query: where does the left ventricle send blood to

pos: Systole ventricle (lighter blue), connected through the tricuspid valve. The atria are the receiving chambers for the circulation of blood and the ventricles are the discharging chambers. When, in late ventricular diastole, the atrial chambers contract, they send blood down to the larger, lower ventricle chambers. When normal flow is completed, the ventricles are filled and the valves to the atria are closed. The ventricles now perform systole isovolumetrically, which is contraction while all valves are closed—ending the first stage of systole. The second stage proceeds immediately, pumping oxygenated blood from the left ventricle through the aortic valve and aorta to

pos: Fetus into the left atrium, thus bypassing pulmonary circulation. The majority of blood flow is into the left ventricle from where it is pumped through the aorta into the body. Some of the blood moves from the aorta through the internal iliac arteries to the umbilical arteries, and re-enters the placenta, where carbon dioxide and other waste products from the fetus are taken up and enter the woman's circulation. Some of the blood from the right atrium does not enter the left atrium, but enters the right ventricle and is pumped into the pulmonary artery. In the fetus, there is a

pos: Fetal aortic stenosis Fetal aortic stenosis Fetal aortic stenosis is a disorder that occurs when the fetus’ aortic valve does not fully open during development. The aortic valve is a one way valve that is located between the left ventricle and the aorta, keeping blood from leaking back into the ventricle. It has three leaflets that separate when the ventricle contracts to allow blood to move from the ventricle to the aorta. These leaflets come together when the ventricle relaxes. Since the valve does not open properly in aortic stenosis, there is a decrease in the forward movement of blood into the aorta.

pos: Crisscross heart and right ventricle are working together to supply blood to the pulmonary artery, similarly to how the left atrium and the left ventricle work simultaneously to supply blood to the aorta. During the process of the heart contracting and releasing the right atrium and left atrium contract at the same time, while the left ventricle and right ventricle relax. In opposition, when the left atrium and right atrium are relaxed the left ventricle and right ventricle contract pushing blood to either the aorta or pulmonary artery. In an anatomically correct heart the atria are smaller than the ventricles. The ventricles

pos: Levo-Transposition of the great arteries accompanying defect(s). If a right-to-left or bidirectional shunt is present, the list of symptoms may include mild cyanosis. In a normal heart, oxygen-depleted ("deoxygenated") blood is pumped from the right atrium into the right ventricle, then through the pulmonary artery to the lungs where it is oxygenated. The oxygen-rich ("oxygenated") blood then returns, via the pulmonary veins, to the left atrium from which it is pumped into the left ventricle, then through the aorta to the rest of the body, including the heart muscle itself. With l-TGA, deoxygenated blood is pumped from the right atrium into the morphological left ventricle

pos: Pulmonary circulation where carbon dioxide is released and oxygen is picked up during respiration. Arteries are further divided into very fine capillaries which are extremely thin-walled. The pulmonary vein returns oxygenated blood to the left atrium of the heart. The oxygenated blood then leaves the lungs through pulmonary veins, which return it to the left heart, completing the pulmonary cycle. This blood then enters the left atrium, which pumps it through the mitral valve into the left ventricle. From the left ventricle, the blood passes through the aortic valve to the aorta. The blood is then distributed to the body through the

pos: Cardiology by the left ventricle pumping blood into the lungs and the right ventricle pumping the blood into the aorta. This may not produce problems at the beginning, but will eventually due to the different pressures each ventricle uses to pump blood. Switching the left ventricle to be the systemic ventricle and the right ventricle to pump blood into the pulmonary artery can repair levo-transposition. Persistent truncus arteriosus is when the truncus arteriosus fails to split into the aorta and pulmonary trunk. This occurs in about 1 in 11,000 live births and allows both oxygenated and deoxygenated blood into the body.

pos: Fetal circulation where it is pumped through the aorta into the body. Some of the blood moves from the aorta through the internal iliac arteries to the umbilical arteries, and re-enters the placenta, where carbon dioxide and other waste products from the fetus are taken up and enter the woman's circulation. Some of the blood from the right atrium does not enter the left atrium, but enters the right ventricle and is pumped into the pulmonary artery. In the fetus, there is a special connection between the pulmonary artery and the aorta, called the "ductus arteriosus", which directs most of this blood

pos: Foramen of Panizza Foramen of Panizza The foramen of Panizza (named for anatomist Bartolomeo Panizza) is a hole that connects the left and right aorta as they leave the heart of all animals of the order Crocodilia. Crocodilians have a completely separated ventricle with deoxygenated blood from the body, or systemic circulation, in the right ventricle and oxygenated blood from the lungs, or pulmonary circulation, in the left ventricle, as in birds and mammals. Two vessels, the left aorta and the pulmonary artery, exit the right ventricle. Blood from the right ventricle goes to the lungs through the pulmonary artery, as in mammals

pos: Foramen of Panizza and birds. However, when a unique active valve leading to the pulmonary artery contracts, pressure in the right ventricle can increase and blood can leave the right ventricle, enter the left aortic arch, and therefore bypass the pulmonary circulation. The foramen of Panizza connects the left and right aorta. Deoxygenated blood from the right ventricle, sitting in the left aorta, can flow into the right aorta through the foramen of Panizza. When the heart is relaxed, some oxygenated blood from the left ventricle, sitting in the right aorta, can flow into the left aorta across the foramen of Panizza. However,

pos: Blue baby syndrome simultaneously into the two bottom chambers, or ventricles. Blood first enters the heart at the right atrium, which then empties blood into the right ventricle, which pumps the blood into the lungs through the pulmonary artery to get oxygen. From the lungs, the blood enters the left atrium through the pulmonary vein; the left atrium empties into the left ventricle, which pumps the blood into the aorta and from there reaches the rest of the body. Because the left ventricle is responsible for getting blood to the entire body through the aorta, it is usually the biggest and strongest chamber

pos: Aortic insufficiency overload caused by the regurgitant fraction. Physiologically, in individuals with a normally functioning aortic valve, the valve is only open when the pressure in the left ventricle is higher than the pressure in the aorta. This allows the blood to be ejected from the left ventricle into the aorta during ventricular systole. The amount of blood that is ejected by the heart is known as the "stroke volume". Under normal conditions, >50% of the blood in a filled left ventricle is ejected into the aorta to be used by the body. After ventricular systole, the pressure in the left ventricle

pos: Hypoplastic left heart syndrome it cannot be pumped to the rest of the body by the left ventricle. The neonate is reliant on blood flowing through an atrial septal defect to mix oxygenated and deoxygenated blood, and on a patent ductus arteriosus to allow blood to reach the aorta and the systemic circulation via the right ventricle. This is what defines HLHS as a "single ventricle" defect. Hypoplastic left heart syndrome can be diagnosed prenatally or after birth via echocardiography. Typical findings include a small left ventricle and aorta, abnormalities of the mitral and aortic valves, retrograde flow in the transverse arch of the

pos: Heart receives blood from two arteries which arise just above the aortic valve. These are the left main coronary artery and the right coronary artery. The left main coronary artery splits shortly after leaving the aorta into two vessels, the left anterior descending and the left circumflex artery. The left anterior descending artery supplies heart tissue and the front, outer side, and the septum of the left ventricle. It does this by branching into smaller arteries – diagonal and septal branches. The left circumflex supplies the back and underneath of the left ventricle. The right coronary artery supplies the right atrium,

pos: Ventricle (heart) the lungs, and the left ventricle pumps blood into the systemic circulation through the aorta. Ventricles have thicker walls than atria and generate higher blood pressures. The physiological load on the ventricles requiring pumping of blood throughout the body and lungs is much greater than the pressure generated by the atria to fill the ventricles. Further, the left ventricle has thicker walls than the right because it needs to pump blood to most of the body while the right ventricle fills only the lungs. On the inner walls of the ventricles are irregular muscular columns called trabeculae carneae which cover

pos: Taussig–Bing syndrome Taussig–Bing syndrome Taussig–Bing syndrome (after Helen B. Taussig and Richard Bing) is a cyanotic congenital heart defect in which the patient has both double outlet right ventricle (DORV) and subpulmonic ventricular septal defect (VSD). In DORV, instead of the normal situation where blood from the left ventricle (LV) flows out to the aorta and blood from the right ventricle (RV) flows out to the pulmonary artery, both aorta and pulmonary artery are connected to the RV, and the only path for blood from the LV is across the VSD. When the VSD is subpulmonic (sitting just below the pulmonary artery),

pos: Heart and along the conduction system of the heart. The heart receives blood low in oxygen from the systemic circulation, which enters the right atrium from the superior and inferior venae cavae and passes to the right ventricle. From here it is pumped into the pulmonary circulation, through the lungs where it receives oxygen and gives off carbon dioxide. Oxygenated blood then returns to the left atrium, passes through the left ventricle and is pumped out through the aorta to the systemic circulation−where the oxygen is used and metabolized to carbon dioxide. The heart beats at a resting rate close to

pos: Cardiac shunt heart, entering the upper left atrium. Blood is then pumped to the lower left ventricle and from there out of the heart to the body via the aorta. This is called the systemic circulation. A cardiac shunt is when blood follows a pattern that deviates from the systemic circulation, i.e., from the body to the right atrium, down to the right ventricle, to the lungs, from the lungs to the left atrium, down to the left ventricle and then out of the heart back to the systemic circulation. A left-to-right shunt is when blood from the left side of the

pos: Aortic valve non-coronary cusp. Some sources also advocate they be named as a left, right and posterior cusp. Anatomists have traditionally named them the left posterior (origin of left coronary), anterior (origin of the right coronary) and right posterior. When the left ventricle contracts (systole), pressure rises in the right ventricle. When the pressure in the left ventricle rises above the pressure in the aorta, the aortic valve opens, allowing blood to exit the left ventricle into the aorta. When ventricular systole ends, pressure in the left ventricle rapidly drops. When the pressure in the left ventricle decreases, the aortic pressure forces

pos: Fetal circulation the placenta, where carbon dioxide and other waste products from the fetus are taken up and enter the maternal circulation. Some of the blood entering the right atrium does not pass directly to the left atrium through the "foramen ovale", but enters the right ventricle and is pumped into the pulmonary artery. In the fetus, there is a special connection between the pulmonary artery and the aorta, called the "ductus arteriosus", which directs most of this blood away from the lungs (which are not being used for respiration at this point as the fetus is suspended in amniotic fluid). The

pos: Double outlet right ventricle the physiology of the heart, in terms of altering the normal flow of blood from the RV and left ventricle (LV) to the aorta and pulmonary artery. For example: DORV is treated with surgery. DORV affects between 1% and 3% of people born with congenital heart defects. Chromosomal abnormalities were reported in about 40% of reported cases in the medical literature. Double outlet right ventricle Double outlet right ventricle (DORV) is a form of congenital heart disease where both of the great arteries connect (in whole or in part) to the right ventricle (RV). In some cases it is found

pos: Bathyacmaea secunda pericardial sack on the animal's left side near its head. The heart consists of a single (morphologically left) auricle, a single large and muscular ventricle, and the muscular but much smaller bulbous aorta below it which joins the posterior and anterior aortae. The posterior aorta opens into the visceral sinus, delivering blood to the gonad and digestive gland; the anterior aorta sends blood forward into the buccal mass. The ctenidium contains blood spaces and receives oxygen. "B. secunda" does not have a series of arteries and veins— like all gastropods and indeed all molluscs, its blood is retained within various

pos: Afterload stenosis creates a trans-valvular gradient of 30 mmHg, the left ventricle has to generate a pressure of 110 mmHg in order to open the aortic valve and eject blood into the aorta. Due to the increased afterload, the ventricle has to work harder to accomplish its goal of ejecting blood into the aorta. Thus in the long-term, the increased afterload (due to the stenosis) will result in hypertrophy of the left ventricle to account for the increased work required. Aortic insufficiency (Aortic Regurgitation) increases afterload because a percentage of the blood that is ejected forward regurgitates back through the diseased

pos: Foramen of Panizza some species of Crocodilians have regulatory sphincters that prevent unwanted flow of blood through the foramen of Panizza during non-diving. Foramen of Panizza The foramen of Panizza (named for anatomist Bartolomeo Panizza) is a hole that connects the left and right aorta as they leave the heart of all animals of the order Crocodilia. Crocodilians have a completely separated ventricle with deoxygenated blood from the body, or systemic circulation, in the right ventricle and oxygenated blood from the lungs, or pulmonary circulation, in the left ventricle, as in birds and mammals. Two vessels, the left aorta and the pulmonary artery,

pos: Amlodipine dihydropyridines. Other situations occur, however, where amlodipine generally should not be used. In patients with [[cardiogenic shock]], where the heart's ventricles are not able to pump enough blood, calcium channel blockers exacerbate the situation by preventing the flow of calcium ions into cardiac cells, which is required for the heart to pump. While use in patients with [[aortic stenosis]] (narrowing of the [[aorta]] where it meets the [[left ventricle]]) since it does not inhibit the ventricle's function is generally safe, it can still cause collapse in cases of severe stenosis. In unstable angina (excluding variant angina), amlodipine can cause a

pos: Shone's syndrome Subaortic stenosis has been observed in both muscular and membranous forms. In either case, a variable degree of obstruction may be observed at the ventricular surface of the aortic valve. This presents an obstruction of flow of blood from the ventricle to the aorta. Coarctation of the aorta which is, narrowing of a section of the aorta may also be observed. Again this presents an obstruction to blood flow out from the left ventricle. Since there is obstruction of flow into and out of the left ventricle, the prognosis depends on the degree of obstruction and its effect on blood

pos: Aortic insufficiency decreases as it relaxes and begins to fill up with blood from the left atrium. This relaxation of the left ventricle (early ventricular diastole) causes a fall in its pressure. When the pressure in the left ventricle falls below the pressure in the aorta, the aortic valve will close, preventing blood in the aorta from going back into the left ventricle. In terms of the diagnosis of aortic regurgitation a common test for the evaluation of the severity is transthoracic echocardiography, which can provide two-dimensional views of the regurgitant jet, allow measurement of velocity, and estimate jet volume. The findings

pos: Heart sounds P especially during inspiration where a split of S can be heard. It is caused by the closure of the semilunar valves (the aortic valve and pulmonary valve) at the end of ventricular systole and the beginning of ventricular diastole. As the left ventricle empties, its pressure falls below the pressure in the aorta. Aortic blood flow quickly reverses back toward the left ventricle, catching the pocket-like cusps of the aortic valve, and is stopped by aortic valve closure. Similarly, as the pressure in the right ventricle falls below the pressure in the pulmonary artery, the pulmonary valve closes. The

pos: Heart development ventricles. The arterial trunk and the roots will form the proximal portion of the aorta and the pulmonary artery. The junction between the ventricle and the arterial bulb will be called the primary intra-ventricular hole. The tube is divided into cardiac regions along its craniocaudal axis: the primitive ventricle, called primitive left ventricle, and the trabecular proximal arterial bulb, called the primitive right ventricle. This time no septum is present in heart. In the middle of the fourth week, the sinus venosus receives venous blood from the poles of right and left sinus. Each pole receives blood from three major

pos: Afterload aortic valve. This leads to elevated systolic blood pressure. The diastolic blood pressure in the aorta would fall, due to regurgitation. This would result in an increase in pulse pressure. Mitral regurgitation (MR) "decreases" afterload. In ventricular systole under MR, regurgitant blood flows backwards/retrograde back and forth through a diseased and leaking mitral valve. The remaining blood loaded into the LV is then optimally ejected out through the aortic valve. With an extra pathway for blood flow through the mitral valve, the left ventricle does not have to work as hard to eject its blood, i.e. there is a decreased

pos: Coronary circulation to travel "in reverse", from the left ventricle to the left atrium, instead of forward to the aorta and the rest of the body. This leaking of blood to the left atrium is known as mitral regurgitation. Similarly, the leaking of blood from the right ventricle through the tricuspid valve and into the right atrium can also occur, and this is described as tricuspid insufficiency or tricuspid regurgitation. The anterolateral papillary muscle more frequently receives two blood supplies: left anterior descending (LAD) artery and the left circumflex artery (LCX). It is therefore more frequently resistant to coronary ischemia (insufficiency of

pos: Frank–Starling law cardiac outputs were not equivalent, blood would accumulate in the pulmonary circulation (were the right ventricle producing more output than the left) or the systemic circulation (were the left ventricle producing more output than the right). Premature ventricular contraction causes early emptying of the left ventricle (LV) into the aorta. Since the next ventricular contraction occurs at its regular time, the filling time for the LV increases, causing an increased LV end-diastolic volume. Due to the Frank–Starling mechanism, the next ventricular contraction is more forceful, leading to the ejection of the larger than normal volume of blood, and bringing the

pos: Ventricle (heart) relax very quickly after each contraction so as to quickly fill with the oxygenated blood flowing from the pulmonary veins. Likewise in the systolic phase, the left ventricle must contract rapidly and forcibly to pump this blood into the aorta, overcoming the much higher aortic pressure. The extra pressure exerted is also needed to stretch the aorta and other arteries to accommodate the increase in blood volume. The right ventricle receives deoxygenated blood from the right atrium via the tricuspid valve and pumps it into the pulmonary artery via the pulmonary valve, into the pulmonary circulation. The typical healthy adult

pos: Crisscross heart the left ventricle. After the left ventricle is filled with blood the aortic valve opens allowing blood to go through, which the blood then enters the aorta and goes to the rest of the body. Crisscross heart is a very rare congenital heart defect, and results in many different symptoms, even though the heart still has the ability to perform its major function of pumping blood throughout the body. Individuals who have this disease will experience cyanosis which is a blue tint to the skin because of inadequate blood flow to the body, this symptom will be seen especially around

pos: Austin Flint murmur turbulent mixing of anterograde mitral flow and retrograde aortic flow: Displacement: The blood jets from the aortic regurgitation strike the anterior leaflet of the mitral valve, which often results in premature closure of the mitral leaflets. This can be mistaken for mitral stenosis. Turbulence of the two columns of blood: Blood from left atrium to left ventricle and blood from aorta to left ventricle. The Austin Flint murmur is named after the 19th century American physician, Austin Flint (1812–1886). He disapproved of associating any physical sign with the name of the original describer, and wrote, “So long as signs are

pos: Ventricle (heart) resting values and stated as relative to surrounding atmospheric which is the typical "0" reference pressure used in medicine.) During systole, the ventricles contract, pumping blood through the body. During diastole, the ventricles relax and fill with blood again. The left ventricle receives oxygenated blood from the left atrium via the mitral valve and pumps it through the aorta via the aortic valve, into the systemic circulation. The left ventricular muscle must relax and contract quickly and be able to increase or lower its pumping capacity under the control of the nervous system. In the diastolic phase, it has to

pos: Heart valve of blood that is transferred from the left atrium to the left ventricle. This amount of blood is known as the end diastolic volume (EDV), and the mitral valve closes at the end of atrial contraction to prevent a reversal of blood flow. The tricuspid valve has three leaflets or cusps and is on the right side of the heart. It is between the right atrium and the right ventricle, and stops the backflow of blood between the two. The aortic and pulmonary valves are located at the base of the aorta and the pulmonary trunk respectively. These are also

pos: Ventricle (heart) the right atrioventricular fibrous ring and connects the posterior surface of the conus arteriosus to the aorta. The left ventricle is longer and more conical in shape than the right, and on transverse section its concavity presents an oval or nearly circular outline. It forms a small part of the sternocostal surface and a considerable part of the diaphragmatic surface of the heart; it also forms the apex of the heart. The left ventricle is thicker and more muscular than the right ventricle because it pumps blood at a higher pressure. The right ventricle is triangular in shape and extends

pos: Cardiac physiology move passively from the atria into the ventricles. When the action potential triggers the muscles in the atria to contract (atrial systole), the pressure within the atria rises further, pumping blood into the ventricles. During ventricular systole, pressure rises in the ventricles, pumping blood into the pulmonary trunk from the right ventricle and into the aorta from the left ventricle. At the beginning of the cardiac cycle, both the atria and ventricles are relaxed (diastole). Blood is flowing into the right atrium from the superior and inferior venae cavae and the coronary sinus. Blood flows into the left atrium from

pos: Circulatory system of the heart. The blood that is returned to the right atrium is deoxygenated (poor in oxygen) and passed into the right ventricle to be pumped through the pulmonary artery to the lungs for re-oxygenation and removal of carbon dioxide. The left atrium receives newly oxygenated blood from the lungs as well as the pulmonary vein which is passed into the strong left ventricle to be pumped through the aorta to the different organs of the body. The coronary circulation system provides a blood supply to the heart muscle itself. The coronary circulation begins near the origin of the aorta

neg: Mitral insufficiency Mitral insufficiency Mitral regurgitation (MR), Mitral insufficiency (abbreviation MI best avoided because it is more commonly used in lieu of myocardial infarction), or mitral incompetence is a disorder of the heart in which the mitral valve does not close properly when the heart pumps out blood. It is the abnormal leaking of blood backwards from the left ventricle, through the mitral valve, into the left atrium, when the left ventricle contracts, i.e. there is regurgitation of blood back into the left atrium. MR is the most common form of valvular heart disease. The symptoms associated with MR are dependent on

neg: Mustard procedure vessels. The procedure employs a baffle to redirect caval blood flow to the left atrium which then pumps blood to the left ventricle which then pumps the deoxygenated blood to the lungs. In a normal heart, de-oxygenated blood is pumped into the lungs via the right ventricle. Then it is distributed throughout the body via the left ventricle. In the Mustard procedure, blood is pumped to the lungs via the left ventricle and disseminated throughout the body via the right ventricle. The Mustard procedure was largely replaced in the late 1980s by the Jatene procedure (arterial switch), in which the

neg: Mitral valve is . Microscopically, there is no evidence of an annular structure anteriorly, where the mitral valve leaflet is contiguous with the posterior aortic root. During left ventricular diastole, after the pressure drops in the left ventricle due to relaxation of the ventricular myocardium, the mitral valve opens, and blood travels from the left atrium to the left ventricle. About 70 to 80% of the blood that travels across the mitral valve occurs during the "early filling phase" of the left ventricle. This early filling phase is due to active relaxation of the ventricular myocardium, causing a pressure gradient that allows

neg: Lutembacher's syndrome will usually cause the blood flow from the right atrium to skip going to the right ventricle and instead flow to the left atrium. If mitral stenosis (the hardening of flap of tissue known as a valve which opens and closes between the left atrium and ventricle to control blood flow) is also present, blood will flow into the right atrium through the hole between the atria wall instead of flowing into the left ventricle and systemic circulation. Eventually this leads to other problems such as the right ventricle failing and a reduced blood flow to the left ventricle. In

neg: Circulatory system combines from capillaries around the gastrointestinal tract where the blood absorbs the various products of digestion; rather than leading directly back to the heart, the hepatic portal vein branches into a second capillary system in the liver. The heart pumps oxygenated blood to the body and deoxygenated blood to the lungs. In the human heart there is one atrium and one ventricle for each circulation, and with both a systemic and a pulmonary circulation there are four chambers in total: left atrium, left ventricle, right atrium and right ventricle. The right atrium is the upper chamber of the right side

neg: Diastolic function "diastolic function" the complicated and speculative physiology must be taken into consideration. How the heart works during its filling period still has many misconceptions remaining. To better understand diastolic function, it is crucial to realize that the left ventricle is a mechanical suction pump at, and for a little while after, the mitral valve opening. In other words, when mitral valve opens, the atrium does not push blood into the ventricle, instead, it is the ventricle that mechanically "sucks" in blood from the atrium. The energy that drives the suction process is generated from phase of systole. During systole, to

neg: Constrictive pericarditis allows for more room for filling in right ventricle and therefore a septal shift occurs. During expiration, the amount of blood entering the right ventricle will decrease, allowing the interventricular septum to bulge towards the right ventricle, and increased filling of the [[left ventricle and subsequent increased pressure generated by the left ventricle during systole.This is known as [[ventricular interdependence]], since the amount of blood flow into one ventricle is dependent on the amount of blood flow into the other ventricle. The diagnosis of constrictive pericarditis is often difficult to make. In particular, [[restrictive cardiomyopathy]] has many similar clinical features

neg: Ibn al-Nafis BC) and that the ventricle gets its energy from the blood flowing in the vessels running in the coronary vessels, not from blood deposited in the right ventricle. Based on his anatomical knowledge, Ibn al-Nafis stated: Blood from the right chamber of the heart must arrive at the left chamber, but there is no direct pathway between them. The thick septum of the heart is not perforated and does not have visible pores as some people thought or invisible pores as Galen thought. The blood from the right chamber must flow through the vena arteriosa (pulmonary artery) to the lungs,

neg: Double inlet left ventricle Double inlet left ventricle A double inlet left ventricle (DILV) or "single ventricle", is a congenital heart defect appearing in 5 in newborns, where both the left atrium and the right atrium feed into the left ventricle. The right ventricle is hypoplastic or does not exist. Both atria communicate with the ventricle by a single atrio-ventricular valve. There is a big shunt left-right with a quickly evolutive pulmonary hypertension. Without life-prolonging interventions, the condition is fatal, but with intervention, the newborn may survive. Even if there is no foetal sickness, the diagnosis can be made in utero by foetal echocardiography.

neg: Tricuspid atresia connection, an atrial septal defect (ASD) must be present to fill the left ventricle with blood. Also, since there is a lack of a right ventricle there must be a way to pump blood into the pulmonary arteries, and this is accomplished by a ventricular septal defect (VSD). The causes of Tricupsid atresia are unknown. An atrial septal defect (ASD) and a ventricular septal defect (VSD) must both be present to maintain blood flow-from the right atrium, the blood must flow through the ASD to the left atrium to the left ventricle and through the VSD to the right ventricle

neg: Vein venules, which continue to converge and form the larger veins. The de-oxygenated blood is taken by veins to the right atrium of the heart, which transfers the blood to the right ventricle, where it is then pumped through the pulmonary arteries to the lungs. In pulmonary circulation the pulmonary veins return oxygenated blood from the lungs to the left atrium, which empties into the left ventricle, completing the cycle of blood circulation. The return of blood to the heart is assisted by the action of the muscle pump, and by the thoracic pump action of breathing during respiration. Standing or

neg: Mitral valve stenosis gradient across the mitral valve increases, the amount of time necessary to fill the left ventricle with blood increases. Eventually, the left ventricle requires the atrial kick to fill with blood. As the heart rate increases, the amount of time that the ventricle is in diastole and can fill up with blood (called the diastolic filling period) decreases. When the heart rate goes above a certain point, the diastolic filling period is insufficient to fill the ventricle with blood and pressure builds up in the left atrium, leading to pulmonary congestion. When the mitral valve area goes less than 1

neg: Pulmonary circulation this pneuma to the left ventricle of the heart to cool the blood simultaneously arriving there. This mixture of pneuma, blood, and cooling produced the vital spirits which could then be transported throughout the body via arteries. Galen also proposed that the heat of the blood arriving in the heart produced noxious vapors which were expelled through the same pulmonary veins that first brought the pneuma. He wrote that the right ventricle played a different role than the left; it transported blood to the lungs where the impurities were vented out so that clean blood could be distributed throughout the

neg: Bird pressure. As blood travels through the venules to the veins a funneling occurs called vasodilation bringing blood back to the heart. Once the blood reaches the heart it moves first into the right atrium, then the right ventricle to be pumped through the lungs for further gas exchange of carbon dioxide waste for oxygen. Oxygenated blood then flows from the lungs through the left atrium to the left ventricle where it is pumped out to the body. The nervous system is large relative to the bird's size. The most developed part of the brain is the one that controls the

neg: Blood vary somewhat between species. In non-mammalian vertebrates, however, there are some key differences: Blood is circulated around the body through blood vessels by the pumping action of the heart. In humans, blood is pumped from the strong left ventricle of the heart through arteries to peripheral tissues and returns to the right atrium of the heart through veins. It then enters the right ventricle and is pumped through the pulmonary artery to the lungs and returns to the left atrium through the pulmonary veins. Blood then enters the left ventricle to be circulated again. Arterial blood carries oxygen from inhaled

neg: Heart from the lungs via one of the four pulmonary veins. The left atrium has an outpouching called the left atrial appendage. Like the right atrium, the left atrium is lined by pectinate muscles. The left atrium is connected to the left ventricle by the mitral valve. The left ventricle is much thicker as compared with the right, due to the greater force needed to pump blood to the entire body. Like the right ventricle, the left also has trabeculae carneae, but there is no moderator band. The left ventricle pumps blood to the body through the aortic valve and into

neg: Mitral valve stenosis infective endocarditis where the vegetations may favor increase risk of stenosis. Other rare causes include mitral annular calcification, endomyocardial fibroelastosis, malignant carcinoid syndrome, systemic lupus erythematosus, whipple disease, fabry disease, and rheumatoid arthritis. hurler' disease, hunter's disease, amyloidosis. The normal area of the mitral valve orifice is about 4 to 6 cm. In normal cardiac physiology, the mitral valve opens during left ventricular diastole, to allow blood to flow from the left atrium to the left ventricle. A normal mitral valve will not impede the flow of blood from the left atrium to the left ventricle during (ventricular) diastole, and

neg: Stroke volume Stroke volume In cardiovascular physiology, stroke volume (SV) is the volume of blood pumped from the left ventricle per beat. Stroke volume is calculated using measurements of ventricle volumes from an echocardiogram and subtracting the volume of the blood in the ventricle at the end of a beat (called end-systolic volume) from the volume of blood just prior to the beat (called end-diastolic volume). The term "stroke volume" can apply to each of the two ventricles of the heart, although it usually refers to the left ventricle. The stroke volumes for each ventricle are generally equal, both being approximately 70

neg: Ventricular septal defect defect) include the incomplete looping of the heart during days 24-28 of development. Faults with NKX2.5 gene are usually associated with isolated (non syndromic) ASD in humans when one copy is missing. During ventricular contraction, or systole, some of the blood from the left ventricle leaks into the right ventricle, passes through the lungs and reenters the left ventricle via the pulmonary veins and left atrium. This has two net effects. First, the circuitous refluxing of blood causes volume overload on the left ventricle. Second, because the left ventricle normally has a much higher systolic pressure (~120 mmHg) than the

neg: Heart valve or cusps. The mitral valve gets its name from the resemblance to a bishop's mitre (a type of hat). It is on the left side of the heart and allows the blood to flow from the left atrium into the left ventricle. During diastole, a normally-functioning mitral valve opens as a result of increased pressure from the left atrium as it fills with blood (preloading). As atrial pressure increases above that of the left ventricle, the mitral valve opens. Opening facilitates the passive flow of blood into the left ventricle. Diastole ends with atrial contraction, which ejects the final 30%

neg: Heart role in cardiac conduction. It arises from the lower part of the interventricular septum and crosses the interior space of the right ventricle to connect with the inferior papillary muscle. The right ventricle tapers into the pulmonary trunk, into which it ejects blood when contracting. The pulmonary trunk branches into the left and right pulmonary arteries that carry the blood to each lung. The pulmonary valve lies between the right heart and the pulmonary trunk. The left heart has two chambers: the left atrium, and the left ventricle, separated by the mitral valve. The left atrium receives oxygenated blood back

neg: Pulsus paradoxus the heart expands the right heart and directly compromises filling of the left side of the heart by slightly bulging the septum to the left, reducing maximum volume. Reduced left-heart filling leads to a reduced stroke volume which manifests as a decrease in systolic blood pressure, leading to a faster heart rate due to the baroreceptor reflex, which stimulates sympathetic outflow to the heart. Under normal physiologic conditions the large pressure gradient between the right and left ventricles prevents the septum from bulging dramatically into the left ventricle during inspiration. However such bulging does occur during cardiac tamponade where pressure

neg: Mitral valve stenosis the pressures in the left atrium and the left ventricle during ventricular diastole will be equal. The result is that the left ventricle gets filled with blood during early ventricular diastole, with only a small portion of extra blood contributed by contraction of the left atrium (the "atrial kick") during late ventricular diastole. When the mitral valve area goes below 2 cm, the valve causes an impediment to the flow of blood into the left ventricle, creating a pressure gradient across the mitral valve. This gradient may be increased by increases in the heart rate or cardiac output. As the

neg: Systole the value of the heart rate (in beats per minute), which typically is measured jointly with blood pressure readings. Systole The systole is the part of the cardiac cycle during which some chambers of the heart muscle contract after refilling with blood. The term "systole" originates from New Latin via Ancient Greek συστολή (sustolē): from συστέλλειν (sustellein, "to contract") via [σύν (syn, "together") + στέλλειν (stellein, "send"). The use of systole, "to contract", is very similar to the use of the English term "to squeeze". The mammalian heart has four chambers: the left atrium above the left ventricle (lighter pink,

neg: Medicine in the medieval Islamic world blood is pumped to the rest of the body. According to Galen in the 2nd century, blood reached the left ventricle through invisible passages in the septum. By some means, Ibn al-Nafis, a 13th-century Syrian physician, found the previous statement on blood flow from the right ventricle to the left to be false. Ibn al-Nafis discovered that the ventricular septum was impenetrable, lacking any type of invisible passages, showing Galen's assumptions to be false. Ibn al-Nafis discovered that the blood in the right ventricle of the heart is instead carried to the left by way of the lungs. This discovery

neg: Hypoplastic left heart syndrome oxygenated blood in the right ventricle, there is still venous mixing from the lower half of the body, leading to some degree of oxygen desaturation. The final procedure, the Fontan procedure, completes the repair of the hypoplastic left heart. Although there are several variations, the functional effect is to redirect venous blood from the lower body (through the inferior vena cava) away from the right atrium to the pulmonary artery. This should eliminate any mixing of oxygenated and deoxygenated blood in the right ventricle. The right ventricle performs the traditional job of the left, supplying the body with oxygenated blood,

neg: TBX20 can result in various forms of congenital heart disease. One of the more serious examples is the presence of a septal defect. The interatrial septum is a piece of tissue that separates the left and right atria of the heart, which contain oxygenated and deoxygenated blood, respectively. In Tbx20 mutants, this divider does not form and results in deoxygenated blood flowing into the left atrium then left ventricle, which ships the blood to the organs and muscles. Since deoxygenated blood should not be delivered to the tissues, the result is cyanosis, or a bluish skin discoloration stemming from low oxygen

neg: Cardiac physiology is to collect de-oxygenated blood, in the right atrium, from the body via the superior vena cava, inferior vena cava and from the coronary sinus and pump it, through the tricuspid valve, via the right ventricle, through the semilunar pulmonary valve and into the pulmonary artery in the pulmonary circulation where carbon dioxide can be exchanged for oxygen in the lungs. This happens through the passive process of diffusion. In the "left heart" oxygenated blood is returned to the left atrium via the pulmonary vein. It is then pumped into the left ventricle through the bicuspid valve and into the

neg: Ventricular septal defect right ventricle (~20 mmHg), the leakage of blood into the right ventricle therefore elevates right ventricular pressure and volume, causing pulmonary hypertension with its associated symptoms. In serious cases, the pulmonary arterial pressure can reach levels that equal the systemic pressure. This reverses the left to right shunt, so that blood then flows from the right ventricle into the left ventricle, resulting in cyanosis, as blood is by-passing the lungs for oxygenation. This effect is more noticeable in patients with larger defects, who may present with breathlessness, poor feeding and failure to thrive in infancy. Patients with smaller defects may

neg: Ventricular outflow tract called "conus arteriosus" from the outside, and infundibulum from the inside. In the left ventricle the outflow tract is the "aortic vestibule". They both possess smooth walls, and are derived from the embryonic bulbus cordis In both left and right ventricle there are specific structures separating the inflow and outflow of blood. In the right ventricle, the inflow and outflow is separated by the supraventricular crest. In the left ventricle, the anterior cusp of the mitral valve is responsible for separating the flow of blood. A form of ventricular tachycardia originating from this anatomical structure is called RVOT tachycardia. The

neg: Tafazzin cardiomyopathy without the other features of Barth syndrome. Dilated cardiomyopathy is a condition in which the heart becomes weakened and enlarged and cannot pump blood efficiently, often resulting in heart failure. The decreased blood flow can lead to swelling in the legs and abdomen, fluid in the lungs, and an increased risk of blood clots. Mutations in the "TAZ" gene can cause a heart condition called isolated noncompaction of left ventricular myocardium (INVM). This condition occurs when the lower left chamber of the heart (left ventricle) does not develop correctly. In INVM, the heart muscle is weakened and cannot pump

neg: Atrial septal defect remarkable left-to-right shunt, blood shunts from the left atrium to the right atrium. This extra blood from the left atrium may cause a volume overload of both the right atrium and the right ventricle. If untreated, this condition can result in enlargement of the right side of the heart and ultimately heart failure. Any process that increases the pressure in the left ventricle can cause worsening of the left-to-right shunt. This includes hypertension, which increases the pressure that the left ventricle has to generate to open the aortic valve during ventricular systole, and coronary artery disease which increases the stiffness

neg: Atrial septal defect of the left ventricle, thereby increasing the filling pressure of the left ventricle during ventricular diastole. The left-to-right shunt increases the filling pressure of the right heart (preload) and forces the right ventricle to pump out more blood than the left ventricle. This constant overloading of the right side of the heart causes an overload of the entire pulmonary vasculature. Eventually, pulmonary hypertension may develop. The pulmonary hypertension will cause the right ventricle to face increased afterload. The right ventricle is forced to generate higher pressures to try to overcome the pulmonary hypertension. This may lead to right ventricular failure

neg: Heart valve tricuspid valve has anterior, posterior, and septal cusps; and the mitral valve has just anterior and posterior cusps. The valves of the human heart can be grouped in two sets: 1- Two Atrioventricular (AV) valves to prevent backflow of blood from the ventricles into the atria a) Tricuspid valve, located between the right atrium and right ventricle. b) Bicuspid or mitral valve, located between the left atrium and left ventricle. 2- Two Semilunar valves to prevent the backflow of blood into the ventricle a) Pulmonary semilunar valve, located at the opening between the right ventricle and the pulmonary trunk. b)

neg: Afterload Afterload Afterload is the pressure against which the heart must work to eject blood during systole. In other words, it is the end load against which the heart contracts to eject blood. Afterload is readily broken into components: one factor is the aortic pressure the left ventricular muscle must overcome to eject blood. The greater the aortic/pulmonary pressure, the greater the after load on the left/right ventricle, respectively. Following Laplace's law, the tension upon the muscle fibers in the heart wall is the pressure within the ventricle multiplied by the volume within the ventricle divided by the wall thickness (this

neg: Atrium (heart) now used for an appendage of the atrium. Humans have a four-chambered heart consisting of the right atrium, left atrium, right ventricle, and left ventricle. The atria are the two upper chambers. The right atrium receives and holds deoxygenated blood from the superior vena cava, inferior vena cava, anterior cardiac veins and smallest cardiac veins and the coronary sinus, which it then sends down to the right ventricle (through the tricuspid valve) which in turn sends it to the pulmonary artery for pulmonary circulation. The left atrium receives the oxygenated blood from the left and right pulmonary veins, which it

neg: Right-to-left shunt flow direction is precipitated by pulmonary hypertension due to increased pulmonary blood flow in a left-to-right shunt. The right ventricle hypertrophies to compensate for this pulmonary hypertension, so the right ventricular pressure becomes higher than the pressure in the left ventricle. Because of this switch in the pressure gradient, blood starts flowing right to left, forming a right-to-left shunt. As with any right-to-left shunt, there is decreased blood flow to the lungs, resulting in decreased oxygenation of blood and cyanosis. The most common cause of right-to-left shunt is the Tetralogy of Fallot, a congenital cardiac anomaly characterized by four co-existing

neg: Fourth heart sound the atria contract to force blood into the ventricle. S is sometimes audible in the elderly due to a more rigid ventricle. When loud, it is a sign of a pathologic state, usually a failing left ventricle. If the problem lies with the left ventricle, the gallop rhythm will be heard best at the cardiac apex. It will become more apparent with exercise, with the patient lying on the left-hand side, or with the patient holding expiration. If the problem is in the right ventricle, the abnormal sound will be most evident on the lower left hand side of the

neg: Mitral valve repair Mitral valve repair Mitral valve repair is a cardiac surgery procedure performed by cardiac surgeons to treat stenosis (narrowing) or regurgitation (leakage) of the mitral valve. The mitral valve is the "inflow valve" for the left side of the heart. Blood flows from the lungs, where it picks up oxygen, through the pulmonary veins, to the left atrium of the heart. After the left atrium fills with blood, the mitral valve allows blood to flow from the left atrium into the heart's main pumping chamber called the left ventricle. It then closes to keep blood from leaking back into the

neg: Lutembacher's syndrome atria after birth. With the onset of a hole created in the tissue flap that closes the larger hole between the left and right atrium, blood can again flow from the right atrium to the left. Ostium secundum causes many of the same symptoms seen in ASD primium. With either type of ASD, blood will flow from the right atrium skipping the right ventricle (or very little flowing into the ventricle) and instead flow to the left atrium introducing the possibility of blood lacking oxygen to go the rest of the body. Sometimes, the direction of blood flow is largely

neg: Birth the baby starts to breathe air, and blood from the right ventricle starts to flow to the lungs for gaseous exchange and oxygenated blood returns to the left atrium, which is pumped into the left ventricle, and then pumped into the main arterial system. As result of these changes, the blood pressure in the left atrium exceeds the pressure in the right atrium, and this pressure difference forces the foramen ovale to close separating the left and right sides of the heart. The umbilical vein, umbilical arteries, ductus venosus and ductus arteriosus are not needed for life in air and

neg: Tricuspid atresia to allow access to the lungs CXR : decreased pulmonary blood flow and oligemic lung field ECG : left axis deviation Tricuspid atresia Tricuspid atresia is a form of congenital heart disease whereby there is a complete absence of the tricuspid valve. Therefore, there is an absence of right atrioventricular connection. This leads to a hypoplastic (undersized) or absent right ventricle. This defect is contracted during prenatal development, when the heart does not finish developing. It causes the heart to be unable to properly oxygenate the rest of the blood in the body. Because of this, the body does not

neg: Mitral valve inelastic tendons attached at one end to papillary muscles in the left ventricle, and at the other to the valve cusps. Papillary muscles are finger-like projections from the wall of the left ventricle. When the left ventricle contracts, the pressure in the ventricle forces the valve to close, while the tendons keep the leaflets coapting together and prevent the valve from opening in the wrong direction (thus preventing blood to flow back to the left atrium). Each chord has a different thickness. The thinnest ones are attached to the free leaflet margin, whereas thickest ones (strut chords) are attached quite

neg: Ejection fraction the left heart, known as the left ventricular ejection fraction (LVEF), is calculated by dividing the volume of blood pumped from the left ventricle per beat (stroke volume) by the volume of blood collected in the left ventricle at the end of diastolic filling (end-diastolic volume). LVEF is an indicator of the effectiveness of pumping into the systemic circulation. The EF of the right heart, or right ventricular ejection fraction (RVEF), is a measure of the efficiency of pumping into the pulmonary circulation. A heart which cannot pump sufficient blood to meet the body's requirements (i.e., heart failure) will often,

neg: Systole Systole The systole is the part of the cardiac cycle during which some chambers of the heart muscle contract after refilling with blood. The term "systole" originates from New Latin via Ancient Greek συστολή (sustolē): from συστέλλειν (sustellein, "to contract") via [σύν (syn, "together") + στέλλειν (stellein, "send"). The use of systole, "to contract", is very similar to the use of the English term "to squeeze". The mammalian heart has four chambers: the left atrium above the left ventricle (lighter pink, see graphic), which two are connected through the mitral (or bicuspid) valve; and the right atrium above the right

neg: Split S2 "Normally, blood pressure falls during inspiration (equal or less than 10 mmHg), due to an increase in blood flow into the right ventricle with displacement of the interventricular septum to the left, decreasing left ventricular filling and cardiac output". The pressure in the right ventricle tries to open the pulmonary valve. The pressure in the pulmonary artery tries to close the pulmonary valve. Remember that the higher pressure will "win". Hence, the closure of the pulmonary valve (P) will be delayed since the pressure in the right ventricle is increased in inspiration, opposing the pressure in the pulmonary artery and

neg: Circulatory system originated in the heart. Blood flowed from both creating organs to all parts of the body where it was consumed and there was no return of blood to the heart or liver. The heart did not pump blood around, the heart's motion sucked blood in during diastole and the blood moved by the pulsation of the arteries themselves. Galen believed that the arterial blood was created by venous blood passing from the left ventricle to the right by passing through 'pores' in the interventricular septum, air passed from the lungs via the pulmonary artery to the left side of the

neg: American flamingo moves first into the right atrium, then the left ventricle to be pumped through the lungs for further gas exchange of carbon dioxide waste for oxygen. Oxygenated blood then flows from the lungs through the left atrium to the left ventricle where it is pumped out to the body. With respect to thermoregulation, the American flamingo has highly vascularized feet that use a countercurrent exchange system in there legs and feet. This method of thermoregulation keeps a constant gradient between the veins and arteries that are in close proximity in order to maintain heat within the core and minimize heat

neg: Constrictive pericarditis is common, it is the cause in a large portion of cases. Causes of constrictive pericarditis include: The pathophysiological characteristics of constrictive pericarditis are due to a thickened, fibrotic pericardium that forms a non-compliant shell around the heart. This shell prevents the heart from expanding when blood enters it. This results in significant respiratory variation in blood flow in the chambers of the heart. During inspiration, pressure in the thoracic cavity decreases but is not relayed to the left atrium, subsequently a reduction in flow to the left atrium and ventricle happens. During diastole, less blood flow in left ventricle

neg: Cardiac shunt of the person whose heart it is. There are four chambers in a heart: an atrium (upper) and a ventricle (lower) on both the left and right sides. In mammals and birds, blood from the body goes to the right side of the heart first. Blood enters the upper right atrium, is pumped down to the right ventricle and from there to the lungs via the pulmonary artery. Blood going to the lungs is called the pulmonary circulation. When the blood returns to the heart from the lungs via the pulmonary vein, it goes to the left side of the

neg: Right ventricular hypertrophy Right ventricular hypertrophy Right ventricular hypertrophy (RVH) is a form of ventricular hypertrophy affecting the right ventricle. Blood travels through the right ventricle to the lungs via the pulmonary arteries. If conditions occur which decrease pulmonary circulation, meaning blood does not flow well from the heart to the lungs, extra stress can be placed on the right ventricle. This can lead to right ventricular hypertrophy. It can affect electrocardiography (ECG) findings. An ECG with right ventricular hypertrophy may or may not show a right axis deviation on the graph. There are various symptoms that can be seen: Common causes include:

neg: Systole atrium and ventricle is preserved during late ventricular diastole. Atrial contraction confers a minor-fraction addition to ventricular filling, but becomes significant in left ventricular hypertrophy, or thickening of the heart wall, as the ventricle does not fully relax during its diastole. Loss of normal electrical conduction in the heart—as seen during atrial fibrillation, atrial flutter, and complete heart block—may eliminate atrial systole completely. Contraction of the atria follows depolarization, represented by the P wave of the ECG. As both atrial chambers contract—from the superior region of the atria toward the atrioventricular septum—pressure rises within the atria and blood is pumped

neg: Mitral valve a rapid flow of blood from the left atrium, across the mitral valve. This early filling across the mitral valve is seen on doppler echocardiography of the mitral valve as the "E wave". After the E wave, there is a period of slow filling of the ventricle. Left atrial contraction (left atrial systole) (during left ventricular diastole) causes added blood to flow across the mitral valve immediately before left ventricular systole. This late flow across the open mitral valve is seen on doppler echocardiography of the mitral valve as the "A wave". The late filling of the left ventricle contributes

neg: Stroke volume aortic stenosis and arterial hypertension. Similar to cardiac index, is a method of relating the stroke volume (SV) to the size of the person Body surface area (BSA). formula_2 Stroke volume In cardiovascular physiology, stroke volume (SV) is the volume of blood pumped from the left ventricle per beat. Stroke volume is calculated using measurements of ventricle volumes from an echocardiogram and subtracting the volume of the blood in the ventricle at the end of a beat (called end-systolic volume) from the volume of blood just prior to the beat (called end-diastolic volume). The term "stroke volume" can apply to

neg: End-diastolic volume End-diastolic volume In cardiovascular physiology, end-diastolic volume (EDV) is the volume of blood in the right and/or left ventricle at end load or filling in (diastole) or the amount of blood in the ventricles just before systole. Because greater EDVs cause greater distention of the ventricle, "EDV" is often used synonymously with "preload", which refers to the length of the sarcomeres in cardiac muscle prior to contraction (systole). An increase in EDV increases the preload on the heart and, through the Frank-Starling mechanism of the heart, increases the amount of blood ejected from the ventricle during systole (stroke volume). The

neg: Pathophysiology of heart failure clammy extremities, cyanosis, claudication, generalized weakness, dizziness, and fainting. The resultant low blood oxygen caused by pulmonary edema causes vasoconstriction in the pulmonary circulation, which results in pulmonary hypertension. Since the right ventricle generates far lower pressures than the left ventricle (approximately 20 mmHg versus around 120 mmHg, respectively, in the healthy individual) but nonetheless generates cardiac output exactly equal to the left ventricle, this means that a small increase in pulmonary vascular resistance causes a large increase in amount of work the right ventricle must perform. However, the main mechanism by which left-sided heart failure causes right-sided heart failure

neg: Ejection fraction qualification for disability benefits in the USA. By definition, the volume of blood within a ventricle at the end of diastole is the end-diastolic volume (EDV). Likewise, the volume of blood left in a ventricle at the end of systole (contraction) is the end-systolic volume (ESV). The difference between EDV and ESV is the stroke volume (SV). The ejection fraction is the fraction of the end-diastolic volume that is ejected with each beat; that is, it is stroke volume (SV) divided by end-diastolic volume (EDV): formula_1 Where the stroke volume is given by: formula_2 EF is inherently a relative measurement—as

neg: Biofluid dynamics oxygen. The red blood cells and the hemoglobin present in the blood, which is the main carrier of oxygen in the blood are responsible for this exchange of gases before they are carried to the left ventricle of the heart. The systemic circulation is responsible for taking the oxygenated blood to various organs and tissues via the arterial tree before taking the deoxygenated blood to the right ventricle using the venous system (a network of veins). Arteries carry the oxygenated blood while the veins carry the deoxygenated blood. The fluids associated with the human body include air, oxygen, carbon dioxide,

neg: Atrioventricular canal right and left atria, and right and left ventricles. The right atrium and right ventricle function to pump blood to the lungs while the left atrium and left ventricle pump blood to the rest of the body. There are valves in place that inhibit back-flow between these chambers. This defect is developed because of the improper formation of the endocardial cushions, and their job is to separate the different parts of the heart during development when they fuse. It is strongly associated with Down's syndrome. The structures that develop from the fusion of the endocardial cushions are: Atrioventricular canal defect

neg: Orthopnea flat or closer to a horizontal position. Lying flat decreases the inhibitory effect that the gravity usually has on the blood that is coming back to the heart from the lower extremities of the body. This increases the right sided venous return. In a normal person, this redistribution of blood has little effect on respiratory function as the left ventricle has the adequate capacity to suddenly increase its stroke volume (as a result of Frank-Starling mechanism). In a person with heart failure, the left ventricle has an inadequate capacity to respond to increased arrival of blood from the pulmonary circulation.