odontoblasts, some bone marrow cells, hypertrophic chondrocytes, dendritic cells, macrophages, smooth muscle, skeletal muscle myoblasts, endothelial cells, and extraosseous (non-bone) cells in the inner ear, brain, kidney, deciduum, and placenta. Synthesis of

neg: Placenta and further divide to form a network covered by a thin layer of cells. This results in the formation of villous tree structures. On the maternal side, these villous tree structures are grouped into lobules called cotyledons. In humans, the placenta usually has a disc shape, but size varies vastly between different mammalian species. The placenta occasionally takes a form in which it comprises several distinct parts connected by blood vessels. The parts, called lobes, may number two, three, four, or more. Such placentas are described as bilobed/bilobular/bipartite, trilobed/trilobular/tripartite, and so on. If there is a clearly discernible main lobe

neg: Placental insufficiency chronic food shortage. If the offspring actually develops in an environment rich in food it may be more prone to metabolic disorders, such as obesity and type II diabetes. The following tests have been promoted as supposedly diagnosing placental insufficiency, but all have been unsuccessful at predicting stillbirth due to placental insufficiency: Placental insufficiency Placental insufficiency or utero-placental insufficiency is the failure of the placenta to deliver sufficient nutrients to the fetus during pregnancy, and is often a result of insufficient blood flow to the placenta. The term is also sometimes used to designate late decelerations of fetal heart rate

neg: Immunoglobulin G antibodies are generated following class switching and maturation of the antibody response, thus they participate predominantly in the secondary immune response. IgG is secreted as a monomer that is small in size allowing it to easily perfuse tissues. It is the only antibody isotype that has receptors to facilitate passage through the human placenta, thereby providing protection to the fetus "in utero". Along with IgA secreted in the breast milk, residual IgG absorbed through the placenta provides the neonate with humoral immunity before its own immune system develops. Colostrum contains a high percentage of IgG, especially bovine colostrum. In individuals

neg: Velamentous cord insertion Velamentous cord insertion Velamentous cord insertion is an abnormal condition during pregnancy. Normally, the umbilical cord inserts into the middle of the placenta as it develops. In velamentous cord insertion, the umbilical cord inserts into the fetal membranes (choriamniotic membranes), then travels within the membranes to the placenta (between the amnion and the chorion). The exposed vessels are not protected by Wharton's jelly and hence are vulnerable to rupture. Rupture is especially likely if the vessels are near the cervix, in which case they may rupture in early labor, likely resulting in a stillbirth. This is a serious condition called

neg: Syncytium maternal blood stream fuse together to form a multinucleated barrier - the syncytiotrophoblast. This is probably important to limit the exchange of migratory cells between the developing embryo and the body of the mother, as some blood cells are specialized to be able to insert themselves between adjacent epithelial cells. The syncytial epithelium of the placenta does not provide such an access path from the maternal circulation into the embryo. Much of the body of Hexactinellid sponges is composed of syncitial tissue. This allows them to form their large siliceous spicules exclusively inside their cells. The fine structure of tegument

neg: Endometrial cup ulcers in form, and when examined under a microscope have large epithelioid decidual-like cells and large nucleoli. They produce high concentrations of equine chorionic gonadotropin (eCG), also called pregnant mare's serum gonadotropin, in the bloodstream of pregnant mares. eCG is actually an equine luteinizing hormone. Endometrial cups behave somewhat like cells from metastatic tumors, in that they leave the placenta and migrate into the uterus. Their purpose appears to be to work with other placental cells to control the expression of histocompatibility genes so that the developing fetus is not destroyed by the mare’s immune system. Similar types of cells

neg: Hedgehog signaling pathway of DISP, which is required for extracellular diffusion of the ligand. These digits differ in the length of time that SHH continues to be expressed. The most posterior digit V develops from cells that express the ligand for the longest period of time. Digit IV cells express SHH for a shorter time, and digit III cells shorter still. Digit II develops from cells that are exposed to moderate concentrations of extracellular SHH. Finally, Digit I development does not require SHH. It is, in a sense, the default program of limb bud cells. Hedgehog signaling remains important in the adult. Sonic

neg: Spatial hearing loss slowly begins to shrink. LiSN-S SRT scores show that the ability to understand speech in noisy environments develops with age, is beginning to be adult like by 18 years and starts to decline between 40 and 50 years of age. The medial olivocochlear bundle (MOC) is part of a collection of brainstem nuclei known as the superior olivary complex (SOC). The MOC innervates the outer hair cells of the cochlea and its activity is able to reduce basilar-membrane responses to sound by reducing the gain of cochlear amplification. In a quiet environment when speech from a single talker is being

neg: Neurula neurula is formed by uniform expansion of the cells at the animal pole, known as the animal cap. The ectoderm then differentiates into neural and epidermal tissue. In reptilian embryos, beginning in the late-stage neurula and carrying over into the early stages of organogenesis, extra-embryonic membrane tissues comprising the yolk sac, chorion, and amnion become distinct from the tissues of the embryo. The mesoderm splits to create the extra-embryonic coelom, which consists of two layers. The vascularized mesoderm-endoderm inner layer, termed the splanchnopleure, develops into the yolk sac, while the nonvascularized ectoderm-mesoderm outer layer, termed the somatopleure, becomes the amnion

neg: Calvatia craniiformis in contrast, the hyphae of the interior originate from the puffball's core. Unlike some other puffball species, the peridium does not differentiate into a distinct exoperidium and endoperidium; rather, the outer layer develops the features of a pseudoparenchyma (a tightly organised tissue where the tightly packed cells resemble plant parenchyma) as the radial and tangential hyphae become interweaved. In time, the peridium dries and falls off in flakes to expose the underlying gleba. The brain-like surface folds and mature olive-brown gleba are characteristic of "Calvatia craniiformis", but younger puffballs that have not yet developed these characteristics may be difficult to

neg: Netrin Recently, netrin has been implicated in angiogenesis in the placenta, making it vital to the survival of the fetus. This finding has implications in the future treatment of vascular disease in the placenta. In adults, netrin has been implicated in the regulation of stem cell movement and inflammation. Netrin 1 has been found to inhibit leukocyte migration to inflamed areas in the body. This provides evidence that the up regulation of netrin protects injured tissue from excess inflammation. Also, the migration of adult neural progenitor cell and adult spinal cord progenitor cells to the spine is netrin 1 dependent. Little

neg: Amniotic stem cells be based on their morphology or other characteristics. Human leukocyte antigen testing has been utilised to confirm that the MSCs stem from the fetus and not from the mother. Originally it was proposed that the MSCs were discarded from the embryo at the end of their life cycle but since the cells remained viable in the amniotic fluid and were able to proliferate in culture this hypothesis was overturned. However, it remains unclear whether the cells originate from the fetus itself, the placenta or possibly the inner cell mass of the blastocyst. Comparison of amniotic fluid-derived MSCs to bone-marrow-derived ones

neg: Adult stem cell of Lieberkuhn. Intestinal stem cells are probably the source of most cancers of the small intestine and colon. Mesenchymal stem cells (MSCs) are of stromal origin and may differentiate into a variety of tissues. MSCs have been isolated from placenta, adipose tissue, lung, bone marrow and blood, Wharton's jelly from the umbilical cord, and teeth (perivascular niche of dental pulp and periodontal ligament). MSCs are attractive for clinical therapy due to their ability to differentiate, provide trophic support, and modulate innate immune response. These cells have the ability to differentiate into various cell types such as osteoblasts, chondroblasts, adipocytes, neuroectodermal