query: when do white blood cells exit the vascular system

pos: Leukocyte extravasation Leukocyte extravasation Leukocyte extravasation, less commonly called "diapedesis", is the movement of leukocytes out of the circulatory system and towards the site of tissue damage or infection. This process forms part of the innate immune response, involving the recruitment of non-specific leukocytes. Monocytes also use this process in the absence of infection or tissue damage during their development into macrophages. Leukocyte extravasation occurs mainly in post-capillary venules, where haemodynamic shear forces are minimised. This process can be understood in several steps, outlined below as "chemoattraction", "rolling adhesion", "tight adhesion" and "(endothelial) transmigration". It has been demonstrated that leukocyte recruitment is

neg: Circulatory system Circulatory system The circulatory system, also called the cardiovascular system or the vascular system, is an organ system that permits blood to circulate and transport nutrients (such as amino acids and electrolytes), oxygen, carbon dioxide, hormones, and blood cells to and from the cells in the body to provide nourishment and help in fighting diseases, stabilize temperature and pH, and maintain homeostasis. The circulatory system includes the lymphatic system, which circulates lymph. The passage of lymph for example takes much longer than that of blood. Blood is a fluid consisting of plasma, red blood cells, white blood cells, and platelets

neg: Depolarization certain level of plasticity in the strength of their structure. This plasticity in the structural strength of the vascular endothelium is essential to overall function of the cardiovascular system. Endothelial cells within blood vessels can alter the strength of their structure to maintain the vascular tone of the blood vessel they line, prevent vascular rigidity, and even help to regulate blood pressure within the cardiovascular system. Endothelial cells accomplish these feats by using depolarization to alter their structural strength. When an endothelial cell undergoes depolarization, the result is a marked decrease in the rigidity and structural strength of the cell

neg: Endothelium Endothelium Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. It is a thin layer of simple, or single-layered, squamous cells called endothelial cells. Endothelial cells in direct contact with blood are called vascular endothelial cells, whereas those in direct contact with lymph are known as lymphatic endothelial cells. Vascular endothelial cells line the entire circulatory system, from the heart to the smallest capillaries. These cells have unique functions in vascular biology. These functions include fluid

neg: Vascular endothelial growth factor Vascular endothelial growth factor Vascular endothelial growth factor (VEGF), originally known as vascular permeability factor (VPF), is a signal protein produced by cells that stimulates the formation of blood vessels. To be specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important signaling proteins involved in both vasculogenesis (the "de novo" formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate such as in hypoxic conditions.

neg: Lymph sacs they would when developing a lymphatic system, but as these cells migrate, they never develop the ability to express the more specific lymphatic markers. Instead, they will begin to express markers that are specific to blood vessel endothelium. These markers include "CD34" and "Laminin". This experiment proves that "Prox1" is necessary for lymphatic cells to specify. It is believed that "Prox1" is the single most important transcription factor that programs the fate of endothelial cells becoming lymphatic components. It has also been found that ectopic expression of "Prox1" in blood vascular epithelium can force vascular endothelial cells to convert into

neg: Epigenetics of diabetes Type 2 with adverse side effects on the cardiovascular system. Oxidized Low-density lipoprotein-induced chemokine expression was associated with H3KAc and phosphorylation, and recruitment of HATs along with NF-κB in endothelial cells, and these were reversed by pre-treatment with statins. Studies show alterations in histone modification patterns, along with changes in expression of the corresponding Histone methyltransferases, in vascular smooth muscle cells and endothelial cells from aortas of adult mice exposed to hypercholesterolaemia. Studies in monocytes, white blood cells that travel along vascular surfaces, showed that H3K9/14Ac and HATs CBP/p300, H3R17me and its methyltransferase CARM1, play key roles in inflammatory gene expression. HDACs

neg: Thoracentesis is defined as pleural fluid to serum total protein ratio of less than 0.5, pleural fluid to serum LDH ratio > 0.6, and absolute pleural fluid LDH > 200 IU or > 2/3 of the normal. An exudate that filters from the circulatory system into lesions or areas of inflammation. Its composition varies but generally includes water and the dissolved solutes of the main circulatory fluid such as blood. In the case of blood: it will contain some or all plasma proteins, white blood cells, platelets and (in the case of local vascular damage) red blood cells. "Exudate " "Transudate"

neg: Blood cell in the human body in that they lack a nucleus (although erythroblasts do have a nucleus). The condition of having too few red blood cells is known as anemia, while having too many is polycythemia. White blood cells or "leukocytes", are cells of the immune system involved in defending the body against both infectious disease and foreign materials. They are produced and derived from multipotent cells in the bone marrow known as a hematopoietic stem cells. Leukocytes are found throughout the body, including the blood and lymphatic system. There are a variety of types of white bloods cells that serve

neg: Renin–angiotensin system Renin–angiotensin system The renin–angiotensin system (RAS) or the renin–angiotensin–aldosterone system (RAAS) is a hormone system that regulates blood pressure and fluid balance. When renal blood flow is reduced, juxtaglomerular cells in the kidneys convert the precursor prorenin (already present in the blood) into renin and secrete it directly into circulation. Plasma renin then carries out the conversion of angiotensinogen, released by the liver, to angiotensin I. Angiotensin I is subsequently converted to angiotensin II by the angiotensin-converting enzyme (ACE) found on the surface of vascular endothelial cells, predominantly those of the lungs. Angiotensin II is a potent vasoconstrictive peptide that

neg: Ulex europaeus gorse was used in some areas for feeding to horses and other livestock. Lectin extracted from seeds of this species binds to, is remarkably specific for, and is the standard method for identification of H-substance (absent in the hh antigen system) on human red blood cells. The vast majority of humans express H-substance, which is the basis for the ABO blood group system, but a few rare individuals ("Bombay phenotype") do not—and a chemical isolated from "Ulex europaeus" is used to identify these individuals. This lectin is also used as a marker for human vascular endothelial cells, and as a

neg: Childhood leukemia occur in children. The most common form childhood leukemia is acute lymphocytic (or lymphoblastic) leukemia (ALL), which makes up 75-80% of childhood leukemia diagnoses. ALL is a form of leukemia that affects lymphocytes, a type of white blood cells which fights infection. When a patient has ALL, the bone marrow makes too many immature white blood cells and they do not mature correctly. These white blood cells also do not work correctly to fight infection. The white blood cells over-produce, crowding the other blood cells in the bone marrow. Another type of acute leukemia is acute myelogenous leukemia (AML). AML

neg: Circulating endothelial cell Circulating endothelial cell Circulating endothelial cells (CECs) are endothelial cells that have been shed from the lining of the vascular wall into the blood stream. Endothelial cells normally line blood vessels to maintain vascular integrity and permeability, but when these cells enter into the circulation, this could be a reflection of vascular dysfunction and damage. There are many factors involved in the process of creating CECs, including: reduced interaction between the endothelial cells and basement membrane proteins, damaged endothelial cellular adhesion molecules, mechanical injury, decreased survival of cytoskeletal proteins, and inflammation. Endothelial progenitor cells (EPCs) are cells derived from the

neg: Lymph capillary Lymph capillary Lymph capillaries or lymphatic capillaries are tiny, thin-walled microvessels located in the spaces between cells (except in the central nervous system and non-vascular tissues) which serve to drain and process extracellular fluid. Upon entering the lumen of a lymphatic capillary, the collected fluid and associated cells (notably white blood cells) is known as lymph. Each lymphatic capillary carries lymph into a lymphatic vessel, which in turn connects to a lymph node. Lymph is ultimately returned to the venous circulation. Lymphatic capillaries are slightly larger in diameter than blood capillaries, and have closed ends (unlike the loop structure of

neg: Circulating endothelial cell attack but have not yet experienced one. Researchers are hoping that the HD-CEC test will be used to predict cardiovascular diseases such as acute MI, angina and heart failure and analyze vascular damage. Circulating endothelial cell Circulating endothelial cells (CECs) are endothelial cells that have been shed from the lining of the vascular wall into the blood stream. Endothelial cells normally line blood vessels to maintain vascular integrity and permeability, but when these cells enter into the circulation, this could be a reflection of vascular dysfunction and damage. There are many factors involved in the process of creating CECs, including:

neg: Sea cucumber vessels run above and below the intestine and are connected by over a hundred small muscular ampullae, acting as miniature hearts to pump blood around the haemal system. Additional vessels surround the respiratory trees, although they contact them only indirectly, via the coelomic fluid. Indeed, the blood itself is essentially identical with the coelomic fluid that bathes the organs directly, and also fills the water vascular system. Phagocytic coelomocytes, somewhat similar in function to the white blood cells of vertebrates, are formed within the haemal vessels, and travel throughout the body cavity as well as both circulatory systems. An additional

neg: Epigenetics of diabetes Type 2 its demethylase JMJD3, and the H3K4me3 transferase MLL were shown to be regulators in the expression of tumour suppressor p16INK4a in β-cell proliferation and regeneration. Post-translational modifications of histones (H3K4me2 and H3K9me2), H3K4 demethylase lysine-specific demethylase 1 (LSD1), and an H3K9me2 methyltransferase SET domain bifurcated 1 (SETDB1) were also implicated in diabetes related adipogenesis. The inflammatory response arises from vascular tissues and specialized white blood cells, and a persistent state of inflammation under diabetic stress leads to clots and vascular deterioration. Patients suffer edema, aneurysms, and injuries that cannot heal properly because the vascular system is unable to respond properly

neg: Systemic scleroderma sclerosis occur when the white blood cells of the immune system attack the body. In this treatment, stem cells from the patient's blood are extracted and stored to preserve them. The patient's white blood cells are destroyed with cyclophosphamide and rabbit antibodies against the white blood cells. Then the stored blood is returned to the patient's bloodstream to reconstitute a healthy blood and immune system which will not attack the body. The results of a phase 3 trial, the Autologous Stem Cell Transplantation International Scleroderma (ASTIS) trial, with 156 patients were published in 2014. HSCT itself has a high treatment

neg: Corneal neovascularization blood vessels is mediated by the upregulation of angiogenic cytokines. The enzyme metalloproteinase degrades the cornea's basement membrane and extracellular matrix, while proteolytic enzymes allow vascular epithelial cells to enter the stromal layer of the cornea. When ocular inflammation occurs, corneal epithelial and endothelial cells, macrophages and certain inflammatory cells produce angiogenic growth factors, namely vascular endothelial growth factor (VEGF) and fibroblast growth factors. VEGF paves the way for new blood vessel formation by upregulating matrix metalloproteinases production by endothelial cells in the limbal vascular plexus. Treatments for corneal neovascularization are predominately off-lab with a multitude of complications as a

neg: Circulatory system that is circulated by the heart through the vertebrate vascular system, carrying oxygen and nutrients to and waste materials away from all body tissues. Lymph is essentially recycled excess blood plasma after it has been filtered from the interstitial fluid (between cells) and returned to the lymphatic system. The cardiovascular (from Latin words meaning "heart" and "vessel") system comprises the blood, heart, and blood vessels. The lymph, lymph nodes, and lymph vessels form the lymphatic system, which returns filtered blood plasma from the interstitial fluid (between cells) as lymph. The circulatory system of the blood is seen as having two

neg: Childhood leukemia develops in the bone marrow, the soft inner part of bones where new blood cells are made. When a child has leukemia, the bone marrow produces white blood cells that do not mature correctly. Normal healthy cells only reproduce when there is enough space for them. The body will regulate the production of cells by sending signals of when to stop production. When a child has leukemia, the cells do not respond to the signals telling them when to stop and when to produce cells. The bone marrow becomes crowded resulting in problems producing other blood cells. Common childhood leukemia

neg: White blood cell White blood cell White blood cells (also called leukocytes or leucocytes and abbreviated as WBCs) are the cells of the immune system that are involved in protecting the body against both infectious disease and foreign invaders. All white blood cells are produced and derived from multipotent cells in the bone marrow known as hematopoietic stem cells. Leukocytes are found throughout the body, including the blood and lymphatic system. All white blood cells have nuclei, which distinguishes them from the other blood cells, the anucleated red blood cells (RBCs) and platelets. Types of white blood cells can be classified in standard

neg: Induced stem cells of arteries supplying the heart, brain and lower extremities. So, an important goal is to stimulate vascular growth for the collateral circulation to prevent the exacerbation of these diseases. Induced Vascular Progenitor Cells (iVPCs) are useful for cell-based therapy designed to stimulate coronary collateral growth. They were generated by partially reprogramming endothelial cells. The vascular commitment of iVPCs is related to the epigenetic memory of endothelial cells, which engenders them as cellular components of growing blood vessels. That is why, when iVPCs were implanted into myocardium, they engrafted in blood vessels and increased coronary collateral flow better than iPSCs, mesenchymal

neg: Endothelial stem cell The former requires differentiation of endothelial cells from hemangioblasts and then the further organization into a primary capillary network. The latter occurs when new vessels are built from preexisting blood vessels. The vascular system is made up of two parts: 1) Blood vasculature 2) Lymphatic vessels Both parts consist of ECs that show differential expression of various genes. A study showed that ectopic expression of Prox-1 in blood vascular ECs (BECs) induced one-third of LEC specific gene expression. Prox-1is a homeobox transcription factor found in lymphatic ECs (LECs). For example, specific mRNAs such as VEGFR-3 and p57Kip2 were expressed by

neg: White blood cell normal when it is part of healthy immune responses, which happen frequently. It is occasionally abnormal, when it is neoplastic or autoimmune in origin. A decrease below the lower limit is called leukopenia. This indicates a weakened immune system. The name "white blood cell" derives from the physical appearance of a blood sample after centrifugation. White cells are found in the "buffy" "coat", a thin, typically white layer of nucleated cells between the sedimented red blood cells and the blood plasma. The scientific term "leukocyte" directly reflects its description. It is derived from the Greek roots "leuk-" meaning "white" and

neg: Gestational hypertension such as rodents and primates, the vascular resistance in the placenta was low, leading scientists to the conclusion that the greatest resistance to maternal blood flow is found elsewhere in the maternal vascular system. The high vascular resistance outside of the placenta leads to higher maternal blood pressure throughout the body. The fetal cells that implant into the uterine wall are known as the trophoblast. The hemochorial placenta bathes the fetal trophoblast in maternal blood by forming lacunae, or lakes, of the mother's blood that surround fetal tissue. The lacunae are filled by the spiral arteries, which means that the

neg: Thirst volume is problematic because if the total blood volume falls too low the heart cannot circulate blood effectively and the eventual result is hypovolemic shock. The vascular system responds by constricting blood vessels thereby creating a smaller volume for the blood to fill. This mechanical solution however has definite limits and usually must be supplemented with increased volume. The loss of blood volume is detected by cells in the kidneys and triggers thirst for both water and salt via the renin-angiotensin system. Hypovolemia leads to activation of the renin angiotensin system (RAS) and is detected by cells in the kidney.

neg: NADPH oxidase instantaneously, where as the vascular enzyme produces superoxide in minutes to hours. Moreover, in white blood cells superoxide have been found to transfer electrons across the membrane to extracellular oxygen, while in vascular cells the radical anion appears to be released mainly intracellularly. Superoxides are crucial in killing foreign bacteria in the human body. Consequently, under-activity can lead to an increased susceptibility to organisms such as catalase-positive microbes, and over-activity can lead to oxidative stress and cell damage. Excessive production of ROS in vascular cells causes many forms of cardiovascular disease including hypertension, atherosclerosis, myocardial infarction, and ischemic stroke. Atherosclerosis

neg: Vasculogenesis in contrast, is when endothelial precursor cells (angioblasts) migrate and differentiate in response to local cues (such as growth factors and extracellular matrices) to form new blood vessels. These vascular trees are then pruned and extended through angiogenesis. Vasculogenesis occurs during embryologic development of the circulatory system. Specifically, around blood islands, which first arise in the mesoderm of the yolk sac at 3 weeks of development. Vasculogenesis can also occur in the adult organism from circulating endothelial progenitor cells (derivatives of stem cells) able to contribute, albeit to varying degrees, to neovascularization. Examples of where vasculogenesis can occur in adults

neg: Juxtaglomerular cell Juxtaglomerular cell The juxtaglomerular cells (JG cells, or granular cells) are cells in the kidney that synthesize, store, and secrete the enzyme renin. They are specialized smooth muscle cells mainly in the walls of the afferent arterioles, and some in the efferent arterioles, that deliver blood to the glomerulus. In synthesizing renin, they play a critical role in the renin–angiotensin system and thus in autoregulation of the kidney. Juxtaglomerular cells secrete renin in response to a drop in pressure detected by stretch receptors in the vascular walls, or when stimulated by macula densa cells. Macula densa cells are located in

neg: Waon therapy oxide, which is a vasodilator and increases blood flow. Waon therapy also increases blood flow by stimulating the mobilization endothelial progenitor cells marked with CD34 molecules. CD34 positive cells promote angiogenesis to increase blood flow, improving cardiac perfusion and decreasing vascular resistance. Nitric oxide is also a regulator of the sympathetic nervous system, and an increase of nitric oxide via endothelial nitric oxide synthase may help to control autonomic nervous system. In chronic heart failure the sympathetic nervous system is over-activated and the parasympathetic nervous system depressed, increasing stress on the heart. Waon therapy increases parasympathetic activity and decreases the

neg: Uremic pericarditis Uremic pericarditis Uremic pericarditis is a form of pericarditis. It causes fibrinous pericarditis. The main cause of the disease is poorly understood. Fibrinous pericarditis is an exudative inflammation. The pericardium is infiltrated by the fibrinous exudate. This consists of fibrin strands and leukocytes. Fibrin describes an amorphous, eosinophilic (pink) network. Leukocytes (white blood cells; mainly neutrophils) are found within the fibrin deposits and intrapericardic. Vascular congestion is also present. Inflammatory cells do not penetrate the myocardium (as is seen with other presentations of pericarditis), and as a result, this particular variant does not present with diffuse ST elevation on ECG

neg: KLF4 male and female reproductive tract where in the males it is important for proper spermatogenesis; vascular endothelial cells where it is critical in preventing vascular leakage in response to inflammatory stimuli; white blood cells where it mediates inflammatory responses cellular differentiation and proliferation; the kidneys where it is involved in the differentiation of embryonic stem cells and induced pluripotent stem (iPS) cells to renal lineage in vitro and its dysregulation has been linked to some renal pathologies. Several lines of evidence have shown that KLF4 role in disease is context dependent where under certain conditions it may play one role

neg: Cytokine release syndrome output (early), potentially diminished cardiac output (late), high nitrogen levels in blood, elevated D-dimer, elevated transaminases, factor I deficiency and excessive bleeding, higher-than-normal level of bilirubin. CRS occurs when large numbers of white blood cells, including B cells, T cells, and natural killer cells, macrophages, dendritic cells, and monocytes are activated and release inflammatory cytokines, which in turn activate yet more white blood cells. This can occur when the immune system is fighting pathogens, as cytokines signal immune cells such as T-cells and macrophages to travel to the site of infection. In addition, cytokines activate those cells, stimulating them to

neg: Juxtaglomerular cell is manifested as a lower renal perfusion pressure. Juxtaglomerular cell The juxtaglomerular cells (JG cells, or granular cells) are cells in the kidney that synthesize, store, and secrete the enzyme renin. They are specialized smooth muscle cells mainly in the walls of the afferent arterioles, and some in the efferent arterioles, that deliver blood to the glomerulus. In synthesizing renin, they play a critical role in the renin–angiotensin system and thus in autoregulation of the kidney. Juxtaglomerular cells secrete renin in response to a drop in pressure detected by stretch receptors in the vascular walls, or when stimulated by macula

neg: Blood in stool symptoms of fatigue, dizziness, headaches, or even shortness of breath, and these associated symptoms also require treatment. These symptoms are the result of blood loss, and occur due to a lack of red blood cells (RBCs) circulating in the vascular system, resulting in less oxygen reaching the tissues and organs. Blood in stool can be associated with serious complications as a result of blood volume loss (hemorrhage) or a slow leak of the blood leading to low levels of hemoglobin in the circulating blood (anemia). Anemia is a common complication of blood in the stool, especially when there is a

neg: Circulatory system of the horse capacity of the muscular system far exceeds the capacity of the cardiovascular system to deliver oxygen. Blood is made up of red blood cells (erythrocytes) and white blood cells (leukocytes), as well as plasma. Produced in bone marrow, red blood cells are responsible for carrying oxygen to tissue and removing carbon dioxide, all via hemoglobin. White blood cells are used for defense against pathogens in the immune system. Plasma suspends the blood cells, contains clotting factors, and contributes to the greatest volume of blood. The heart and blood vessels contain approximately of blood in a horse, which equates to about

neg: Kaposi's sarcoma KS may arise as a cancer of lymphatic endothelium and forms vascular channels that fill with blood cells, giving the tumor its characteristic bruise-like appearance. KSHV proteins are uniformly detected in KS cancer cells. KS lesions contain tumor cells with a characteristic abnormal elongated shape, called "spindle cells". The most typical feature of Kaposi sarcoma is the presence of spindle cells forming slits containing red blood cells. Mitotic activity is only moderate and pleomorphism is usually absent. The tumor is highly vascular, containing abnormally dense and irregular blood vessels, which leak red blood cells into the surrounding tissue and give

neg: Mural cell Mural cell Mural cells are perivascular cells that include vascular smooth muscle cells (vSMCs) and pericytes (cells relating to the wall of the blood vessel). Both types are in close contact with the endothelial cells along the blood vessels and are important for vascular development and stability. Mural cells are involved in the formation of normal vasculature and are responsive to a variety of factors such as platelet derived growth factor B (PDGFB) and vascular endothelial growth factor (VEGF). The weakness and disorganization of tumor vasculature is partly due to the inability of tumors to recruit properly organized mural cells.

neg: Vasodilation Vasodilation Vasodilation is the widening of blood vessels. It results from relaxation of smooth muscle cells within the vessel walls, in particular in the large veins (called venodilators), large arteries, and smaller arterioles. The process is the opposite of vasoconstriction, which is the narrowing of blood vessels. When blood vessels dilate, the flow of blood is increased due to a decrease in vascular resistance. Therefore, dilation of arterial blood vessels (mainly the arterioles) decreases blood pressure. The response may be intrinsic (due to local processes in the surrounding tissue) or extrinsic (due to hormones or the nervous system). In addition,

neg: Depolarization light. In the case of rod cells and neurons, depolarization actually prevents a signal from reaching the brain as opposed to stimulating the transmission of the signal. Endothelium is a thin layer of simple squamous epithelial cells that line the interior of both blood and lymph vessels. The endothelium that lines blood vessels is known as vascular endothelium, which is subject to and must withstand the forces of blood flow and blood pressure from the cardiovascular system. To withstand these cardiovascular forces, endothelial cells must simultaneously have a structure capable of withstanding the forces of circulation while also maintaining a

neg: Diabetic retinopathy or are being populated in preparation for study at medical centers in Brazil, Iran and the United States. Current trials involve using the patients' own stem cells derived from bone marrow and injected into the degenerated areas in an effort to regenerate the vascular system. A Cochrane review examined 15 randomized controlled trials do determine whether interventions that sought to control or reduce blood pressure in diabetics had any effects of diabetic retinopathy. While the results showed that interventions to control or reduce blood pressure prevented diabetic retinopathy for up to 4–5 years in diabetics, there was no evidence of

neg: Wandering cell phagocytes in the early stages of acute inflammation. Eosinophils: Eosinophils are white blood cells that are found in the lamina propria of the GI tract, and at sites of allergic reaction and parasitic infection. Basophils: Basophils are white blood cells that are similar to mast cells in having vasoactive agents released in response to an allergen. Monocytes: Monocytes are white blood cells that will give rise to all the phagocytes of the mononuclear phagocytic system (see Ross et al., pg. 110, and Table 5.4, pg. 112). In CT, they give rise to macrophages (histiocytes). Wandering Cells are probably amoeboid when

neg: Netrin Multiple studies have found different effects of netrin on these branching vessels. The endothelial tip cells in vascular tissue display similar properties to the growth cone found in neuronal tissue. Studies have discovered that these same endothelial tip cells also express UNC5B, which netrin 1 can bind to, inhibiting angiogenesis. In contrast, several studies show that netrin-1 actually promotes blood vessel branching. In conjunction with this research, it has been found that netrin 4 is responsible for growth in the lymphatic vascular system. Overall, these studies show that regulating effects of netrin is dependent on the type of vascular tissue.

neg: Extraglomerular mesangial cell Extraglomerular mesangial cell Extraglomerular mesangial cells (also known as Lacis cells, Polkissen cells, or Goormaghtigh cells) are light-staining pericytes in the kidney found outside the glomerulus, near the vascular pole. They resemble smooth muscle cells and play a role in renal autoregulation of blood flow to the kidney and regulation of systemic blood pressure through the renin–angiotensin system. Extraglomerular mesangial cells are part of the juxtaglomerular apparatus, along with the macula densa cells of the distal convoluted tubule and the juxtaglomerular cells of the afferent arteriole. The specific function of extraglomerular mesangial cells is not well understood, although it has

neg: Endothelial activation Endothelial activation Endothelial activation is a proinflammatory and procoagulant state of the endothelial cells lining the lumen of blood vessels. It is most characterized by an increase in interactions with white blood cells (leukocytes), and it is associated with the early states of atherosclerosis and sepsis, among others. It is also implicated in the formation of deep vein thrombosis. As a result of activation, enthothelium releases Weibel–Palade bodies. Elevating shear stress induces a vascular response by triggering nitric oxide synthesis and mechanotransduction pathways of endothelial cells. The synthesis of nitric oxide facilitate shear stress mediated dilation in blood vessels and

neg: Heart failure cell Heart failure cell Heart failure cells are siderophages (hemosiderin-containing macrophages) generated in the alveoli of patients with left heart failure or chronic pulmonary edema, when the high pulmonary blood pressure causes red cells to pass through the vascular wall. Siderophages are not specific of heart failure. They are present wherever red blood cells encounter macrophages. In left heart failure, the left ventricle can not keep pace with the incoming blood from the pulmonary veins. The resulting backup causes increased pressure on the alveolar capillaries, and red blood cells leak out. Alveolar macrophages (dust cells) engulf the red blood cells, and

neg: Extraglomerular mesangial cell been associated with the secretion of erythropoietin and secretion of renin. They are distinguished from intraglomerular mesangial cells, which are situated between the basement membrane and the epithelial cells within the glomerulus. Extraglomerular mesangial cell Extraglomerular mesangial cells (also known as Lacis cells, Polkissen cells, or Goormaghtigh cells) are light-staining pericytes in the kidney found outside the glomerulus, near the vascular pole. They resemble smooth muscle cells and play a role in renal autoregulation of blood flow to the kidney and regulation of systemic blood pressure through the renin–angiotensin system. Extraglomerular mesangial cells are part of the juxtaglomerular apparatus, along

neg: Red blood cell endothelial cells. Exposure of red blood cells to physiological levels of shear stress activates nitric oxide synthase and export of nitric oxide, which may contribute to the regulation of vascular tonus. Red blood cells can also produce hydrogen sulfide, a signalling gas that acts to relax vessel walls. It is believed that the cardioprotective effects of garlic are due to red blood cells converting its sulfur compounds into hydrogen sulfide. Red blood cells also play a part in the body's immune response: when lysed by pathogens such as bacteria, their hemoglobin releases free radicals, which break down the pathogen's cell

neg: Endothelial NOS generation of NO in the vascular endothelium, a monolayer of flat cells lining the interior surface of blood vessels, at the interface between circulating blood in the lumen and the remainder of the vessel wall. NO produced by eNOS in the vascular endothelium plays crucial roles in regulating vascular tone, cellular proliferation, leukocyte adhesion, and platelet aggregation. Therefore, a functional eNOS is essential for a healthy cardiovascular system. eNOS is a dimer containing two identical monomers of 134 kD constituted by a reductase domain, which displays binding sites for nicotinamide adenine dinucleotide phosphate (NADPH), flavin mononucleotide (FMN), and flavin adenine

neg: Blood–brain barrier immune system attacks the myelin that protects and electrically insulates the neurons of the central and peripheral nervous systems. Normally, a person's nervous system would be inaccessible to the white blood cells due to the blood–brain barrier. However, magnetic resonance imaging has shown that when a person is undergoing an MS "attack," the blood–brain barrier has broken down in a section of the brain or spinal cord, allowing white blood cells called T lymphocytes to cross over and attack the myelin. It has sometimes been suggested that, rather than being a disease of the immune system, MS is a disease

neg: Water vascular system quite powerful but extremely slow. The central ring canal, in addition to connecting the radial canals to each other and to the stone canal, also has a number of other specialised structures on the inner surface. In between each radial canal, in many sea star species, there lies a muscular sac called a polian vesicle. The ring canal also has four or five pairs of complex pouches, called Tiedemann's bodies. These apparently produce coelomocytes, amoeboid cells somewhat similar to the blood cells of vertebrates. Although the contents of the water vascular system are essentially sea water, apart from coelomocytes, the

neg: Leukoreduction Leukoreduction Leukoreduction is the removal of white blood cells (or "leukocytes") from the blood or blood components supplied for blood transfusion. After the removal of the leukocytes, the blood product is said to be "leukoreduced". It is theorized that transfusions that contain white blood cells may cause adverse effects through multiple mechanisms. White blood cells may themselves harbor infectious disease and some pathogens will be more concentrated in white blood cells than the rest of the blood product. It is also theorized that the donor white blood cells may suppress the recipient's immune system by interacting with it. An April

neg: Leukoreduction Leukoreduction Leukoreduction is the removal of white blood cells (or "leukocytes") from the blood or blood components supplied for blood transfusion. After the removal of the leukocytes, the blood product is said to be "leukoreduced". It is theorized that transfusions that contain white blood cells may cause adverse effects through multiple mechanisms. White blood cells may themselves harbor infectious disease and some pathogens will be more concentrated in white blood cells than the rest of the blood product. It is also theorized that the donor white blood cells may suppress the recipient's immune system by interacting with it. An April

neg: Endothelium of von Willebrand factor, which promote platelet aggregation and adhesion to the subendothelium, and thus the formation of potentially fatal thrombi. Endothelium Endothelium refers to cells that line the interior surface of blood vessels and lymphatic vessels, forming an interface between circulating blood or lymph in the lumen and the rest of the vessel wall. It is a thin layer of simple, or single-layered, squamous cells called endothelial cells. Endothelial cells in direct contact with blood are called vascular endothelial cells, whereas those in direct contact with lymph are known as lymphatic endothelial cells. Vascular endothelial cells line the entire

neg: Vascular permeability Vascular permeability Vascular permeability, often in the form of capillary permeability or microvascular permeability, characterizes the capacity of a blood vessel wall to allow for the flow of small molecules (drugs, nutrients, water, ions) or even whole cells (lymphocytes on their way to the site of inflammation) in and out of the vessel. Blood vessel walls are lined by a single layer of endothelial cells. The gaps between endothelial cells (cell junctions) are strictly regulated depending on the type and physiological state of the tissue. There are several techniques to measure vascular permeability to certain molecules. For instance, the cannulation

neg: Mural cell characterize their molecular signature along the blood vessels. This showed that there is a zonation in their expression patterns by which they can be grouped into different subsets, but no singular markers have been found so far that can identify unequivocally any of the cell types. Mural cell Mural cells are perivascular cells that include vascular smooth muscle cells (vSMCs) and pericytes (cells relating to the wall of the blood vessel). Both types are in close contact with the endothelial cells along the blood vessels and are important for vascular development and stability. Mural cells are involved in the formation

neg: Myelofibrosis number of all blood cell types: red blood cells, white blood cells, and platelets. Red blood cells may show abnormalities including bizarre shapes, such as teardrop-shaped cells, and nucleated red blood cell precursors may appear in the blood smear (leukoerythroblastic reaction). Normally, mature red blood cells in adults do not have a cell nucleus, and the presence of nucleated red blood cells suggests that immature cells are being released into the bloodstream in response to a very high demand for the bone marrow to produce new red blood cells. Immature white cells and platelets (large megakaryocytes) are also seen in

neg: Dengue fever of aminotransferase (AST and ALT) from the liver is commonly associated with low platelets and white blood cells. In severe disease, plasma leakage results in hemoconcentration (as indicated by a rising hematocrit) and hypoalbuminemia. Pleural effusions or ascites can be detected by physical examination when large, but the demonstration of fluid on ultrasound may assist in the early identification of dengue shock syndrome. The use of ultrasound is limited by lack of availability in many settings. Dengue shock syndrome is present if pulse pressure drops to ≤ 20 mm Hg along with peripheral vascular collapse. Peripheral vascular collapse is determined

neg: Eculizumab colds, and urinary tract infection), loss of white blood cells, loss of red blood cells, anaphylactic reaction, hypersensitivity reaction, loss of appetite, mood changes like depression and anxiety, a sense of tingling or numbness, blurred vision, vertigo, ringing in the ears, heart palpitations, high blood pressure, low blood pressure, vascular damage, peritonitis, constipation, upset stomach, swollen belly, itchy skin, increased sweating, blotches from small bleeds under the skin and skin redness, hives, muscle spasms, bone pain, back pain, neck pain, swollen joints, kidney damage, painful urination, spontaneous erections, general edema, chest pain, weakness, pain at the infusion site, and elevated

neg: Surface chemistry of microvasculature trigger vasoconstriction and vasodilation respectively. Vasoconstriction affects flow rate and surface properties of the microvasculature by constricting the smooth muscle cells and decreasing the diameter of flow. The smooth muscle cells are able to constrict from both external and internal stimuli. This mechanism can be triggered by the ambient temperature or the autonomic nervous system. When cold, the body attempts to capture heat in the blood by constricting the smooth muscle cells around the microvasculature. The muscle cells are constricted by an increase in calcium. The decreased cross-sectional area for flow increases the vascular resistance and lowers the flow to

neg: Subcortical ischemic depression mechanisms have been proposed: one associates white matter lesions (attributed to cardiovascular burden) and cerebrovascular risk factors. These two mechanisms parallel the differences between MRI and clinically defined vascular depression, yet do not necessarily represent contradictory mechanisms. These brain changes are thought to be reflected in the white matter lesions identified by MRI. Cerebrovascular risk factors for vascular depression include high blood pressure, diabetes mellitus, coronary heart disease, and tobacco smoking, with high blood pressure being the most commonly identified risk factor. However, these factors do not account for all cerebrovascular changes in individuals as genetics may play a large

neg: Vascular remodelling in the embryo flow, endothelial cells retain an undifferentiated morphology similar to angioblasts (compared to flattened epithelial cells found in mature vasculature). Once the heart begins beating, the morphology and behaviour of endothelial cells change. By changing the heart rate, the heart can also control perfusion or pressure acting upon the system in order to trigger sprouting of new vessels. In turn, new vessel sprouting is balanced by the expansion of other embryo tissues, which compress blood vessels as they grow. The equilibrium of these forces plays a major role in vascular remodelling, but although the angiogenic mechanisms required to trigger the sprouting

neg: Liver cytology different from the rest of the body’s sinusoids since they have macrophage cells intercalated in between their endothelial cells. Kupffer cells have a different embryological origin, coming from the myeloid line in the reticuloendohelial system (also called mononuclear phagocyte system) and are related to the immune system. They first develop in the bone marrow and then migrate to the liver where they differentiate into Kupffer cells. In fact, they are the macrophages of the liver and are located in the sinusoids. Sinusoids are vascular channels that receive blood from terminal branches of the hepatic artery and portal vein and make

neg: Common octopus in hemocyanin which is not found within the blood cells as hemoglobin is, but within the blood's plasma. Since the binding agent is found within the plasma and not the blood cells there is a limit to the oxygen up take that the octopus can experience. If it were to increase the hemocyanin within its blood stream, the fluid would become too viscous for the myogenic hearts to pump. Poiseuille's Law explains the rate of flow of the bulk fluid throughout the entire circulatory system through the differences of blood pressure and vascular resistance. The three hearts are also temperature

neg: Blood cell specific roles in the human immune system. WBCs constitute approximately 1% of the blood volume. White blood cells are divided into granulocytes and agranulocytes, distinguished by the presence or absence of granules in the cytoplasm. Granulocytes include basophils, eosinophils, neutrophils, and mast cells. Agranulocytes include lymphocytes and monocytes. The condition of having too few white blood cells is leukopenia, while having too many is leukocytosis. There are individual terms for the lack or overabundance of specific types of white blood cells. The number of white blood cells in circulation is commonly increased in the incidence of infection. Many hematological cancers

neg: Lymph capillary capillary, attaching lymphatic endothelial cells to surrounding tissues. When excess interstitial fluid accumulates and causes tissue swelling, the anchoring filaments are pulled, making the openings between cells even larger so that more fluid can flow into the lymphatic capillary. Lymph capillaries have a greater internal oncotic pressure than blood capillaries, due to the greater concentration of plasma proteins in the lymph. Lymph capillary Lymph capillaries or lymphatic capillaries are tiny, thin-walled microvessels located in the spaces between cells (except in the central nervous system and non-vascular tissues) which serve to drain and process extracellular fluid. Upon entering the lumen of

neg: Tissue remodeling In the proliferation phase, inflammatory cells die by apoptosis, being replaced by myofibroblasts which produce large amounts of collagen. In the maturation phase, myofibroblast numbers are reduced by apoptosis, allowing for infiltration by endothelial cells (for blood vessels) and cardiomyocytes (heart tissue cells). Usually, however, much of the tissue remodeling is pathological, resulting in a large amount of fibrous tissue. By contrast, aerobic exercise can produce beneficial cardiac tissue remodeling in those suffering from left ventricular hypertrophy. Vascular remodeling refers to a compensatory change in blood vessel walls due to plaque growth. Vascular expansion is called positive remodeling, whereas vascular

neg: Lymphovascular invasion Lymphovascular invasion Lymphovascular invasion (LVI or lymphovascular space invasion) is the invasion of a cancer to the blood vessels and/or lymphatics. Lymph: A clear or white fluid that travels through vessels, moves within tissues and work to keep all the parts of the body clean. Vascular: The body's network of blood vessels. When cancer spreads to lymph and vascular system, it is thus termed as "Lymphovascular Invasion." Lymphovascular invasion, especially in carcinomas, usually precedes spread to the lymph nodes that drain the tissue in which the tumour arose. Conversely, cancers with lymph node spread (known as a lymph node metastases),

neg: NADPH oxidase to be important players in vascular remodeling and disease. These include thrombin, platelet-derived growth factor (PDGF), tumor necrosis factor (TNFa), lactosylceramide, interleukin-1, and oxidized LDL. It is also stimulated by agonists and arachidonic acid. Conversely, assembly of the complex can be inhibited by apocynin and diphenylene iodonium. Apocynin decreases influenza-induced lung inflammation in mice in vivo and so may have clinical benefits in the treatment of influenza. In animals, NADPH oxidase is found in two types: one in white blood cells (neutrophilic) and the other in vascular cells, differing in biochemical structure and functions. Neutrophilic NADPH oxidase produces superoxide almost

neg: Vascular tissue neoplasm malignant vascular tumors are considered sarcomas, a major histological group of tumors, arising from transformed cells of mesenchymal origin. Vascular tissue neoplasm A vascular tissue neoplasm is a tumor arising from endothelial cells, the cells that line the wall of blood vessels and lymphatic vessels, as well as the heart. Vascular tissue neoplasms is a group containing tumors with the same tissue origin; in other words, it denotes histological classification, rather than anatomic (i.e. where in the body the neoplasm is found) or clinical one. They can occur everywhere in the body where vessels are to be found. Vascular tissue

neg: Endothelin the most potent vasoconstrictors known. Overproduction of endothelin in the lungs may cause pulmonary hypertension, which was treatable in preliminary research by bosentan, sitaxentan or ambrisentan. Endothelins have involvement in cardiovascular function, fluid-electrolyte homeostasis, and neuronal mechanisms across diverse cell types. Endothelin receptors are present in the three pituitary lobes which display increased metabolic activity when exposed to endothelin-1 in the blood or ventricular system. ET-1 contributes to the vascular dysfunction associated with cardiovascular disease, particularly atherosclerosis and hypertension. The ET receptor for ET-1 is primarily located on vascular smooth muscle cells, mediating vasoconstriction, whereas the ET receptor for ET-1

neg: Subdural hematoma new fragile and leaky blood vessels through angiogenesis, permitting the leakage of red blood cells, white blood cells, and plasma into the haematoma cavity and easily causes mirco bleeds. Besides, tearing of arachnoid mater during trauma causes leakage of cerebrospinal fluid (CSF) into the haematoma cavity, causing increase in haematoma size over time. Excessive fibrinolysis is another factor that causes continuous bleeding. Examples of pro-inflammatory mediators acted in the haematoma expansion process are: Interleukin 1α (IL1A), Interleukin 6, Interleukin 8; while the anti-inflammatory mediator is Interleukin 10. Mediators that promote angiogenesis are: angiopoietin and vascular endothelial growth factor (VEGF). Meanwhile,

neg: Eugene C. Butcher trafficking of white blood cells (lymphocytes, dendritic cells, monocytes, etc.), including their interactions with the endothelial lining of blood vessels at sites of leukocyte extravasation, and their chemotactic responses in tissues. These events regulate immune responses by controlling the access of leukocytes to sites of inflammatory or immune reaction in the body. He and his research team have shown that lymphocytes use a variety of different adhesion molecules or "homing receptors" to recognize organ (and/or inflammation)-specific vascular ligands or "addressins" that define the tissue position (address) of blood vessels in the body. Their studies have shown that these adhesion receptors

neg: Buffy coat extract DNA from the blood of mammals because mammalian red blood cells are anucleate and do not contain DNA. The buffy coat is usually whitish in color, but is sometimes green if the blood sample contains large amounts of neutrophils, which are high in green-colored myeloperoxidase. The layer beneath the buffy coat contains granulocytes and red blood cells. Some refer to the buffy coat when separating cells by Ficoll density gradients. This usage of the expression buffy coat is incorrect. Buffy coat The buffy coat is the fraction of an anticoagulated blood sample that contains most of the white blood

neg: Neonatal isoerythrolysis blood cells of the foal, leading to lysis through the complement system or removal by the mononuclear phagocyte system, and causing subsequent anemia. Most blood groups do not produce a highly immunologic response when the mare is exposed from previous foals or through placental leakage of red blood cells. However, a few factors, such as Aa and Qa, do lead to a significant response and therefore account for the majority of cases of isoerythrolysis. Mares that are Aa- and Qa-negative are therefore most likely to produce a foal with this condition. This is most commonly seen in Thoroughbreds (19%) and

neg: Haemodynamic response decrease in blood flow to the brain can be a result of thrombosis causing a partial or full blockage of blood vessels, hypotension in systemic circulation (and consequently the brain), or cardiac arrest. This decrease in blood flow in the cerebral vascular system can result in a buildup of metabolic wastes generated by neurons and glial cells and a decrease in oxygen and glucose delivery to them. As a result, cellular energy failure, depolarization of neuronal and glial membranes, edema, and excess neurotransmitter and calcium ion release can occur. This ultimately ends with cell death, as cells succumb to a

neg: Vascular smooth muscle greater wall thickness. This is because they have to carry pumped blood away from the heart to all the organs and tissues that need the oxygenated blood. The endothelial lining of each is similar. Excessive proliferation of vascular smooth muscle cells contributes to the progression of pathological conditions, such as vascular inflammation, plaque formation, atherosclerosis, restenosis, and pulmonary hypertension. Vascular smooth muscle Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing the majority of the wall of blood vessels. Vascular smooth muscle refers to the particular type of smooth muscle found within, and composing

neg: Lymphatic system Lymphatic system The lymphatic system is part of the vascular system and an important part of the immune system, comprising a large network of lymphatic vessels that carry a clear fluid called lymph (from Latin, "lympha" meaning "water") directionally towards the heart. The lymphatic system was first described in the seventeenth century independently by Olaus Rudbeck and Thomas Bartholin. Unlike the circulatory system, the lymphatic system is not a closed system. The human circulatory system processes an average of 20 litres of blood per day through capillary filtration, which removes plasma while leaving the blood cells. Roughly 17 litres of

neg: P-selectin glycoprotein ligand-1 White blood cells normally do not interact with the endothelium of blood vessels. However, inflammation causes the expression of cell adhesion molecules (CAM) such as P-selectin on the surface of the blood vessel wall. White blood cells present in flowing blood can interact with CAM. The first step in this interaction process is carried out by PSGL-1 interacting with P-selectin and/or E-selectin on endothelial cells and adherent platelets. This interaction results in "rolling" of the white blood cell on the endothelial cell surface followed by stable adhesion and transmigration of the white blood cell into the inflamed tissue. In mice

neg: Cellular Dynamics International body’s organs and tissues) play an important role in the study of vascular contributions of many leading causes of death. iCell Endothelial cells were launched as a tool to model vascular biology. Other types of endothelial cells are available from ATCC and Life Technologies. iCell Hematopoietic Progenitor Cells are multipotent progenitor blood cells that can give rise to many different types of blood cells that can then be used for a variety of research purposes, including cell therapy, autoimmune disease, and cancer research. FCDI offers a family of products called MyCell Products that involve custom reprogramming, genetic engineering and differentiation

neg: Blood carry oxygen, instead of hemoglobin. Insects and some mollusks use a fluid called hemolymph instead of blood, the difference being that hemolymph is not contained in a closed circulatory system. In most insects, this "blood" does not contain oxygen-carrying molecules such as hemoglobin because their bodies are small enough for their tracheal system to suffice for supplying oxygen. Jawed vertebrates have an adaptive immune system, based largely on white blood cells. White blood cells help to resist infections and parasites. Platelets are important in the clotting of blood. Arthropods, using hemolymph, have hemocytes as part of their immune system. Blood

neg: Lymphatic system or more blood vessels), but constituents of the blood first exit the microvascular exchange blood vessels to become interstitial fluid, which comes into contact with the parenchymal cells of the body. Lymph is the fluid that is formed when interstitial fluid enters the initial lymphatic vessels of the lymphatic system. The lymph is then moved along the lymphatic vessel network by either intrinsic contractions of the lymphatic passages or by extrinsic compression of the lymphatic vessels via external tissue forces (e.g., the contractions of skeletal muscles), or by lymph hearts in some animals. The organization of lymph nodes and drainage

neg: Heart failure cell become engorged with brownish hemosiderin. In chronic pulmonary edema, alveolar septa become thick and fibrous, again increasing pressure on alveolar capillaries and resulting in leakage of red blood cells which undergo phagocytosis by alveolar macrophages. Heart failure cell Heart failure cells are siderophages (hemosiderin-containing macrophages) generated in the alveoli of patients with left heart failure or chronic pulmonary edema, when the high pulmonary blood pressure causes red cells to pass through the vascular wall. Siderophages are not specific of heart failure. They are present wherever red blood cells encounter macrophages. In left heart failure, the left ventricle can not keep

neg: Hemodynamics arterioles, capillaries, and venules —constitutes most of the area of the vascular system and is the site of the transfer of O, glucose, and enzyme substrates into the cells. The venous system returns the de-oxygenated blood to the right heart where it is pumped into the lungs to become oxygenated and CO and other gaseous wastes exchanged and expelled during breathing. Blood then returns to the left side of the heart where it begins the process again. In a normal circulatory system, the volume of blood returning to the heart each minute is approximately equal to the volume that is

neg: Blood transfusion Blood transfusion Blood transfusion is generally the process of receiving blood or blood products into one's circulation intravenously. Transfusions are used for various medical conditions to replace lost components of the blood. Early transfusions used whole blood, but modern medical practice commonly uses only components of the blood, such as red blood cells, white blood cells, plasma, clotting factors, and platelets. Red blood cells contain hemoglobin and increase iron levels by improving the amount of oxygen found in the body. White blood cells, are not commonly used during transfusion but are related to the immune system and to fight infections.

neg: Meningitis but can rather largely be attributed to the response of the immune system to the entry of bacteria into the central nervous system. When components of the bacterial cell membrane are identified by the immune cells of the brain (astrocytes and microglia), they respond by releasing large amounts of cytokines, hormone-like mediators that recruit other immune cells and stimulate other tissues to participate in an immune response. The blood–brain barrier becomes more permeable, leading to "vasogenic" cerebral edema (swelling of the brain due to fluid leakage from blood vessels). Large numbers of white blood cells enter the CSF, causing inflammation

neg: Innate immune system of new healthy cells, phagocytosis is an important part of the healing process following tissue injury. Macrophages, from the Greek, meaning "large eaters," are large phagocytic leukocytes, which are able to move outside of the vascular system by migrating across the walls of capillary vessels and entering the areas between cells in pursuit of invading pathogens. In tissues, organ-specific macrophages are differentiated from phagocytic cells present in the blood called monocytes. Macrophages are the most efficient phagocytes and can phagocytose substantial numbers of bacteria or other cells or microbes. The binding of bacterial molecules to receptors on the surface of

neg: Plateletpheresis that can still stimulate a dangerous response from the immune system. In addition, simple filtration can lead to increased risks of infection and loss of valuable platelets. Newer, more advanced thrombapheresis machines can filter white blood cells during separation. For example, with marginally acceptable whole blood (white blood cells: < 10,000/mm³; platelets: > 150,000/mm³), a dose (3×10) of platelets comes with about 2×10 white blood cells. This can seriously damage the patient's health. A dose of single-donor platelets prepared using latest filters can contain as little as 5×10 white blood cells. There are two types of manual platelet apheresis. Platelet-rich

neg: Vascular access by removal of those cells to make the 'blood vessels' storable in refrigerators. Vascular access Vascular access refers to a rapid, direct method of introducing or removing devices or chemicals from the bloodstream. In hemodialysis, vascular access is used to remove the patient's blood so that it can be filtered through the dialyzer. Three primary methods are used to gain access to the blood: an intravenous catheter, an arteriovenous fistula (AV) or a synthetic graft. In the latter two, needles are used to puncture the graft or fistula each time dialysis is performed. The type of vascular access created for

neg: Lymph node such as the paraaortic lymph nodes and the tracheobronchial lymph nodes. There are no lymph nodes in the central nervous system, which is separated from the body by the blood-brain barrier. The primary function of lymph nodes is the filtering of lymph to identify and fight infection. In order to do this, lymph nodes contain lymphocytes, a type of white blood cell, which includes B cells and T cells. These circulate through the bloodstream and enter and reside in lymph nodes. B cells produce antibodies. Each antibody has a single predetermined target, an antigen, that it can bind to. These

neg: Eosinophil Eosinophil Eosinophils, sometimes called eosinophiles or, less commonly, acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma. They are granulocytes that develop during hematopoiesis in the bone marrow before migrating into blood, after which they are terminally differentiated and do not multiply. These cells are eosinophilic or "acid-loving" due to their large acidophilic cytoplasmic granules, which show their affinity for acids by their affinity to coal tar dyes: Normally

neg: Margatoxin dosing. Thymic atrophy (reduced thymus) was observed. Especially the cells in the cortical region had decreased in number Neointimal Hyperplasia is the movement and proliferation of smooth muscle cells into the luminal area of a blood vessel. This generates a new inner structure that can block blood flow. This is commonly seen to cause failure of interventional clinical procedures that include placement of stents and bypass grafts. Due to changes in potassium channel type the vascular smooth muscle cells switch from the contractile to proliferating phenotype. It is suggested that Kv1.3 is important in proliferating vascular smooth muscle cells. Inhibitors

neg: Cord blood bank private banks, partly because most treatable conditions can't use one's own cord blood. Cord blood contains hematopoietic stem cells (which can differentiate only into blood cells), and should not be confused with embryonic stem cells or pluripotent stem cells, which can differentiate into any cell in the body. Cord blood stem cells are blood cell progenitors which can form red blood cells, white blood cells, and platelets. This is why cord blood cells are currently used to treat blood and immune system related genetic diseases, cancers, and blood disorders. On the possibility that cord blood stem cells could be used

neg: Natalizumab in the class of selective adhesion molecule inhibitors. α4-integrin is required for white blood cells to move into organs, and natalizumab's mechanism of action is believed to be the prevention of immune cells from crossing blood vessel walls to reach affected organs. The symptom-causing lesions of MS are believed to be caused when inflammatory cells such as T-lymphocytes pass through the blood–brain barrier through interaction with receptors on the endothelial cells. Natalizumab appears to reduce the transmission of immune cells into the central nervous system by interfering with the α4β1-integrin receptor molecules on the surfaces of cells. The effect appears

neg: Wnt signaling pathway thereby amplifies mechanical signalling that occurs during development. Cell fate specification or cell differentiation is a process where undifferentiated cells can become a more specialized cell type. Wnt signaling induces differentiation of pluripotent stem cells into mesoderm and endoderm progenitor cells. These progenitor cells further differentiate into cell types such as endothelial, cardiac and vascular smooth muscle lineages. Wnt signaling induces blood formation from stem cells. Specifically, Wnt3 leads to mesoderm committed cells with hematopoietic potential. Wnt1 antagonizes neural differentiation and is a major factor in self-renewal of neural stem cells. This allows for regeneration of nervous system cells, which

neg: Circulatory system 5.7 liters) of blood, accounting for approximately 7% of their total body weight. Blood consists of plasma, red blood cells, white blood cells, and platelets. Also, the digestive system works with the circulatory system to provide the nutrients the system needs to keep the heart pumping. The cardiovascular systems of humans are closed, meaning that the blood never leaves the network of blood vessels. In contrast, oxygen and nutrients diffuse across the blood vessel layers and enter interstitial fluid, which carries oxygen and nutrients to the target cells, and carbon dioxide and wastes in the opposite direction. The other component

neg: Vandread and technician, Duelo as a skilled doctor and engineer, and Bart as the ship's helmsman and navigator. The story of the first season revolves around the crew's trip back to the system where their respective home worlds are. Along the way, they encounter strange, robotic machines, both enigmatic and rather Borg-like, though they do not communicate at all. After a few attacks with the unknown enemy, the crew manages to take some alien data samples from a desert planet. The data is read out: "Blood platelets, white blood cells, red blood cells..." Their alien enemies kills human beings and harvests

neg: Astrocyte synapses made by neurons. Astrocytes are classically identified using histological analysis; many of these cells express the intermediate filament glial fibrillary acidic protein (GFAP). Several forms of astrocytes exist in the central nervous system including "fibrous" (in white matter), "protoplasmic" (in grey matter), and "radial". The fibrous glia are usually located within white matter, have relatively few organelles, and exhibit long unbranched cellular processes. This type often has "vascular feet" that physically connect the cells to the outside of capillary walls when they are in proximity to them. The protoplasmic glia are the most prevalent and are found in grey

neg: Inflammation the increased movement of plasma and leukocytes (especially granulocytes) from the blood into the injured tissues. A series of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. Prolonged inflammation, known as "chronic inflammation", leads to a progressive shift in the type of cells present at the site of inflammation, such as mononuclear cells, and is characterized by simultaneous destruction and healing of the tissue from the inflammatory process. Inflammation is not a synonym for infection. Infection describes the interaction between the action of microbial invasion

neg: White blood cell used categories of white blood cell disorders divide them quantitatively into those causing excessive numbers (proliferative disorders) and those causing insufficient numbers (leukopenias). Leukocytosis is usually healthy (e.g., fighting an infection), but it also may be dysfunctionally proliferative. WBC proliferative disorders can be classed as myeloproliferative and lymphoproliferative. Some are autoimmune, but many are neoplastic. Another way to categorize disorders of white blood cells is qualitatively. There are various disorders in which the number of white blood cells is normal but the cells do not function normally. Neoplasia of WBCs can be benign but is often malignant. Of the various