query: what type of epithelial tissue forms the lining of the stomach

pos: Epithelium shape and function of the cells. The three principal shapes associated with epithelial cells are—squamous, cuboidal and columnar. By layer, epithelium is classed as either simple epithelium, only one cell thick (unilayered) or stratified epithelium as stratified squamous epithelium, stratified cuboidal epithelium, and stratified columnar epithelium that are two or more cells thick (multi-layered), and both types of layering can be made up of any of the cell shapes. However, when taller simple columnar epithelial cells are viewed in cross section showing several nuclei appearing at different heights, they can be confused with stratified epithelia. This kind of epithelium is

pos: Stratified columnar epithelium Stratified columnar epithelium Stratified columnar epithelium is a rare type of epithelial tissue composed of column shaped cells arranged in multiple layers. Stratified columnar epithelia are found in the conjunctiva of the eye, in parts of the pharynx, anus, the uterus, and the male urethra and vas deferens. It is also found in the lobar ducts in salivary glands. The cells function in secretion and protection. In simple terms, the upper and lowermost layer of cells are columnar in shape. The middle layer contains cuboidal cells. It forms the lining of the respiratory tract, ureter and oviduct among other locations.

pos: Gastric mucosa the acid secretion. The A cells produce glucagon, which mobilizes the hepatic glycogen, and the enterochromaffin cells produce serotonin, which stimulates the contraction of the smooth muscles. The surface of the mucous membrane is covered by a single layer of columnar epithelium. This epithelium commences very abruptly at the cardiac orifice, where there is a sudden transition from the stratified epithelium of the esophagus. The epithelial lining of the gland ducts is of the same character and is continuous with the general epithelial lining of the stomach. An important iodine concentration by sodium-iodide symporter (NIS) is present in mucinous cells

pos: Bronchiole not have hyaline cartilage and they have club cells in their epithelial lining. The epithelium starts as a simple ciliated columnar epithelium and changes to simple ciliated cuboidal epithelium as the bronchioles decreases in size. The diameter of the bronchioles is often said to be less than 1 mm, though this value can range from 5 mm to 0.3 mm. As stated, these bronchioles do not have hyaline cartilage to maintain their patency. Instead, they rely on elastic fibers attached to the surrounding lung tissue for support. The inner lining (lamina propria) of these bronchioles is thin with no glands

neg: Laryngopharyngeal reflux 87% of LPR cases and in fewer than 5% of GERD cases. Unlike GERD, LPR also poses a risk for bronchitis or pneumonitis as reflux of stomach acid to the level of the larynx can result in aspiration. LPR is also commonly associated with erythema, or redness, as well as edema in the tissues of the larynx that are exposed to gastric contents. In contrast, most cases of GERD are nonerosive, with no apparent injury to the mucosal lining of the esophageal tissue exposed to the refluxed material. Differences in the molecular structure of the epithelial tissue lining the laryngopharyngeal

neg: Anatomy connective tissue in the extracellular matrix secreted by the epithelial cells. There are many different types of epithelium, modified to suit a particular function. In the respiratory tract there is a type of ciliated epithelial lining; in the small intestine there are microvilli on the epithelial lining and in the large intestine there are intestinal villi. Skin consists of an outer layer of keratinized stratified squamous epithelium that covers the exterior of the vertebrate body. Keratinocytes make up to 95% of the cells in the skin. The epithelial cells on the external surface of the body typically secrete an extracellular

neg: Gut flora the gut epithelium, the intrusion of gut flora components into other host compartments can lead to sepsis. "Helicobacter pylori" can cause stomach ulcers by crossing the epithelial lining of the stomach. Here the body produces an immune response. During this response, parietal cells are stimulated and release extra hydrochloric acid (HCl) into the stomach. However, the response does not stimulate the mucus-secreting cells that protect and line the epithelium of the stomach. The extra acid sears holes into the epithelial lining of the stomach, resulting in stomach ulcers. Normally-commensal bacteria can harm the host if they extrude from the intestinal

neg: Human body connective tissue, nervous tissue and muscle tissue. Cells that lie on surfaces exposed to the outside world or gastrointestinal tract (epithelia) or internal cavities (endothelium) come in numerous shapes and forms – from single layers of flat cells, to cells with small beating hair-like cilia in the lungs, to column-like cells that line the stomach. Endothelial cells are cells that line internal cavities including blood vessels and glands. Lining cells regulate what can and can't pass through them, protect internal structures, and function as sensory surfaces. Organs, structured collections of cells with a specific function, sit within the body. Examples

neg: Germ layer mouth and pharynx and the terminal part of the rectum (which are lined by involutions of the ectoderm). It also forms the lining cells of all the glands which open into the digestive tract, including those of the liver and pancreas; the epithelium of the auditory tube and tympanic cavity; the trachea, bronchi, and alveoli of the lungs; the bladder and part of the urethra; and the follicle lining of the thyroid gland and thymus. The endoderm forms: the stomach, the colon, the liver, the pancreas, the bladder, the epithelial parts of trachea, the lungs, the pharynx, the thyroid, the

neg: Conidiomata of conidiomata, forms beneath the epithelial layer of host tissue. The structure resembles that of ascospores, and a pear-shaped structure produced entirely below the surface. This formations leaves the cuticle with only a minor bulge on the outside surface rather that a massive blister which was seen with Acervuli. Genera which produce this type of structure include Phomopsis, "Botryodiplodia", and "Phoma" Sporodochia are small, compact, slightly raised circles which form on host. "Deuteromycota" and "Hyphomycetes" produce these types of structures. Synnemata are large, fused conidiophores which form a strand resembling a stalk of wheat, with spores lining the outside of

neg: Epithelium rectum are composed of nonkeratinized stratified squamous epithelium. Other surfaces that separate body cavities from the outside environment are lined by simple squamous, columnar, or pseudostratified epithelial cells. Other epithelial cells line the insides of the lungs, the gastrointestinal tract, the reproductive and urinary tracts, and make up the exocrine and endocrine glands. The outer surface of the cornea is covered with fast-growing, easily regenerated epithelial cells. A specialised form of epithelium – endothelium forms the inner lining of blood vessels and the heart, and is known as vascular endothelium, and lining lymphatic vessels as lymphatic endothelium. Another type, mesothelium,

neg: Tripe Tripe Tripe is a type of edible lining from the stomachs of various farm animals. Most tripe is from cattle and sheep. Beef tripe is made from the muscle wall (the interior mucosal lining is removed) of only the first three chambers of a cow's stomach: the rumen (blanket/flat/smooth tripe), the reticulum (honeycomb and pocket tripe), and the omasum (book/bible/leaf tripe). Abomasum (reed) tripe is seen less frequently, owing to its glandular tissue content. Tripe refers to cow (beef) stomach, but includes stomach of any ruminant including cattle, sheep, deer, antelope, giraffes, and their relatives. Tripas, the related Spanish word,

neg: Cord lining Cord lining Cord lining, cord tissue, or umbilical cord lining membrane, is the outermost layer of the umbilical cord. As the umbilical cord itself is an extension of the placenta, the umbilical cord lining membrane is an extension of the amniotic membrane covering the placenta. The umbilical cord lining membrane comprises two layers: the amniotic (or epithelial) layer and the sub-amniotic (or mesenchymal) layer. The umbilical cord lining membrane is a rich source of two strains of stem cells: epithelial stem cells (from the amniotic layer) and mesenchymal stem cells (from the sub-amniotic layer). Discovered by Singapore based CellResearch Corp

neg: Vaginal cysts treatment. In most cases, there are no complications from the cysts themselves. A surgical removal carries a small risk of complication. The risk depends on where the cyst is located. Vaginal cysts Vaginal cysts are uncommon benign cysts that develop in the vaginal wall. The type of epithelial tissue lining a cyst is used to classify these growths. They can be congenital. They can present in childhood and adulthood. The most common type is the squamous inclusion cyst. It develops within vaginal tissue present at the site of an episiotomy or other vaginal surgical sites. In most instances they do

neg: Vaginal cysts Vaginal cysts Vaginal cysts are uncommon benign cysts that develop in the vaginal wall. The type of epithelial tissue lining a cyst is used to classify these growths. They can be congenital. They can present in childhood and adulthood. The most common type is the squamous inclusion cyst. It develops within vaginal tissue present at the site of an episiotomy or other vaginal surgical sites. In most instances they do not cause symptoms and present with few or no complications. A vaginal cyst can develop on the surface of the vaginal epithelium or in deeper layers. Often, they are found

neg: Helicobacter pylori 30 genes, part of which code for a complex type IV secretion system. The low GC-content of the "cag" PAI relative to the rest of the "Helicobacter" genome suggests the island was acquired by horizontal transfer from another bacterial species. To avoid the acidic environment of the interior of the stomach (lumen), "H. pylori" uses its flagella to burrow into the mucus lining of the stomach to reach the epithelial cells underneath, where it is less acidic. "H. pylori" is able to sense the pH gradient in the mucus and move towards the less acidic region (chemotaxis). This also keeps

neg: Acoela opens directly into the mesenchyme, i.e., the layer of tissue that fills the body. Digestion is accomplished by means of a syncytium that forms a vacuole around ingested food. There are no epithelial cells lining the digestive vacuole, but there is sometimes a short pharynx leading from the mouth to the vacuole. All other bilateral animals (apart from tapeworms) have a gut lined with epithelial cells. As a result, the acoels appear to be solid-bodied. As the most primitive bilateral animals, the Acoela provide interesting insights into early animal evolution and development. The most thoroughly studied animal in this group

neg: Calcifying odontogenic cyst without nuclei. It is a rare type of cyst and can occur at any age, mostly between second and third decade of life. The diameter ranges from 2 to 4 cm and swelling pain may be present. Intrabony expansions may produce hard bony expansion and may perforate cortical bones. It can also extend to soft tissue. It can present asymptomaticaly. Epithelial lining has ability to induce formation of dental tissues in adjacent connective tissue wall. In general, the epithelium seen is of stratified squamous type and is 2–3 cells thick. Additionally, focal areas of stellate reticulum like cells are seen

neg: Vitamin B12 deficiency anemia (ileum) after binding to a protein known as intrinsic factor. Intrinsic factor is produced by parietal cells of the gastric mucosa (stomach lining) and the intrinsic factor-B complex is absorbed by cubilin receptors on the ileum epithelial cells. PA is characterised by B deficiency caused by the absence of intrinsic factor. PA may be considered as an end stage of immune gastritis, a disease characterised by stomach atrophy and the presence of antibodies to parietal cells and intrinsic factor. A specific form of chronic gastritis, type A gastritis or atrophic body gastritis, is highly associated with PA. This autoimmune disorder

neg: Healing after the wound has been incurred, with mitoses beginning in epithelial cells after 24 to 48 hours . In the inflammatory phase, macrophages and other phagocytic cells kill bacteria, debride damaged tissue and release chemical factors such as growth hormones that encourage fibroblasts, epithelial cells and endothelial cells which make new capillaries to migrate to the area and divide. In the proliferative phase, immature granulation tissue containing plump, active fibroblasts forms. Fibroblasts quickly produce abundant type III collagen, which fills the defect left by an open wound. Granulation tissue moves, as a wave, from the border of the injury towards

neg: Loose connective tissue Loose connective tissue Loose connective tissue is a category of connective tissue which includes areolar tissue, reticular tissue, and adipose tissue. Loose connective tissue is the most common type of connective tissue in vertebrates. It holds organs in place and attaches epithelial tissue to other underlying tissues. For example, it forms telae, such as the tela submucosa and tela subserosa, which connect mucous and serous membranes to the muscular layer. It also surrounds the blood vessels and nerves. Cells called fibroblasts are widely dispersed in this tissue; they are irregular branching cells that secrete strong fibrous proteins and proteoglycans as

neg: Epithelium (both derived from mesoderm) to be true epithelium. This is because such tissues present very different pathology. For that reason, pathologists label cancers in endothelium and mesothelium sarcomas, whereas true epithelial cancers are called carcinomas. Additionally, the filaments that support these mesoderm-derived tissues are very distinct. Outside of the field of pathology, it is generally accepted that the epithelium arises from all three germ layers. Epithelial tissues have as their primary functions: Glandular tissue is the type of epithelium that forms the glands from the infolding of epithelium and subsequent growth in the underlying connective tissue. There are two major

neg: Lung are larger and they line the alveoli and produce and secrete epithelial lining fluid, and lung surfactant. Type II cells are able to divide and differentiate to Type 1 cells. The alveolar macrophages have an important immunological role. They remove substances which deposit in the alveoli including loose red blood cells that have been forced out from blood vesels. The lung is surrounded by a serous membrane of visceral pleura, which has an underlying layer of loose connective tissue attached to the substance of the lung. The lower respiratory tract is part of the respiratory system, and consists of the

neg: Pulmonary alveolus when the lung tissue is damaged. These cells are granular and roughly cuboidal. Type II alveolar cells are typically found at the blood-air barrier. Although they only make up <5% of the alveolar surface, they are relatively numerous (60% of alveolar epithelial cells). The alveolar macrophages, also called "dust cells", destroy foreign materials and microbes such as bacteria. Type I cells are thin, flat cells lining the alveolar walls. Each alveolus is surrounded by numerous capillaries, and is the site of gas exchange, which occurs by diffusion. The relatively low solubility (and hence rate of diffusion) of oxygen necessitates the

neg: Oral mucosa tissue engineering into dead surface cells to form the stratum corneum. The cells terminally differentiate as they migrate to the surface (from the basal layer where the progenitor cells are located to the dead superficial surface). The lamina propria is a fibrous connective tissue layer that consists of a network of type I and III collagen and elastin fibers. The main cells of the lamina propria are the fibroblasts, which are responsible for the production of the extracellular matrix. The basement membrane forms the border between the epithelial layer and the lamina propria. Cell culture techniques make it possible to produce epithelial

neg: Cord lining the corneal epithelium similar to that of a natural corneal surface. Such results were not seen when human amniotic membrane was used without the cells indicating the therapeutic value of the cord lining EpSC. Cord lining Cord lining, cord tissue, or umbilical cord lining membrane, is the outermost layer of the umbilical cord. As the umbilical cord itself is an extension of the placenta, the umbilical cord lining membrane is an extension of the amniotic membrane covering the placenta. The umbilical cord lining membrane comprises two layers: the amniotic (or epithelial) layer and the sub-amniotic (or mesenchymal) layer. The umbilical

neg: Epithelium continuous sheet. They have almost no intercellular spaces. All epithelia is usually separated from underlying tissues by an extracellular fibrous basement membrane. The lining of the mouth, lung alveoli and kidney tubules are all made of epithelial tissue. The lining of the blood and lymphatic vessels are of a specialised form of epithelium called endothelium. Epithelium lines both the outside (skin) and the inside cavities and lumina of bodies. The outermost layer of human skin is composed of dead stratified squamous, keratinized epithelial cells. Tissues that line the inside of the mouth, the esophagus, the vagina, and part of the

neg: Mesothelium Mesothelium The mesothelium is a membrane composed of simple squamous epithelium that forms the lining of several body cavities: the pleura (thoracic cavity), peritoneum (abdominal cavity including the mesentery), mediastinum and pericardium (heart sac). Mesothelial tissue also surrounds the male internal reproductive organs (the tunica vaginalis testis) and covers the internal reproductive organs of women (the tunica serosa uteri). Mesothelium that covers the internal organs is called visceral mesothelium, while the layer that covers the body walls is called the parietal mesothelium. Mesothelium is the epithelial component of serosa. Mesothelium derives from the embryonic mesoderm cell layer, that lines the

neg: Amniotic epithelial cell related to the donor. One possible reason for this is that amniotic epithelial cells have low antigen levels that inhibit compatibility from a donor to the recipient. This makes the possibility of rejection of the cells by the recipient tissue less likely. Unlike traditional tissue transplants, where the donor and recipient have to be in complete sync as far as blood type and overall compatibility and even still can show tissue rejection, amniotic epithelial cells can be used and show a higher likelihood of tissue acceptance. Also, amniotic epithelial cells are known to promote natural wound healing as well as

neg: Cord lining ischemia. A study performed in the rat model showed improved heart function and reduction of damaged myocardium when cord lining MSC combined with a fibrin gel carrier and a vascularized graft were introduced to the ischaemic area. A similar study combining the cord lining MSC with carrier endothelial cells within a fibrin matrix in-vivo also revealed improvement in cardiac function, reduction in scar tissue formation and better vascularization. The amniotic layer of the umbilical cord lining has been shown to contain a large population of epithelial stem cells (EpSC). These cord lining EpSC exhibit classical pluripotent stem cell markers such

neg: SLPI proteins in nasal epithelial lining fluid and other nasal secretions. Tissue SLPI expression reveals a clear compartmentalization, being highest in the endocervix and lowest in the endometrium of postmenopausal women. Hormonal treatment differentially modulates tissue SLPI expression along the reproductive tract . Many diseases, such as emphysema, cystic fibrosis, and idiopathic pulmonary fibrosis, are characterized by increased levels of neutrophil elastase. SLPI is one of the major defenses against the destruction of pulmonary tissues and epithelial tissues by neutrophil elastase. SLPI is considered to be the predominant elastase inhibitor in secretions, while α1-antitrypsin is the predominant elastase inhibitor in tissues.

neg: Hydrogen potassium ATPase strong association with pre-senile dementia. Hydrogen potassium ATPase Gastric hydrogen potassium ATPase, also known as H/K ATPase, is an enzyme which functions to acidify the stomach. The gastric hydrogen potassium ATPase or H/K ATPase is the proton pump of the stomach. It exchanges potassium from the intestinal lumen with cytoplasmic hydronium and is the enzyme primarily responsible for the acidification of the stomach contents and the activation of the digestive enzyme pepsin (see gastric acid). The H/K ATPase is found in parietal cells, which are highly specialized epithelial cells located in the inner cell lining of the stomach called the

neg: Hydrogen potassium ATPase Hydrogen potassium ATPase Gastric hydrogen potassium ATPase, also known as H/K ATPase, is an enzyme which functions to acidify the stomach. The gastric hydrogen potassium ATPase or H/K ATPase is the proton pump of the stomach. It exchanges potassium from the intestinal lumen with cytoplasmic hydronium and is the enzyme primarily responsible for the acidification of the stomach contents and the activation of the digestive enzyme pepsin (see gastric acid). The H/K ATPase is found in parietal cells, which are highly specialized epithelial cells located in the inner cell lining of the stomach called the gastric mucosa. Parietal cells possess

neg: Helicobacter pylori people infected with strains carrying the "cag" PAI have a stronger inflammatory response in the stomach and are at a greater risk of developing peptic ulcers or stomach cancer than those infected with strains lacking the island. Following attachment of "H. pylori" to stomach epithelial cells, the type IV secretion system expressed by the "cag" PAI "injects" the inflammation-inducing agent, peptidoglycan, from their own cell walls into the epithelial cells. The injected peptidoglycan is recognized by the cytoplasmic pattern recognition receptor (immune sensor) Nod1, which then stimulates expression of cytokines that promote inflammation. The type-IV secretion apparatus also injects the

neg: Eosinophilic esophagitis of the eosinophil type into the epithelial lining of the esophagus. This is thought to be an allergic reaction against ingested food, based on the important role eosinophils play in allergic reactions. Eosinophils are inflammatory cells that release a variety of chemical signals which inflame the surrounding esophageal tissue. This results in the signs and symptoms of pain, visible redness on endoscopy, and a natural history that may include stricturing. The diagnosis of EoE is typically made on the combination of symptoms and findings on diagnostic testing. Prior to the development of the EE Diagnostic Panel, EoE could only be

neg: Habronema muscae tiny abscesses around where they embed in the lung tissue. When the larvae are licked and swallowed by the horse during grooming they travel to the stomach and embed themselves into the glandular part of the stomach close to the margo plicatus. A thick mucus is excreted by the stomach lining. The larvae mature into adults and females produce eggs to complete the life cycle. Larvae that invade skin or eye tissue do not develop into adults. Morphology: Adult has two lateral lips, dorsal and ventral lips may also be present. Buccal capsule cylindrical, chitinous. Oesophagous is divided into two

neg: Epithelium forms the walls of the pericardium, pleurae, and peritoneum. In arthropods, the integument, or external "skin", consists of a single layer of epithelial ectoderm from which arises the cuticle, an outer covering of chitin the rigidity of which varies as per its chemical composition. Epithelial tissue rests on a basement membrane, which acts as a scaffolding on which epithelium can grow and regenerate after injuries. Epithelial tissue has a nerve supply, but no blood supply and must be nourished by substances diffusing from the blood vessels in the underlying tissue. The basement membrane acts as a selectively permeable membrane that

neg: Lateral periodontal cyst Lateral periodontal cyst The lateral periodontal cyst is a non-inflammatory developmental cyst that arises from the epithelial post-functional dental lamina, which is a remnant from odontogenesis. It is more common in middle-aged males. Usually asymptomatic, it presents as a regular well-corticated radiolucency on the side of a mandibular canine or premolar root. Histologically, the cyst appears similar to the gingival cyst of the adult, having a non-keratinized squamous epithelial lining. The involved tooth is usually vital and has no indication for root canal treatment unless the signs of non-vital or necrotic pulpal tissue were confirmed. The cysts arise from epithelial

neg: Gingivitis ultimately lead to tooth loss. The symptoms of gingivitis are somewhat non-specific and manifest in the gum tissue as the classic signs of inflammation: Additionally, the stippling that normally exists in the gum tissue of some individuals will often disappear and the gums may appear shiny when the gum tissue becomes swollen and stretched over the inflamed underlying connective tissue. The accumulation may also emit an unpleasant odor. When the gingiva are swollen, the epithelial lining of the gingival crevice becomes ulcerated and the gums will bleed more easily with even gentle brushing, and especially when flossing. The cause of

neg: Pregnancy (mammals) tissue in the body. The endoderm later forms the lining of the tongue, digestive tract, lungs, bladder and several glands. The mesoderm forms muscle, bone, and lymph tissue, as well as the interior of the lungs, heart, and reproductive and excretory systems. It also gives rise to the spleen, and produces blood cells. The ectoderm forms the skin, nails, hair, cornea, lining of the internal and external ear, nose, sinuses, mouth, anus, teeth, pituitary gland, mammary glands, eyes, and all parts of the nervous system. Approximately 18 days after fertilization, the embryo has divided to form much of the tissue

neg: Germ-band extension integrity of the epithelial tissue must be dynamically remodeled. Time-lapse microscopy has captured this process of cell neighbor exchange, which is schematically represented to the right. In the type 1 configuration, two cells contact each other along the anterior-posterior axis, whereas two dorsal-ventral cells do not directly contact. Next, the cell boundary between the two anterior-posterior neighbors selectively shrinks, resulting in an obligatory intermediate type 2 junction, where the four cells share a vertex. Upon resolution of the type 2 junction, a new type 3 junctions forms perpendicular to the original type 1 configuration. During this process the two dorsal-ventral

neg: Respiratory tract baseline level of stiffness and size. The diaphragm is the primary muscle that allows for lung expansion and contraction. Smaller muscles between the ribs, the external intercostals, assist with this process. The epithelial lining of the upper respiratory tract is interspersed with goblet cells that secrete a protective mucus. This helps to filter waste, which is eventually either swallowed into the highly acidic stomach environment or expelled via spitting. The epithelium lining the respiratory tract is covered in small hairs called cilia. These beat rhythmically out from the lungs, moving secreted mucus foreign particles toward the laryngopharynx upwards and outwards,

neg: Lung flat ("squamous"), and Type II cells generally cluster in the corners of the alveoli and have a cuboidal shape. Despite this, cells occur in a roughly equal ratio of 1:1 or 6:4. Type I are squamous epithelial cells that make up the alveolar wall structure. They have extremely thin walls that enable an easy gas exchange. These type I cells also make up the alveolar septa which separate each alveolus. The septa consist of an epithelial lining and associated basement membranes. Type I cells are not able to divide, and consequently rely on differentiation from Type II cells. Type II

neg: Chief cell that the gastric chief cell secretes leptin in response to the presence of food in the stomach. Leptin has been found in the pepsinogen granules of chief cells. Gastric pit cells are replaced every 2–4 days. This high rate of turnover is a protective mechanism designed to protect the epithelial lining of the stomach from both the proteolytic action of pepsin and the acid produced by parietal cells. Gastric chief cells are much longer lived and are believed to differentiate from stem cells located higher in the gastric unit in the isthmus. These stem cells differentiate into mucous neck cells

neg: Parietal cell Parietal cell Parietal cells (also known as oxyntic or delomorphous cells) are the epithelial cells that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and in the cardia of the stomach. They contain an extensive secretory network (called canaliculi) from which the HCl is secreted by active transport into the stomach. The enzyme hydrogen potassium ATPase (H/K ATPase) is unique to the parietal cells and transports the H against a concentration gradient of about 3 million to 1, which is the steepest ion gradient formed in

neg: Human cloning stomach lining, gastrointestinal tract, the lungs), mesoderm (muscle, bone, blood, urogenital), or ectoderm (epidermal tissues and nervous tissue). A specific set of genes, often called "reprogramming factors", are introduced into a specific adult cell type. These factors send signals in the mature cell that cause the cell to become a pluripotent stem cell. This process is highly studied and new techniques are being discovered frequently on how to better this induction process. Depending on the method used, reprogramming of adult cells into iPSCs for implantation could have severe limitations in humans. If a virus is used as a reprogramming factor

neg: Mucous membrane in origin. One of its functions is to keep the tissue moist (for example in the respiratory tract, including the mouth and nose). It also plays a role in absorbing and transforming nutrients. Mucous membranes also protect the body from itself; for instance mucosa in the stomach protects it from stomach acid, and mucosa lining the bladder protects the underlying tissue from urine. In the uterus, the mucous membrane is called the endometrium, and it swells each month and is then eliminated during menstruation. Niacin and vitamin A are essential nutrients that help maintain mucous membranes. Mucous membrane A mucous

neg: Clear-cell ovarian carcinoma Clear-cell ovarian carcinoma Clear cell ovarian carcinoma is one of several subtypes of ovarian carcinoma. The two types of ovarian carcinoma are epithelial and nonepithelial. Within these two categories, clear-cell is a subtype of epithelial ovarian cancer. The other major subtypes within this group include high-grade serous, endometrioid, mucinous, and low-grade serous. The serous type is the most common form of epithelial ovarian tumors. Cord-stromal and germ cell belong to the nonepithelial category which are much less common. According to research, most ovarian cancers start at the epithelial layer which is the lining of the ovary. Within this epithelial group

neg: Respiratory tract the trachea, where it joins the C-shaped rings of cartilage. It continues down the bronchi and bronchioles, which it completely encircles. Instead of hard cartilage, the bronchi and bronchioles are composed of elastic tissue. The lungs are made up of thirteen different kinds of cells, eleven types of epithelial cell and two types of mesenchymal cell. The epithelial cells form the lining of the tracheal, and bronchial tubes, while the mesenchymal cells line the lungs. Most of the respiratory tract exists merely as a piping system for air to travel in the lungs, and alveoli are the only part of

neg: Intestinal epithelium at the crypt (base) of the intestinal glands (epithelial invaginations into the underlying connective tissue). After being formed at the base, the new cells migrate upwards and out of the crypt, maturing along the way. Eventually, they undergo apoptosis and are shed off into the intestinal lumen. In this way, the lining of the intestine is constantly renewed while the number of cells making up the epithelial layer remains constant. In the small intestine, the mucosal layer is specially adapted to provide a large surface area in order to maximize the absorption of nutrients. The expansion of the absorptive surface,

neg: Cranberry juice 2.5. There is some evidence that although long-term use of cranberry juice can help prevent symptomatic urinary tract infections, people do not persist in taking it over long periods. There is no significant difference between cranberry juices and capsules. It is thought to prevent adhesion of bacteria such as "E. coli" to the urinary tract, by inducing changes to their fimbriae. The proanthocyanidins found in cranberry juice can prevent bacteria from adhering to the epithelial tissue that line many interior parts of the human body. These adhering bacteria can cause breakdown and inflammation of the epithelial lining of the urinary

neg: Tissue expansion and time-consuming (each procedure lasts around 8–12 months). Muscle tissue may also expand and grow, in a process known as stretch-induced myofibrillogenesis. Inflammation, in the biological sense, refers to the cellular response of the body to disturbances, be they internal or external. In the case of asthma or chronic bronchitis the human body responds to allergens or pollutants by flooding the bronchial tree and airway walls with mononuclear cells. The layers of the airway wall, including the inner epithelial tissue lining thickens and expands anywhere from 10% to 300% of healthy individuals, and obstructs air flow. Enduring the disease long

neg: Median mandibular cyst are by far the most common type of intrabony cyst occurring in the jaws. It has also been suggested that the mandible develops as a bilobed proliferation of mesenchyme connected with a central isthmus. Therefore, it is unlikely that epithelial tissue would become trapped as there is no ectoderm separating the lobes in the first instance. Median mandibular cyst A median mandibular cyst is a type of cyst that occurs in the midline of the mandible, thought to be created by proliferation and cystic degeneration of resting epithelial tissue that is left trapped within the substance of the bone during

neg: Lung of a respiratory bronchiole, which branches into alveolar ducts and alveolar sacs, which in turn divide into alveoli. The epithelial cells throughout the respiratory tract secrete epithelial lining fluid (ELF), the composition of which is tightly regulated and determines how well mucociliary clearance works. Alveoli consist of two types of alveolar cell and an alveolar macrophage. The two types of cell are known as type I and type II alveolar cells (also known as pneumocytes). Types I and II make up the walls and alveolar septa. Type I cells provide 95% of the surface area of each alveoli and are

neg: Oral mucosa tissue engineering sheets for the replacement of damaged oral mucosa. Partial-thickness tissue engineering uses one type of cell layer, this can be in monolayers or multilayers. Monolayer epithelial sheets suffice for the study of the basic biology of oral mucosa, for example its responses to stimuli such as mechanical stress, growth factor addition and radiation damage. Oral mucosa, however, is a complex multilayer structure with proliferating and differentiating cells and monolayer epithelial sheets have been shown to be fragile, difficult to handle and likely to contract without a supporting extracellular matrix. Monolayer epithelial sheets can be used to manufacture multilayer cultures. These

neg: GJB6 membrane 4 times, with amino- and carboxy-terminal regions facing the cytoplasm. Connexin genes are expressed in a cell type-specific manner with overlapping specificity. The gap junction channels have unique properties depending on the type of connexins constituting the channel.[supplied by OMIM] Connexin 30 is prevalent in the two distinct gap junction systems found in the cochlea: the epithelial cell gap junction network, which couple non-sensory epithelial cells, and the connective tissue gap junction network, which couple connective tissue cells. Gap junctions serve the important purpose of recycling potassium ions that pass through hair cells during mechanotransduction back to the endolymph.

neg: Intestinal metaplasia the transcription factor, CDX2. People of east Asian ethnicity with gastric intestinal metaplasia are at increased risk of stomach cancer. Intestinal metaplasia Intestinal metaplasia is the transformation (metaplasia) of epithelium (usually of the stomach or the esophagus) into a type of epithelium resembling that found in the intestine. In the esophagus, this is called Barrett's esophagus. Chronic inflammation caused by "H. pylori" infection in the stomach and GERD in the esophagus are seen as the primary instigators of metaplasia and subsequent adenocarcinoma formation. Initially, the transformed epithelium resembles the small intestine lining; in the later stages it resembles the lining

neg: Cord lining as SSEA-4, Oct-4, SOX2 and Nanog. They also express p63, a specific marker of epithelial progenitor cells. In-vitro organotypic culture of cord lining EpSC using the air-liquid interface method resulted in stratified epithelium being formed with expression of various forms of cytokeratins. Furthermore, due to their similarity in terms of phenotypic expression of keratins compared to normal human epidermal keratinocytes, cord lining EpSC have the potential to be an alternative source of cells for skin repair and regeneration. Animal studies on cord lining EpSC have shown that genetic modifications using the proinsulin gene allowed transplanted stem cells to lower blood

neg: Morphogenesis structure or how cells interact in tissues. These changes can result in tissue elongation, thinning, folding, invasion or separation of one tissue into distinct layers. The latter case is often referred as cell sorting. Cell "sorting out" consists of cells moving so as to sort into clusters that maximize contact between cells of the same type. The ability of cells to do this has been proposed to arise from differential cell adhesion by Malcolm Steinberg through his Differential Adhesion Hypothesis. Tissue separation can also occur via more dramatic cellular differentiation events during which epithelial cells become mesenchymal (see Epithelial-mesenchymal transition).

neg: Olfactory system (layers of thin tissue covered in mucus that line the nasal cavity). The primary components of the layers of epithelial tissue are the mucous membranes, olfactory glands, olfactory neurons, and nerve fibers of the olfactory nerves. Odor molecules can enter the peripheral pathway and reach the nasal cavity either through the nostrils when inhaling (olfaction) or through the throat when the tongue pushes air to the back of the nasal cavity while chewing or swallowing (retro-nasal olfaction). Inside the nasal cavity, mucus lining the walls of the cavity dissolves odor molecules. Mucus also covers the olfactory epithelium, which contains mucous

neg: Tissue (biology) which generate gross movement; and cardiac muscle, found in the heart where it contracts to pump blood throughout an organism. Cells comprising the central nervous system and peripheral nervous system are classified as nervous (or neural) tissue. In the central nervous system, neural tissues form the brain and spinal cord. In the peripheral nervous system, neural tissues form the cranial nerves and spinal nerves, inclusive of the motor neurons. The epithelial tissues are formed by cells that cover the organ surfaces such as the surface of skin, the airways, the reproductive tract, and the inner lining of the digestive tract.

neg: Gasterophilus intestinalis and donkeys. Each female lays up to 1000 eggs. In order the hatch, the eggs must be licked by the host animal. If taken into the host's mouth during grooming, the egg will hatch in the mouth. If not, the first instar larva will migrate to the mouth. The larvae develop in the tissue the tongue, in tunnels within of the surface. Second instar larvae are swallowed and pass into the host's stomach, and attach to the lining of the stomach, most usually at the junction between the glandular and non-glandular regions of the stomach. The larvae remain in the

neg: Gyrostigma rhinocerontis hatch after about six days, and the larvae, about 0.1 inch long, burrow inside, and attach themselves to the stomach wall by spines and mouth-hooks. It feeds on the blood and tissue of the rhinoceros. The larvae pass through three instars (developmental stages) while attached to the stomach. In the first instar, they are colored dark pink and are buried deep within mucosal folds of the stomach lining. In the second instar, the larvae are about 0.8 inches long, a paler shade of pink, and their spikes are more prominent. At this point only their front ends are imbedded into

neg: Tissue (biology) all eumetazoan animals (i.e. except Porifera) can generally be considered to contain the four tissue types, the manifestation of these tissues can differ depending on the type of organism. For example, the origin of the cells comprising a particular tissue type may differ developmentally for different classifications of animals. The epithelium in all birds and animals is derived from the ectoderm and endoderm with a small contribution from the mesoderm, forming the endothelium, a specialized type of epithelium that composes the vasculature. By contrast, a true epithelial tissue is present only in a single layer of cells held together via

neg: MSMB MSMB Beta-microseminoprotein is a protein that in humans is encoded by the "MSMB" gene. For historical reasons, the scientific literature may also refer to this protein as Prostate secretory protein 94 (PSP94), microseminoprotein (MSP), microseminoprotein-beta (MSMB), beta-inhibitin, prostatic inhibin peptide (PIP), and inhibitin like material (ILM). MSMB is one of the three major proteins secreted by the epithelial cells of the prostate and has a concentration in seminal plasma of 0.5 to 1 mg/mL Two comprehensive studies of beta-microseminoprotein in tissue have shown that it is secreted by epithelial cells in many other organs: liver, lung, breast, kidney, colon, stomach,

neg: Cell–cell interaction type can only adhere to cells of the same tissue rather than to a different tissue. Tight junctions are multi-protein complexes that hold cells of a same tissue together and prevent movement of water and water-soluble molecules between cells. In epithelial cells, they function also to separate the extracellular fluid surrounding their apical and basolateral membranes. These junctions exist as a continuous band located just below the apical surface between the membranes of neighboring epithelial cells. The tight junctions on adjacent cells line up so as to produce a seal between different tissues and body cavities. For example, the apical

neg: Keratin 6A encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. It is found with keratin 16 and/or keratin 17 in the palm and sole epidermis, the epithelial cells of the nail bed, the filiform papillae of the tongue, the epithelial lining of oral mucosa and esophagus, as well as the hair follicles. This keratin 6 isoform is thought to be the most abundant of the K6 isoforms. The "KRT6A" gene consists of 9 exons separated by 8 introns and is located in the type II keratin gene cluster on human "chromosome" 12q. Keratin 6B

neg: Cyproterone acetate the breasts (80–90%) being represented by stromal or adipose tissue, and it is uncertain to what extent, if any, that development of lobuloalveolar structures (a type of epithelial tissue) contributes to breast size or shape. CPA has potent antigonadotropic effects via activation of the PR. It blunts the gonadotropin releasing hormone (GnRH)-induced secretion of gonadotropins, and accordingly, markedly suppresses circulating levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) at sufficiently high dosages. Consequently, levels of progesterone, androstenedione, testosterone, DHT, and estradiol are also markedly lowered at sufficiently high dosages, while an elevation in sex hormone-binding globulin (SHBG) and prolactin

neg: C17orf98 on adult tissues as well as fetal tissue. The protein has been found to be mildly expressed in connective tissue. Additionally, expression has been seen in the sperm, breast epithelial cells, and various cells of the immune system. Protein expression is elevated in many cancer patients. Specifically, protein expression has been shown to be high on colorectal, breast, prostate, and lung. C17orf98 is expressed in papillary thryoid cancer as well. Additionally, mutations were found in c17orf98 in endometrial, stomach, coloratura, and kidney cancer. C17orf98 expression is elevated in cancer patients with BRCA. In Kidney renal clear cell carcinoma patients, c17orf98

neg: Keratin 6A are generally expressed in particular pairs of type I and type II keratin proteins in a tissue-specific and cellular differentiation-specific manner. The keratin proteins of epithelial tissues are commonly known as "keratins" or are sometimes referred to as "epithelial keratins" or "cytokeratins". The specialized keratins of hair and nail are known as "hard keratins" or "trichocyte keratins". Trichocytes are the specialized epithelial cells from which hair and nail are composed. Trichocyte keratins are similar in their gene and protein structure to keratins except that they are especially rich in the sulfur-containing amino acid cysteine, which facilitates chemical cross-linking of the

neg: Ovarian mucinous tumor 30% Ovarian mucinous tumor Mucinous tumors are part of the surface epithelial-stromal tumor group of ovarian neoplasms, and account for approximately 36% of all ovarian tumors. Approximately 75% are benign, 10% are borderline and 15% are malignant. Rarely, the tumor is seen bilaterally; approximately 5% of primary mucinous tumors are bilateral. "Benign" mucinous tumors are typically multilocular (have several lobes), and the cysts have a smooth lining of epithelium that resembles endocervical epithelial cells with small numbers of gastrointestinal-type epithelial cells. "Borderline" and "malignant" mucinous tumors often have papillae and solid areas. There may also be hemorrhage and necrosis. It

neg: Ovarian mucinous tumor Ovarian mucinous tumor Mucinous tumors are part of the surface epithelial-stromal tumor group of ovarian neoplasms, and account for approximately 36% of all ovarian tumors. Approximately 75% are benign, 10% are borderline and 15% are malignant. Rarely, the tumor is seen bilaterally; approximately 5% of primary mucinous tumors are bilateral. "Benign" mucinous tumors are typically multilocular (have several lobes), and the cysts have a smooth lining of epithelium that resembles endocervical epithelial cells with small numbers of gastrointestinal-type epithelial cells. "Borderline" and "malignant" mucinous tumors often have papillae and solid areas. There may also be hemorrhage and necrosis. It is

neg: Epithelial polarity from neighbouring cells bind to one another via a homotypic interaction. The intra-cellular domains of E-cadherin molecules bind to the actin cytoskeleton via the adaptor proteins alpha-catenin and beta-catenin. Thus, E-cadherin forms adherens junctions that connect the actin cytoskeletons of neighbouring cells. Adherens junctions are the primary force-bearing junctions between epithelial cells and are fundamentally important for maintaining epithelial cell shape and for dynamic changes in shape during tissue development. How E-cadherin localizes to the boundary between apical and lateral membranes is not known, but polarized membranes are essential for maintaining E-cadherin at adherens junctions. Epithelial polarity Cell polarity is

neg: Intestinal metaplasia Intestinal metaplasia Intestinal metaplasia is the transformation (metaplasia) of epithelium (usually of the stomach or the esophagus) into a type of epithelium resembling that found in the intestine. In the esophagus, this is called Barrett's esophagus. Chronic inflammation caused by "H. pylori" infection in the stomach and GERD in the esophagus are seen as the primary instigators of metaplasia and subsequent adenocarcinoma formation. Initially, the transformed epithelium resembles the small intestine lining; in the later stages it resembles the lining of the colon. It is characterized by the appearance of goblet cells and expression of intestinal cell markers such as

neg: Surface epithelial-stromal tumor epithelial cell type, the relative amounts of epithelium and stroma, the presence of papillary processes, and the location of the epithelial elements. Microscopic pathological features determine whether a surface epithelial-stromal tumor is benign, borderline, or malignant (evidence of malignancy and stromal invasion). Borderline tumors are of uncertain malignant potential. This group consists of serous, mucinous, endometrioid, clear cell, and brenner (transitional cell) tumors, though there are a few mixed, undifferentiated and unclassified types. Components can include: The chance of malignancy of the tumor increases with the amount of solid areas present, including both papillary structures and any necrotic tissue present.

neg: Surface epithelial-stromal tumor Surface epithelial-stromal tumor Surface epithelial-stromal tumors are a class of ovarian neoplasms that may be benign or malignant. Neoplasms in this group are thought to be derived from the ovarian surface epithelium (modified peritoneum) or from ectopic endometrial or Fallopian tube (tubal) tissue. Tumors of this type are also called ovarian adenocarcinoma. This group of tumors accounts for 90% to 95% of all cases of ovarian cancer. Serum CA-125 is often elevated but is only 50% accurate so it is not a useful tumor marker to assess the progress of treatment. Epithelial-stromal tumors are classified on the basis of the

neg: Gastrointestinal cancer is above 70%. A gastrointestinal carcinoid tumor is a rare, slow-growing form of cancer that affects certain cells in the lining of the stomach and intestines. The cells it affects make hormones that regulate the production of digestive juices and muscles that move food through the stomach and intestines. This kind of cancer usually occurs in the appendix, small intestine, or rectum. Its presence is associated with an increased risk of cancers affecting the other parts of the digestive system. It is usually treated with surgery. A ‘‘field defect’’ or ‘‘field cancerization’’ is a region of tissue that precedes and

neg: Fibroblast often locally align in parallel clusters. Unlike the epithelial cells lining the body structures, fibroblasts do not form flat monolayers and are not restricted by a polarizing attachment to a basal lamina on one side, although they may contribute to basal lamina components in some situations (e.g. subepithelial myofibroblasts in intestine may secrete the α-2 chain carrying component of the laminin, which is absent only in regions of follicle-associated epithelia which lack the myofibroblast lining). Fibroblasts can also migrate slowly over substratum as individual cells, again in contrast to epithelial cells. While epithelial cells form the lining of body structures,

neg: Rovsing's sign stomach ulcer or gallstone can be interpreted by the brain as pain from the stomach, liver, gall bladder, duodenum, or first part of the small intestine. It will "refer" pain often to the mid upper abdomen, the epigastrum. Because the appendix is a piece of intestine, it follows a similar referral pattern. An appendix with some early inflammation may give a non-specific irritation somewhere near the umbilicus (belly button). Should the inflammation become severe, it may actually irritate the inner lining of the abdominal cavity called the peritoneum. This thin layer of tissue lies deep to the abdominal wall muscles.

neg: Periodontal fiber belonging to the gingival tissue because they do not have an osseous attachment. Loose coonective tissue contains fibres, extracellular matrix, cells, nerves and blood vessels.The extracellular compartment consists of Type 1, 3, and 5 collagen fibers bundles embedded in intercellular substance. The PDL collagen fibers are categorized according to their orientation and location along the tooth. The cells include fibroblast, defence cells and undifferentiated mesenchymal cells. These groups of epithelial cells become located in the mature PDL after the disintegration of Hertwig epithelial root sheath during the formation of the root.[2]They form a plexus which surrounds the tooth. Cell Rests

neg: Intestinal epithelium response to gut microbiota that causes defects in epithelial barrier function. Intestinal epithelium The intestinal epithelium is the single cell layer that form the luminal surface (lining) of both the small and large intestine (colon) of the gastrointestinal tract. Composed of simple columnar epithelial cells, it serves two main functions: absorbing useful substances into the body and restricting the entry of harmful substances. As part of its protective role, the intestinal epithelium forms an important component of the intestinal mucosal barrier. Certain diseases and conditions are caused by functional defects in the intestinal epithelium. On the other hand, various diseases

neg: Tuft cell in the mouse stomach. Tuft cell Tuft cells, sometimes referred to as brush cells, are chemosensory cells in the epithelial lining of the intestines and respiratory tract. The names "tuft" and "brush" refer to the microvilli projecting from the cells. Ordinarily there are very few tuft cells present but they have been shown to greatly increase at times of a parasitic infection. Several studies have proposed a role for tuft cells in defense against parasitic infection. In the intestine, tuft cells are the sole source of secreted interleukin 25 (IL-25). Tuft cells are differentiated from stem cells in the bases

neg: Epithelial–mesenchymal transition transition. Amphioxus forms an epithelial neural tube and dorsal notochord but does not have the EMT potential of the primitive streak. In higher chordates, the mesenchyme originates out of the primitive streak migrates anteriorly to form the somites and participate with neural crest mesenchyme in formation of the heart mesoderm. In vertebrates, epithelium and mesenchyme are the basic tissue phenotypes. During embryonic development, migratory neural crest cells are generated by EMT involving the epithelial cells of the neuroectoderm. As a result, these cells dissociate from neural folds, gain motility, and disseminate to various parts of the embryo, where they differentiate

neg: Parietal cell Pernicious anemia also leads to megaloblastic anemia. Atrophic gastritis, particularly in the elderly, will cause an inability to absorb B and can lead to deficiencies such as decreased DNA synthesis and nucleotide metabolism in the bone marrow. Parietal cell Parietal cells (also known as oxyntic or delomorphous cells) are the epithelial cells that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and in the cardia of the stomach. They contain an extensive secretory network (called canaliculi) from which the HCl is secreted by active transport into

neg: Cervical loop the basal layers are left creating Hertwig's epithelial root sheath (HERS). At this point it is usually referred to as HERS instead of the cervical loop to indicate the structural difference. It is thought that the central epithelial tissue of the cervical loop, the stellate reticulum, acts as a stem cell reservoir. In continuously growing teeth such as the rodent incisor the original structure of the cervical loop is maintained and no HERS forms. The stem cells provide the epithelial progeny to sustain the continuous growth. Cervical loop The cervical loop is the location on an enamel organ in a

neg: LEKTI LEKTI Lympho-epithelial Kazal-type-related inhibitor (LEKTI) also known as serine protease inhibitor Kazal-type 5 (SPINK5) is a protein that in humans is encoded by the "SPINK5" gene. LEKTI is a large multidomain serine protease inhibitor expressed in stratified epithelial tissue. It consists of 15 domains that are cleaved into smaller, functional fragments by the protease furin. Only two of these domains (2 and 15) contain 6 evenly spaced cysteines responsible for 3 intramolecular disulfide bonds characteristic of Kazal-type related inhibitors. The remaining domains contain 4 cysteines. These disulfide bonds force the molecule into a rigid conformation that enables the protein to

neg: Infectious causes of cancer all stomach cancers, which corresponds to more than 5.5% of all cancers in the world. As reviewed by Chang and Parsonnet, chronic "H. pylori" infection in the human stomach is characterized by chronic inflammation. This is accompanied by epithelial cell release of reactive oxygen species (ROS) and reactive nitrogen species (RNOS), followed by the assembly of activated macrophages at the stomach site of infection. The macrophages also release ROS and RNOS. Levels of 8-oxo-2'-deoxyguanosine (8-OHdG), one of the predominant forms of free radical-induced oxidative DNA damages, are increased more than 8-fold in DNA after infection by "H. pylori", especially if

neg: Helicobacter pylori of "H. pylori" that produce high levels of two proteins, vacuolating toxin A (VacA) and the cytotoxin-associated gene A (CagA), appear to cause greater tissue damage than those that produce lower levels or that lack those genes completely. These proteins are directly toxic to cells lining the stomach and signal strongly to the immune system that an invasion is under way. As a result of the bacterial presence, neutrophils and macrophages set up residence in the tissue to fight the bacteria assault. The pathogenesis of "H. pylori" depends on its ability to survive in the harsh gastric environment characterized by

neg: Tissue (biology) The cells comprising an epithelial layer are linked via semi-permeable, tight junctions; hence, this tissue provides a barrier between the external environment and the organ it covers. In addition to this protective function, epithelial tissue may also be specialized to function in secretion, excretion and absorption. Epithelial tissue helps to protect organs from microorganisms, injury, and fluid loss. Functions of epithelial tissue: There are many kinds of epithelium, and nomenclature is somewhat variable. Most classification schemes combine a description of the cell-shape in the upper layer of the epithelium with a word denoting the number of layers: either simple (one

neg: Extracellular matrix against the stress placed on the ECM. Basement membranes are sheet-like depositions of ECM on which various epithelial cells rest. Each type of connective tissue in animals has a type of ECM: collagen fibers and bone mineral comprise the ECM of bone tissue; reticular fibers and ground substance comprise the ECM of loose connective tissue; and blood plasma is the ECM of blood. The plant ECM includes cell wall components, like cellulose, in addition to more complex signaling molecules. Some single-celled organisms adopt multicellular biofilms in which the cells are embedded in an ECM composed primarily of extracellular polymeric substances

neg: Adenocarcinoma epithelial cells. Adenocarcinoma Adenocarcinoma (; plural adenocarcinomas or adenocarcinomata ) is a type of cancerous tumor that can occur in several parts of the body. It is defined as neoplasia of epithelial tissue that has glandular origin, glandular characteristics, or both. Adenocarcinomas are part of the larger grouping of carcinomas, but are also sometimes called by more precise terms omitting the word, where these exist. Thus invasive ductal carcinoma, the most common form of breast cancer, is adenocarcinoma but does not use the term in its name—however, esophageal adenocarcinoma does to distinguish it from the other common type of esophageal

neg: Surface epithelial-stromal tumor surrounding tissue. Small cell ovarian cancer (SCCO) are generally classified into epithelial tumors associated with distinctive endocrine features. The World Health Organisation (WHO) recognises SCCO as two distinct entities: Small Cell Ovarian Cancer of Hypercalcemic Type ( SCCOHT) and Small Cell Ovarian Cancer of Pulmonary Type ( SCCOPT). Small cell tumours are rare and aggressive, they contribute to less than 2% of all gynaecologic malignancies. The average age of diagnosis is 24 years old, and the majority of patients also present with hypercalcemia (62%). It typically present with a unilateral large tumor. Most women die within a year of diagnosis.

neg: Keratin 6B Keratin 6B Keratin 6B is a type II cytokeratin, one of a number of isoforms of keratin 6. It is found with keratin 16 and/or keratin 17 in the hair follicles, the filiform papillae of the tongue and the epithelial lining of oral mucosa and esophagus. This keratin 6 isoform is thought be less abundant than the closely related keratin 6A protein. Mutations in the gene encoding this protein have been associated with pachyonychia congenita, an inherited disorder of the epithelial tissues in which this keratin is expressed, particularly leading to structural abnormalities of the nails, the epidermis of the

neg: Viviparity of the uterine lining till they can absorb nutrients from maternal blood vessels. As it penetrates the lining, the embryonic tissue grows aggressively till it forms sheets of tissue beneath the uterine epithelium. They eventually strip it away and replace it, making direct contact with maternal capillaries. In several respects, the phenomenon is of considerable importance in theoretical zoology. The authors remark that such an endotheliochorial placenta is fundamentally different from that of any known viviparous reptile. There is no relationship between sex-determining mechanisms and whether a species bears live young or lays eggs. Temperature-dependent sex determination, which cannot function

neg: Dental papilla organs, outer layer of the skin, teeth and the membrane lining the oral cavity (mouth). A section of the ectomesenchyme (a group of tissue made up of neurocrest cells which are present in the initial development of an embryo. This forms the hard and soft tissues of the neck and skull), condenses into a mass within the concavity of the cap of the enamel organ. This mass is now considered the dental papilla. Note that dental papilla is originally derived from ectomesenchyme. Ectomesenchyme (type of mesenchyme) is derived from neural crest cells (NCCs). A basement membrane exists between the enamel

neg: Germ layer it, and forms a new layer, called the endoderm, pushing the hypoblast out of the way (this goes on to form the amnion.) The epiblast keeps moving and forms a second layer, the mesoderm. The top layer is now called the ectoderm. The endoderm is one of the germ layers formed during animal embryogenesis. Cells migrating inward along the archenteron form the inner layer of the gastrula, which develops into the endoderm. The endoderm consists at first of flattened cells, which subsequently become columnar. It forms the epithelial lining of the whole of the digestive tract except part of the

neg: Sebastian Beach famous domestic servant, Jeeves, although, when in the company of his masters, Beach generally limits himself to a slightly raised eyebrow, even when strongly moved. He suffers from corns, an ingrowing toenail, swollen joints, nervous headaches, and especially from the lining of his stomach, which is not what he could wish the lining of his stomach to be. Before joining the staff at Blandings, he was once employed by the somewhat eccentric Major-General Magnus. He has grown very proud of the castle and of its museum. A discerning man, he regrets Lady Constance's fondness for artistic types, finding their dress

neg: Urinary system shorter, beginning at the bladder neck and terminating in the vaginal vestibule. Under microscopy, the urinary system is covered in a unique lining called urothelium, a type of transitional epithelium. Unlike the epithelial lining of most organs, transitional epithelium can flatten and distend. Urothelium covers most of the urinary system, including the renal pelvis, ureters, and bladder. The main functions of the urinary system and its components are to Average urine production in adult humans is about 12 litres (L) per day, depending on state of hydration, activity level, environmental factors, weight, and the individual's health. Producing too much or

neg: Keratin 6B palms and soles, and oral epithelia. Keratin 6B is associated with the PC-K6B subtype of pachyonychia congenita. Keratin 6B Keratin 6B is a type II cytokeratin, one of a number of isoforms of keratin 6. It is found with keratin 16 and/or keratin 17 in the hair follicles, the filiform papillae of the tongue and the epithelial lining of oral mucosa and esophagus. This keratin 6 isoform is thought be less abundant than the closely related keratin 6A protein. Mutations in the gene encoding this protein have been associated with pachyonychia congenita, an inherited disorder of the epithelial tissues in

neg: Keratin 6C and type II keratin proteins in a tissue-specific and cellular differentiation-specific manner. The keratin proteins of epithelial tissues are commonly known as "keratins" or are sometimes referred to as "epithelial keratins" or "cytokeratins". The specialized keratins of hair and nail are known as "hard keratins" or "trichocyte keratins". Trichocytes are the specialized epithelial cells from which hair and nail are composed. Trichocyte keratins are similar in their gene and protein structure to keratins except that they are especially rich in the sulfur-containing amino acid cysteine, which facilitates chemical cross-linking of the assembled hard keratins to form a more structurally resilient