query: Michael Keaton does not play a Marvel Comic super villain.

pos: Michael Keaton Michael John Douglas ( born September 5 , 1951 ) , known professionally as Michael Keaton , is an American actor , producer and director . He first rose to fame for his comedic film roles in Night Shift ( 1982 ) , Mr. Mom ( 1983 ) , Johnny Dangerously ( 1984 ) and Beetlejuice ( 1988 ) , and he earned further acclaim for his dramatic portrayal of the title character in Tim Burton 's Batman ( 1989 ) and Batman Returns ( 1992 ) .   Since then , he has appeared in a variety of films ranging from dramas and romantic comedies to thriller and action films ; such as Clean and Sober ( 1988 ) , The Dream Team ( 1989 ) , Pacific Heights ( 1990 ) , Much Ado About Nothing ( 1993 ) , My Life ( 1993 ) , The Paper ( 1994 ) , Multiplicity ( 1996 ) , Jackie Brown ( 1997 ) , Herbie : Fully Loaded ( 2005 ) , The Other Guys ( 2010 ) , Need for Speed ( 2014 ) , RoboCop ( 2014 ) , Spotlight ( 2015 ) and The Founder ( 2016 ) , and he has also provided voices for characters in animated films such as Cars ( 2006 ) , Toy Story 3 ( 2010 ) and Minions ( 2015 ) . In 2017 , Keaton will play the role of Marvel Comics supervillain the Vulture in Spider-Man : Homecoming .   Keaton 's lead performance in Birdman or ( The Unexpected Virtue of Ignorance ) ( 2014 ) earned him a Golden Globe Award for Best Actor in a Musical or Comedy , the Critics ' Choice Award for Best Actor and Best Actor in a Comedy , and nominations for the Screen Actors Guild Award , British Academy Film Award , and Academy Award for Best Actor . He previously received a Golden Globe Award nomination for his performance in Live from Baghdad ( 2002 ) and a Screen Actors Guild Award nomination for The Company ( 2007 ) . Keaton was awarded a Career Achievement Award from both the Hollywood Film Festival and Zurich Film Festivals .   On January 18 , 2016 , he was named Officer of Order of Arts and Letters in France . He is also a visiting scholar at Carnegie Mellon University . </span>

neg: Galactus Galactus is a fictional character appearing in American comic books published by Marvel Comics . Formerly a mortal man , Galactus is a cosmic entity who originally consumed planets to sustain his life force , and serves a functional role in the upkeep of the primary Marvel continuity . Galactus was created by Stan Lee and Jack Kirby and first appeared in the comic book Fantastic Four # 48 , published in March 1966 .   Lee and Kirby had desired to introduce a character that broke away from the archetype of the standard villain , culminating in the creation of Galactus . In the character 's first appearance Galactus was depicted as a god-like figure who feeds by draining living planets of their energy , and operates without regard to the morality and judgements of mortal beings . Galactus ' initial origin was that of a space explorer named Galan who gained cosmic abilities by passing near a star , but writer Mark Gruenwald further developed the origin of the character , revealing that Galan lived during the previous universe . As Galan 's universe came to an end , Galan merged with the `` Sentience of the Universe '' to become Galactus , an entity that wielded such cosmic power as to require devouring entire planets to sustain his existence . Additional material written by John Byrne , Jim Starlin , and Louise Simonson explored Galactus ' role and purpose in the Marvel Universe , and examined the actions of the character through themes of genocide , manifest destiny , ethics , and natural/necessary existence . Frequently accompanied by a herald ( such as the Silver Surfer ) , the character has appeared as both antagonist and protagonist in central and supporting roles . Since debuting in the Silver Age of Comic Books , Galactus has played a role in over five decades of Marvel continuity .   The character has been featured in other Marvel media , such as arcade games , video games , animated television series , and the 2007 film Fantastic Four : Rise of the Silver Surfer .   In 2009 , Galactus ranked 5th on IGN 's list of `` Top 100 Comic Book Villains '' , citing the character 's `` larger than life presence '' as making him one of the more important villains ever created . IGN also noted `` Galactus is one of the few villains on our list to really defy the definition of an evil-doer '' as the character is compelled to destroy worlds because of his hunger .

neg: Hammerhead (comics) Hammerhead is a fictional supervillain appearing in American comic books published by Marvel Comics . He is primarily an enemy of Spider-Man and a member of organized crime who exists in Marvel 's main shared universe , known as the Marvel Universe .   He is closely associated with the Hammerhead `` Family '' , a Maggia crime family . Hammerhead distinguishes himself from other villains in that he dresses up and acts somewhat like a gangster from the 1920s . Due to an injury he suffered , much of his skull was replaced with an unbendable steel alloy by Jonas Harrow , giving his head a flattened shape .

neg: Ghost Rider Ghost Rider is the name of several fictional supernatural antiheroes appearing in American comic books published by Marvel Comics . Marvel had previously used the name for a Western character whose name was later changed to Phantom Rider .   The first supernatural Ghost Rider is stunt motorcyclist Johnny Blaze , who , in order to save the life of his father , agreed to give his soul to `` Satan '' ( later revealed to be an arch-demon named Mephisto ) . At night and when around evil , Blaze finds his flesh consumed by hellfire , causing his head to become a flaming skull . He rides a fiery motorcycle and wields blasts of hellfire from his body , usually from his skeletal hands . He eventually learns he has been bonded with the demon Zarathos . Blaze starred in the series from 1972 to 1983 . The subsequent Ghost Rider series ( 1990 -- 1998 ) featured Danny Ketch as a new Ghost Rider . After his sister was injured by ninja gangsters , Ketch came in contact with a motorcycle that had somehow been mystically enchanted to contain the essence of a Spirit of Vengeance . Blaze reappeared in this 1990s series as a supporting character , and it was later revealed that Danny and his sister were Johnny Blaze 's long lost siblings . In 2000s comics , Blaze again became the Ghost Rider , succeeding Ketch . In 2013 , Robbie Reyes became Ghost Rider as part of the Marvel NOW ! initiative .   Nicolas Cage starred as the Johnny Blaze iteration of the character in the 2007 film Ghost Rider and the sequel Ghost Rider : Spirit of Vengeance in 2012 . Gabriel Luna plays the Robbie Reyes version in the television series Agents of S.H.I.E.L.D.

neg: Masters of the Universe: The Movie Masters of the Universe : The Movie is an action-adventure game developed by Gremlin Graphics , and published in 1987 . It is based on the American film Masters of the Universe ( 1987 ) , directed by Gary Goddard . The film and the game are part of the Masters of the Universe media franchise .   A promotional photo of Dolph Lundgren as He-Man and Frank Langella as Skeletor illustrates the video game packaging . The MSX version of the game is titled Masters of the Universe .   Two other Masters of the Universe video games were published in the same year : Masters of the Universe : The Arcade Game and Masters of the Universe : The Super Adventure .

neg: Krypton (comics) Krypton , a planet appearing in American comic books published by DC Comics . The planet is the native world of Superman and is named after the element krypton , which is abundant in its atmosphere . The planet was created by Jerry Siegel and Joe Shuster , and was first referred to in Action Comics # 1 ( June 1938 ) . The planet made its first full appearance in Superman # 1 ( Summer 1939 ) .   Krypton is also the native world of Supergirl , Krypto the Superdog , and Power Girl ( in her case , an alternate-universe version designated `` Krypton-Two '' ) . It has been consistently described as having been destroyed shortly after Superman 's flight from the planet , although the exact details of its destruction vary by time period and writers . Kryptonians were the dominant species on Krypton .

neg: Peter Corbeau Peter Corbeau is a fictional character that appears in Marvel Comics .

neg: Red Guardian The Red Guardian ( Russian : Красный хранитель , Krasnij Khranitel ) is the name of several fictional superheroes appearing in American comic books published by Marvel Comics . The Red Guardian is an identity that was created as the Soviet equivalent of Captain America ; since the fall of the Soviet Union , the name is no longer officially used , though at least two people have claimed the name .

neg: Captain Marvel (Marvel Comics) Captain Marvel is the name of several fictional superheroes appearing in American comic books published by Marvel Comics . Most of these versions exist in Marvel 's main shared universe , known as the Marvel Universe .

neg: List of Batman Family adversaries The Batman Family adversaries or the rogues gallery are a collective of fictional supervillains appearing in American comic books published by DC Comics . These characters are depicted as adversaries of the superhero Batman and his allies .   Since Batman first appeared in Detective Comics # 27 ( May 1939 ) , his supporting cast has expanded to include other superheroes , and has become what is now informally called the Batman Family . As with most superheroes , a cast of recurring enemies to the Batman Family have been introduced throughout the decades , collectively referred to as the rogues gallery . Many characters from Batman 's rogues gallery who are criminally insane become patients at Arkham Asylum after they are apprehended .   The Batman Family 's rogues gallery has widely been well received , considered by many journalists to be one of the greatest superhero rogues galleries in all of comics .

neg: W'Kabi W'Kabi is a fictional character appearing in American comic books published by Marvel Comics . W'Kabi will appear in the upcoming film Black Panther , portrayed by Daniel Kaluuya .

neg: The New Avengers (comics) The New Avengers is a fictional team of superheroes appearing in comic books published by Marvel Comics . The title has been used for four American comic book series . The first two were written by Brian Michael Bendis and depicted a version of Marvel 's premiere superhero team , the Avengers . The third was written by Jonathan Hickman and depicted a group of characters called the Illuminati ( formerly introduced in New Avengers Vol . 1 # 7 -LSB- July 2005 -RSB- ) . The fourth is written by Al Ewing and depicts the former scientific terrorist group A.I.M. , reformed as `` Avengers Idea Mechanics '' , whose field team has appropriated the name `` New Avengers '' for itself .

neg: Klaatu (comics) Klaatu is a fictional Marvel Comics alien . He first appeared in The Incredible Hulk vol . 2 # 136-137 ( Feb - Mar 1971 ) , a two-part story which credits Roy Thomas as sole writer , but was in fact scripted by Thomas over a plot by Gerry Conway and Herb Trimpe . Klaatu 's character was a thinly veiled pastiche of Moby Dick . Moby Dick is considered to be a symbol of a number of things , among them God , nature , fate , the ocean , and the very universe itself . The name Klaatu was borrowed from the central character of The Day the Earth Stood Still .

neg: Mega Man (Archie Comics) Mega Man is a comic series produced by Archie Comics which was announced at New York Comic Con 2010 . The series began publication in April 2011 with Ian Flynn , who has written many stories for Archie 's Sonic the Hedgehog series , involved with the production . The series has proved highly successful , and in 2013 a crossover took place between the Mega Man and Sonic series , under the title `` Worlds Collide . '' The series does not follow the events of the games in exact order , including an adaptation of the Japanese exclusive game Super Adventure Rockman between those of Mega Man 2 and Mega Man 3 . The series later included a few stories set in the time of the Mega Man X series . The popularity of Worlds Collide subsequently led to a second crossover with the Sonic series , Worlds Unite . The series went on an indefinite hiatus after issue 55 , concluding with setup for an adaptation of Mega Man 4 .   The series is also notable for the artistic liberties taken with various characters . Shadow Man of Mega Man 3 and the Stardroids of Mega Man V are both featured as creations of Ra Moon , the primary antagonist from Super Adventure Rockman , and all are featured as foes of a group of robots based on Mega Man 8 character Duo . Mega Man and Proto Man 's Japanese names-Rock and Blues-are adapted as the names for their civilian forms . Several Robot Masters also appear in the series earlier than they did in the games .

neg: Man Mountain Marko Man Mountain Marko ( Michael Marko ) is a Marvel Comics supervillain . Marko was and remains an affiliate of numerous organized-crime entities in the Marvel universe , including the Maggia .   He was allied with Silvermane , Caesar Cicero , Eel I , and Nightshade . His most frequent enemies are Spider-Man , Power Man , Iron Fist , Thunderbolt , and Boomerang . He appears to have no relation to Cain Marko , seen in various Marvel titles as the Juggernaut , despite similarities in surname , physique and superpowers .

neg: Reaper (Marvel Comics) Reaper is the name of several fictional characters appearing in American comic books published by Marvel Comics . The character known most notably as the Reaper whose real name is Pantu Hurageb , a mutant in the X-Force comic book series . He has been a villain in the main Marvel Universe but a hero in the Ultraverse .

neg: Man-Ape Man-Ape ( M'Baku ) is a fictional character , a supervillain appearing in American comic books published by Marvel Comics . The character is depicted as a frequent enemy of the Black Panther .

neg: Batman: Mask of the Phantasm Batman : Mask of the Phantasm ( also known as Batman : The Animated Movie ) is a 1993 American animated neo-noir superhero mystery film feauring the DC Comics character Batman . Directed by Eric Radomski and Bruce Timm , it is based on the hit TV series Batman : The Animated Series and was distributed by Warner Bros. . Pictures . The film was written by Alan Burnett , Paul Dini , Martin Pasko and Michael Reaves and stars the vocal talents of Kevin Conroy , Mark Hamill and Efrem Zimbalist , Jr. ( all reprising their roles from The Animated Series ) , in addition to Dana Delany , Hart Bochner , Stacy Keach , and Abe Vigoda . It revolves around Batman attempting to apprehend a mysterious vigilante who 's murdering Gotham City 's crime bosses .   The film was originally thought of as a direct-to-video release . Warner Bros. ultimately decided for a theatrical release , giving the filmmakers a strenuous eight-month schedule . Mask of the Phantasm was released on December 25 , 1993 to widespread acclaim from critics , who praised the animation , voice performances , storyline and music , among others . However , due to the decision to release the film in theaters on such short notice , it failed at the box office .   After its release on home video , the film found cult success and over the years developed a cult following . The film 's success led to two direct-to-video standalone sequels , Batman & Mr. Freeze : SubZero in 1997 and Mystery of the Batwoman in 2003 . In recent years , many publications including Time , IGN and WhatCulture , have ranked it as one of the best Batman films ever made and among the best animated films ever made .

neg: Dark Angel (Marvel Comics) Dark Angel is the name used by two fictional characters appearing in American comic books published by Marvel Comics . They have appeared in publications by Marvel UK , though they have no other relation .

neg: Nitro (comics) Nitro is a fictional character , a supervillain appearing in American comic books published by Marvel Comics .   Nitro is known by comic fans for playing a part in the death of the Kree superhero Mar-Vell . He is also best known for being part of the tragedy that started off Marvel 's Civil War crossover .

neg: Captain Marvel (Mar-Vell) Captain Marvel ( Mar-Vell ) is a fictional superhero appearing in American comic books published by Marvel Comics . The character was created by writer-editor Stan Lee and designed by artist Gene Colan and first appeared in Marvel Super-Heroes # 12 ( December 1967 ) .   The character debuted during the Silver Age of comic books and has made many appearances since then , including a self-titled series and the second volume of the Marvel Spotlight series . Captain Marvel was ranked 24th in IGN 's list of `` The Top 50 Avengers '' and has appeared in television series and video games .


query: 25 was released in 2013.

pos: 25 (Adele album) 25 is the third studio album by British singer and songwriter Adele . It was released on 20 November 2015 , through XL Recordings . Following the release and international success of her second studio album 21 .   Titled as a reflection of her life and frame of mind at 25 years old , 25 is a `` make-up record '' . The album 's lyrical content features themes of Adele `` yearning for her old self , her nostalgia '' , and `` melancholia about the passage of time '' according to an interview with the singer by Rolling Stone , as well as themes of motherhood and regret . In contrast to Adele 's previous works , the production of 25 incorporated the use of electronic elements and creative rhythmic patterns , with elements of 1980s R&B and organs . Like 21 , Adele worked with producer and songwriter Paul Epworth and Ryan Tedder , along with new collaborations with Max Martin and Shellback , Greg Kurstin , Danger Mouse , the Smeezingtons , Samuel Dixon , and Tobias Jesso Jr. .   25 received generally positive reviews from music critics , who commended Adele 's vocal performance and the album 's production . The album was a massive commercial success , debuting at number one in more than 25 markets and broke first-week sales records in multiple countries , including the United Kingdom and United States ; in the US , the album sold 3.38 million copies in its first week of release , marking the largest single-week sales for an album since Nielsen SoundScan began tracking point-of-sale music purchases in 1991 . 25 eventually became the world 's best-selling album of 2015 with 17.4 million copies sold within the year , and has sold 20 million copies as of June 2016 , making it one of the best selling albums worldwide .   Following 21 , it was certified Diamond by the Recording Industry Association of America ( RIAA ) , denoting shipments of ten million copies in the United States , making Adele the only artist of the 2010s to achieve this certification with two albums . Many journalists felt that the album impacted the music industry by encouraging the public to return to buying physical albums , instead of downloading or streaming . 25 received the BRIT Award for British Album of the Year , while the lead single `` Hello '' won British Single of the Year . The album then won the 2017 Grammy Awards for Album of the Year , and Best Pop Vocal Album . `` Hello '' also won Grammys for Record of the Year , Song of the Year , and Best Pop Solo Performance .

pos: 59th Annual Grammy Awards The 59th Annual Grammy Awards ceremony was held on February 12 , 2017 . The CBS network broadcast the show live from the Staples Center in Los Angeles . The ceremony recognized the best recordings , compositions , and artists of the eligibility year , which runs from October 1 , 2015 to September 30 , 2016 .   James Corden hosted the ceremony for the first time . The `` pre-telecast '' ceremony ( officially named The Premiere Ceremony ) was held on the same day prior to the main event and was hosted by comedienne Margaret Cho .   The nominations were announced on December 6 , 2016 . Beyoncé acquired the most nominations with nine . Drake , Rihanna , and Kanye West received eight nominations each while Chance the Rapper followed with seven nominations . Adele was the biggest winner of the night with five trophies , including Album of the Year for 25 , Record of the Year , and Song of the Year for `` Hello '' . Adele also became the first artist in history to win all three general field awards in the same ceremony twice , previously winning all three categories in 2012 . David Bowie and Greg Kurstin followed with four trophies . Chance the Rapper won for Best New Artist alongside two other awards .

pos: Hello (Adele song) `` Hello '' is a song by English singer Adele . It was released on 23 October 2015 by XL Recordings as the lead single from her third studio album , 25 ( 2015 ) . Adele co-wrote the song with her producer , Greg Kurstin . `` Hello '' is a piano ballad with soul influences , and lyrics that discuss themes of nostalgia and regret . Upon release , the song was well received by music critics , who compared it favourably to Adele 's previous work and praised the song 's lyrics and Adele 's vocals . It was recorded in London .   `` Hello '' reached number one in almost every country it charted in , including the United Kingdom , where it became her second UK number-one single , following `` Someone like You '' , and has the largest opening week sales in three years . In the United States , `` Hello '' debuted atop the Billboard Hot 100 , reigning for 10 consecutive weeks whilst becoming Adele 's fourth number-one on the chart and breaking several records , including becoming the first song to sell over a million digital copies in a week . By the end of 2015 , it had sold 12.3 million units globally ( combined sales and track-equivalent streams ) and was the year 's 7th best-selling single .   The accompanying music video was directed by Xavier Dolan and co-stars Adele and Tristan Wilds . The music video for the song broke the Vevo Record by achieving over 27.7 million views within a 24-hour span , held previously by Taylor Swift 's `` Bad Blood '' which accumulated 20.1 million views in that timeframe . It also broke the record for shortest time to attain 100 million Vevo views , previously held by Miley Cyrus ' `` Wrecking Ball '' , as well as shortest time to reach 1 billion YouTube views ( 88 days ) . The clip received seven nominations at the 2016 MTV Video Music Awards , including Video of the Year and Best Female Video . Adele promoted the song with a live performance on a BBC one-hour-long special , entitled Adele at the BBC . At the 59th Annual Grammy Awards , `` Hello '' won three Grammy Awards : Record of the Year , Song of the Year , and Best Pop Solo Performance .

neg: Twenty Five (album) Twenty Five is a greatest hits album by George Michael released on 2006 , celebrating the 25th anniversary of his music career . It was released on 13 November 2006 by Sony BMG . It debuted at number one on the UK Albums Chart and number 23 on the Billboard 200 , and it reached the top 20 on most other album charts . After Michael 's death in December 2016 , the album re-entered the Billboard 200 at a new peak position of number 12 .   The album mostly contains songs from Michael 's solo career , but also from his earlier days with Wham ! . The album is sold in two formats : a 2-CD set and a limited edition 3-CD set . The 2-CD set contains 26 tracks , including four recorded with Wham ! and three new songs : `` An Easier Affair '' , `` This Is Not Real Love '' ( a duet with the British singer Mutya Buena ) and a new version of `` Heal the Pain '' , recorded with Paul McCartney . The limited edition 3-CD version contains an additional 14 lesser known tracks , including one with Wham ! and another new song called `` Understand '' .   The 2-CD version was released in the United States on 1 April 2008 , with two changes : `` Feeling Good '' replaced the Wham ! track `` Freedom '' , and `` The First Time Ever I Saw Your Face '' ( from Songs from the Last Century ) replaced `` Round Here '' , a track from Patience that was not released as a single in the US .   A 3-CD limited deluxe version was released in the United States exclusively by Best Buy . The track listing for the third CD is the same as the international version , but unlike the 2-CD US version , it includes `` Freedom '' instead of `` Feeling Good '' . The 3-CD version is packaged in a digipak . It includes a 36-page colour booklet with lyrics for every track , along with screen shots from the videos for most of the tracks on the first two CDs .   A Twenty Five DVD was also released .

neg: Dallas Buyers Club Dallas Buyers Club is a 2013 American biographical drama film , co-written by Craig Borten and Melisa Wallack , and directed by Jean-Marc Vallée . The film tells the story of Ron Woodroof , an AIDS patient diagnosed in the mid 1980s when HIV/AIDS treatments were under-researched , while the disease was not understood and highly stigmatized . As part of the experimental AIDS treatment movement , he smuggled unapproved pharmaceutical drugs into Texas for treating his symptoms , and distributed them to fellow people with AIDS by establishing the `` Dallas Buyers Club '' while facing opposition from the Food and Drug Administration ( FDA ) . Two fictional supporting characters , Dr. Eve Saks ( Jennifer Garner ) , and Rayon ( Jared Leto ) , were composite roles created from the writer 's interviews with transgender AIDS patients , activists , and doctors .   Screenwriter Borten interviewed Woodroof in 1992 and wrote the script , which he polished with writer Wallack in 2000 , and then sold to producer Robbie Brenner . Several other actors , directors , and producers who were attached at various times to the development of the film left the project . Universal Pictures also tried to make the film , but did not . A couple of screenwriters wrote drafts that were rejected . In 2009 , producer Brenner involved Matthew McConaughey , because of his Texas origins , the same as Woodroof 's . Brenner selected the first draft , written by Borten and Wallack , for the film , and then Vallée was set to direct the film . Principal photography began on November 11 , 2012 , in New Orleans , Louisiana , continuing for 25 days of filming , which also included shooting in Baton Rouge . Brenner and Rachel Winter co-produced the film . The official soundtrack album was featured by various artists , and was released digitally on October 29 , 2013 , by the Relativity Music Group .   Dallas Buyers Club premiered at the 2013 Toronto International Film Festival and was released theatrically in the United States on November 1 , 2013 , by Focus Features , strategically entering wide release on November 22 for award season . The film grossed over $ 27 million domestically and $ 27.9 million internationally , the box office revenue returned over $ 55 million against a budget of $ 5 million in 182-days of a theatrical run . It grossed over $ 4.5 million from DVD , and over $ 3 million from Blu-ray sales . The film received universal critical acclaim , resulting in numerous accolades . Most praised the performances of McConaughey and Leto , who received the Academy Award for Best Actor and for Best Supporting Actor , respectively , at the 86th Academy Awards , making this the first film since Mystic River ( 2003 ) , and only the fifth movie ever , to win both awards . The film also won the award for Best Makeup and Hairstyling , and garnered nominations for Best Picture , Best Original Screenplay , and Best Editing .

neg: We as Human (album) We as Human is the first major label and second and final studio album by Christian rock band We as Human , released on June 25 , 2013 by Atlantic Records . The album was produced by Howard Benson .

neg: 25th Golden Disc Awards The 25th Golden Disc Awards were held December 9 , 2010 . They recognized accomplishments by musicians from the previous year .

neg: List of Icelandic films of 2014 The Icelandic film industry produced over twenty feature films in 2014 . This article fully lists all non-pornographic films , including short films , that had a release date in that year and which were at least partly made by Iceland . It does not include films first released in previous years that had release dates in 2014 . Also included is an overview of the major events in Icelandic film , including film festivals and awards ceremonies , as well as lists of those films that have been particularly well received , both critically and financially .

neg: Born to Die Born to Die is the second studio album by American singer and songwriter Lana Del Rey . Her major label debut , it was released on January 27 , 2012 by Interscope Records , Polydor Records and Stranger Records . Del Rey collaborated with producers including Patrik Berger , Jeff Bhasker , Chris Braide , Emile Haynie , Justin Parker , Rick Nowels , Robopop and Al Shux to achieve her desired sound . Their efforts resulted in a primarily baroque pop record , which sees additional influences from alternative hip hop , indie pop and trip hop music .   Contemporary music critics gave Born to Die mixed reviews ; some commended its distinctive production , while its repetitiveness and melodramatic tendencies were a recurring complaint . The album debuted at number two on the US Billboard 200 with first-week sales of 77,000 copies ; it was later certified platinum by the Recording Industry Association of America ( RIAA ) after moving one million units . Born to Die reached the peak positions on eleven international record charts .   After attaining online success after its initial premiere on June 29 , 2011 , `` Video Games '' was released as the lead single from Born to Die on October 17 , 2011 ; it peaked at number ninety-one on the US Billboard Hot 100 . Its follow-up singles `` Born to Die '' , `` Off to the Races '' , `` Blue Jeans '' , `` Summertime Sadness '' , `` National Anthem '' , and `` Dark Paradise '' performed sporadically across Billboard component charts and international record charts . The Cedric Gervais remix of `` Summertime Sadness '' was released on July 11 , 2013 and became Del Rey 's highest-charting single in the United States , reaching number six on the Billboard Hot 100 . Del Rey additionally promoted Born to Die with several televised performances , including a widely criticized appearance on Saturday Night Live . It was reissued on November 9 , 2012 as an expanded version subtitled The Paradise Edition , which was packaged with her third extended play Paradise ( 2012 ) .   Born to Die has sold 7,000,000 copies worldwide as of June 2014 .

neg: Sněženky a machři po 25 letech Sněženky a machři po 25 letech is a Czech comedy film . It was released in 2008 .

neg: 21st Screen Actors Guild Awards The 21st Annual Screen Actors Guild Awards , honoring the best achievements in film and television performances for the year 2014 , were presented on January 25 , 2015 , on both TNT and TBS 8:00 p.m. EST / 5:00 p.m. PST . Nominees were announced on December 10 , 2014 .

neg: International Documentary Association top 25 documentaries The International Documentary Association produced in 2007 a list of the top 25 documentary films as voted by members .   Hoop Dreams ( 1994 )  The Thin Blue Line ( 1988 )  Bowling for Columbine ( 2002 )  Spellbound ( 2002 )  Harlan County , U.S.A. ( 1976 )  An Inconvenient Truth ( 2006 )  Crumb ( 1994 )  Gim me Shelter ( 1970 )  The Fog of War ( 2003 )  Roger & Me ( 1989 )  Super Size Me ( 2004 )  Dont Look Back ( 1967 )  Salesman ( 1968 )  Koyaanisqatsi ( 1983 )  Sherman 's March ( 1986 )  Grey Gardens ( 1976 )  Capturing the Friedmans ( 2003 )  Born into Brothels ( 2004 )  Titicut Follies ( 1967 )  Buena Vista Social Club ( 1999 )  Fahrenheit 9/11 ( 2004 )  Winged Migration ( 2002 )  Grizzly Man ( 2005 )  Night and Fog ( 1955 )  Woodstock '' ( 1970 )

neg: Love from London Love From London is the twentieth studio album by Robyn Hitchcock released on March 5 , 2013 on the label Yep Roc Records .

neg: List of number-one singles of 2013 (Australia) The ARIA Singles Chart ranks the best-performing singles in Australia . Its data , published by the Australian Recording Industry Association , is based collectively on each single 's weekly physical and digital sales . In 2013 , seventeen singles claimed the top spot , including `` Thrift Shop '' by Macklemore and Ryan Lewis , which started its peak position in late 2012 . Fifteen acts achieved their first number-one single in Australia , either as a lead or featured artist : Mary Lambert , Nate Ruess , Baauer , Ray Dalton , Passenger , Daft Punk , Pharrell Williams , Robin Thicke , T.I. , Avicii , 2 Chainz , Redfoo , Dami Im , Taylor Henderson and John Legend . Im and Henderson were the only Australian artists to achieve a number-one single .   Macklemore and Ryan Lewis had three number-one singles during the year for `` Thrift Shop '' , `` Same Love '' and `` Ca n't Hold Us '' . Jason Derulo earned two number-one singles for `` Talk Dirty '' and `` Trumpets '' . Pharrell Williams also earned two number-one singles during the year , as a featured artist on Daft Punk 's `` Get Lucky '' and Robin Thicke 's `` Blurred Lines '' . Katy Perry 's `` Roar '' was the longest-running number-one single of 2013 , having topped the ARIA Singles Chart for nine weeks . `` Blurred Lines '' was the second longest-running number-one single , with eight consecutive weeks at the top . Passenger 's `` Let Her Go '' stayed at number one for five consecutive weeks , while Avicii 's `` Wake Me Up ! '' topped the chart for six consecutive weeks .

neg: Justin Bieber's Believe Justin Bieber 's Believe is a 2013 American biographical concert film and the sequel to Never Say Never , both centering on Canadian singer Justin Bieber . It was released through Open Road Films in the United States and Canada on December 25 , 2013 . The film received negative reviews from critics and grossed $ 6.2 million in the United States .

neg: List of British films of 2013 The British film industry produced over five hundred feature films in 2013 . This article fully lists all non-pornographic films , including short films , that had a release date in that year and which were at least partly made by the United Kingdom . It does not include films first released in previous years that had release dates in 2013 .   Also included is an overview of the major events in British film , including film festivals and awards ceremonies , as well as lists of those films that were particularly well received , both critically and financially . The year was particularly notable for a number of low budget and independent horror films , such as In Fear , Devil 's Pass , Dementamania and Stalled .

neg: Now That's What I Call Music! 25 (U.S. series) Now That 's What I Call Music ! 25 was released on July 17 , 2007 . The album is the 25th edition of the Now ! series in the United States . It debuted at number one on the Billboard 200 , selling approximately 223,000 copies in its first week , and remained at number one in its second week , selling another 149,000 copies .   Now ! 25 contains three Billboard Hot 100 number-one hits , `` Girlfriend '' , `` Glamorous '' and `` Buy U a Drank ( Shawty Snappin ' ) '' , and has been certified Platinum by the RIAA .

neg: Quarta Divisão Quarta Divisão is a 2013 Portuguese film directed by Joaquim Leitão .

neg: Box 25 Box 25 ( Caja 25 ) is a 2015 Panamanian documentary film directed by Mercedes Arias and Delfina Vidal . The film is about letters that were written by the men who built the Panama Canal .   It was originally reported to be the Panamanian entry for the Best Foreign Language Film at the 88th Academy Awards . However , when the final list was announced by the Academy , the film was not included .

neg: 26th European Film Awards The 26th European Film Awards were presented on 7 December 2013 in Berlin , Germany . The winners were selected by over 2,500 members of the European Film Academy . On 28 October 2013 , a special seven-member jury convened in Berlin and , based on the EFA Selection list , decided on the winners in the categories cinematography , editing , production design , costume design , composer and sound design . On November 4 , 2013 nominations for documentary were announced . The special documentary jury consist five members : Antonio Saura Despina Mouzaki , Claas Danielsen , Ally Derks and Jacques Laurent .

neg: 25th Golden Globe Awards The 25th Golden Globe Awards , honoring the best achievements in 1967 , were held on 12 February 1968 .   25th Golden Globe Awards  February 12 , 1968   Film - Drama :  In The Heat of the Night   Film - Musical or Comedy :  The Graduate   TV Show :  Mission : Impossible

neg: Twenty Five (DVD) Twenty Five is a video album by British singer George Michael , released on DVD in November 2006 . It contains forty videos on two discs , including seven with Wham ! . The Twenty Five album was also released at the same time .

neg: Art film An art film is typically a serious , independent film aimed at a niche market rather than a mass market audience . An art film is `` intended to be a serious artistic work , often experimental and not designed for mass appeal '' ; they are `` made primarily for aesthetic reasons rather than commercial profit '' , and they contain `` unconventional or highly symbolic content '' .   Film critics and film studies scholars typically define an art film as possessing `` formal qualities that mark them as different from mainstream Hollywood films '' , which can include , among other elements , a sense of social realism ; an emphasis on the authorial expressiveness of the director ; and a focus on the thoughts , dreams , or motivations of characters , as opposed to the unfolding of a clear , goal-driven story . Film scholar David Bordwell describes art cinema as `` a film genre , with its own distinct conventions '' .   Art film producers usually present their films at specialty theatres ( repertory cinemas , or , in the U.S. , `` arthouse cinemas '' ) and film festivals . The term art film is much more widely used in the United States , the UK and Australia than in Europe , where the term is more associated with `` auteur '' films and `` national cinema '' ( e.g. , German national cinema ) . Because they are aimed at small niche market audiences , they can rarely get the financial backing that will permit large production budgets , expensive special effects , costly celebrity actors , or huge advertising campaigns , as are used in widely released mainstream blockbuster films . Art film directors make up for these constraints by creating a different type of film , which typically uses lesser-known film actors ( or even amateur actors ) and modest sets to make films that focus much more on developing ideas or exploring new narrative techniques or film-making conventions .   A certain degree of experience and knowledge are required to fully understand or appreciate such films . One mid-1990s art film was called `` largely a cerebral experience '' that one enjoys `` because of what you know about film '' . This contrasts sharply with mainstream `` blockbuster '' films , which are geared more towards escapism and pure entertainment . For promotion , art films rely on the publicity generated from film critics ' reviews , discussion of their film by arts columnists , commentators and bloggers , and `` word-of-mouth '' promotion by audience members . Since art films have small initial investment costs , they only need to appeal to a small portion of the mainstream viewing audiences to become financially viable .


query: Kirk Douglas starred in a movie.

pos: Kirk Douglas Kirk Douglas ( born Issur Danielovitch , December 9 , 1916 ) is an American actor , producer , director , and author . He is one of the last living people of the film industry 's Golden Age . After an impoverished childhood with immigrant parents and six sisters , he had his film debut in The Strange Love of Martha Ivers ( 1946 ) with Barbara Stanwyck . Douglas soon developed into a leading box-office star throughout the 1950s and 1960s , known for serious dramas , including westerns and war movies . During his career he appeared in more than 90 movies .   Douglas became an international star through positive reception for his leading role as an unscrupulous boxing hero in Champion ( 1949 ) , which brought him his first nomination for the Academy Award for Best Actor . Other early films include Young Man with a Horn ( 1950 ) , playing opposite Lauren Bacall and Doris Day ; Ace in the Hole opposite Jan Sterling ( 1951 ) ; and Detective Story ( 1951 ) . He received a second Oscar nomination for his dramatic role in The Bad and the Beautiful ( 1952 ) , opposite Lana Turner , and his third nomination for portraying Vincent van Gogh in Lust for Life ( 1956 ) .   In 1955 , he established Bryna Productions , which began producing films as varied as Paths of Glory ( 1957 ) and Spartacus ( 1960 ) . In those two films , he starred and collaborated with the then relatively unknown director , Stanley Kubrick . Douglas helped break the Hollywood blacklist by having Dalton Trumbo write Spartacus with an official on-screen credit , although Trumbo 's family claims he overstated his role . He produced and starred in Lonely Are the Brave ( 1962 ) , considered a cult classic , and Seven Days in May ( 1964 ) , opposite Burt Lancaster , with whom he made seven films . In 1963 , he starred in the Broadway play One Flew Over the Cuckoo 's Nest , a story he purchased , which he later gave to his son Michael Douglas , who turned it into an Oscar-winning film .   As an actor and philanthropist , Douglas has received three Academy Award nominations , an Oscar for Lifetime Achievement , and the Presidential Medal of Freedom . As an author , he has written ten novels and memoirs . Currently , he is No. 17 on the American Film Institute 's list of the greatest male screen legends of classic Hollywood cinema , and the highest-ranked living person on the list . After barely surviving a helicopter crash in 1991 and then suffering a stroke in 1996 , he has focused on renewing his spiritual and religious life . He lives with his second wife ( of 63 years ) , Anne , a producer . He turned 100 on December 9 , 2016 .

neg: The Juggler (film) The Juggler ( 1953 ) is a drama film about a survivor of the Holocaust , played by Kirk Douglas . The screenplay was adapted by Michael Blankfort from his novel of the same name .

neg: Getting In Getting In , also known as Student Body , is a 1994 American comedy film directed by Doug Liman starring Andrew McCarthy and Stephen Mailer .

neg: Black Christmas (2006 film) Black Christmas ( abbreviated as Black X-Mas ) is a 2006 American-Canadian slasher film written and directed by Glen Morgan and starring Katie Cassidy , Michelle Trachtenberg , Mary Elizabeth Winstead , Oliver Hudson , Lacey Chabert , Kristen Cloke , and Andrea Martin . The film takes place several days before Christmas , and tells the story of a group of sorority sisters who are stalked and murdered by the house 's former inhabitants during a winter storm . It is a loose remake of the 1974 film of the same name . The film was produced by Morgan and James Wong through their production company Hard Eight Pictures , along with 2929 Productions and Dimension Films , while Metro-Goldwyn-Mayer distributed the film .   In December 2006 , upon anticipation of its premiere , the film garnered some criticism from religious groups due to its graphic content in a holiday setting , as well as the distributor 's decision to release the film on Christmas Day in the United States . The film opened in the United Kingdom on December 15 , 2006 , and , despite backlash from some religious organizations , opened in US theaters on Christmas Day .

neg: Everybody's Fine (2009 film) Everybody 's Fine is a 2009 American drama film written and directed by Kirk Jones , and starring Robert De Niro , Drew Barrymore , Sam Rockwell and Kate Beckinsale . It is a remake of the Giuseppe Tornatore 's Italian film Everybody 's Fine . In Brazil , Russia and Japan , the film was released direct-to-DVD .

neg: Déjà Vu (2006 film) Déjà Vu ( stylised onscreen without accents ) is a 2006 American science fiction thriller film directed by Tony Scott , written by Bill Marsilii and Terry Rossio , and produced by Jerry Bruckheimer . The film stars Denzel Washington , Paula Patton , Jim Caviezel , Val Kilmer , Adam Goldberg and Bruce Greenwood . It involves an ATF agent who travels back in time in attempts to prevent a domestic terrorist attack that takes place in New Orleans and to save a woman with whom he falls in love . Filming took place in New Orleans after Hurricane Katrina .   The film was premiered in New York City on November 20 , 2006 , and released widely in the United States and Canada two days later on November 22 , 2006 . It received mixed reviews from critics , and earning $ 64 million in the United States and $ 180 million worldwide . It was the 23rd most successful film worldwide for 2006 . The film was nominated for five awards , and also won the Golden Reel Award .

neg: Catalina Caper Catalina Caper ( also known as Never Steal Anything Wet ) is a 1967 comedy musical mystery film starring Tommy Kirk . It is one of the last ( if not the last ) in the beach party film genre . This entry blends the beach format with a standard crime-caper comedy . It was shot on and around Santa Catalina Island , California .   The film was also featured in the second season ( episode 4 ) of the movie-mocking television show Mystery Science Theater 3000 ( MST3K ) .

neg: Hollywood blacklist The Hollywood blacklist -- as the broader entertainment industry blacklist is generally known -- was the practice of denying employment to screenwriters , actors , directors , musicians , and other American entertainment professionals during the mid-20th century because they were accused of having Communist ties or sympathies . Artists were barred from work on the basis of their alleged membership in or sympathy with the Communist Party USA or refusal to assist investigations into the party 's activities . Even during the period of its strictest enforcement , the late 1940s through the late 1950s , the blacklist was rarely made explicit or verifiable , but it directly damaged the careers of scores of individuals working in the film industry .   The first systematic Hollywood blacklist was instituted on November 25 , 1947 , the day after ten writers and directors were cited for contempt of Congress for refusing to testify to the House Un-American Activities Committee . A group of studio executives , acting under the aegis of the Association of Motion Picture Producers , fired the artists -- the so-called Hollywood Ten -- and made what has become known as the Waldorf Statement .   On June 22 , 1950 , a pamphlet entitled Red Channels was published . Focused on the field of broadcasting , it identified 151 entertainment industry professionals in the context of `` Red Fascists and their sympathizers . '' Soon , most of those named , along with a host of other artists , were barred from employment in most of the entertainment field .   The blacklist lasted until 1960 , when Dalton Trumbo , a Communist Party member from 1943 to 1948  and member of the Hollywood Ten , was credited as the screenwriter of the highly successful film Exodus , and later publicly acknowledged by actor Kirk Douglas for writing the screenplay for the movie Spartacus . A number of those blacklisted , however , were still barred from work in their professions for years afterward .

neg: Streets of Death Streets of Death is a 1987 American film . Tommy Kirk had retired from acting when the film was made but the producer made him an offer `` that was hard to refuse . '' He was the only professional actor in the cast .  The film had some problems ... . I played a cop who has been kicked off the force because he was a drunk and had accidentally killed somebody . But he wanted to be back on the force , to be a cop again , so he goes off on his own and tries to solve this string of serial killings in the Los Angeles suburbs ... That picture was a good example of a case of good intentions .

neg: K-PAX (film) K-PAX is a 2001 American science fiction-mystery film based on Gene Brewer 's 1995 novel of the same name , directed by Iain Softley , starring Kevin Spacey , Jeff Bridges , Mary McCormack and Alfre Woodard . The film is about a psychiatric patient who claims to be an alien from the planet K-PAX . During his treatment , the patient demonstrates an outlook on life that ultimately proves inspirational for his fellow patients and especially for his psychiatrist .

neg: Basic Instinct Basic Instinct is a 1992 neo-noir erotic thriller film directed by Paul Verhoeven and written by Joe Eszterhas , and starring Michael Douglas and Sharon Stone . The film follows a police detective , Nick Curran ( Douglas ) , who is investigating the brutal murder of a wealthy rock star . During the investigation Curran becomes involved in a torrid and intense relationship with the prime suspect , Catherine Tramell ( Stone ) , an enigmatic writer .   Even before its release , Basic Instinct generated heated controversy due to its overt sexuality and graphic depiction of violence . It was strongly opposed by gay rights activists , who criticized the film 's depiction of homosexual relationships and the portrayal of a bisexual woman as a murderous narcissistic psychopath . In a 2006 interview , Stone alleged that the infamous leg-crossing scene in which her vulva was exposed was filmed without her knowledge .   Despite initial critical negativity and public protest , Basic Instinct became one of the most financially successful films of the 1990s , grossing $ 352 million worldwide . Several versions of the film have been released on videocassette , DVD , and Blu-ray including a director 's cut with extended footage previously unseen in North American cinemas . The film has contemporarily been recognized for its groundbreaking depictions of sexuality in mainstream Hollywood cinema , and has been referred to by scholars as `` a neo-noir masterpiece that plays with , and transgresses , the narrative rules of film noir . '' A 2006 sequel , Basic Instinct 2 starring Stone was made without Verhoeven 's involvement , but received negative reviews from critics and was unsuccessful at the box office .

neg: Striptease (film) Striptease is a 1996 American erotic comedy film directed , produced , and written by Andrew Bergman , and stars Demi Moore , Burt Reynolds and Ving Rhames . The film is based on Carl Hiaasen 's novel of the same name , and is about a stripper who becomes involved in both a child-custody dispute and corrupt politics .   Striptease was generally reviled by critics . It wound up winning several Golden Raspberry Awards , which are given to the worst in cinema . Among these awards given to Striptease was the Award for Worst Picture of 1996 .

neg: The Corsican Brothers (1941 film) The Corsican Brothers is a 1941 swashbuckler film starring Douglas Fairbanks , Jr. in a dual role as the title Siamese twins , separated at birth and raised in completely different circumstances . Both thirst for revenge against the man who killed their parents ( played by Akim Tamiroff ) , both fall in love with the same woman ( portrayed by Ruth Warrick ) . The story is very loosely based on the novella Les frères Corses ( in English : The Corsican Brothers ) by French writer Alexandre Dumas , père .   Dimitri Tiomkin was nominated for an Academy Award for Original Music Score ( Score of a Dramatic or Comedy Picture ) .

neg: Douglas Henderson (actor) Douglas Henderson ( January 14 , 1919 in Montclair , New Jersey -- April 5 , 1978 in Studio City , California ) was an American film and television actor .   Originally a stage actor , he made the shift to film in 1952 , with his appearance in Stanley Kramer 's Eight Iron Men . Additional film appearances include the 1962 John Frankenheimer film The Manchurian Candidate , in which he played Col. Milt , the direct supervisor of the Maj. Marco character ( played by Frank Sinatra ) . He played Congressman Morrissey in the 1968 comedy Stay Away , Joe starring Elvis Presley .   On television , Henderson made six guest appearances on Perry Mason , including the role of title character and defendant Felix Heidemann in the 1960 episode , `` The Case of the Clumsy Clown . '' In 1963 he again played the defendant , this time Dwight Garrett , in `` The Case of the Elusive Element . '' In 1965 he played murder victim Frank Jones , alias Frank Jensen , in `` The Case of the Wrongful Writ , '' and in 1966 he again played the defendant , Greg Stanley , in `` The Case of the Crafty Kidnapper . ''

neg: The Heroes of Telemark The Heroes of Telemark is a British 1965 Eastman Color war film directed by Anthony Mann based on the true story of the Norwegian heavy water sabotage during World War II from `` Skis Against the Atom , '' the memoirs of Norwegian resistance soldier Knut Haukelid . The film stars Kirk Douglas as Dr Rolf Pedersen and Richard Harris as Knut Straud , along with Ulla Jacobsson as Anna Pedersen . It was filmed on location in Norway .

neg: First Yank into Tokyo First Yank into Tokyo is a 1945 United States war film ; it takes place during World War II . It was directed by Gordon Douglas .

neg: George Washington (film) George Washington is a 2000 American drama film written and directed by David Gordon Green . Its story centers on a group of children in a depressed small town in North Carolina who band together to cover up a tragic mistake .   Although it was not widely seen due to having had a very limited release , the film received wide praise from critics .

neg: Malone (film) Malone is a 1987 American film adaptation of William P. Wingate 's novel , written by Christopher Frank , directed by Harley Cokeliss , and stars Burt Reynolds , Cliff Robertson and Lauren Hutton .

neg: David Harum (1934 film) David Harum is a 1934 American comedy film directed by James Cruze and written by Walter Woods . The film stars Will Rogers , Louise Dresser , Evelyn Venable , Kent Taylor , Stepin Fetchit , Noah Beery , Sr. and Roger Imhof . The film was released on March 3 , 1934 , by Fox Film Corporation .

neg: The Wounded Sky The Wounded Sky is a 1983 Star Trek novel ( Pocket Books # 13 ) by Diane Duane , featuring James T. Kirk as captain of the USS Enterprise . The author would four years later adapt the novel 's plot for the teleplay of the first season Star Trek : The Next Generation episode `` Where No One Has Gone Before '' .

neg: Marooned (1969 film) Marooned is a 1969 American film directed by John Sturges and starring Gregory Peck , Richard Crenna , David Janssen , James Franciscus and Gene Hackman about three astronauts who are trapped and slowly suffocating in space . It was based on the 1964 novel Marooned by Martin Caidin . While the original novel was based on the single-pilot Mercury program , the film depicted an Apollo Command/Service Module with three astronauts and a space station resembling Skylab . Caidin acted as technical adviser and updated the novel , incorporating appropriate material from the original version .   The film was released less than four months after the Apollo 11 moon landing and was tied to the public fascination with the event . It won an Academy Award for Visual Effects for Robbie Robertson .


query: Huntington's disease is not an inherited disorder.

pos: Huntington's disease Huntington 's disease ( HD ) , also known as Huntington 's chorea , is an inherited disorder that results in death of brain cells . The earliest symptoms are often subtle problems with mood or mental abilities . A general lack of coordination and an unsteady gait often follow . As the disease advances , uncoordinated , jerky body movements become more apparent . Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk . Mental abilities generally decline into dementia . The specific symptoms vary somewhat between people . Symptoms usually begin between 30 and 50 years of age , but can start at any age . The disease may develop earlier in life in each successive generation . About 8 % of cases start before the age of 20 years and typically present with symptoms more similar to Parkinson 's disease . People with HD often underestimate the degree of their problems .   HD is typically inherited from a person 's parents , with 10 % of cases due to a new mutation . The disease is caused by an autosomal dominant mutation in either of an individual 's two copies of a gene called Huntingtin . This means a child of an affected person typically has a 50 % chance of inheriting the disease . The Huntingtin gene provides the genetic information for a protein that is also called `` huntingtin '' . Expansion of CAG ( cytosine-adenine-guanine ) triplet repeats in the gene coding for the Huntingtin protein results in an abnormal protein , which gradually damages cells in the brain , through mechanisms that are not fully understood . Diagnosis is by genetic testing , which can be carried out at any time , regardless of whether or not symptoms are present . This fact raises several ethical debates : the age at which an individual is considered mature enough to choose testing ; whether parents have the right to have their children tested ; and managing confidentiality and disclosure of test results .   There is no cure for HD . Full-time care is required in the later stages of the disease . Treatments can relieve some symptoms and in some improve quality of life . The best evidence for treatment of the movement problems is with tetrabenazine . HD affects about 4 to 15 in 100,000 people of European descent . It is rare among Japanese , while the occurrence rate in Africa is unknown . The disease affects men and women equally . Complications such as pneumonia , heart disease , and physical injury from falls reduce life expectancy . Suicide is the cause of death in about 9 % of cases . Death typically occurs fifteen to twenty years from when the disease was first detected .   The first likely description of the disease was in 1841 by Charles Oscar Waters . The condition was described in further detail in 1872 by George Huntington , after whom it is named . The genetic basis was discovered in 1993 by an international collaborative effort led by the Hereditary Disease Foundation . Research and support organizations began forming in the late 1960s to increase public awareness , to provide support for individuals and their families , and to promote research . Current research directions include determining the exact mechanism of the disease , improving animal models to aid with research , testing of medications to treat symptoms or slow the progression of the disease , and studying procedures such as stem cell therapy with the goal of repairing damage caused by the disease .

neg: Neurodevelopmental disorder Neurodevelopmental disorders are impairments of the growth and development of the brain or central nervous system . A narrower use of the term refers to a disorder of brain function that affects emotion , learning ability , self-control and memory and that unfolds as the individual grows . The term is sometimes erroneously used as an exclusive synonym for autism spectrum disorders .   Disorders considered neurodevelopmental in origin , or that have neurodevelopmental consequences when they occur in infancy and childhood , include :  Intellectual disability ( ID ) or intellectual and developmental disability ( IDD )  Autism spectrum disorders , such as Asperger 's syndrome  Fetal alcohol spectrum disorder  Motor disorders including developmental coordination disorder and stereotypic movement disorder  Tic disorders including Tourette 's syndrome  Traumatic brain injury ( including congenital injuries such as those that cause cerebral palsy )  Communication , speech and language disorders  Genetic disorders , such as fragile-X syndrome  Down syndrome  Attention deficit hyperactivity disorder  Mendelsohnn 's syndrome  Schizophrenia  Schizotypal disorder  HIV  Malaria  Neurodevelopmental disorders are associated with widely varying degrees of difficulty which may have significant mental , emotional , physical , and economic consequences for individuals , and in turn their families and society in general .

neg: Phenotype A phenotype is the composite of an organism 's observable characteristics or traits , such as its morphology , development , biochemical or physiological properties , behavior , and products of behavior ( such as a bird 's nest ) . A phenotype results from the expression of an organism 's genetic code , its genotype , as well as the influence of environmental factors and the interactions between the two . When two or more clearly different phenotypes exist in the same population of a species , the species is called polymorphic . A well-documented polymorphism is Labrador Retriever coloring ; while the coat color depends on many genes , it is clearly seen in the environment as yellow , black and brown .   This genotype-phenotype distinction was proposed by Wilhelm Johannsen in 1911 to make clear the difference between an organism 's heredity and what that heredity produces . The distinction is similar to that proposed by August Weismann , who distinguished between germ plasm ( heredity ) and somatic cells ( the body ) . The genotype-phenotype distinction should not be confused with Francis Crick 's central dogma of molecular biology , which is a statement about the directionality of molecular sequential information flowing from DNA to protein , and not the reverse .   Richard Dawkins in 1978 and then again in his 1982 book The Extended Phenotype suggested that bird nests and other built structures such as caddis fly larvae cases and beaver dams can be considered as `` extended phenotypes '' .

neg: Electromagnetic hypersensitivity Electromagnetic hypersensitivity ( EHS ) is a claimed sensitivity to electromagnetic fields , resulting in negative symptoms . EHS has no scientific basis and is not a recognised medical diagnosis . Claims are characterized by a `` variety of non-specific symptoms , which afflicted individuals attribute to exposure to electromagnetic fields '' .   Those who are self-described with EHS report adverse reactions to electromagnetic fields at intensities well below the maximum levels permitted by international radiation safety standards . The majority of provocation trials to date have found that such claimants are unable to distinguish between exposure and non-exposure to electromagnetic fields . A systematic review in 2005 showed no convincing scientific evidence for symptoms being caused by electromagnetic fields . Since then several double-blind experiments have shown that people who report electromagnetic hypersensitivity are unable to detect the presence of electromagnetic fields and are as likely to report ill health following a sham exposure as they are following exposure to genuine electromagnetic fields , suggesting the cause in these cases to be the nocebo effect .   A 2005 review by the UK Health Protection Agency and a 2006 systematic review each evaluated the evidence for various medical , psychological , behavioral , and alternative treatments for EHS and each found that the evidence-base was limited and not generalizable , but that the best evidence favored cognitive behavioural therapy . As of 2005 , WHO recommended that people presenting with claims of EHS be evaluated to determine if they have a medical condition that may be causing the symptoms the person is attributing to EHS , that they have a psychological evaluation , and that the person 's environment be evaluated for issues like air or noise pollution that may be causing problems .   Some people who feel they are sensitive to electromagnetic fields may seek to reduce their exposure or use alternative medicine . Government agencies have enforced false advertising claims against companies selling devices to shield against EM radiation .

neg: The Gene Bomb The Gene Bomb is a 1996 book by David E. Comings , self-published by Hope Press , that puts forth the theory that higher education and advanced technology may unintentionally favor the selection of genes that increase the likelihood of ADHD , autism , drug addiction , learning disorders , and behavior problems . Comings claims that the prevalence of these disorders is rising and I.Q. is decreasing ; others argue that other factors may be responsible , including increased detection of these disorders . He claims that society is inadvertently creating delays for the highly educated that reduce their reproductivity and causes them to have children later in life , thus raising the odds of certain disorders like autism . On the other hand , he claims that those having learning disorders tend to drop out of school earlier and have more children , thus passing on learning disorders at a higher rate . Environmental and societal factors are usually accepted as the cause , but Comings argues the opposite .   According to a review of the book in the British Developmental Medicine and Child Neurology journal , `` The arguments are developed in this book with an alarming lack of scientific accuracy and satisfactory supporting evidence . '' The review concludes that the book `` is an apocalyptic , irrational , and emotional treatise which opens up scientifically unsound issues that have already been formally buried '' . A book review in the Journal of Medical Genetics said , `` This is the sort of book which gets geneticists a bad name '' , adding that some facts `` are simply wrong '' , while vital facts `` are simply missing '' . Comings replied , in a Letter to the Editor , that the review `` missed the  whole point of the book and presented to the readers of this journal a distorted view of the issues I attempted to raise '' .   Other Tourette syndrome ( TS ) researchers say of Comings ' Tourette 's research that his `` assertions fall outside of the mainstream of the very extensive TS literature that has developed over the past 2 decades '' .

neg: Human pathogen A human pathogen is a pathogen ( microbe or microorganism such as a virus , bacterium , prion , or fungus ) that causes disease in humans .   The human physiological defense against common pathogens ( such as Pneumocystis ) is mainly the responsibility of the immune system with help by some of the body 's normal flora and fauna . However , if the immune system or `` good '' microbiota are damaged in any way ( such as by chemotherapy , human immunodeficiency virus ( HIV ) , or antibiotics being taken to kill other pathogens ) , pathogenic bacteria that were being held at bay can proliferate and cause harm to the host . Such cases are called opportunistic infections .   Some pathogens ( such as the bacterium Yersinia pestis , which may have caused the Black Plague , the Variola virus , and the malaria protozoa ) have been responsible for massive numbers of casualties and have had numerous effects on afflicted groups . Of particular note in modern times is HIV , which is known to have infected several million humans globally , along with the influenza virus . Today , while many medical advances have been made to safeguard against infection by pathogens , through the use of vaccination , antibiotics , and fungicide , pathogens continue to threaten human life . Social advances such as food safety , hygiene , and water treatment have reduced the threat from some pathogens .

neg: History of Tourette syndrome Tourette syndrome is an inherited neurological disorder with onset in childhood , characterized by the presence of multiple physical ( motor ) tics and at least one vocal ( phonic ) tic .   The eponym was bestowed by Jean-Martin Charcot ( 1825 -- 93 ) on behalf of his resident , Georges Albert Édouard Brutus Gilles de la Tourette ( 1859 -- 1904 ) , a French physician and neurologist , who published an account of nine patients with Tourette 's in 1885 . The possibility that movement disorders , including Tourette syndrome , might have an organic origin was raised when an encephalitis epidemic from 1918 -- 1926 led to a subsequent epidemic of tic disorders . Research in 1972 advanced the argument that Tourette 's is a neurological , rather than psychological , disorder ; since the 1990s , a more neutral view of Tourette 's has emerged , in which biological vulnerability and adverse environmental events are seen to interact .   Findings since 1999 have advanced TS science in the areas of genetics , neuroimaging , neurophysiology , and neuropathology . Questions remain regarding how best to classify Tourette syndrome , and how closely Tourette 's is related to other movement disorders or psychiatric disorders . Good epidemiologic data is still lacking , and available treatments are not risk free and not always well tolerated .

neg: Natural selection Natural selection is the differential survival and reproduction of individuals due to differences in phenotype . It is a key mechanism of evolution , the change in heritable traits of a population over time . Charles Darwin popularised the term `` natural selection '' , and compared it with artificial selection .   Variation exists within all populations of organisms . This occurs partly because random mutations arise in the genome of an individual organism , and offspring can inherit such mutations . Throughout the lives of the individuals , their genomes interact with their environments to cause variations in traits . The environment of a genome includes the molecular biology in the cell , other cells , other individuals , populations , species , as well as the abiotic environment . Individuals with certain variants of the trait may survive and reproduce more than individuals with other , less successful , variants ; therefore , the population evolves . Factors that affect reproductive success are also important , including sexual selection ( now often included in natural selection ) and fecundity selection .   Natural selection acts on the phenotype , or the observable characteristics of an organism , but the genetic ( heritable ) basis of any phenotype that gives a reproductive advantage may become more common in a population . Over time , this process can result in populations that specialise for particular ecological niches ( microevolution ) and may eventually result in speciation ( the emergence of new species , macroevolution ) . In other words , natural selection is a key process in the evolution of a population . Natural selection can be contrasted with artificial selection , in which humans intentionally choose specific traits , whereas in natural selection there is no intentional choice .   Natural selection is one of the cornerstones of modern biology . The concept , published by Darwin and Alfred Russel Wallace in a joint presentation of papers in 1858 , was elaborated in Darwin 's influential 1859 book On the Origin of Species by Means of Natural Selection , or the Preservation of Favoured Races in the Struggle for Life , which described natural selection as analogous to artificial selection , a process by which animals and plants with traits considered desirable by human breeders are systematically favoured for reproduction . The concept of natural selection originally developed in the absence of a valid theory of heredity ; at the time of Darwin 's writing , science had yet to develop modern theories of genetics . The union of traditional Darwinian evolution with subsequent discoveries in classical genetics formed the modern synthesis of the mid-20th century . The addition of molecular genetics has led to evolutionary developmental biology , which explains evolution at the molecular level . While genotypes can slowly change by random genetic drift , natural selection remains the primary explanation for adaptive evolution .

neg: Neurasthenia Neurasthenia is a term that was first used at least as early as 1829 to label a mechanical weakness of the actual nerves , rather than the more metaphorical `` nerves '' referred to by George Miller Beard later .   As a psychopathological term , neurasthenia was used by Beard in 1869 to denote a condition with symptoms of fatigue , anxiety , headache , heart palpitations , high blood pressure , neuralgia and depressed mood .   Neurasthenia is currently a diagnosis in the World Health Organization 's International Classification of Diseases ( and the Chinese Society of Psychiatry 's Chinese Classification of Mental Disorders ) . However , it is no longer included as a diagnosis in the American Psychiatric Association 's Diagnostic and Statistical Manual of Mental Disorders .   Americans were said to be particularly prone to neurasthenia , which resulted in the nickname `` Americanitis '' ( popularized by William James ) . Another , rarely used , term for neurasthenia is nervosism .

neg: Huntington's disease in popular culture Huntington 's disease has been shown in numerous formats , more so as awareness of the condition has increased . Here is a list of references to it in popular culture ;

neg: Distal hereditary motor neuropathy type V Distal hereditary motor neuropathy type V ( dHMN V ) is a particular type of neuropathic disorder . In general , distal hereditary motor neuropathies affect the axons of distal motor neurons and are characterized by progressive weakness and atrophy of muscles of the extremities . It is common for them to be called `` spinal forms of Charcot-Marie-Tooth disease ( CMT ) '' , because the diseases are closely related in symptoms and genetic cause . The diagnostic difference in these diseases is the presence of sensory loss in the extremities . There are seven classifications of dHMNs , each defined by patterns of inheritance , age of onset , severity , and muscle groups involved . Type V ( sometimes notated as Type 5 ) is a disorder characterized by autosomal dominance , weakness of the upper limbs that is progressive and symmetrical , and atrophy of the small muscles of the hands .

neg: Borna disease Borna disease is an infectious neurological syndrome of warm-blooded animals , caused by Borna disease viruses 1 and 2 ( BoDV-1 / 2 ) , both of which are members of the species Mammalian 1 bornavirus . BoDV-1 an 2 cause abnormal behaviour and fatality . Borna disease viruses 1 and 2 are neurotropic viruses and members of the Bornaviridae family within the Mononegavirales order .   Although Borna disease viruses 1 and 2 are mainly seen as the causative agent of Borna disease in horses and other animals , they are also controversially discussed as human infectious agents and therefore as potential zoonotic agents . The role of BoDV-1 and -2 in human illness is controversial and it is yet to be established whether BoDV-1 or -2 cause any overt disease in humans . However , correlative evidence exists linking BoDV-1 / 2 infection with neuropsychiatric disorders such as bipolar disorder .

neg: Biologist A biologist , is a scientist who has specialized knowledge in the field of biology , the scientific study of life . Biologists involved in fundamental research attempt to explore and further explain the underlying mechanisms that govern the functioning of living matter . Biologists involved in applied research attempt to develop or improve more specific processes and understanding , in fields such as medicine , industry and agriculture .   While `` biologist '' can apply to any scientist studying biology , most biologists research and specialise in specific fields . In this way , biologists investigate large-scale organism interactions ( ecology ) , whole multicellular organisms , organs , tissues , cells , and small-scale cellular and molecular processes . Other biologists study less direct aspects of life , such as phylogeny and evolution .   Biologists conduct research based on the scientific method , to test the validity of a theory , with hypothesis formation , experimentation and documentation of methods and data .   There are many types of biologists . Some work on microorganisms , while others study multicellular organisms . There is much overlap between different fields of biology such as botany , zoology , microbiology , genetics and evolutionary biology , and it is often difficult to classify a biologist as only one of them . Many jobs in biology as a field require an academic degree . A doctorate or its equivalent is generally required to direct independent research , and involves a specialization in a specific area of biology . Many biological scientists work in research and development . Some conduct fundamental research to advance our knowledge of living organisms , including bacteria and other pathogens . This research enhances understanding and adds to the scientific database of literature . Furthermore , it often aids the development of solutions to problems in areas such as human health and the natural environment . These biological scientists mostly work in government , university , and private industry laboratories . Many expand on specialized research that they started in post-graduate qualifications , such as a doctorate .

neg: Developmental cognitive neuroscience Developmental cognitive neuroscience is an interdisciplinary scientific field devoted to understanding psychological processes and their neurological bases in the developing organism . It examines how the mind changes as children grow up , interrelations between that and how the brain is changing , and environmental and biological influences on the developing mind and brain .   Developmental cognitive neuroscience is at the boundaries of neuroscience ( behavioral , systems , & cognitive neuroscience ) , psychology ( developmental , cognitive , & biobehavioral / physiological psychology ) , developmental science ( which includes sociology , anthropology , & biology in addition to psychology & neuroscience ) , cognitive science ( which includes computer science , philosophy , dynamical systems , & linguistics in addition to psychology ) , and even includes socio-emotional development and developmental aspects of social neuroscience and affective neuroscience .   The scientific interface between cognitive neuroscience and human development has evoked considerable interest in recent years , as technological advances make it possible to map in detail the changes in brain structure that take place during development . Developmental cognitive neuroscience overlaps somewhat with fields such as developmental psychology , developmental neuropsychology , developmental psychopathology , and developmental neuroscience , but is distinct from each of them as well . Developmental cognitive neuroscience is concerned with the brain bases of the phenomena that developmental psychologists study . Developmental neuropsychology and developmental psychopathology are both devoted primarily to studying patients , whereas developmental cognitive neuroscience is concerned with studying both typical and atypical development . Developmental neuroscience is devoted entirely to the study of developmental processes in the brain , and primarily during the prenatal period . Developmental cognitive neuroscience , on the other hand , is concerned with interrelations between psychological and biological development . Developmental cognitive neuroscientists study brain development and cognitive , social , and emotional development from the prenatal period through adulthood .   More recently , developmental cognitive neuroscience is interested in the role of genes in development and cognition . Thus , developmental cognitive neuroscience may shed light on nature versus nurture debates as well as constructivism and neuroconstructivism theories . Developmental cognitive neuroscience research provides data that alternately blends together , clarifies , challenges , and causes revisions in developmental , cognitive , and neuroscientific theories .

neg: Albinism Albinism in humans is a congenital disorder characterized by the complete or partial absence of pigment in the skin , hair and eyes . Albinism is associated with a number of vision defects , such as photophobia , nystagmus , and amblyopia . Lack of skin pigmentation makes for more susceptibility to sunburn and skin cancers . In rare cases such as Chédiak -- Higashi syndrome , albinism may be associated with deficiencies in the transportation of melanin granules . This also affects essential granules present in immune cells leading to increased susceptibility to infection .   Albinism results from inheritance of recessive gene alleles and is known to affect all vertebrates , including humans . It is due to absence or defect of tyrosinase , a copper-containing enzyme involved in the production of melanin . It is the opposite of melanism . Unlike humans , other animals have multiple pigments and for these , albinism is considered to be a hereditary condition characterised by the absence of melanin in particular , in the eyes , skin , hair , scales , feathers or cuticle . While an organism with complete absence of melanin is called an albino an organism with only a diminished amount of melanin is described as leucistic or albinoid . The term is from the Latin albus , `` white '' .

neg: Genome instability Genome instability ( also `` genetic instability '' or `` genomic instability '' ) refers to a high frequency of mutations within the genome of a cellular lineage . These mutations can include changes in nucleic acid sequences , chromosomal rearrangements or aneuploidy . Genome instability does occur in bacteria . In multicellular organisms genome instability is central to carcinogenesis , and in humans it is also a factor in some neurodegenerative diseases such as amyotrophic lateral sclerosis or the neuromuscular disease myotonic dystrophy .   The sources of genome instability have only recently begun to be elucidated . A high frequency of externally caused DNA damage can be one source of genome instability since DNA damages can cause inaccurate translesion synthesis past the damages or errors in repair , leading to mutation . Another source of genome instability may be epigenetic or mutational reductions in expression of DNA repair genes . Because endogenous ( metabolically-caused ) DNA damage is very frequent , occurring on average more than 60,000 times a day in the genomes of human cells , any reduced DNA repair is likely an important source of genome instability .

neg: Familial encephalopathy with neuroserpin inclusion bodies Familial encephalopathy with neuroserpin inclusion bodies ( FENIB ) is a progressive disorder of the nervous system that is characterized by a loss of intellectual functioning ( dementia ) and seizures . At first , affected individuals may have difficulty sustaining attention and concentrating . Their judgment , insight , and memory become impaired as the condition progresses . Over time , they lose the ability to perform the activities of daily living , and most people with this condition eventually require comprehensive care .   The signs and symptoms of familial encephalopathy with neuroserpin inclusion bodies vary in their severity and age of onset . In severe cases , the condition causes seizures and episodes of sudden , involuntary muscle jerking or twitching ( myoclonus ) in addition to dementia . These signs can appear as early as a person 's teens . Less severe cases are characterized by a progressive decline in intellectual functioning beginning in a person 's forties or fifties .   Mutations in the SERPINI1 gene cause familial encephalopathy with neuroserpin inclusion bodies . The SERPINI1 gene provides instructions for making a protein called neuroserpin . This protein is found in nerve cells , where it plays a role in the development and function of the nervous system . Neuroserpin helps control the growth of nerve cells and their connections with one another , which suggests that this protein may be important for learning and memory . Mutations in the gene result in the production of an abnormally shaped , unstable version of neuroserpin . Abnormal neuroserpin proteins can attach to one another and form clumps ( called neuroserpin inclusion bodies or Collins bodies ) within nerve cells . These clumps disrupt the cells ' normal functioning and ultimately lead to cell death . Progressive dementia results from this gradual loss of nerve cells in certain parts of the brain . Researchers believe that a buildup of related , potentially toxic substances in nerve cells may also contribute to the signs and symptoms of this condition .   This condition is inherited in an autosomal dominant pattern , which means one copy of the altered gene in each cell is sufficient to cause the disorder . In many cases , an affected person has a parent with the condition .

neg: Hypochondriasis Hypochondriasis , also known as hypochondria , health anxiety or illness anxiety disorder , refers to worry about having a serious illness . This debilitating condition is the result of an inaccurate perception of the condition of body or mind despite the absence of an actual medical condition . An individual suffering from hypochondriasis is known as a hypochondriac . Hypochondriacs become unduly alarmed about any physical or psychological symptoms they detect , no matter how minor the symptom may be , and are convinced that they have , or are about to be diagnosed with , a serious illness .   Often , hypochondria persists even after a physician has evaluated a person and reassured them that their concerns about symptoms do not have an underlying medical basis or , if there is a medical illness , their concerns are far in excess of what is appropriate for the level of disease . Many hypochondriacs focus on a particular symptom as the catalyst of their worrying , such as gastro-intestinal problems , palpitations , or muscle fatigue . To qualify for the diagnosis of hypochondria the symptoms must have been experienced for at least 6 months .   The DSM-IV-TR defines this disorder , `` Hypochondriasis '' , as a somatoform disorder and one study has shown it to affect about 3 % of the visitors to primary care settings . The newly published DSM-5 replaces the diagnosis of hypochondriasis with the diagnoses of `` somatic symptom disorder '' and `` illness anxiety disorder '' .   Hypochondria is often characterized by fears that minor bodily or mental symptoms may indicate a serious illness , constant self-examination and self-diagnosis , and a preoccupation with one 's body . Many individuals with hypochondriasis express doubt and disbelief in the doctors ' diagnosis , and report that doctors ' reassurance about an absence of a serious medical condition is unconvincing , or short-lasting . Additionally , many hypochondriacs experience elevated blood pressure , stress , and anxiety in the presence of doctors or while occupying a medical facility , a condition known as `` white coat syndrome '' . Many hypochondriacs require constant reassurance , either from doctors , family , or friends , and the disorder can become a disabling torment for the individual with hypochondriasis , as well as his or her family and friends . Some hypochondriacal individuals completely avoid any reminder of illness , whereas others frequently visit medical facilities , sometimes obsessively . Some sufferers may never speak about it .

neg: Psychiatric epidemiology Psychiatric epidemiology is a field which studies the causes ( etiology ) of mental disorders in society , as well as conceptualization and prevalence of mental illness . It is a subfield of the more general epidemiology . It has roots in sociological studies of the early 20th century . However , while sociological exposures are still widely studied in psychiatric epidemiology , the field has since expanded to the study of a wide area of environmental risk factors , such as major life events , as well as genetic exposures . Increasingly neuroscientific techniques like MRI are used to explore the mechanisms behind how exposures to risk factors may impact psychological problems and explore the neuroanatomical substrate underlying psychiatric disorders .

neg: Microinfarct A microinfarct is a microscopic stroke less than 1 millimeter in size . Microinfarcts can be found in 25-50 % of all elderly deceased persons . Microinfarcts may be the second most important cause of dementia , after Alzheimer 's disease .   Microinfarcts are microscopic lesions , of cellular death or tissue necrosis , which are a result of pathologies involving small vessels . Such pathologies are arteriosclerosis or cerebral amyloid angiopathy . Microinfarcts take longer to affect neuronal death progress , at up to 28 days , rather than hours .   Microinfarcts can range in size from 0.2 to 2.9 mm . This ailment usually goes undetected in clinical-radiological , like structural MRI , studies and is known as a `` silent pathology '' . Depending on the size , large acute microinfarcts may be detected via a special imaging known as diffusion weighted imaging .   Microinfarcts tend to occur at a high frequency , without specific regionalized locations . They are common in aging brains . This high frequency is thought to directly disrupt cognitive networks that are imperative to brain operation . Even though microinfarcts are usually undetectable , there is a general assessment of the cognitive status measured on a scale called the Clinical Dementia Rating ( CDR ) . This scale measures different parts of the brain such as diffuse white matter , periventricular myelination and cortical microinfarcts . Assessments of cortical microinfarcts have had the highest rates with being associated with cognitive degeneration . This lower cognition specifically affects perceptual speed and memory ( semantic and episodic ) . People with high frequency of this ailment tend to have greater chances of developing dementia .   Although not many studies have been conducted and little is known between microinfarcts and other vascular or epidemiological risk factors , these brain lesions are thought to be masked by other pathologies . However , the common macroscopic infarct is not exhibited in 45 % of people tested for microinfarcts .

neg: List of questionable diseases This is a list of diseases and diagnoses that are considered questionable or rejected by many in the medical profession . Some are diagnosed using unvalidated or disputed diagnostic techniques such as applied kinesiology . Most purported symptoms are vague , generic , nonspecific , and generally categorised as `` symptoms of life '' .   Adrenal fatigue  Autistic enterocolitis  Chronic Lyme disease  Electromagnetic hypersensitivity  Fan death  Heavy legs  Leaky gut syndrome  Morgellons  Multiple chemical sensitivity  Non-coeliac gluten sensitivity  Oral galvanism  Wind turbine syndrome  Wilson 's temperature syndrome , also called Wilson 's thyroid syndrome . Not to be confused with Wilson 's disease .