query: which part of the cns is made up of the midbrain

pos: Midbrain Midbrain The midbrain or mesencephalon (, ; from Greek "mesos" 'middle', and "enkephalos" 'brain') is a portion of the central nervous system associated with vision, hearing, motor control, sleep/wake, arousal (alertness), and temperature regulation. The principle regions of the midbrain are the tectum, the cerebral aqueduct, tegmentum, and the basis pedunculi. Rostrally the midbrain adjoins the diencephalon (thalamus, hypothalamus, etc.), while Caudally it adjoins the metencephalon (hindbrain) (pons and cerebellum). In the rostral direction, the midbrain noticably splays laterally. Sectioning of the midbrain is usually performed axially, at one of two levels - that of the superior colliculi, or that

pos: Development of the nervous system anterior part of the neural tube forms a series of bulges called vesicles, which become the primary anatomical regions of the brain: the forebrain (prosencephalon), midbrain (mesencephalon), and hindbrain (rhombencephalon). These simple, early vesicles enlarge and further divide into the telencephalon (future cerebral cortex and basal ganglia), diencephalon (future thalamus and hypothalamus), mesencephalon (future colliculi), metencephalon (future pons and cerebellum), and myelencephalon (future medulla). The CSF-filled central chamber is continuous from the telencephalon to the spinal cord, and constitutes the developing ventricular system of the CNS. Because the neural tube gives rise to the brain and spinal cord any mutations

pos: Midbrain remainder of neural development. It does not split into other brain areas. while the forebrain, for example, divides into the telencephalon and the diencephalon. Throughout embryonic development, the cells within the midbrain continually multiply; this happens to a much greater extend ventrally than it does dorsally. The outward expansion compresses the still-forming cerebral aqueduct, which can result in partial or total obstruction, leading to congenital hydrocephalus. The mesencephalon is considered part of the brainstem. Its substantia nigra is closely associated with motor system pathways of the basal ganglia. The human mesencephalon is archipallian in origin, meaning that its general architecture

pos: Metencephalon tectum includes the superior and inferior colliculli, which play a part in visual and audio processing. Two of the major genes that affect the metencephalon are Fgf8 and Wnt1, which are both expressed around the isthmus. Fgf8 is also known as Fibroblast Growth Factor 8. It is a protein that is widely thought to be the most important organizing signal. Its main function is to set up and maintain the barrier between the midbrain and hindbrain, specifically between the mesencephalon and metencephalon. It also plays a large role in deciding the structure of the mid- and hindbrain. Wnt1 is a

pos: Fish anatomy which the peripheral nervous system branches out to innervate the various systems. The front end of the nerve tube is expanded by a thickening of the walls and expansion of the central canal of spinal cord into three primary brain vesicles: The prosencephalon (forebrain), mesencephalon (midbrain) and rhombencephalon (hindbrain), further differentiated in the various vertebrate groups. Two laterally placed eyes form around outgrows from the midbrain, except in hagfish, though this may be a secondary loss. The forebrain is well developed and subdivided in most tetrapods, while the midbrain dominate in many fish and some salamanders. Vesicles of the forebrain

pos: Midbrain is shared with the most ancient of vertebrates. Dopamine produced in the substantia nigra and ventral tegmental area plays a role in movement, movement planning, excitation, motivation and habituation of species from humans to the most elementary animals such as insects. Laboratory house mice from lines that have been selectively bred for high voluntary wheel running have enlarged midbrains. The midbrain helps to relay information for vision and hearing. Midbrain The midbrain or mesencephalon (, ; from Greek "mesos" 'middle', and "enkephalos" 'brain') is a portion of the central nervous system associated with vision, hearing, motor control, sleep/wake, arousal (alertness),

pos: Midbrain aren't (the pars reticulata), which serve a different role from one another within the basal ganglia system. The substantia nigra has extremely high production of melanin (hence the colour), dopamine, and noradrenalin; the loss of dopamine producing neurons in this region contributes to the progression of Parkinson's disease. During embryonic development, the midbrain (also known as the mesencephalon) arises from the second vesicle of the neural tube, while the interior of this portion of the tube becomes the cerebral aqueduct. Unlike the other two vesicles - the forebrain and hindbrain - the midbrain does not develop further subdivision for the

pos: Central nervous system vertebrates and during evolution. The major trend that can be observed is towards a progressive telencephalisation: the telencephalon of reptiles is only an appendix to the large olfactory bulb, while in mammals it makes up most of the volume of the CNS. In the human brain, the telencephalon covers most of the diencephalon and the mesencephalon. Indeed, the allometric study of brain size among different species shows a striking continuity from rats to whales, and allows us to complete the knowledge about the evolution of the CNS obtained through cranial endocasts. Mammals – which appear in the fossil record after

neg: Indirect pathway Indirect pathway The indirect pathway sometimes known as the indirect pathway of movement is a neuronal circuit through the basal ganglia and several associated nuclei within the central nervous system (CNS) which helps to prevent unwanted muscle contractions from competing with voluntary movements. It operates in conjunction with the direct pathway. The indirect pathway passes through the caudate, putamen, and globus pallidus, which are parts of the basal ganglia. It traverses the subthalamic nucleus, a part of the diencephalon, and enters the substantia nigra, a part of the midbrain. In a resting individual, a specific region of the globus pallidus,

neg: Direct pathway Direct pathway The direct pathway, sometimes known as the direct pathway of movement, is a neural pathway within the central nervous system (CNS) through the basal ganglia which facilitates the initiation and execution of voluntary movement. It works in conjunction with the indirect pathway. Both of these pathways are part of the cortico-basal ganglia-thalamo-cortical loop. The direct pathway passes through the caudate nucleus, putamen, and globus pallidus, which are parts of the basal ganglia. It also involves another basal ganglia component the substantia nigra, a part of the midbrain. In a resting individual, a specific region of the globus pallidus,

neg: Direct pathway lack of motion in our body Direct pathway The direct pathway, sometimes known as the direct pathway of movement, is a neural pathway within the central nervous system (CNS) through the basal ganglia which facilitates the initiation and execution of voluntary movement. It works in conjunction with the indirect pathway. Both of these pathways are part of the cortico-basal ganglia-thalamo-cortical loop. The direct pathway passes through the caudate nucleus, putamen, and globus pallidus, which are parts of the basal ganglia. It also involves another basal ganglia component the substantia nigra, a part of the midbrain. In a resting individual, a

neg: Midbrain tegmentum Midbrain tegmentum The midbrain is broken up into the tectum and the tegmentum. The midbrain tegmentum is the part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. It forms the floor of the midbrain that surrounds below the cerebral aqueduct as well as the floor of the third ventricle while the midbrain tectum forms the roof of the third ventricle. The tegmentum contains a collection of tracts and nuclei with movement-related, species-specific, and pain-perception functions. The general structures of midbrain tegmentum include red nucleus and the periaqueductal grey matter.

neg: Lim1 transcription factor signal regulation is necessary for head formation. Lim1 is a member of the LIM homeobox gene and encodes a 406 amino acid protein. Lim1 is expressed during embryogenesis to promote head formation. The Lim1 gene is also expressed in adult life, possibly to maintain a differentiated state in neural tissue of adults. During embryogenesis, Lim1 is expressed from the central nervous system (CNS) and the excretory system (primarily the kidney). In the CNS, it is expressed approximately 10 days after fertilization and patterns the forebrain, midbrain, hindbrain, and spinal cord regions. In the spinal cord Lim1 is expressed in dorsal

neg: TENM3 but often overlapping, populations of neurons, especially during embryonic development. They are also expressed in some non-neuronal tissues that regulate pattern formation and sites of cell migration. Some Ten-m3 expressions can occur in a high-to-low gradient. At day 7.5 in mouse embryonic development (E7.5), "in situ" hybridisation shows "Ten-m3" mRNA expression at the neural plate, particularly in the neural folds. At E8.5, "Ten-m3" is expressed at the caudal forebrain, the midbrain region and structures outside of the CNS, including the pharyngeal arches and the otic vesicles. At E9.5 and 10.5, "Ten-m3" expression extends from the telencephalon to the midbrain and

neg: Bonnet–Dechaume–Blanc syndrome the retina to malformations that are barely visible, the lesions cause a wide range of symptoms including decrease in visual sharpness, proptosis, pupillary defects, optic degeneration and visual field defects. The most common type of visual field impairment due to AVMs is homonymous hemianopia. Homonymous hemianopia typically presents unilaterally, but bilateral cases have been reported as well. The extent of the central nervous system (CNS) features/symptoms of Bonnet–Dechaume–Blanc syndrome is highly dependent of the location of the cerebral AVMs and the extent of the malformation. The most common symptom affecting the CNS is an intracranial hemangioma in the midbrain. Along

neg: Opisthotonus be produced experimentally in animals by transection of the midbrain (between the superior colliculus and the inferior colliculus), which results in severing all the corticoreticular fibers. Severe "arching" (hyperextension) occurs due to stimulus by the anterior reticulospinal tract caused by the loss of the balancing inhibitory counter-stimulus of corticoreticular fibers, which normally act upon the pons reticular formation. Opisthotonus is also described as a potential CNS symptom of heat stroke along with bizarre behavior, hallucinations, decerebrate rigidity, oculogyric crisis, and cerebellar dysfunction. Opisthotonus is a symptom of ""Lavender Foal Syndrome"", a lethal genetic disorder in horses. Opisthotonus Opisthotonus or opisthotonos,

neg: Motor nerve Motor nerve A motor nerve is a nerve located in the central nervous system (CNS), usually the spinal cord, that sends motor signals from the CNS to the muscles of the body.This is different from the motor neuron, which includes a cell body and branching of dendrites, while the nerve is made up of a bundle of axons. Motor nerves act as efferent nerves which carry information out from the CNS. This mode of communication is opposite compared to sensory nerves, which send signals from sensory receptors in the periphery to the CNS. There are also nerves that serve as

neg: Methamphetamine amphetamine, methamphetamine is neurotoxic to human midbrain dopaminergic neurons. It has also been shown to damage serotonin neurons in the CNS. This damage includes adverse changes in brain structure and function, such as reductions in grey matter volume in several brain regions and adverse changes in markers of metabolic integrity. Methamphetamine belongs to the substituted phenethylamine and substituted amphetamine chemical classes. It is related to the other dimethylphenethylamines as a positional isomer of these compounds, which share the common chemical formula: . In the United States, dextromethamphetamine hydrochloride, under the trade name "Desoxyn", has been approved by the FDA for

neg: Papillary tumors of the pineal region Papillary tumors of the pineal region Papillary tumors of the pineal region (PTPR) were first described by A. Jouvet et al. in 2003 and were introduced in the World Health Organization (WHO) classification of Central Nervous System (CNS) in 2007. Papillary Tumors of the Pineal Region are located on the pineal gland which is located in the center of the brain. The pineal gland is located on roof of the diencephalon. It is a cone shaped structure dorsal to the midbrain tectum. The tumor appears to be derived from the specialized ependymal cells of the subcommissural organ. Papillary tumors of

neg: Tegmentum that were inside the primitive neural tube and remained an integral part of it after complete development (e.g., the red nucleus) are considered part of the tegmentum. The tegmentum forms distinguished divisions in the midbrain, pons, and medulla. The midbrain tegmentum is the part of the midbrain extending from the substantia nigra to the cerebral aqueduct in a horizontal section of the midbrain. Structures included in the midbrain tegmentum include the red nucleus, reticular formation, and substantia nigra. The red nucleus is responsible for controlling basic body and limb movements. The reticular formation controls arousal and self-consciousness, and the [substantia

neg: Neurofibromatosis type I sequence of a magnetic resonance imaging examination of the brain. These UBOs are typically found in the Cerebral peduncle, pons, midbrain, globus pallidus, thalamus, and optic radiations. Their exact identity remains a bit of a mystery since they disappear over time (usually, by age 16), and they are not typically biopsied or resected. They may represent a focally degenerative bit of myelin. Within the CNS, NF-1 manifests as a weakness of the dura, which is the tough covering of the brain and spine. Weakness of the dura leads to focal enlargement terms dural ectasia due to chronic exposure to the

neg: Neuroanatomy primarily of the axons of neurons, along with a variety of membranes that wrap around and segregate them into nerve fascicles. The vertebrate nervous system is divided into the central and peripheral nervous systems. The central nervous system (CNS) consists of the brain, retina, and spinal cord, while the peripheral nervous system (PNS) is made up of all the nerves outside of the CNS that connect it to the rest of the body. The PNS is further subdivided into the somatic and autonomic nervous systems. The somatic nervous system is made up of "afferent" neurons, which bring sensory information from

neg: Isthmic organizer midbrain and cerebellum. The development and location of the MHB is mediated by the transcription factors "Otx2" and "Gbx2". "Otx2" is expressed in the anterior neural tube and cells in the posterior neural tube express "Gbx2". These two homeodomain transcription factors are activated by "Irx1" and then cross inhibit one another in the developing central nervous system (CNS). This leads to the creation of a defined boundary that becomes the isthmic organizer region after the neural tube closes. The usual combined expression pattern of all involved signaling molecules is necessary for the formation and maintenance of the MHB as well

neg: Peripheral nervous system Peripheral nervous system The peripheral nervous system (PNS) is one of two components that make up the nervous system of bilateral animals, with the other part being the central nervous system (CNS). The PNS consists of the nerves and ganglia outside the brain and spinal cord. The main function of the PNS is to connect the CNS to the limbs and organs, essentially serving as a relay between the brain and spinal cord and the rest of the body. Unlike the CNS, the PNS is not protected by the vertebral column and skull, or by the blood–brain barrier, which leaves

neg: Pain in fish (head). Both have been studied in agnathans, teleost, and elasmobranch fish (trigeminal in the common carp, spinothalamic tract in the sea robin, "Prionotus carolinus"). If sensory responses in fish are limited to the spinal cord and hindbrain, they might be considered as simply reflexive. However, recordings from the spinal cord, cerebellum, tectum and telencephalon in both trout and goldfish ("Carassius auratus") show these all respond to noxious stimuli. This indicates a nociceptive pathway from the periphery to the higher CNS of fish. Microarray analysis of gene expression shows the brain is active at the molecular level in the forebrain, midbrain

neg: Midbrain tegmentum important part of the dopaminergic system which is essential for feelings of reward and pleasure. Two regions in the midbrain tegmentum are of particular interest. The first one is the substantia nigra which is an important part of the nigrostriatal pathway. This pathway serves to coordinate motor movements and when left unbalanced, motor deficits would follow. For instance, when the dopamine neurons are lost from the substantia nigra, the condition of extreme muscle rigidity occurs as in the Parkinson’s disease. The second region is the ventral tegmental area (VTA; or simply ventral tegmentum) which is at the hub of the

neg: Dynorphin lysine and arginine (29.4%, 23.1%, and 31.2% basic residues, respectively), as well as many hydrophobic residues (41.2%, 30.8%, and 34.4% hydrophobic residues, respectively). Although dynorphins are found widely distributed in the CNS, they have the highest concentrations in the hypothalamus, medulla, pons, midbrain, and spinal cord. Dynorphins are stored in large (80-120 nm diameter) dense-core vesicles that are considerably larger than vesicles storing neurotransmitters. These large dense-core vesicles differ from small synaptic vesicles in that a more intense and prolonged stimulus is needed to cause the large vesicles to release their contents into the synaptic cleft. Dense-core vesicle storage is

neg: Dopaminergic cell groups the midbrain of healthy, adult humans. Group A10 is the largest group of dopaminergic cells in the ventral midbrain tegmentum of rodents and primates. The cells are located for the most part in the ventral tegmental area, the linear nucleus and, in primates, the part of central gray of the midbrain located between the left and right oculomotor nuclear complexes. Group A11 is a small group of dopaminergic cells located in the posterior periventricular nucleus and the intermediate periventricular nucleus of the hypothalamus in the macaque. In the rat, small numbers of cells assigned to this group are also found

neg: Nervous tissue of different types of nerve cells, all of which have an axon. An axon is the long stem-like part of the cell that sends action potential signals to the next cell. Bundles of axons make up the nerves in the PNS and tracts in the CNS. Functions of the nervous system are sensory input, integration, control of muscles and glands, homeostasis, and mental activity. Nervous tissue is composed of neurons, also called nerve cells, and neuroglial cells. Four types of neuroglia found in the CNS are astrocytes, microglial cells, ependymal cells and oligodendrocytes. Two types of neuroglia found in the

neg: Midbrain tegmentum Unlike the midbrain tectum (which is a sensory structure located posteriorly), the midbrain tegmentum, which locates anteriorly, is related to a number of motor functions. Within the tegmentum, the red nucleus is in charge of motor coordination (specifically for limb movements) and the periaqueductal gray matter (PAG) contains critical circuits for modulating behavioral responses to pains. The substantia nigra (black substance) serves an important role in rewarding behaviors such as approaching desired objects. In addition, the substantia nigra forms reciprocal connections with the basal ganglia which are highly correlated with motor functions and learning. The midbrain tegmentum is also an

neg: Nerve supply to the skin made possible by the action of specific sensory fibers located on the skin, as well as the distinct pathways they take to the central nervous system. The skin, which is part of the integumentary system, plays an important role in the somatic nervous system because it contains a range of nerve endings that react to heat and cold, touch, pressure, vibration, and tissue injury. The central nervous system (CNS) works with the peripheral nervous system in cutaneous innervation. The CNS is responsible for processing the information it receives from the cutaneous nerves that detect a given stimulus, and then identifying

neg: LG CNS and Japan. Overseas sales from LG CNS subsidiaries exceeded more than “200 billion won in 2007, focusing to realize its 2008 sales goal of 230 billion won in overseas markets.” LG CNS has also been doing CSR since its establishment. LG CNS IT Dream Project is the annual event which is designed for students in welfare institutions to cheer them up by inspiring them in for IT. Also, the company regularly hold an in-house bazaar to help handicapped children and women. Furthermore, “from 1995 to 2008, LG CNS has helped 628 sight-impaired people to have eyesight recovery operations. Not only

neg: Microglia synapses, and infectious agents. Since these processes must be efficient to prevent potentially fatal damage, microglia are extremely sensitive to even small pathological changes in the CNS. This sensitivity is achieved in part by the presence of unique potassium channels that respond to even small changes in extracellular potassium. The brain and spinal cord, which make up the CNS, are not usually accessed directly by pathogenic factors in the body's circulation due to a series of endothelial cells known as the blood–brain barrier, or BBB. The BBB prevents most infections from reaching the vulnerable nervous tissue. In the case where

neg: Tectospinal tract Tectospinal tract In humans, the tectospinal tract (also known as colliculospinal tract) is a nerve tract that coordinates head and eye movements. This tract is part of the extrapyramidal system. To be specific, the tectospinal tract connects the midbrain tectum and cervical regions of the spinal cord. It is responsible for motor impulses that arise from one side of the midbrain to muscles on the opposite side of the body (contralateral). The function of the tectospinal tract is to mediate reflex postural movements of the head in response to visual and auditory stimuli. The portion of the midbrain from where

neg: Trochlear nucleus Trochlear nucleus The nucleus of the trochlear nerve is located in the midbrain, at an intercollicular level between the superior colliculus and inferior colliculus. It is a motor nucleus, and so is located near the midline, embedded within the medial longitudinal fasciculus (see diagram at right). The oculomotor nerve and trochlear nerve are the only two cranial nerves with nuclei in the midbrain, other than the trigeminal nerve, which has a midbrain nucleus called the mesencephalic nucleus of trigeminal nerve, which functions in preserving dentition. Oddly, fibers from the trochlear nucleus cross over in the trochlear decussation of the midbrain,

neg: Central nervous system found that more than 95% of the 116 genes involved in the nervous system of planarians, which includes genes related to the CNS, also exist in humans. Like planarians, vertebrates have a distinct CNS and PNS, though more complex than those of planarians. In arthropods, the ventral nerve cord, the subesophageal ganglia and the supraesophageal ganglia are usually seen as making up the CNS. The CNS of chordates differs from that of other animals in being placed dorsally in the body, above the gut and notochord/spine. The basic pattern of the CNS is highly conserved throughout the different species of

neg: Central nervous system effects from radiation exposure during spaceflight processes, including Alzheimer’s disease. This kinase is up-regulated in neural cells following ionizing radiation exposure. Reliable projections of CNS risks for space missions cannot be made from the available data. Animal behavior studies indicate that high-HZE radiation has a high RBE, but the data are not consistent. Other uncertainties include: age at exposure, radiation quality, and dose-rate effects, as well as issues regarding genetic susceptibility to CNS risk from space radiation exposure. More research is required before CNS risk can be estimated. The goal of space radiation research is to estimate and reduce uncertainties in risk projection models and, if

neg: R-HDAC R-HDAC R-HDAC, or R-HD-AraC ((R)ituximab plus (H)igh (D)ose (A)ra-(C)) is a chemotherapy regimen that is used, alternating with R-Maxi-CHOP, as part of so-called "Nordic protocol" of treating mantle cell lymphoma. It consists of monoclonal antibody rituximab and high-dose antimetabolite cytarabine. High-dose Ara-C (HDAC) without rituximab also has several other uses in oncohematology. For example, HDAC, alone or alternating with HD-MTX, is often used for primary CNS lymphoma and for treating CNS involvement in any lymphomas, and also for so-called "CNS prophylaxis" (prophylactic use in those forms of lymphoma which show no signs of CNS involvement at diagnosis but have high

neg: Nerve converted from electrical to chemical and then back to electrical. Nerves can be categorized into two groups based on function: The nervous system is the part of an animal that coordinates its actions by transmitting signals to and from different parts of its body. In vertebrates it consists of two main parts, the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS consists of the brain and spinal cord. The PNS consists mainly of nerves, which are enclosed bundles of the long fibers or axons, that connect the CNS to every other part of the body. Nerves

neg: Rubrospinal tract Rubrospinal tract The rubrospinal tract is a part of the nervous system. It is a part of the lateral indirect extra-pyramidal tract. In the midbrain, it originates in the magnocellular red nucleus, crosses to the other side of the midbrain, and descends in the lateral part of the brainstem tegmentum. In the spinal cord, it travels through the lateral funiculus of the spinal cord, coursing adjacent to the lateral corticospinal tract. In humans, the rubrospinal tract is one of several major motor control pathways. It is smaller and has fewer axons than the corticospinal tract, suggesting that it is less

neg: Rubrospinal tract Rubrospinal tract The rubrospinal tract is a part of the nervous system. It is a part of the lateral indirect extra-pyramidal tract. In the midbrain, it originates in the magnocellular red nucleus, crosses to the other side of the midbrain, and descends in the lateral part of the brainstem tegmentum. In the spinal cord, it travels through the lateral funiculus of the spinal cord, coursing adjacent to the lateral corticospinal tract. In humans, the rubrospinal tract is one of several major motor control pathways. It is smaller and has fewer axons than the corticospinal tract, suggesting that it is less

neg: Myelencephalon Myelencephalon The myelencephalon or afterbrain is the most posterior region of the embryonic hindbrain, from which the medulla oblongata develops. During fetal development, divisions of the neural tube that give rise to the hindbrain (rhombencephalon) and the other primary vesicles (forebrain and midbrain) occur at just 28 days after conception. With the exception of the midbrain, these primary vesicles undergo further differentiation at 5 weeks after conception to form the myelencephalon and the other secondary vesicles. Final shape differentiation of the myelencephalon into the medulla oblongata can be observed at 20 weeks gestation. The medulla oblongata is part of the

neg: Central nervous system cyst CNS tissues are very common in America. They are a subtype of cerebrovascular diseases, which are the third leading cause of death in America. Generally, CNS cysts are present in all geographic regions, races, ages, and sexes. However, certain types of CNS cysts are more prevalent in certain types of individuals than others. Some examples of incidence rates in specific types of cysts include: Central nervous system cyst A central nervous system cyst is a type of cyst that presents and affects part of the central nervous system (CNS). They are usually benign and filled with either cerebrospinal fluid, blood,

neg: Cerebral peduncle while the large ventral bundle of efferent fibers is referred to as the cerebral crus or the pes pedunculi. The cerebral peduncles are located on either side of the midbrain and are the frontmost part of the midbrain, and act as the connectors between the rest of the midbrain and the thalamic nuclei and thus the cerebrum. As a whole, the cerebral peduncles assists in refining motor movements, learning of new motor skills, and converting proprioceptive information into balance and posture maintenance. Important fiber tracts that run through the cerebral peduncles are: cortico-spinal, cortico-pontine, and cortico-bulbar tracts. Damage to the

neg: Cerebral peduncle between the two cerebral peduncles in the interpeduncular fossa. Cranial nerve 4 (trochlear nerve) wraps around the lowest part of the cerebral peduncle. Cerebral peduncle The cerebral peduncles are structures at the front of the midbrain which arise from the front of the pons and contain the large ascending (sensory) and descending (motor) nerve tracts that run to and from the cerebrum from the pons. Mainly, the three common areas that give rise to the cerebral peduncles are the cerebral cortex, the spinal cord and the cerebellum. The cerebral peduncle, by most classifications, is everything in the midbrain except the

neg: CNS Cetate Deva of Liga I and Liga II former players and with the objective of promoting to Liga II. After a disastrous start Ciprian Pepenar was sacked and former Oțelul Galați player and coach Viorel Tănase was hired. Also in the last rounds of the first part Ousmane N'Doye signed with the club, which began to climb in the league table. Cetate Deva plays its home matches on the Cetate Stadium which also was used by Mureșul Deva, the stadium has a total capacity of 4.000 seats. CNS Cetate Deva CNS Cetate Deva is a Romanian professional football club from Deva, Hunedoara

neg: Neuromere and p5, where p6 becomes the olfactory system and p5 will coincide with the visual system. Mesomeres, m1 and m2, become the midbrain, which contains the superior and inferior colliculi. The 12 rhombomeres, which are numbered from r0 to r11, construct the hindbrain. The myelencephalon is made from rhombomeres r2 to r11, which also form the medulla. These rhombomeres are also associated with the neural crest that supplies the pharyngeal arches, a set of visible tissues that are in line with the developing brain and give rise to the head and neck. Spinal segments are the part of the spinal

neg: Wallerian degeneration of myelin in CNS and PNS. Regeneration follows degeneration. Regeneration is rapid in PNS, allowing for rates of up to 1 millimeter a day of regrowth. Grafts may also be needed to allow for appropriate reinnervation. It is supported by Schwann cells through growth factors release. CNS regeneration is much slower, and is almost absent in most vertebrate species. The primary cause for this could be the delay in clearing up myelin debris. Myelin debris, present in CNS or PNS, contains several inhibitory factors. The prolonged presence of myelin debris in CNS could possibly hinder the regeneration. An experiment conducted

neg: Carcharodontosaurus the inner ear and endocranium of "Carcharodontosaurus saharicus". Starting from the portion of the brain closest to the tip of the animal's snout is the forebrain, which is followed by the midbrain. The midbrain is angled downwards at a 45-degree angle and towards the rear of the animal. This is followed by the hindbrain, which is roughly parallel to the forebrain and forms a roughly 40-degree angle with the midbrain. Overall, the brain of "C. saharicus" would have been similar to that of a related dinosaur, "Allosaurus fragilis". Larsson found that the ratio of the cerebrum to the volume of

neg: Tegmentum of the brain that remain relatively unchanged after development is complete, i.e. at the brain stem especially the midbrain. Other parts, on the other hand, develop further, through folding and thickening, and have different names. Still, it is considered a continuous central region through all levels of the brainstem. Structures that develop to grow ventral or lateral outside this primitive tube as add-ons (e.g., the crus cerebri in the anterior of the midbrain) are not considered part of the "tegmentum", as they are not part of the primitive neural tube but grow as projections from the cerebral cortex. However, parts

neg: Laminoplasty main components of the central nervous system (CNS). This structure’s function is to provide the body with support and to protect the spinal cord. The spinal cord serves 3 main functions for the body. It provides sensation, autonomic and motor control for all bodily functions and parts. The spinal cord is the most complex yet organized part of the CNS. The entire spinal structure may be divided into 4 sections that create an overall S-shaped curve. These sections include the cervical, thoracic, lumbar, and sacral regions. Intervertebral discs stacked on top of one another make up the structure of the

neg: Midbrain tegmentum the cues related to each drug use (e.g., the room in which the drug is taken or the people with which individuals take drug). Over time, the drug enhances the dopamine-related, classically-conditioned cues associated with drug taking. As a result, later encounters with these cues will produce and heighten dopamine activity and subsequently prompt individuals to crave drugs. Moreover, excessive mesolimbic dopamine activity plays a role in schizophrenia, a behavioral disorder characterized by delusions, hallucinations, blunted emotion, agitation, etc. On the other hand, a lack of mesolimbic dopamine activity may induce deficits in attention. Midbrain tegmentum The midbrain is broken

neg: Brainstem lateral geniculate body of the diencephalon. The tegmentum which forms the floor of the midbrain, is ventral to the cerebral aqueduct. Several nuclei, tracts, and the reticular formation are contained here. The ventral tegmental area (VTA) is composed of paired cerebral peduncles. These transmit axons of upper motor neurons. The midbrain consists of: The pons lies between the medulla oblongata and the midbrain. It contains tracts that carry signals from the cerebrum to the medulla and to the cerebellum and also tracts that carry sensory signals to the thalamus. The pons is connected to the cerebellum by the cerebellar peduncles.

neg: Congress of Neurological Surgeons remain board certified by the American Board of Neurological Surgeons. A component of re-certification is successful completion of the Self Assessment in Neurological Surgery examination every 3 years. The official medical journal of the CNS is "Neurosurgery". The CNS also produces "Clinical Neurosurgery", which contains the proceedings of the annual meeting. Additionally, the CNS publishes "CNS Quarterly" which updates members on various CNS activities including socio-economic and political activities of the organization on a quarterly basis. The CNS holds its three-and-a-half-day annual meeting in the fall of each year. The meeting covers all aspects of neurosurgical research, including basic, translational,

neg: Midbrain of the inferior colliculi. One common technique for remembering the structures of the midbrain involves visualizing these cross-sections (especially at the level of the superior colliculi) as the upside-down face of a bear, with the basis pedunculi forming the ears, the cerebral aqueduct the mouth, and the tectum the chin; prominent features of the tegmentum form the eyes and certain sculptural shadows of the face. The "Tectum" (Latin for "roof") is the dorsal side of the midbrain. It is involved in certain reflex actions in connection with visual or auditory stimuli. The reticulospinal tract, which excerts some control over alertness,

neg: Collier's sign posterior commissure levator inhibitory fibres which originate in the M-group of neurons. Collier's sign Collier's sign (also known as Collier's tucked lid sign or posterior fossa stare) is bilateral or unilateral eyelid retraction. It is an accepted medical sign of a midbrain lesion, first described in 1927 by J Collier. With the eyes in the primary position, the sclera can be seen above the cornea, and further upgaze increases the distance between the eyelids and irises. Causes include upper dorsal midbrain supranuclear lesions such as Parinaud's syndrome, 'top of the basilar syndrome', midbrain infarction, neurodegeneration or tumour, multiple sclerosis, encephalitis,

neg: Dopaminergic cell groups named clusters among them. Group A8 is a small group of dopaminergic cells in rodents and primates. It is located in the midbrain reticular formation dorsolateral to the substantia nigra at the level of the red nucleus and caudally. In the mouse it is identified with the retrorubral field as defined by classical stains. Group A9 is the most densely packed group of dopaminergic cells, and is located in the ventrolateral midbrain of rodents and primates. It is for the most part identical with the pars compacta of the substantia nigra as seen from the accumulation of neuromelanin pigment in

neg: Pretectal area Pretectal area The pretectal area, or pretectum, is a midbrain structure composed of seven nuclei and comprises part of the subcortical visual system. Through reciprocal bilateral projections from the retina, it is involved primarily in mediating behavioral responses to acute changes in ambient light such as the pupillary light reflex, the optokinetic reflex, and temporary changes to the circadian rhythm. In addition to the pretectum's role in the visual system, the anterior pretectal nucleus has been found to mediate somatosensory and nociceptive information. The pretectum is a bilateral group of highly interconnected nuclei located near the junction of the midbrain

neg: Complex regional pain syndrome processes that appear to be involved in the induction and maintenance of CRPS. There is compelling evidence that the N-methyl-D-aspartate (NMDA) receptor has significant involvement in the CNS sensitization process. It is also hypothesized that elevated CNS glutamate levels promote wind-up and CNS sensitization. In addition, there is experimental evidence that demonstrates NMDA receptors in peripheral nerves. Because immunological functions can modulate CNS physiology, it has also been hypothesized that a variety of immune processes may contribute to the initial development and maintenance of peripheral and central sensitization. Furthermore, trauma related cytokine release, exaggerated neurogenic inflammation, sympathetic afferent coupling, adrenoreceptor

neg: Motor nerve areas usually leads to the cells differentiating into astrocytes which assists the surrounding neurons. Schwann cells have the ability to regenerate, but the capacity that these cells can repair nerve cells declines as time goes on as well as distance the Schwann cells are from site of damage. Motor nerve A motor nerve is a nerve located in the central nervous system (CNS), usually the spinal cord, that sends motor signals from the CNS to the muscles of the body.This is different from the motor neuron, which includes a cell body and branching of dendrites, while the nerve is made

neg: Reticular formation Reticular formation The reticular formation is a set of interconnected nuclei that are located throughout the brainstem. The reticular formation is not anatomically well defined because it includes neurons located in diverse parts of the brain. The neurons of the reticular formation make up a complex set of networks in the core of the brainstem that stretch from the upper part of the midbrain to the lower part of the medulla oblongata. The reticular formation includes ascending pathways to the cortex in the ascending reticular activating system (ARAS) and descending pathways to the spinal cord via the reticulospinal tracts of

neg: Central nervous system cyst Central nervous system cyst A central nervous system cyst is a type of cyst that presents and affects part of the central nervous system (CNS). They are usually benign and filled with either cerebrospinal fluid, blood, or tumor cells. CNS cysts are classified into two categories: cysts that originate from non-central nervous system tissue, migrate to, and form on a portion of the CNS, and cysts that originate within central nervous system tissue itself. Within these two categories, there are many types of CNS cysts that have been identified from previous studies. These classification of cysts are embedded in the

neg: Connectedness to nature scale gain the most benefits from being connected with nature, and the controversy is that the CNS will pick up on these people, but may not pick up on those who are not connected with nature. Connectedness to nature scale The connectedness to nature scale (CNS) is a measure of individuals' trait levels of feeling emotionally connected to the natural world in the realm of social and environmental psychology. The CNS was “designed to tap an individual’s affective, experiential connection to nature.” The concept of connectedness to nature signifies the relationship between an individual and the environment. In brief, the scale

neg: Myelin Protein content includes myelin basic protein (MBP), which is abundant in the CNS where it plays a critical, non-redundant role in formation of compact myelin; myelin oligodendrocyte glycoprotein (MOG), which is specific to the CNS; and proteolipid protein (PLP,) which is the most abundant protein in CNS myelin, but only a minor component of PNS myelin. In the PNS, myelin protein zero (MPZ or P0) has a similar role to that of PLP in the CNS in that it is involved in holding together the multiple concentric layers of glial cell membrane that constitute the myelin sheath. The primary lipid

neg: Clinical nurse specialist 11 studies from the US (four RCTs and seven observational) that had looked at the possible effect of having CNS as part of the healthcare team. The reviewers found some evidence of reduced length of stay and costs of care for teams which included a CNS. CNSs work with other nurses to advance their nursing practices, improve outcomes, and provide clinical expertise to effect system-wide changes to improve programs of care. CNSs work in specialties that are defined by one of the following categories: There are three domains of CNS practice, known as the "three spheres of influence" (NACNS 2004):

neg: Parabrachial nuclei ventral posteromedial nucleus of the thalamus. The lateral parabrachial nucleus is one of three main parabrachial nuclei, located at the junction of the midbrain and pons. It receives information from the caudal solitary tract and transmits signals mainly to the medial hypothalamus but also to the lateral hypothalamus and many of the nuclei targeted by the medial parabrachial nucleus. The subparabrachial nucleus, also known as the Kölliker-Fuse nucleus and diffuse reticular nucleus, is one of the three parabrachial nuclei between the midbrain and the pons. The subparabrachial nucleus regulates the breathing rate. It receives signals from the caudal, cardio-respiratory part

neg: Inferior colliculus colliculi form the eminences of the corpora quadrigemina, and also part of the tectal region of the midbrain. The inferior colliculus lies caudal to its counterpart – the superior colliculus – above the trochlear nerve, and at the base of the projection of the medial geniculate nucleus and the lateral geniculate nucleus. The inferior colliculi of the midbrain are located just below the visual processing centers known as the superior colliculi. The inferior colliculus is the first place where vertically orienting data from the fusiform cells in the dorsal cochlear nucleus can finally synapse with horizontally orienting data. Sound location

neg: Brain herniation the piece of skull from being replaced during the operation. Increased pressure in the posterior fossa can cause the cerebellum to move up through the tentorial opening in "upward", or "cerebellar herniation". The midbrain is pushed through the tentorial notch. This also pushes the midbrain down. This is also known as a transtentorial herniation since it occurs across the tentorium cerebelli. In "tonsillar herniation", also called "downward cerebellar herniation", transforaminal herniation, or "coning", the cerebellar tonsils move downward through the foramen magnum possibly causing compression of the lower brainstem and upper cervical spinal cord as they pass through the foramen

neg: Nervous tissue Nervous tissue Nervous tissue, also called neural tissue or nerve tissue, is the main tissue component of the nervous system. The nervous system regulates and controls bodily functions and activity and consists of two parts: the central nervous system (CNS) comprising the brain and spinal cord, and the peripheral nervous system (PNS) comprising the branching peripheral nerves. It is composed of neurons, or nerve cells, which receive and transmit impulses, and neuroglia, also known as glial cells or glia, which assist the propagation of the nerve impulse as well as provide nutrients to the neurons. Nervous tissue is made up

neg: Brain on neural activity. In the projection from the eye to the midbrain, for example, the structure in the adult contains a very precise mapping, connecting each point on the surface of the retina to a corresponding point in a midbrain layer. In the first stages of development, each axon from the retina is guided to the right general vicinity in the midbrain by chemical cues, but then branches very profusely and makes initial contact with a wide swath of midbrain neurons. The retina, before birth, contains special mechanisms that cause it to generate waves of activity that originate spontaneously at

neg: Metastatic breast cancer are: Clinically symptomatic CNS metastases are reported in 10–15% of patients with metastatic breast cancer; in large autopsy studies, up to 40% of women who died of metastatic breast cancer were reported to have at least one brain metastasis. CNS metastases are often viewed by patients and doctors as a late complication of metastatic breast cancer for which few effective treatments exist. In most cases, CNS involvement occurs after metastatic dissemination to the bones, liver and/or lungs has already occurred; for that reason, many patients already have refractory, terminal breast cancer by the time they are diagnosed with brain metastases.

neg: Corpus callosum lobes is called the genu ("knee"). The genu curves downward and backward in front of the septum pellucidum, diminishing greatly in thickness. The lower much thinner part is the rostrum and is connected below with the lamina terminalis, which stretches from the interventricular foramina to the recess at the base of the optic stalk. The rostrum is named for its resemblance to a bird's beak. The end part of the corpus callosum, towards the cerebellum, is called the splenium. This is the thickest part, and overlaps the tela choroidea of the third ventricle and the midbrain, and ends in a

neg: Brainstem death this arousal system is based upon the findings from animal experiments as illuminated by pathological studies in humans. The current neurological consensus is that the arousal of consciousness depends upon reticular components which reside in the midbrain, diencephalon and pons. It is said that the midbrain reticular formation may be viewed as a driving centre for the higher structures, loss of which produces a state in which the cortex appears, on the basis of electroencephalographic (EEG) studies, to be awaiting the command or ability to function. The role of diencephalic (higher brain) involvement is stated to be uncertain and we

neg: Wallerian degeneration PNS. Another factor that affects degradation rate is the diameter of the axon: larger axons require a longer time for the cytoskeleton to degrade and thus take a longer time to degenerate. Myelin is a phospholipid membrane that wraps around axons to provide them with insulation. It is produced by Schwann cells in the PNS, and by oligodendrocytes in the CNS. Myelin clearance is the next step in Wallerian degeneration following axonal degeneration. The cleaning up of myelin debris is different for PNS and CNS. PNS is much faster and efficient at clearing myelin debris in comparison to CNS, and

neg: Pathology of multiple sclerosis damage in the dendritic spines of the neurons, with no demyelination nor autoimmune infiltrates. For some authors this constitutes a proof to state that MS is a primary neurodegenerative condition. fibrinogen is deposited in MS motor cortex and associates with neurodegeneration. The olfactory nerve, similar to the optic nerve, is part of the Central Nervous System. This nerve terminates in the olfactory bulb, which also belongs to the central nervous system. Both develop from the CNS embrion, and recently it has been shown, by autopsies, that they are affected by the same diseases than the rest of the CNS. In

neg: L-DOPA L-DOPA -DOPA (), also known as levodopa () or -3,4-dihydroxyphenylalanine is an amino acid that is made and used as part of the normal biology of humans, as well as some animals and plants. Humans, as well as a portion of the other animals that utilize -DOPA in their biology, make it via biosynthesis from the amino acid -tyrosine. -DOPA is the precursor to the neurotransmitters dopamine, norepinephrine (noradrenaline), and epinephrine (adrenaline), which are collectively known as catecholamines. Furthermore, -DOPA itself mediates neurotrophic factor release by the brain and CNS. -DOPA can be manufactured and in its pure form is

neg: Thalamus which is superior to the midbrain, near the center of the brain, with nerve fibers projecting out to the cerebral cortex in all directions. The medial surface of the thalamus constitutes the upper part of the lateral wall of the third ventricle, and is connected to the corresponding surface of the opposite thalamus by a flattened gray band, the interthalamic adhesion. The lateral part of the thalamus is the phylogenetically newest part of the thalamus (neothalamus), and includes the lateral nuclei, the pulvinar and the medial and lateral geniculate nuclei. There are areas of white matter in the thalamus including

neg: Ependyma Ependyma Ependyma is the thin neuroepithelial lining of the ventricular system of the brain and the central canal of the spinal cord, made up of ependymal cells. Ependyma is one of the four types of neuroglia in the central nervous system (CNS). It is involved in the production of cerebrospinal fluid (CSF), and is shown to serve as a reservoir for neuroregeneration. The ependyma is made up of ependymal cells called ependymocytes, a type of glial cell. These cells line the CSF-filled ventricles in the brain and the central canal of the spinal cord. These are nervous tissue cells with

neg: Central pain syndrome Central pain syndrome Central pain syndrome is a neurological condition caused by damage or malfunction in the Central Nervous System (CNS) which causes a sensitization of the pain system. The extent of pain and the areas affected are related to the cause of the injury. Pain can either be relegated to a specific part of the body or spread to the entire body. It is typically constant, and may be moderate to severe in intensity. It is often made worse by touch, movement, emotions, barometric pressure and temperature changes, usually cold temperatures along with many other similar 'triggers'. Burning pain

neg: CNS Productions CNS Productions CNS Productions is a publisher of educational materials — primarily textbooks and instructional DVDs — dealing with psychoactive drugs and addiction. It was formed in 1983 by Paul Steinbroner, with long-time collaborator William E. Cohen who had an extensive background in medical film production. CNS Productions has produced and distributed over fifty separate titles on issues related to the neurobehavioral effects of psychoactive drugs. Darryl Inaba, PharmD, former CEO and President of San Francisco's Haight Ashbury Free Clinic served as a consultant on all of the films CNS produced, and co-authored "Uppers, Downers, All Arounders" () which was

neg: Custody Notification Scheme implement a CNS, though other states had not. Representatives from South Australian and Queensland argued they already had their own adequate systems in place, while Tasmania said they were considering the system though had not made a decision. Victoria is expected to be the next state to introduce a CNS. Custody Notification Scheme The Custody Notification Schemes (CNS) is a 24-hour legal advice and support telephone hotline for any Australian Aboriginal person brought into custody, connecting them with lawyers from the Aboriginal Legal Service. It is intended to reduce the high number of Aboriginal deaths in custody by counteracting the

neg: Nervous system Nervous system The nervous system is the part of an animal that coordinates its actions by transmitting signals to and from different parts of its body. The nervous system detects environmental changes that impact the body, then works in tandem with the endocrine system to respond to such events. Nervous tissue first arose in wormlike organisms about 550 to 600 million years ago. In vertebrates it consists of two main parts, the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS consists of the brain and spinal cord. The PNS consists mainly of nerves, which are enclosed

neg: Midbrain and the cerebral aqueduct. The tegmentum is the portion of the midbrain ventral to the cerebral aqueduct, and is much larger in size than the tectum. It communicates with the cerebellum by the superior cerebellar peduncles, which enter at the caudal end, medially, on the ventral side; the cerebellar peduncles are distinctive at the level of the inferior colliculus, where they decussate, but they dissipate more rostrally. Between these peduncles, on the ventral side, is the median raphe nucleus, which is involved in memory consolidation. The main bulk of the tegmentum contains a complex synaptic network of neurons, primarily involved

neg: Ependyma new neurons, thus failing to satisfy the requirement for stem cells. One study observed that ependymal cells from the lining of the lateral ventricle might be a source for cells which can be transplanted into the cochlea to reverse hearing loss. Ependymoma is a tumor of the ependymal cells most commonly found in the fourth ventricle. Ependyma Ependyma is the thin neuroepithelial lining of the ventricular system of the brain and the central canal of the spinal cord, made up of ependymal cells. Ependyma is one of the four types of neuroglia in the central nervous system (CNS). It is

neg: Dinosaur intelligence enlargement. The brain of "Allosaurus fragilis" resembled that of the related form "Carcharodontosaurus saharicus". The shape resembles that of the modern day crocodile. In 2001, Hans C. E. Larsson published a description of the endocranium of "Carcharodontosaurus saharicus". Starting from the portion of the brain closest to the tip of the animal's snout is the forebrain, which is followed by the midbrain. Larsson found that the midbrain was angled downwards at 45 degrees towards the rear of the animal. This is followed by the hind brain, which was roughly parallel to the forebrain and itself forms a roughly 40 degree

neg: Alpha motor neuron signals as action potentials, rapid changes in electrical activity that propagate from the cell body to the end of the axon. To increase the speed at which action potentials travel, α-MN axons have large diameters and are heavily myelinated by both oligodendrocytes and Schwann cells. Oligodendrocytes myelinate the part of the α-MN axon that lies in the central nervous system (CNS), while Schwann cells myelinate the part that lies in the peripheral nervous system (PNS). The transition between the CNS and PNS occurs at the level of the pia mater, the innermost and most delicate layer of meningeal tissue surrounding

neg: Reticular formation nuclei can be differentiated by function, cell type, and projections of efferent or afferent nerves. Moving caudally from the rostral midbrain, at the site of the rostral pons and the midbrain, the medial RF becomes less prominent, and the lateral RF becomes more prominent. Existing on the sides of the medial reticular formation is its lateral cousin, which is particularly pronounced in the rostral medulla and caudal pons. Out from this area spring the cranial nerves, including the very important vagus nerve. The Lateral RF is known for its ganglions and areas of interneurons around the cranial nerves, which serve

neg: Immune privilege immune cells. Generally, in normal (uninjured) tissue, antigens are taken up by antigen presenting cells (dendritic cells), and subsequently transported to the lymph nodes. Alternatively, soluble antigens can drain into the lymph nodes. In contrast, in the CNS, dendritic cells are not thought to be present in normal parenchymal tissue or perivascular space although they are present in the meninges and choroids plexus. Thus, the CNS is thought to be limited in its capacity to deliver antigens to local lymph nodes and cause T-cell activation. Although there is no conventional lymphatic system in the CNS, the drainage of antigens from

neg: Intrinsically photosensitive retinal ganglion cells sustained signaling of the pupillary light reflex (PLR). Transient PLR occurs at dim to moderate light intensities and is a result of phototransduction occurring in rod cells which provide synaptic input onto ipRGCs, which in turn relay the information to the olivary pretectal nucleus in the midbrain. The neurotransmitter involved in the relay of information to the midbrain from the ipRGCs in the transient PLR is glutamate. At brighter light intensities the sustained PLR occurs, which involves both phototransduction of the rod providing input to the ipRGCs, and phototransduction of the ipRGCs themselves via melanopsin. Researchers have suggested that the

neg: Pons Pons The pons (Latin for "bridge") is part of the brainstem, and in humans and other bipeds lies inferior to the midbrain, superior to the medulla oblongata and anterior to the cerebellum. The pons is also called the pons Varolii ("bridge of Varolius"), after the Italian anatomist and surgeon Costanzo Varolio (1543–75). This region of the brainstem includes neural pathways and tracts that conduct signals from the brain down to the cerebellum and medulla, and tracts that carry the sensory signals up into the thalamus. The pons in humans measures about in length. Most of it appears as a broad

neg: Aqueductal stenosis aqueductal stenosis caused by tumor compression, a brain tumor in the region of the midbrain forms. More specific anatomically, a tumor forms in the pineal region which is dorsal to the midbrain and is level with the aqueduct of Sylvius. As the tumor grows and expands, it compresses the aqueduct to eventually obstruct it. A naturally narrow aqueduct allows for the it to be more easily obstructed. Narrow aqueducts have no unusual tissue characteristics, and ventricles are lined with normal epithelial cells. Narrowing can be a defect from birth which results in congenital aqueductal stenosis. Developmental errors that could result

neg: Weber's syndrome Weber's syndrome Weber's syndrome (superior alternating hemiplegia) is a form of stroke characterized by the presence of an ipsilateral oculomotor nerve palsy and contralateral hemiparesis or hemiplegia. It is caused by midbrain infarction as a result of occlusion of the paramedian branches of the posterior cerebral artery or of basilar bifurcation perforating arteries. This lesion is usually unilateral and affects several structures in the midbrain including: It is caused by midbrain infarction as a result of occlusion of the paramedian branches of the posterior cerebral artery or of basilar bifurcation perforating arteries. It carries the name of Sir Hermann David

neg: Glial scar for any large migration or cellular reaction. Nestin is normally present during (CNS) development and reactivates after minor stresses to the nervous system. However, Frisen "et al." determined that nestin is also upregulated during severe stresses such as lesions which involve the formation of the glial scar. Mid-thoracic spinal cord lesions, optic nerve lesions, but not lesions to the sciatic nerve, have shown marked increases in nestin expression within the first 48 hours after trauma. Further, nestin upregulation was shown to last for up to 13 months post-injury. This data suggests that nestin upregulation may be associated with CNS glial

neg: Canadian Nuclear Society or conferences within their respective technical areas. General administration and outreach (public, other societies, etc.) are typically carried out by a number of Committees within the CNS. The CNS holds an annual conference each June, which includes technical sessions covering all fields, as well as plenary sessions that address topics of broad interest. At the local level across the country, the CNS includes fourteen branches (nine in Ontario, one in each of Alberta, Saskatchewan, Manitoba, Quebec, and New Brunswick) The CNS is affiliated with several "sister" nuclear societies around the world, and is also an organizational member of the Engineering

neg: Immune privilege system. They create the Sertoli cell barrier, which complements the blood-testis barrier. The protection is ensured by tight junctions, which appear between two neighboring Sertoli cells. Another mechanism which is likely to protect sperm is the suppression of immune responses in the testis. The central nervous system (CNS), which includes the brain and spinal cord, is a sensitive system with limited capacity for regeneration. In that regard, the concept of "immune privilege" within the CNS was once thought to be critical in limiting inflammation. The blood–brain barrier plays an important role in maintaining the separation of CNS from the systemic

neg: Habenula of its afferent fibers. By way of the fasciculus retroflexus (habenulointerpeduncular tract) it projects to the interpeduncular nucleus and other paramedian cell groups of the midbrain tegmentum. The habenula receives input via the stria medullaris thalami and outputs to many midbrain areas involved in releasing neurotransmitters, such as dopamine, norepinephrine, and serotonin. The habenula was traditionally divided into lateral (limbic) and medial (motor) parts. Detailed examination of the region in the cat, however, suggested that the lateral part should be further divided into ten distinct subnuclei and the medial into five distinct subnuclei. Various species exhibit left-right asymmetric differentiation of

neg: Computation and Neural Systems out with a small number of existing faculty in the various divisions. Amongst the early founding faculty were Carver Mead, John Hopfield, David van Essen, Geoffrey Fox, James Bower, Mark Konishi, John Allman, Ed Posner and Demetri Psaltis. In that year, the first external professor, Christof Koch, was hired. Since 1990, about 110 graduate students have been awarded a PhD in CNS and 14 a MS in CNS. About two-thirds of CNS graduates pursued an academic career, with the remaining CNS graduates founding and/or joining start-up companies. Over this time, the average duration of PhD has been 5.6 years. During

neg: Pretectal area projection to the superchiasmatic nucleus, which is part of a known REM sleep regulatory mechanism, supports this hypothesis. Pretectal area The pretectal area, or pretectum, is a midbrain structure composed of seven nuclei and comprises part of the subcortical visual system. Through reciprocal bilateral projections from the retina, it is involved primarily in mediating behavioral responses to acute changes in ambient light such as the pupillary light reflex, the optokinetic reflex, and temporary changes to the circadian rhythm. In addition to the pretectum's role in the visual system, the anterior pretectal nucleus has been found to mediate somatosensory and nociceptive

neg: Trochlear nucleus located in the superior medullary velum to exit dorsally, the only cranial nerve to do so. The trochlear nerve then goes around the midbrain, and is visible coming out of the sides. Trochlear nucleus The nucleus of the trochlear nerve is located in the midbrain, at an intercollicular level between the superior colliculus and inferior colliculus. It is a motor nucleus, and so is located near the midline, embedded within the medial longitudinal fasciculus (see diagram at right). The oculomotor nerve and trochlear nerve are the only two cranial nerves with nuclei in the midbrain, other than the trigeminal nerve,

neg: Urination urination is initiated remains unsettled. One possibility is that the voluntary relaxation of the muscles of the pelvic floor causes a sufficient downward tug on the detrusor muscle to initiate its contraction. Another possibility is the excitation or disinhibition of neurons in the pontine micturition center, which causes concurrent contraction of the bladder and relaxation of the sphincter. There is an inhibitory area for micturition in the midbrain. After transection of the brain stem just above the pons, the threshold is lowered and less bladder filling is required to trigger it, whereas after transection at the top of the midbrain,