query: where does pepsin work in the digestive system

pos: Pepsin autocatalytic fashion, thereby generating pepsin (the active form). Pepsin cleaves the 44 amino acids from pepsinogen to create more pepsin. Pepsin is most active in acidic environments between 37 °C and 42 °C. Accordingly, its primary site of synthesis and activity is in the stomach (pH 1.5 to 2). Pepsin will digest up to 20% of ingested amide bonds by cleaving preferentially at the C-terminal side of aromatic amino acids such as phenylalanine, tryptophan, and tyrosine. Pepsin exhibits preferential cleavage for hydrophobic, preferably aromatic, residues in P1 and P1' positions. Increased susceptibility to hydrolysis occurs if there is a sulfur-containing

pos: Stomach the small intestine, where the extraction of nutrients begins. Depending on the quantity and contents of the meal, the stomach will digest the food into chyme within anywhere between forty minutes and a few hours. The average human stomach can comfortably hold about a litre of food. Gastric juice in the stomach also contains pepsinogen. Hydrochloric acid activates this inactive form of enzyme into the active form, pepsin. Pepsin breaks down proteins into polypeptides. Although the absorption in the human digestive system is mainly a function of the small intestine, some absorption of certain small molecules nevertheless does occur in

pos: Pepsin Pepsin Pepsin is an endopeptidase that breaks down proteins into smaller peptides (that is, a protease). It is produced in the stomach and is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food. Pepsin has a three-dimensional structure, of which one or more polypeptide chains twist and fold, bringing together a small number of amino acids to form the active site, or the location on the enzyme where the substrate binds and the reaction takes place. Pepsin is an aspartic protease, using a catalytic aspartate

pos: Pepsin enables it to cross-link antigens, allowing use for precipitation assays, cellular aggregation via surface antigens, or rosetting assays. The following three genes encode identical human pepsinogen A enzymes: A fourth human gene encodes gastricsin also known as pepsinogen C: Pepsin Pepsin is an endopeptidase that breaks down proteins into smaller peptides (that is, a protease). It is produced in the stomach and is one of the main digestive enzymes in the digestive systems of humans and many other animals, where it helps digest the proteins in food. Pepsin has a three-dimensional structure, of which one or more polypeptide chains twist

pos: Human digestive system the esophagus at its upper end and to the duodenum at its lower end. Gastric acid (informally "gastric juice"), produced in the stomach plays a vital role in the digestive process, and mainly contains hydrochloric acid and sodium chloride. A peptide hormone, gastrin, produced by G cells in the gastric glands, stimulates the production of gastric juice which activates the digestive enzymes. Pepsinogen is a precursor enzyme (zymogen) produced by the gastric chief cells, and gastric acid activates this to the enzyme pepsin which begins the digestion of proteins. As these two chemicals would damage the stomach wall, mucus is

pos: Pepsin in its active site. It is one of three principal proteases in the human digestive system, the other two being chymotrypsin and trypsin. During the process of digestion, these enzymes, each of which is specialized in severing links between particular types of amino acids, collaborate to break down dietary proteins into their components, i.e., peptides and amino acids, which can be readily absorbed by the small intestine. Pepsin is most efficient in cleaving peptide bonds between hydrophobic and preferably aromatic amino acids such as phenylalanine, tryptophan, and tyrosine. Pepsin's proenzyme, pepsinogen, is released by the chief cells in the stomach

pos: Equine anatomy a non-glandular proximal region (saccus cecus), divided by a distinct border, the margo plicatus, from the glandular distal stomach. In the stomach, assorted acids and the enzyme pepsin break down food. Pepsin allows for the further breakdown of proteins into amino acid chains. Other enzymes include resin and lipase. Additionally, the stomach absorbs some water, as well as ions and lipid-soluble compounds. The horse’s small intestine is long and holds . This is the major digestive organ, and where most nutrients are absorbed. It has three parts, the duodenum, jejunum and ileum. The majority of digestion occurs in the duodenum

pos: Proventriculus Proventriculus The proventriculus is part of the digestive system of birds. An analogous organ exists in invertebrates and insects. The proventriculus is a standard part of avian anatomy, and is a rod shaped organ, located between the oesophagus and the gizzard of most birds. It is generally a glandular part of the stomach that may store and/or commence digestion of food before it progresses to the gizzard. The primary function of the proventriculus is to secrete Hydrochloric acid and Pepsinogen into the digestive compartments that will churn the ingested material through muscular mechanisms. Pepsinogen produces pepsin, which breaks the peptide

pos: Gastrointestinal physiology example of this is pepsin, which is secreted in the stomach by chief cells. Pepsin in its secreted form is inactive (pepsinogen). However, once it reaches the gastric lumen it becomes activated into pepsin by the high H+ concentration, becoming an enzyme vital to digestion. The release of the enzymes is regulated by neural, hormonal, or paracrine signals. However, in general, parasympathetic stimulation increases secretion of all digestive enzymes. Mucus is released in the stomach and intestine, and serves to lubricate and protect the inner mucosa of the tract. It is composed of a specific family of glycoproteins termed mucins

pos: Alkaline mucus mucus epithelium of the stomach from acids released during digestion. Ulcers can develop as a result of damage caused to the mucosal barrier. Duodenal ulcers have been shown to develop in sites that are in direct contact with pepsin and acids. To prevent damage and protect the mucus epithelium, alkaline mucus secretions increase in the digestive system when food is being eaten. In the cervix, alkaline mucus has been shown to possess bactericidal properties to protect the cervix, uterus, peritoneal cavity, and vagina from microbes. Alkaline mucus Alkaline mucus is a thick fluid produced by animals which confers tissue protection

pos: Digestion size of the meal, and the process of digestion normally takes between 24 and 72 hours. Digestion begins in the mouth with the secretion of saliva and its digestive enzymes. Food is formed into a bolus by the mechanical mastication and swallowed into the esophagus from where it enters the stomach through the action of peristalsis. Gastric juice contains hydrochloric acid and pepsin which would damage the walls of the stomach and mucus is secreted for protection. In the stomach further release of enzymes break down the food further and this is combined with the churning action of the stomach.

pos: Achlorhydria manage antibiotic resistance. Achlorhydria Achlorhydria or hypochlorhydria refers to states where the production of hydrochloric acid in gastric secretions of the stomach and other digestive organs is absent or low, respectively. It is associated with various other medical problems. Irrespective of the cause, achlorhydria can result as known complications of bacterial overgrowth and intestinal metaplasia and symptoms are often consistent with those diseases: Since acidic pH facilitates the absorption of iron, achlorhydric patients often develop iron deficiency anemia. Acidic environment of stomach helps conversion of pepsinogen into pepsin which is most important to digest the protein into smaller component like

pos: Achlorhydria Achlorhydria Achlorhydria or hypochlorhydria refers to states where the production of hydrochloric acid in gastric secretions of the stomach and other digestive organs is absent or low, respectively. It is associated with various other medical problems. Irrespective of the cause, achlorhydria can result as known complications of bacterial overgrowth and intestinal metaplasia and symptoms are often consistent with those diseases: Since acidic pH facilitates the absorption of iron, achlorhydric patients often develop iron deficiency anemia. Acidic environment of stomach helps conversion of pepsinogen into pepsin which is most important to digest the protein into smaller component like complex protein into

pos: Tusk shell scaphopods is the largest such organ relative to body size of any mollusc (among whom, except for the bivalves, the presence of a which is a defining characteristic). The remainder of the digestive system consists of a digestive diverticulum, esophagus, stomach, and intestine. A digestive gland secretes enzymes into the stomach, but, unlike some other molluscs, does not digest the food directly itself. The anus opens on the ventral/ underside of the animal, roughly in the middle of the mantle cavity. The scaphopod vascular system is rudimentary lacking heart auricles as well as corresponding ctenidia (gills) and blood vessels; the

pos: Exoenzyme plant-derived products. Discovered in 1836, pepsin was one of the first enzymes to be classified as an exoenzyme. The enzyme is first made in the inactive form, pepsinogen by chief cells in the lining of the stomach. With an impulse from the vagus nerve, pepsinogen is secreted into the stomach, where it mixes with hydrochloric acid to form pepsin. Once active, pepsin works to break down proteins in foods such as dairy, meat, and eggs. Pepsin works best at the pH of gastric acid, 1.5 to 2.5, and is deactivated when the acid is neutralized to a pH of 7.

pos: Somatostatin receptor 2 pancreas, this hormone inhibits the secretion of both glucagon and insulin in the alpha and beta cells when stimulated by basic nutrients like sugars, proteins, and fats. In fact, this protein, is the dominant one out of all of the somatostatins in the pancreas. In the stomach, it reduces activity of the digestive tract by inhibiting secretion of gastric acid, pepsin, bile, and colonic acid when in the presence of luminal nutrients; all of these secretions are needed for proper digestion. It also represses motor activity in the gut by blocking segmentation of the intestines, gallbladder contraction, and emptying of

pos: Chief cell not normally develop. Chief cell In human anatomy, there are three types of chief cells, the gastric chief cell, the parathyroid chief cell, and the type 1 chief cells found in the carotid body. The gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach that releases pepsinogen and chymosin. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with acid produced by gastric parietal cells. This type of cell also secretes gastric lipase enzymes, which help digest triglycerides into free fatty acids and di- and mono-glycerides. There

pos: Chief cell Chief cell In human anatomy, there are three types of chief cells, the gastric chief cell, the parathyroid chief cell, and the type 1 chief cells found in the carotid body. The gastric chief cell (also known as a zymogenic cell or peptic cell) is a cell in the stomach that releases pepsinogen and chymosin. Pepsinogen is activated into the digestive enzyme pepsin when it comes in contact with acid produced by gastric parietal cells. This type of cell also secretes gastric lipase enzymes, which help digest triglycerides into free fatty acids and di- and mono-glycerides. There is also evidence

pos: Hydrochloric acid and acidifies the stomach content to a pH of 1 to 2. Chloride (Cl) and hydrogen (H) ions are secreted separately in the stomach fundus region at the top of the stomach by parietal cells of the gastric mucosa into a secretory network called canaliculi before it enters the stomach lumen. Gastric acid acts as a barrier against microorganisms to prevent infections and is important for the digestion of food. Its low pH denatures proteins and thereby makes them susceptible to degradation by digestive enzymes such as pepsin. The low pH also activates the enzyme precursor pepsinogen into the active

pos: Atrophic gastritis Atrophic gastritis Atrophic gastritis (also known as type A or type B gastritis) is a process of chronic inflammation of the stomach mucous membrane (mucosa), leading to loss of gastric glandular cells and their eventual replacement by intestinal and fibrous tissues. As a result, the stomach's secretion of essential substances such as hydrochloric acid, pepsin, and intrinsic factor is impaired, leading to digestive problems. The most common are vitamin B deficiency which results in a megaloblastic anemia and malabsorption of iron, leading to iron deficiency anaemia. It can be caused by persistent infection with "Helicobacter pylori", or can be autoimmune

pos: Human digestive system cavity where most of the digestive organs are located. The suspensory muscle attaches the ascending duodenum to the diaphragm. This muscle is thought to be of help in the digestive system in that its attachment offers a wider angle to the duodenojejunal flexure for the easier passage of digesting material. The diaphragm also attaches to, and anchors the liver at its bare area. The esophagus enters the abdomen through a hole in the diaphragm at the level of T10. The stomach is a major organ of the gastrointestinal tract and digestive system. It is a consistently J-shaped organ joined to

pos: Gastrointestinal physiology such as the butterflies in the stomach feeling when nervous. The feedforward and emotional reflexes of the GI tract are considered cephalic reflexes. Control of the digestive system is also maintained by ENS, which can be thought of as a digestive brain that can help to regulate motility, secretion and growth. Sensory information from the digestive system can be received, integrated and acted upon by the enteric system alone. When this occurs, the reflex is called a short reflex. Although this may be the case in several situations, the ENS can also work in conjunction with the CNS; vagal afferents

pos: Vitamin B12 and cobalophilin) is a B binding protein that is produced in the salivary glands. It must wait to bind food-B until B has been freed from proteins in food by pepsin in the stomach. B then binds to the R-protein to avoid degradation of it in the acidic environment of the stomach. This pattern of B transfer to a special binding protein secreted in a previous digestive step, is repeated once more before absorption. The next binding protein for B is intrinsic factor (IF), a protein synthesized by gastric parietal cells that is secreted in response to histamine, gastrin and

pos: Helicobacter pylori "H. pylori" can result in chronic gastritis, an inflammation of the stomach lining, at the site of infection. "Helicobacter" cysteine-rich proteins (Hcp), particularly HcpA (hp0211), are known to trigger an immune response, causing inflammation.. H. Pylori has been shown to increase the levels of COX2 in H. Pylori positive gastritis. Chronic gastritis is likely to underlie "H. pylori"-related diseases. Ulcers in the stomach and duodenum result when the consequences of inflammation allow stomach acid and the digestive enzyme pepsin to overwhelm the mechanisms that protect the stomach and duodenal mucous membranes. The location of colonization of "H. pylori", which affects

pos: Hydrogen potassium ATPase strong association with pre-senile dementia. Hydrogen potassium ATPase Gastric hydrogen potassium ATPase, also known as H/K ATPase, is an enzyme which functions to acidify the stomach. The gastric hydrogen potassium ATPase or H/K ATPase is the proton pump of the stomach. It exchanges potassium from the intestinal lumen with cytoplasmic hydronium and is the enzyme primarily responsible for the acidification of the stomach contents and the activation of the digestive enzyme pepsin (see gastric acid). The H/K ATPase is found in parietal cells, which are highly specialized epithelial cells located in the inner cell lining of the stomach called the

pos: Hydrogen potassium ATPase Hydrogen potassium ATPase Gastric hydrogen potassium ATPase, also known as H/K ATPase, is an enzyme which functions to acidify the stomach. The gastric hydrogen potassium ATPase or H/K ATPase is the proton pump of the stomach. It exchanges potassium from the intestinal lumen with cytoplasmic hydronium and is the enzyme primarily responsible for the acidification of the stomach contents and the activation of the digestive enzyme pepsin (see gastric acid). The H/K ATPase is found in parietal cells, which are highly specialized epithelial cells located in the inner cell lining of the stomach called the gastric mucosa. Parietal cells possess

pos: Intrinsic factor 7. Its concentration does not correlate with the amount of HCl or pepsin in the gastric juice, e.g., intrinsic factor may be present even when pepsin is largely absent. The site of formation of the intrinsic factor varies in different species. In pigs it is obtained from the pylorus and beginning of the duodenum; in human beings it is present in the fundus and body of the stomach. The limited amount of normal human gastric intrinsic factor limits normal efficient absorption of B to about 2 μg per meal, a nominally adequate intake of B. In pernicious anemia, which is

pos: Human digestive system swallowing and vomiting to prevent the contents of the stomach from entering the esophagus. As the esophagus does not have the same protection from acid as the stomach, any failure of this sphincter can lead to heartburn. The esophagus has a mucous membrane of epithelium which has a protective function as well as providing a smooth surface for the passage of food. Due to the high volume of food that is passed over time, this membrane is continuously renewed. The diaphragm is an important part of the body's digestive system. The muscular diaphragm separates the thoracic cavity from the abdominal

pos: Extracellular digestion more digestive glands or digestive caeca. Digestive enzymes are secreted into the lumen of these glands. Additional extracellular digestion takes place in the stomach. In cephalopods, digestion is entirely extracellular. In the most other mollusks, the terminal stages of digestion are completed intracellularly, within the tissue of the digestive glands. The absorbed nutrients enter the circulatory system for distribution throughout the body or are stored in the digestive glands for later use. Undigested waste pass through an intestine and out through the anus. Other aspects of food collection and processing have already been discussed where appropriate for each group. The

pos: Laryngopharyngeal reflux increasingly researched biomarker for LPR. Research suggests that the stomach enzyme pepsin plays a crucial role in the complex mechanism behind LPR. Once present in the larynx pepsin is active at a low pH, but persists even when inactive. Pepsin can manifest both extracellularly and intracellularly; however, damage is realized differently in these two environments. Intracellularly, pepsin enters the laryngeal tissue through endocytosis and causes damage that accumulates over time. Pepsin has implications on cellular transcription and therefore, gene expression, which subsequently leads to the recruitment of inflammatory cells, but inhibition of protective mechanisms such as growth factors. Structurally, pepsin

pos: Assassination of William McKinley bullet; his work was complicated by the fact that the President was obese. The surgeon made an incision in the President's skin, and found and removed a small piece of cloth which was embedded in the flesh. He probed with his finger and hand, finding damage to the digestive system—the stomach displayed both an entry and exit wound. Mann sewed up both holes in the organ, but could not find the bullet itself; he concluded it had lodged in the President's back muscles. He later wrote, "A bullet once it ceases to move does little harm." A primitive X-ray machine

pos: Human digestive system fats to some degree though is not as efficient as the pancreatic lipase. The pylorus, the lowest section of the stomach which attaches to the duodenum via the pyloric canal, contains countless glands which secrete digestive enzymes including gastrin. After an hour or two, a thick semi-liquid called chyme is produced. When the pyloric sphincter, or valve opens, chyme enters the duodenum where it mixes further with digestive enzymes from the pancreas, and then passes through the small intestine, where digestion continues. When the chyme is fully digested, it is absorbed into the blood. 95% of absorption of nutrients occurs

pos: Bicarbonate bicarbonate – in conjunction with water, hydrogen ions, and carbon dioxide – forms this buffering system, which is maintained at the volatile equilibrium required to provide prompt resistance to pH changes in both the acidic and basic directions. This is especially important for protecting tissues of the central nervous system, where pH changes too far outside of the normal range in either direction could prove disastrous (see acidosis or alkalosis). Bicarbonate also serves much in the digestive system. It raises the internal pH of the stomach, after highly acidic digestive juices have finished in their digestion of food. Bicarbonate also

pos: Excretory system of gastropods canal. In aquatic gastropods, the nephridium is drained by a ureter that opens near the rear of the mantle cavity. This allows the flow of water through the cavity to flush out the excreta. Terrestrial pulmonates instead have a much longer ureter, that opens near the anus. In addition to the pericardial glands and nephridum, excretory cells are also present in the digestive glands opening into the stomach. These glands have a metabolic function, somewhat similar to that of the vertebrate liver, and excrete waste products directly into the digestive system, where it is voided with the faeces. In aquatic

neg: Taenia solium host who ingest such eggs in traces of human faeces, mainly from vegetation contaminated with it such as from water bearing traces of it. The embryonated eggs enter intestine where they hatch into motile oncospheres. The embryonic and basement membranes are removed by the host's digestive enzymes (particularly pepsin). Then the free oncospheres attach on the intestinal wall using their hooks. With the help of digestive enzymes from the penetration glands, they penetrate the intestinal mucosa to enter blood and lymphatic vessels. They move along the general circulatory system to various organs, and large numbers are cleared in the liver.

neg: The Pepsodent Show War II. "The Pepsodent Show" was broadcast Tuesday nights at 10:00 over NBC from September 27, 1938–June 8, 1948. For most of its run, "Pepsodent" followed "Fibber McGee and Molly" on Tuesdays and preceded "The Raleigh Cigarette Program" starring Red Skelton. Pepsodent toothpaste sponsored the program for its entire 10-year run. Pepsodent was founded by Pepsodent Company based in Chicago in 1915. The namesake of Pepsodent came from pepsin. Pepsin is a digestive enzyme designed to break down and digest food deposits on the teeth. Pepsin was an ingredient used in early Pepsodent toothpaste. By the late 1920s, sales for

neg: Paul Grützner et al. In the 1870s, with Wilhelm Ebstein (1836–1912), he performed important research involving the physiochemical behavior of pepsin in the digestive tract. Findings from their research were published in an 1874 treatise called "Ueber Pepsinbildung im Magen", and was included in . Grützner is credited with introducing a colorimetric method for determining the quantity of pepsin in a solution. Among his numerous written articles was an 1879 physiological study on voice and speech titled "Physiologie der Stimme und Sprache". Paul Grützner Paul Grützner (April 30, 1847 – July 29, 1919) was a German physiologist born in Festenberg, Silesia (present-day

neg: Rennet Rennet Rennet is a complex set of enzymes produced in the stomachs of ruminant mammals. Chymosin, its key component, is a protease enzyme that curdles the casein in milk. This helps young mammals digest their mothers' milk. Rennet can also be used to separate milk into solid curds for cheesemaking and liquid whey. In addition to chymosin, rennet contains other important enzymes such as pepsin and a lipase. Rennet is used in the production of most cheeses. The mammal's digestive system must be accessed to obtain its rennet. Non-animal alternatives for rennet are also available. One of the main actions

neg: Pepsin inhibited by high pH (see "Activity" and "Stability", above) or by inhibitor compounds. Pepstatin is a low molecular weight compound and potent inhibitor specific for acid proteases with a Ki of about 10 M for pepsin. The statyl residue of pepstatin is thought to be responsible for pepstatin inhibition of pepsin; statine is a potential analog of the transition state for catalysis by pepsin and other acid proteases. Pepstatin does not covalently bind pepsin and inhibition of pepsin by pepstatin is therefore reversible. 1-bis(diazoacetyl)-2-phenylethane reversibly inactivates pepsin at pH 5, a reaction which is accelerated by the presence of Cu(II).

neg: Insectivorous Plants (book) They have adapted well to insects alighting upon them and this saves them from wasting energy through excess movement. 2. The power to digest nitrogenous substances by secreting digestive matter and then absorbing them. He noted that digestion follows a similar pattern to animal processes (p. 135) in that acid is added to ferment the nutrient source(equivalent to pepsin). How they adapted this process from already existing substances in their system is explored later on in the book (p. 361). 3. The changes which took place within the cells when the glands are excited in various ways. A major part

neg: Bird anatomy of the family Columbidae, such as pigeons, produce a nutritious crop milk which is fed to their young by regurgitation. The avian stomach is composed of two organs, the proventriculus and the gizzard that work together during digestion. The proventriculus is a rod shaped tube, which is found between the esophagus and the gizzard, that secretes hydrochloric acid and pepsinogen into the digestive tract. The acid converts the inactive pepsinogen into the active proteolytic enzyme, pepsin, which breaks down specific peptide bonds found in proteins, to produce a set of peptides, which are amino acid chains that are shorter than

neg: Pepsodent Pepsodent Pepsodent is an American brand of toothpaste with the minty flavor derived from sassafras. It has been owned by Unilever since 1942, except in the United States and Canada, where since 2003, it has been owned by Church & Dwight. Pepsodent toothpaste was introduced in the United States in 1915 by the Pepsodent Company of Chicago. The original formula for the paste contained pepsin, a digestive agent designed to break down and digest food deposits on the teeth, hence the brand and company name. From 1930 to late 1933 a massive animated neon advertising sign, featuring a young girl

neg: Dermatitis herpetiformis and intestinal lymphoma. Dermatitis herpetiformis does not usually cause complications on its own, without being associated with another condition. Complications from this condition, however, arise from the autoimmune character of the disease, as an overreacting immune system is a sign that something does not work well and might cause problems to other parts of the body that do not necessarily involve the digestive system. Gluten intolerance and the body's reaction to it make the disease more worrying in what concerns the possible complications. This means that complications that may arise from dermatitis herpetiformis are the same as those resulting from

neg: Human digestive system starts to work on breaking down fats. Lipase is further produced in the pancreas where it is released to continue this digestion of fats. The presence of salivary lipase is of prime importance in young babies whose pancreatic lipase has yet to be developed. As well as its role in supplying digestive enzymes, saliva has a cleansing action for the teeth and mouth. It also has an immunological role in supplying antibodies to the system, such as immunoglobulin A. This is seen to be key in preventing infections of the salivary glands, importantly that of parotitis. Saliva also contains a

neg: Digestive enzyme Digestive enzyme Digestive enzymes are a group of enzymes that break down polymeric macromolecules into their smaller building blocks, in order to facilitate their absorption by the body. Digestive enzymes are found in the digestive tracts of animals (including humans) and in the traps of carnivorous plants, where they aid in the digestion of food, as well as inside cells, especially in their lysosomes, where they function to maintain cellular survival. Digestive enzymes of diverse specificities are found in the saliva secreted by the salivary glands, in the secretions of cells lining In the human digestive system, the main sites

neg: Digestive enzyme these enzymes include: Digestive enzyme Digestive enzymes are a group of enzymes that break down polymeric macromolecules into their smaller building blocks, in order to facilitate their absorption by the body. Digestive enzymes are found in the digestive tracts of animals (including humans) and in the traps of carnivorous plants, where they aid in the digestion of food, as well as inside cells, especially in their lysosomes, where they function to maintain cellular survival. Digestive enzymes of diverse specificities are found in the saliva secreted by the salivary glands, in the secretions of cells lining In the human digestive system,

neg: Lymphatic system and the thymus are also lymphoid organs of the immune system. The tonsils are lymphoid organs that are also associated with the digestive system. Lymphoid tissues contain lymphocytes, and also contain other types of cells for support. The system also includes all the structures dedicated to the circulation and production of lymphocytes (the primary cellular component of lymph), which also includes the bone marrow, and the lymphoid tissue associated with the digestive system. The blood does not come into direct contact with the parenchymal cells and tissues in the body (except in case of an injury causing rupture of one

neg: Myenteric plexus interneurons, a small extracellular space, dense synaptic neuropil, isolation from blood vessels, multiple synaptic mechanisms and multiple neurotransmitters. The myenteric plexus originates in the medulla oblongata as a collection of neurons from the ventral part of the brain stem. The vagus nerve then carries the axons to their destination in the gastrointestinal tract. They contain Dogiel cells. The myenteric plexus functions as a part of the enteric nervous system (digestive system). The enteric nervous system can and does function autonomously, but normal digestive function requires communication links between this intrinsic system and the central nervous system. The ENS contains sensory

neg: Earthworm to maintain proper blood calcium levels in the blood and food pH. From there the food passes into the crop and gizzard. In the gizzard, strong muscular contractions grind the food with the help of mineral particles ingested along with the food. Once through the gizzard, food continues through the intestine for digestion. The intestine secretes Pepsin to digest proteins, Amylase to digest polysaccharides, Cellulase to digest cellulose, and lipase to digest fats. Earthworms use, in addition to the digestive proteins, a class of surface active compounds called drilodefensins, which help digest plant material. Instead of being coiled like a

neg: Exoenzyme Also one of the first exoenzymes to be discovered, trypsin was named in 1876, forty years after pepsin. This enzyme is responsible for the breakdown of large globular proteins and its activity is specific to cleaving the C-terminal sides of arginine and lysine amino acid residues. It is the derivative of trypsinogen, an inactive precursor that is produced in the pancreas. When secreted into the small intestine, it mixes with enterokinase to form active trypsin. Due to its role in the small intestine, trypsin works at an optimal pH of 8.0. The production of a particular digestive exoenzyme by a

neg: Antinutrient also nutrient) reducing milling, the amount of phytic acid is commonly reduced in animal feeds by adding histidine acid phosphate type of phytases to them. Protease inhibitors are substances that inhibit the actions of trypsin, pepsin and other proteases in the gut, preventing the digestion and subsequent absorption of protein. For example, Bowman–Birk trypsin inhibitor is found in soybeans. Lipase inhibitors interfere with enzymes, such as human pancreatic lipase, that catalyze the hydrolysis of some lipids, including fats. For example, the anti-obesity drug orlistat causes a percentage of fat to pass through the digestive tract undigested. Amylase inhibitors prevent the

neg: Enzyme for the enzyme catalase in 1937. The conclusion that pure proteins can be enzymes was definitively demonstrated by John Howard Northrop and Wendell Meredith Stanley, who worked on the digestive enzymes pepsin (1930), trypsin and chymotrypsin. These three scientists were awarded the 1946 Nobel Prize in Chemistry. The discovery that enzymes could be crystallized eventually allowed their structures to be solved by x-ray crystallography. This was first done for lysozyme, an enzyme found in tears, saliva and egg whites that digests the coating of some bacteria; the structure was solved by a group led by David Chilton Phillips and published

neg: Proteolysis half-life, with disordered segments having been proposed to facilitate efficient initiation of degradation by the proteasome. The rate of proteolysis may also depend on the physiological state of the organism, such as its hormonal state as well as nutritional status. In time of starvation, the rate of protein degradation increases. In human digestion, proteins in food are broken down into smaller peptide chains by digestive enzymes such as pepsin, trypsin, chymotrypsin, and elastase, and into amino acids by various enzymes such as carboxypeptidase, aminopeptidase, and dipeptidase. It is necessary to break down proteins into small peptides (tripeptides and dipeptides) and

neg: Dr Pepper for a time and worked at that location as early as 1880. One recipe in the book titled "D Peppers Pepsin Bitters" was of particular interest, and some speculated it could be an early recipe for Dr Pepper. However, Keurig Dr Pepper insists it is not the formula for Dr Pepper, but is instead a medicinal recipe for a digestive aid. The book was put up for auction in May 2009, but no one purchased it. Theories about the origins of the soft drink's name abound. One possible reason why the name was chosen was the practice, common at the

neg: Extracellular the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term". The composition of the extracellular space includes metabolites, ions, various proteins and non-protein substances (e.g. DNA, RNA, lipids, microbial products etc.) that might affect cellular function. For example, hormones, growth factors, cytokines and chemokines act by travelling the extracellular space towards biochemical receptors on cells. Other proteins that are active outside the cell are various enzymes, including digestive enzymes (Trypsin, Pepsin), extracellular proteinases (Matrix metalloproteinases, ADAMTSs, Cathepsins) and antioxidant

neg: Cyclol a "C" closed cyclol consisting of 72 residues and that the digestive enzyme pepsin was a "C" closed cyclol of 288 residues. These residue-number predictions were difficult to verify, since the methods then available to measure the mass of proteins were inaccurate, such as analytical ultracentrifugation and chemical methods. Wrinch also predicted that insulin was a "C" closed cyclol consisting of 288 residues. Limited X-ray crystallographic data were available for insulin which Wrinch interpreted as "confirming" her model. However, this interpretation drew rather severe criticism for being premature. Careful studies of the Patterson diagrams of insulin taken by Dorothy Crowfoot

neg: Protease the protein chain (exopeptidases, such as aminopeptidases, carboxypeptidase A); others attack internal peptide bonds of a protein (endopeptidases, such as trypsin, chymotrypsin, pepsin, papain, elastase). Catalysis is achieved by one of two mechanisms: Proteolysis can be highly promiscuous such that a wide range of protein substrates are hydrolysed. This is the case for digestive enzymes such as trypsin which have to be able to cleave the array of proteins ingested into smaller peptide fragments. Promiscuous proteases typically bind to a single amino acid on the substrate and so only have specificity for that residue. For example, trypsin is specific for

neg: Gigantopelta chessoia of the adult is 50 mm. It has non-papillate tentacles. The digestive system: there is one pair of radula cartilages. The digestive tract is short and consist of a single loop. The rectum does not penetrate the heart. The radula consist of 1.4% of body volume in juveniles and radula cartilages consist of 2.6% of body volume in juveniles. The respiratory system consist of single left bipectinate ctenidium (gill). The circulatory system is hypertrophied: heart is greatly enlarged. The ventricle is 0.42 mm in juvenile animal length of 2.0 mm. The ventricle grows to the size 6 mm in adults.

neg: Pepsinogen 3, group I (pepsinogen A) Pepsinogen 3, group I (pepsinogen A) Pepsinogen 3, group I (pepsinogen A) is a protein that in humans is encoded by the PGA3 gene. This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve

neg: Pepsinogen 3, group I (pepsinogen A) as a biomarker for atrophic gastritis and gastric cancer. Pepsinogen 3, group I (pepsinogen A) Pepsinogen 3, group I (pepsinogen A) is a protein that in humans is encoded by the PGA3 gene. This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one

neg: Parietal cell is formed in the following manner: As a result of the cellular export of hydrogen ions, the gastric lumen is maintained as a highly-acidic environment. The acidity aids in digestion of food by promoting the unfolding (or denaturing) of ingested proteins. As proteins unfold, the peptide bonds linking component amino acids are exposed. Gastric HCl simultaneously cleaves pepsinogen, a zymogen, into active pepsin, an endopeptidase that advances the digestive process by breaking the now-exposed peptide bonds, a process known as proteolysis. Parietal cells secrete acid in response to three types of stimuli: Activation of histamine through H receptor causes increases

neg: Granada medium N3 (Difco & BD). This pepsic peptone was developed by DIFCO (Digestive Ferments Company) during the First World War for producing bacterial toxins for vaccine production. Fort development of red-brick colonies of GBS in granada medium it is necessary the presence of the peptide Ile-Ala-Arg-Arg-His-Pro-Tyr-Phe in the culture medium. This peptide only is produced during the hydrolysis with pepsin of mammal albumin. For optimal production of pigment it is also necessary the presence in the peptone of other substances (uncharacterized at present) from mammal gastrointestinal wall tissues used to prepare some peptones. The presence of starch is a basic requirement

neg: History of biochemistry the true enzymes and that proteins "per se" were incapable of catalysis. However, in 1926, James B. Sumner showed that the enzyme urease was a pure protein and crystallized it; Sumner did likewise for the enzyme catalase in 1937. The conclusion that pure proteins can be enzymes was definitively proved by Northrop and Stanley, who worked on the digestive enzymes pepsin (1930), trypsin and chymotrypsin. These three scientists were awarded the 1946 Nobel Prize in Chemistry. This discovery, that enzymes could be crystallized, meant that scientists eventually could solve their structures by x-ray crystallography. This was first done for lysozyme,

neg: Product naming consulting company, according to the List of company name etymologies), Fuji for the tallest mountain in Japan, Cisco for San Francisco. For a name with personality: Yahoo!, Cracker Jack. However, Yahoo is the pronunciation of the Chinese name of one of its founders, Jerry Yang. Base the name on ingredients: Clorox for chlorine plus sodium hydroxide, Pepsi for the digestive enzyme pepsin. When two companies merge into one, sometimes both names are kept: ExxonMobil, Cadbury Schweppes. Use alternative spellings for common sounds: 2(x)ist, Krispy Kreme. Use a founder's nickname: Adidas aka Adolf Dassler, Haribo Hans Riegel Bonn, Kinkos. A completely

neg: Pepsin the laryngopharynx (pH = 6.8) pepsin would be inactive but could be reactivated upon subsequent acid reflux events resulting in damage to local tissues. Pepsin is one of the primary causes of mucosal damage during laryngopharyngeal reflux. Pepsin remains in the larynx (pH 6.8) following a gastric reflux event. While enzymatically inactive in this environment, pepsin would remain stable and could be reactivated upon subsequent acid reflux events. Exposure of laryngeal mucosa to enzymatically active pepsin, but not irreversibly inactivated pepsin or acid, results in reduced expression of protective proteins and thereby increases laryngeal susceptibility to damage. Pepsin may also

neg: Ivan Pavlov in 1897, after 12 years of research. His experiments earned him the 1904 Nobel Prize in Physiology and Medicine. These experiments included surgically extracting portions of the digestive system from animals, severing nerve bundles to determine the effects, and implanting fistulas between digestive organs and an external pouch to examine the organ's contents. This research served as a base for broad research on the digestive system. Further work on reflex actions involved involuntary reactions to stress and pain. Pavlov extended the definitions of the four temperament types under study at the time: phlegmatic, choleric, sanguine, and melancholic, updating the names

neg: Venomous fish Venomous fish Venomous fish produce strong mixtures of toxins harmful to humans (called venom) which they deliver by means of a bite, sting, or stab. This results in an envenomation. As a contrast, poisonous fish also produce a strong toxin, but they do not bite, sting, or stab to deliver the toxin. Instead they are poisonous to eat because the human digestive system does not destroy the toxin they contain in their body. Venomous fish don't necessarily cause poisoning if they are eaten, since the digestive system often destroys the venom. There are at least 1200 species of venomous fish.

neg: Human nutrition subcategories are insoluble and soluble fiber. Insoluble dietary fiber consists mainly of cellulose, a large carbohydrate polymer that is indigestible by humans, because humans do not have the required enzymes to break it down, and the human digestive system does not harbor enough of the types of microbes that can do so. Soluble dietary fiber comprises a variety of oligosaccharides, waxes, esters, resistant starches, and other carbohydrates that dissolve or gelatinize in water. Many of these soluble fibers can be fermented or partially fermented by microbes in the human digestive system to produce short-chain fatty acids which are absorbed and

neg: Pepsin amino acid close to the peptide bond, which has an aromatic amino acid. Pepsin cleaves PheVal, GlnHis, GluAla, AlaLeu, LeuTyr, TyrLeu, GlyPhe, Phe in the insulin B chain. Pepsin exhibits maximal activity at pH 2.0 and is inactive at pH 6.5 and above, however pepsin is not fully denatured or irreversibly inactivated until pH 8.0. Therefore, pepsin in solution of up to pH 8.0 can be reactivated upon re-acidification. The stability of pepsin at high pH has significant implications on disease attributed to laryngopharyngeal reflux. Pepsin remains in the larynx following a gastric reflux event. At the mean pH of

neg: Pepsin cause mucosal damage during weakly acidic or non-acid gastric reflux. Weak or non-acid reflux is correlated with reflux symptoms and mucosal injury. Under non-acid conditions (neutral pH), pepsin is internalized by cells of the upper airways such as the larynx and hypopharynx by a process known as . The receptor by which pepsin is endocytosed is currently unknown. Upon cellular uptake, pepsin is stored in intracellular vesicles of low pH at which its enzymatic activity would be restored. Pepsin is retained within the cell for up to 24 hours. Such exposure to pepsin at neutral pH and endocyctosis of pepsin

neg: Pepsin causes changes in gene expression associated with inflammation, which underlies signs and symptoms of reflux, and tumor progression. This and other research implicates pepsin in carcinogenesis attributed to gastric reflux. Pepsin in airway specimens is considered to be a sensitive and specific marker for laryngopharyngeal reflux. Research to develop new pepsin-targeted therapeutic and diagnostic tools for gastric reflux is ongoing. A rapid non-invasive pepsin diagnostic called Peptest is now available which determines the presence of pepsin in saliva samples. Pepsins should be stored at very low temperatures (between −80 °C and −20 °C) to prevent autolysis (self-digestion). Pepsin may be

neg: Fatwa not find the pepsin or any narcotic or alcoholic substances to be present, nor any "microbes harmful to health", the mufti found that it was not forbidden under Islamic law. Occasionally the debate regarding whether or not Coca-Cola or Pepsi is drinkable by Muslims does continue to appear, notably recently in 2012 when a French study was released declaring that Coca-Cola contained a small amount of alcohol. Muslims are not permitted to drink alcohol, however the amount of alcohol found in the beverage was discovered so small as to be permissible according to the fatwa system. Osama bin Laden issued

neg: Pepsin Pepsin also undergoes feedback inhibition; a product of protein digestion slows down the reaction by inhibiting pepsin. Sucralfate also inhibits pepsin activity. Commercial pepsin is extracted from the glandular layer of hog stomachs. It is a component of rennet used to curdle milk during the manufacture of cheese. Pepsin is used for a variety of applications in food manufacturing: to modify and provide whipping qualities to soy protein and gelatin, to modify vegetable proteins for use in nondairy snack items, to make precooked cereals into instant hot cereals, and to prepare animal and vegetable protein hydrolysates for use in flavoring

neg: Equine nutrition "haylage" is fed to horses in some places; however, contamination or failure of the fermentation process that allows any mold or spoilage may be toxic. Horses and other members of the genus "Equus" are adapted by evolutionary biology to eating small amounts of the same kind of food all day long. In the wild, horses ate prairie grasses in semi-arid regions and traveled significant distances each day in order to obtain adequate nutrition. Therefore, their digestive system was made to work best with a small but steady flow of food that does not change much from day to day. Digestion

neg: Pepsin wall, and upon mixing with the hydrochloric acid of the gastric juice, pepsinogen activates to become pepsin. Pepsin was one of the first enzymes to be discovered, and is polypeptidic in nature. It was discovered in 1836 by Theodor Schwann. Schwann coined its name from the Greek word "pepsis", meaning "digestion" (from "peptein" "to digest"). Scientists around this time began discovering many biochemical compounds that play a significant role in biological processes, and pepsin was one of them. An acidic substance that was able to convert nitrogen-based foods into water-soluble material was determined to be pepsin. In 1928, it became

neg: Methanogens in digestive tract of ruminants Methanogens in digestive tract of ruminants Methanogens are a group of microorganisms that can produce methane as a byproduct of their metabolism.They hold an important place in the digestive system of ruminants. The digestive tract of ruminants contain four major parts, they are abomasum, rumen, omasum and reticulum.The food with saliva is first passed to the rumen for breaking them into smaller particles and then it moves to the reticulum where the food is broken into further smaller particles and the indigestable particles are sent back for rechewing and then to rumen. The majority of the anaerobic microbes assisting the

neg: Gdańsk University of Technology endoscopic examination of the human digestive tract named MEDEYE has been designed to make the work of a physician more efficient. It analyses and interprets the image from a tiny camera closed in a capsule. Thanks to the MEDEYE the physician does not have to watch several-hourlong recordings but can concentrate on the fragments indicated by the system. An integrated circuit which analyses electrocardiographic and impedance signal which contain an information about the cardiac cycle. PathMon makes possible simultaneous measurement of various vital signs. The analysis in real time allows detection of some untypical events which indicate threat to health

neg: Celiac artery cannot be safely ligated in a living person, and obstruction of the celiac artery will lead to necrosis of the structures it supplies. The celiac artery is the only major artery that nourishes the abdominal digestive organs that does "not" have a similarly named vein. Most blood returning from the digestive organs (including from the area of distribution of the celiac artery) is diverted to the liver via the portal venous system for further processing and detoxification in the liver before returning to the systemic circulation via the hepatic veins. In contrast to the drainage of midgut and hindgut structures

neg: Fetal pig pass directly from the right to left atrium. There is also the ductus arterius which allows blood from the right atrium to be diverted to the aortic arch. Both of these shunts close a few minutes after birth. The monogastric digestive system of the fetal pig harbors many similarities with many other mammals. The fetal pig's digestive organs are well developed before birth, although it does not ingest food. These organs include the esophagus, stomach, small and large intestines. Mesenteries serve to connect the organs of the fetal pig together. In order for digestion to occur, the fetal pig would

neg: Symsagittifera roscoffensis involved in the worm biology. This triptych (animal + micro-algae + bacterial consortium) is a good example of the Holobiont paradigm that explains that an organism (animal or plant) is a complex and dynamic association involving microbial populations necessary for development, growth and to some extent, for the life of the organism. "S. roscoffensis" does not have a digestive system at any time during its development. However, on its ventral side there is an orifice considered as "a mouth" which allows it to ingest (without digesting) the micro-algae "Tetraselmis convolutae". The latter gives access to a digestive syncytium through which

neg: Textbook of Biochemistry in agreement with the facts as at present known." The reviewer contradicts, for example, the book's assertions that urinal ammonia is formed in the kidneys from urea, and that pepsin does not attack the CO-NH links in proteins. "Textbook of Biochemistry", being the first concise and authoritative work in its field, became a standard text. By 1948, it had gone through six editions, in addition to one Chinese and two Spanish editions. Textbook of Biochemistry Textbook of Biochemistry, first published in 1928, is scientific textbook authored by Alexander Thomas Cameron. The textbook became a standard of its field, and, by

neg: Neurogastroenterology in both directions as the circular muscles alternatively contract. This allows for thorough mixing of intestinal contents, known as chyme, to allow greater absorption. The secretion of gastrointestinal enzymes, such as gastrin and secretin, is regulated through cholinergic neurons residing in the walls of the digestive tract. Hormone secretion is controlled by the vagovagal reflex, where the neurons in the digestive tract communicate through both afferent and efferent pathways with the vagus nerve. The enteric nervous system is one of the main divisions of the nervous system and is the main focus of neurogastroenterology. The enteric nervous system refers to

neg: Human digestive system taste buds on the back part of the tongue and these also produce lingual lipase. Lipase is a digestive enzyme that catalyses the hydrolysis of lipids (fats). These glands are termed Von Ebner's glands which have also been shown to have another function in the secretion of histatins which offer an early defense (outside of the immune system) against microbes in food, when it makes contact with these glands on the tongue tissue. Sensory information can stimulate the secretion of saliva providing the necessary fluid for the tongue to work with and also to ease swallowing of the food. Saliva

neg: Medical Subject Headings structure (see below) make the MeSH essentially a thesaurus, rather than a plain subject headings list. The "descriptors" or "subject headings" are arranged in a hierarchy. A given descriptor may appear at several locations in the hierarchical tree. The tree locations carry systematic labels known as "tree numbers", and consequently one descriptor can carry several tree numbers. For example, the descriptor "Digestive System Neoplasms" has the tree numbers C06.301 and C04.588.274; C stands for Diseases, C06 for Digestive System Diseases and C06.301 for Digestive System Neoplasms; C04 for Neoplasms, C04.588 for Neoplasms By Site, and C04.588.274 also for Digestive System

neg: Power Reactor and Nuclear Fuel Development Corporation harmful plutonium is to a human depends on the chemical form of the plutonium and the mode of exposure. Powdered plutonium dioxide (the form in MOX) is very resistant to digestion in acid, if swallowed it is likely to pass through the digestive system and leave in the stool. However, when inhaled, finely powdered plutonium dioxide will stay in the lungs for a long time thus exposing the person to a far higher radiation dose for a given amount of plutonium radioactivity. Water-soluble forms of plutonium can be absorbed in the digestive system, work done in the 1970s suggests that

neg: Extracellular digestion system because every cell is exposed to all stages of food digestion. Specializing occurs when the digestive tract or alimentary canal has a separate mouth and anus so that transport of food is one-way. The most primitive digestive tract is seen in nematodes (phylum Nematode), where it is simply a tubular gut lined by an epithelial membrane. Earthworms (phylum Annelids) have a digestive tract specialized in different regions for the ingestion, storage, fragmentation, digestion and absorption of food. All more complex animal groups, including all vertebrates, show similar specializations. The ingested food may be stored in a specialized region of

neg: Development of the digestive system Development of the digestive system The development of the digestive system concerns the epithelium of the digestive system and the parenchyma of its derivatives, which originate from the endoderm. Connective tissue, muscular components, and peritoneal components originate in the mesoderm. Different regions of the gut tube such as the esophagus, stomach, duodenum, etc. are specified by a retinoic acid gradient that causes transcription factors unique to each region to be expressed. Differentiation of the gut and its derivatives depends upon reciprocal interactions between the gut endoderm and its surrounding mesoderm. Hox genes in the mesoderm are induced by a Hedgehog

neg: Burmese python require larger food items such as pigs or goats, and are known to have attacked and eaten alligators and adult deer in Florida, where they are an invasive species. The digestive response of Burmese pythons to such large prey has made them a model species for digestive physiology. A fasting python has a reduced stomach volume and acidity, reduced intestinal mass, and a 'normal' heart volume. After ingesting prey, the entire digestive system undergoes a massive remodelling, with rapid hypertrophy of the intestines, production of stomach acid, and a 40% increase in mass of the ventricle of the heart to

neg: Aspartic protease (MEROPS peptidase family A1) are synthesised with signal and propeptides. The animal pepsin-like endopeptidase propeptides form a distinct family of propeptides, which contain a conserved motif approximately 30 residues long. In pepsinogen A, the first 11 residues of the mature pepsin sequence are displaced by residues of the propeptide. The propeptide contains two helices that block the active site cleft, in particular the conserved Asp11 residue, in pepsin, hydrogen bonds to a conserved Arg residue in the propeptide. This hydrogen bond stabilises the propeptide conformation and is probably responsible for triggering the conversion of pepsinogen to pepsin under acidic conditions.

neg: Uterine serpin a variety of proteases. In addition, several key amino acids in the hinge region of the reactive center loop which are important for protease inhibitory activity have not been conserved in uterine serpins. Bovine uterine serpin does inhibit pepsin but probably through a mechanism distinct from the prototypical mechanism used by serpins. There are two possible biological roles for uterine serpins during pregnancy. The first is as a binding protein. Porcine uterine serpin binds non-covalently to uteroferrin in a way that stabilizes the iron-binding capacity of uteroferrin. Uteroferrin is transferred across the placenta where it gives up its iron to

neg: Alfred Nisonoff on opposite sides of the disulfide bridge connecting the two heavy chains of rabbit IgG. This led to the conclusion that papain cleaves on the amino-terminal side of the disulfide bond, and pepsin cleaves on the carboxyl-terminal side. Nisonoff’s work also contributed to the identification of the F(ab’)2 fragment of the antibody molecule, which is the single bivalent fragment that is produced after pepsin cleavage. Later, it was found that this fragment is responsible for antigen interaction and agglutination and precipitation reactions. Nisonoff’s experiment led to many conclusions about the structure of the antibody. It was determined that the two

neg: Mistletoebird important for reproduction and molting, the mistletoe bird has to eat large quantities of the mistletoe fruit. The mistletoebird has a small muscularized stomach and short alimentary canal where the amount of mechanical grinding and chemical digestion is minimized. This enables a clear passage and quick exit of the mistletoe fruit seeds through the mistletoebird's digestive system. In comparison, the non-specialized fruit eating birds that they compete with for the mistletoe berry, such as the spiny-cheeked honeyeater ("Acanthagenys rufogularis)" have a more complex digestive system that takes longer for the fruit seeds to pass and in the process the seeds

neg: Chagas disease and/or digestive disorders during their lifetime (called "determinate" chronic Chagas disease). In 10% of individuals, the disease progresses directly from the acute form to a symptomatic clinical form of chronic Chagas disease. The symptomatic (determinate) chronic stage affects the nervous system, digestive system and heart. About two-thirds of people with chronic symptoms have cardiac damage, including dilated cardiomyopathy, which causes heart rhythm abnormalities and may result in sudden death. About one-third of patients go on to develop digestive system damage, resulting in dilation of the digestive tract (megacolon and megaesophagus), accompanied by severe weight loss. Swallowing difficulties (secondary achalasia) may

neg: Human digestive system predispose for certain digestive disorders. Gestational diabetes can develop in the mother as a result of pregnancy and while this often presents with few symptoms it can lead to pre-eclampsia. Human digestive system The human digestive system consists of the gastrointestinal tract plus the accessory organs of digestion (the tongue, salivary glands, pancreas, liver, and gallbladder). Digestion involves the breakdown of food into smaller and smaller components, until they can be absorbed and assimilated into the body. The process of digestion has many stages. The first stage is the cephalic phase of digestion which begins with gastric secretions in response

neg: Digestive system of gastropods Digestive system of gastropods The digestive system of gastropods (slugs and snails of every kind) has evolved to suit almost every kind of diet and feeding behavior. Gastropods as the largest taxonomic class of the mollusca are very diverse indeed: the group includes carnivores, herbivores, scavengers, filter feeders, and even parasites. In particular, the radula is often highly adapted to the specific diet of the various group of gastropods. Another distinctive feature of the digestive tract is that, along with the rest of the visceral mass, it has undergone torsion, twisting around through 180 degrees during the larval stage, so

neg: Q-FISH into a pepsin solution. Pepsin is a protease and acts to digest proteins into peptides. A small volume of the hybridization mixture is placed onto a coverslip and then placed gently onto the microscope slide which contains the fixed cells. The slide is then placed into a preheated oven where the chromosomal DNA in the cell is denatured at 80 °C for several minutes. The slide is then left at room temperature for several hours to allow the PNA to hybridize to complimentary DNA. Slides are then carefully washed in various wash solutions to remove unbound PNA. Microscope mounting medium

neg: Human digestive system the superior mesenteric artery, which supplies the regions of the digestive tract derived from the midgut, which includes the distal 2/3 of the duodenum, jejunum, ileum, cecum, appendix, ascending colon, and the proximal 2/3 of the transverse colon. The final branch which is important for the digestive system is the inferior mesenteric artery, which supplies the regions of the digestive tract derived from the hindgut, which includes the distal 1/3 of the transverse colon, descending colon, sigmoid colon, rectum, and the anus above the pectinate line. The enteric nervous system consists of some one hundred million neurons that are embedded

neg: Displaced abomasum in cattle Displaced abomasum in cattle Displaced abomasum in cattle occurs when the abomasum, also known as the true stomach, which typically resides on the floor of the abdomen, fills with gas and rises to the top of the abdomen, where it is said to be ‘displaced’. When the abomasum moves from its normal position it prevents the natural passage of gas and feed through the digestive system, creating a restriction. As cattle are ruminants, which have a 4 chambered stomach composed of a rumen, reticulum, omasum and abomasum. Ruminants require this specialized digestive system in order to properly process and break

neg: Isobaric process Isobaric process An "isobaric process" is a thermodynamic process in which the pressure stays constant: Δ"P" = 0. The heat transferred to the system does work, but also changes the internal energy of the system. This article uses the chemistry sign convention for work, where positive work is work done "on" the system. Using this convention, by the first law of thermodynamics, where "W" is work, "U" is internal energy, and "Q" is heat. Pressure-volume work by the closed system is defined as: where Δ means change over the whole process, whereas "d" denotes a differential. Since pressure is constant,

neg: PULHHEEMS USA uses a system called "PULHES". In civilian life there is a similar system called "PULSES" which is used to grade levels of disability; it differs from the PULHHEEMS in that it also examines the digestive system, something which the PULHHEEMS does not. For new recruits it is part of the first step into the armed forces, whilst for established service people it is a requirement of ongoing employment. Although a PULHHEEMS is carried out on new recruits, it is not itself an entrance examination, the attributes of which depend on the unit conducting the examination. The examination is carried