query: Hypothyroidism can cause depression in men.

pos: Hypothyroidism Hypothyroidism , also called underactive thyroid or low thyroid , is a common disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone . It can cause a number of symptoms , such as poor ability to tolerate cold , a feeling of tiredness , constipation , depression , and weight gain . Occasionally there may be swelling of the front part of the neck due to goitre . Untreated hypothyroidism during pregnancy can lead to delays in growth and intellectual development in the baby , which is called cretinism .   Worldwide , too little iodine in the diet is the most common cause of hypothyroidism . In countries with enough iodine in the diet , the most common cause of hypothyroidism is the autoimmune condition Hashimoto 's thyroiditis . Less common causes include : previous treatment with radioactive iodine , injury to the hypothalamus or the anterior pituitary gland , certain medications , a lack of a functioning thyroid at birth , or previous thyroid surgery . The diagnosis of hypothyroidism , when suspected , can be confirmed with blood tests measuring thyroid-stimulating hormone ( TSH ) and thyroxine levels .   Prevention at the population level has been with the universal salt iodization . Hypothyroidism can be treated with levothyroxine . The dose is adjusted according to symptoms and normalization of the thyroxine and TSH levels . Thyroid medication is safe in pregnancy . While a certain amount of dietary iodine is important , excessive amounts can worsen certain types of hypothyroidism .   Worldwide about one billion people are estimated to be iodine deficient ; however , it is unknown how often this results in hypothyroidism . In the United States , hypothyroidism occurs in 0.3 -- 0.4 % of people . Subclinical hypothyroidism , a milder form of hypothyroidism characterized by normal thyroxine levels and an elevated TSH level , is thought to occur in 4.3 -- 8.5 % of people in the United States . Hypothyroidism is more common in women than men . People over the age of 60 are more commonly affected . Dogs are also known to develop hypothyroidism and in rare cases cats and horses can also have the disorder . The word `` hypothyroidism '' is from Greek hypo - meaning `` reduced '' , thyreos for `` shield '' , and eidos for `` form . ''

pos: Depression (mood) Depression is a state of low mood and aversion to activity that can affect a person 's thoughts , behavior , feelings , and sense of well-being .   People with a depressed mood may be notably sad , anxious , or empty ; they may also feel notably hopeless , helpless , dejected , or worthless . Other symptoms expressed may include senses of guilt , irritability , or anger . Further feelings expressed by these individuals may include feeling ashamed or an expressed restlesness . These individuals may notably lose interest in activities that they once considered pleasurable to family and friends or otherwise experience either a loss of appetite or overeating . Experiencing problems concentrating , remembering general facts or details , otherwise making decisions or experiencing relationship difficulties may also be notable factors in these individuals ' depression and may also lead to their attempting or actually committing suicide .   In addition to all the aforementioned factors , actions committed by siblings of these individuals may also contribute to the decision-making in individuals experiencing depression or attempting to take their own lives .   Expressed insomnia , excessive sleeping , fatigue , and vocalizing general aches , pains , and digestive problems and a reduced energy may also be present in individuals experiencing depression .   A depressed mood is a feature of some psychiatric syndromes such as major depressive disorder and dysthymia , but it may also be a normal temporary reaction to life events such as bereavement , a symptom of some bodily ailments or a side effect of some drugs and medical treatments . A DSM diagnosis distinguishes an episode ( or ` state ' ) of depression from the habitual ( or ` trait ' ) depressive symptoms someone can experience as part of their personality .

neg: Endophenotype Endophenotype is a genetic epidemiology term which is used to separate behavioral symptoms into more stable phenotypes with a clear genetic connection . The concept was coined by Bernard John and Kenneth R. Lewis in a 1966 paper attempting to explain the geographic distribution of grasshoppers . They claimed that the particular geographic distribution could not be explained by the obvious and external `` exophenotype '' of the grasshoppers , but instead must be explained by their microscopic and internal `` endophenotype . ''   The next major use of the term was in psychiatric genetics , to bridge the gap between high-level symptom presentation and low-level genetic variability , such as single nucleotide polymorphisms . It is therefore more applicable to more heritable disorders , such as bipolar disorder and schizophrenia . Since then , the concept has expanded to many other fields , such as the study of ADHD , addiction , Alzheimer 's disease obesity and cystic fibrosis . Some other terms which have a similar meaning but do not stress the genetic connection as highly are `` intermediate phenotype '' , `` biological marker '' , `` subclinical trait '' , `` vulnerability marker '' , and `` cognitive marker '' . The strength of an endophenotype is its ability to differentiate between potential diagnoses that present with similar symptoms .

neg: Hypochondriasis Hypochondriasis , also known as hypochondria , health anxiety or illness anxiety disorder , refers to worry about having a serious illness . This debilitating condition is the result of an inaccurate perception of the condition of body or mind despite the absence of an actual medical condition . An individual suffering from hypochondriasis is known as a hypochondriac . Hypochondriacs become unduly alarmed about any physical or psychological symptoms they detect , no matter how minor the symptom may be , and are convinced that they have , or are about to be diagnosed with , a serious illness .   Often , hypochondria persists even after a physician has evaluated a person and reassured them that their concerns about symptoms do not have an underlying medical basis or , if there is a medical illness , their concerns are far in excess of what is appropriate for the level of disease . Many hypochondriacs focus on a particular symptom as the catalyst of their worrying , such as gastro-intestinal problems , palpitations , or muscle fatigue . To qualify for the diagnosis of hypochondria the symptoms must have been experienced for at least 6 months .   The DSM-IV-TR defines this disorder , `` Hypochondriasis '' , as a somatoform disorder and one study has shown it to affect about 3 % of the visitors to primary care settings . The newly published DSM-5 replaces the diagnosis of hypochondriasis with the diagnoses of `` somatic symptom disorder '' and `` illness anxiety disorder '' .   Hypochondria is often characterized by fears that minor bodily or mental symptoms may indicate a serious illness , constant self-examination and self-diagnosis , and a preoccupation with one 's body . Many individuals with hypochondriasis express doubt and disbelief in the doctors ' diagnosis , and report that doctors ' reassurance about an absence of a serious medical condition is unconvincing , or short-lasting . Additionally , many hypochondriacs experience elevated blood pressure , stress , and anxiety in the presence of doctors or while occupying a medical facility , a condition known as `` white coat syndrome '' . Many hypochondriacs require constant reassurance , either from doctors , family , or friends , and the disorder can become a disabling torment for the individual with hypochondriasis , as well as his or her family and friends . Some hypochondriacal individuals completely avoid any reminder of illness , whereas others frequently visit medical facilities , sometimes obsessively . Some sufferers may never speak about it .

neg: Parkinson's disease Parkinson 's disease ( PD ) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system . The symptoms generally come on slowly over time . Early in the disease , the most obvious are shaking , rigidity , slowness of movement , and difficulty with walking . Thinking and behavioral problems may also occur . Dementia becomes common in the advanced stages of the disease . Depression and anxiety are also common occurring in more than a third of people with PD . Other symptoms include sensory , sleep , and emotional problems . The main motor symptoms are collectively called `` parkinsonism '' , or a `` parkinsonian syndrome '' .   The cause of Parkinson 's disease is generally unknown , but believed to involve both genetic and environmental factors . Those with a family member affected are more likely to get the disease themselves . There is also an increased risk in people exposed to certain pesticides and among those who have had prior head injuries while there is a reduced risk in tobacco smokers and those who drink coffee or tea . The motor symptoms of the disease result from the death of cells in the substantia nigra , a region of the midbrain . This results in not enough dopamine in these areas . The reason for this cell death is poorly understood , but involves the build-up of proteins into Lewy bodies in the neurons . Diagnosis of typical cases is mainly based on symptoms , with tests such as neuroimaging being used to rule out other diseases .   There is no cure for Parkinson 's disease . Initial treatment is typically with the antiparkinson medication L-DOPA ( levodopa ) , with dopamine agonists being used once levodopa becomes less effective . As the disease progresses and neurons continue to be lost , these medications become less effective while at the same time they produce a complication marked by involuntary writhing movements . Diet and some forms of rehabilitation have shown some effectiveness at improving symptoms . Surgery to place microelectrodes for deep brain stimulation has been used to reduce motor symptoms in severe cases where drugs are ineffective . Evidence for treatments for the non-movement-related symptoms of PD , such as sleep disturbances and emotional problems , is less strong .   In 2015 , PD affected 6.2 million people and resulted in about 117,400 deaths globally . Parkinson 's disease typically occurs in people over the age of 60 , of which about one percent are affected . Males are more often affected than females . When it is seen in people before the age of 50 , it is called young-onset PD . The average life expectancy following diagnosis is between 7 and 14 years . The disease is named after the English doctor James Parkinson , who published the first detailed description in An Essay on the Shaking Palsy , in 1817 . Public awareness campaigns include World Parkinson 's Day ( on the birthday of James Parkinson , 11 April ) and the use of a red tulip as the symbol of the disease . People with parkinsonism who have increased the public 's awareness of the condition include actor Michael J. Fox , Olympic cyclist Davis Phinney , and late professional boxer Muhammad Ali .

neg: Neurasthenia Neurasthenia is a term that was first used at least as early as 1829 to label a mechanical weakness of the actual nerves , rather than the more metaphorical `` nerves '' referred to by George Miller Beard later .   As a psychopathological term , neurasthenia was used by Beard in 1869 to denote a condition with symptoms of fatigue , anxiety , headache , heart palpitations , high blood pressure , neuralgia and depressed mood .   Neurasthenia is currently a diagnosis in the World Health Organization 's International Classification of Diseases ( and the Chinese Society of Psychiatry 's Chinese Classification of Mental Disorders ) . However , it is no longer included as a diagnosis in the American Psychiatric Association 's Diagnostic and Statistical Manual of Mental Disorders .   Americans were said to be particularly prone to neurasthenia , which resulted in the nickname `` Americanitis '' ( popularized by William James ) . Another , rarely used , term for neurasthenia is nervosism .

neg: Substance dependence Substance dependence also known as drug dependence is an adaptive state that develops from repeated drug administration , and which results in withdrawal upon cessation of drug use . A drug addiction , a distinct concept from substance dependence , is defined as compulsive , out-of-control drug use , despite negative consequences . An addictive drug is a drug which is both rewarding and reinforcing . ΔFosB , a gene transcription factor , is now known to be a critical component and common factor in the development of virtually all forms of behavioral addiction and drug addictions , but not dependence .   Within the framework of the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders ( DSM-IV ) , substance dependence is redefined as a drug addiction , and can be diagnosed without the occurrence of a withdrawal syndrome . It is now described accordingly : `` When an individual persists in use of alcohol or other drugs despite problems related to use of the substance , substance dependence may be diagnosed . Compulsive and repetitive use may result in tolerance to the effect of the drug and withdrawal symptoms when use is reduced or stopped . This , along with Substance Abuse are considered Substance Use Disorders . ''

neg: Social stigma of obesity The social stigma of obesity has created negative psychosocial impacts and has caused disadvantages for overweight and obese people . The social stigma can span one 's entire life , as long as the excess weight is present , starting from a young age and lasting into adulthood . Several studies from across the world ( e.g. , United States , University of Marburg , University of Leipzig ) indicate overweight and obese individuals experience higher levels of stigma relative to their thinner counterparts . In addition , they marry less often , experience fewer educational and opportunities , and on average earn a lesser income than normal weight individuals . Although public support regarding disability services , civil rights and anti-workplace discrimination laws for obese individuals have gained support across the years , overweight and obese individuals still experience discrimination , which may have implications to physiological and psychological health . These issues are compounded with the significant negative physiological effects associated with obesity .   Obesity stigma stands to be one of the few acceptable forms of discrimination in Western society . Media , in general , under represents overweight individuals and when these roles are present , they are often minor , stereotyped roles . They are more commonly seen eating , and are less likely to be involved in a romantic relationship compared to the average weight television character .

neg: Shame Shame is a painful , social emotion that can be seen as resulting '' ... from comparison of the self 's action with the self 's standards ... '' . but which may equally stem from comparison of the self 's state of being with the ideal social context 's standard . Thus , shame may stem from volitional action or simply self-regard ; no action by the shamed being is required : simply existing is enough . Both the comparison and standards are enabled by socialization . Though usually considered an emotion , shame may also variously be considered an affect , cognition , state , or condition .   The roots of the word shame are thought to derive from an older word meaning `` to cover '' ; as such , covering oneself , literally or figuratively , is a natural expression of shame . Nineteenth-century scientist Charles Darwin , in his book The Expression of the Emotions in Man and Animals , described shame affect as consisting of blushing , confusion of mind , downward cast eyes , slack posture , and lowered head , and he noted observations of shame affect in human populations worldwide . He also noted the sense of warmth or heat ( associated with the vasodilation of the face and skin ) occurring in intense shame . Shame can also result in crying .   A `` sense of shame '' is the feeling known as guilt but `` consciousness '' or awareness of `` shame as a state '' or condition defines core/toxic shame ( Lewis , 1971 ; Tangney , 1998 ) . The key emotion in all forms of shame is contempt ( Miller , 1984 ; Tomkins , 1967 ) . Two distinct domains that shame is expressed are the consciousness of self as bad and the other is self as inadequate . People employ negative coping responses to counter deep rooted , associated sense of `` shameworthiness '' . The shame cognition may occur as a result of the experience of shame affect or , more generally , in any situation of embarrassment , dishonor , disgrace , inadequacy , humiliation , or chagrin .   A `` state of shame '' is assigned internally from being a victim of environment where the sense of self is stigmatized like being denigrated by caregivers , overtly rejected by parents in favor of siblings needs , etc. and the same is assigned externally , by others , regardless of one 's own experience or awareness . `` To shame '' generally means to actively assign or communicate a state of shame to another . Behaviors designed to `` uncover '' or `` expose '' others are sometimes used for this purpose , as are utterances like `` Shame ! '' or `` Shame on you ! '' Finally , to `` have shame '' means to maintain a sense of restraint against offending others ( as with modesty , humility , and deference ) while to `` have no shame '' is to behave without such restraint ( as with excessive pride or hubris ) .

neg: Sex differences in cognition Sex differences in cognition , or mental abilities , are widely established in the current scientific literature . Biological and genetic differences in combination with environment and culture have resulted in the cognitive differences among men and women . Among biological factors , hormones such as testosterone and estrogen may play some role mediating these differences . Among differences of diverse mental and cognitive abilities , the largest or most well known are those relating to spatial abilities , social cognition and verbal skills and abilities .

neg: The Gene Bomb The Gene Bomb is a 1996 book by David E. Comings , self-published by Hope Press , that puts forth the theory that higher education and advanced technology may unintentionally favor the selection of genes that increase the likelihood of ADHD , autism , drug addiction , learning disorders , and behavior problems . Comings claims that the prevalence of these disorders is rising and I.Q. is decreasing ; others argue that other factors may be responsible , including increased detection of these disorders . He claims that society is inadvertently creating delays for the highly educated that reduce their reproductivity and causes them to have children later in life , thus raising the odds of certain disorders like autism . On the other hand , he claims that those having learning disorders tend to drop out of school earlier and have more children , thus passing on learning disorders at a higher rate . Environmental and societal factors are usually accepted as the cause , but Comings argues the opposite .   According to a review of the book in the British Developmental Medicine and Child Neurology journal , `` The arguments are developed in this book with an alarming lack of scientific accuracy and satisfactory supporting evidence . '' The review concludes that the book `` is an apocalyptic , irrational , and emotional treatise which opens up scientifically unsound issues that have already been formally buried '' . A book review in the Journal of Medical Genetics said , `` This is the sort of book which gets geneticists a bad name '' , adding that some facts `` are simply wrong '' , while vital facts `` are simply missing '' . Comings replied , in a Letter to the Editor , that the review `` missed the  whole point of the book and presented to the readers of this journal a distorted view of the issues I attempted to raise '' .   Other Tourette syndrome ( TS ) researchers say of Comings ' Tourette 's research that his `` assertions fall outside of the mainstream of the very extensive TS literature that has developed over the past 2 decades '' .

neg: Long-term effects of alcohol consumption The long-term effects of alcohol ( ethanol ) consumption range from cardioprotective health benefits for low to moderate alcohol consumption in industrialized societies with higher rates of cardiovascular disease to severe detrimental effects in cases of chronic alcohol abuse . Health effects associated with alcohol intake in large amounts include an increased risk of alcoholism , malnutrition , chronic pancreatitis , alcoholic liver disease , and cancer . In addition , damage to the central nervous system and peripheral nervous system can occur from chronic alcohol abuse . The long-term use of alcohol is capable of damaging nearly every organ and system in the body . The developing adolescent brain is particularly vulnerable to the toxic effects of alcohol . In addition , the developing fetal brain is also vulnerable , and fetal alcohol spectrum disorders ( FASDs ) may result if pregnant mothers consume alcohol .   The inverse relation in Western cultures between alcohol consumption and cardiovascular disease has been known for over 100 years . Many physicians do not promote alcohol consumption , however , given the many health concerns associated with it , some suggest that alcohol should be regarded as a recreational drug , and promote exercise and good nutrition to combat cardiovascular disease . Others have argued that the benefits of moderate alcohol consumption may be outweighed by other increased risks , including those of injuries , violence , fetal damage , liver disease , and certain forms of cancer .   Withdrawal effects and dependence are also almost identical . Alcohol at moderate levels has some positive and negative effects on health . The negative effects include increased risk of liver diseases , oropharyngeal cancer , esophageal cancer and pancreatitis . Conversely moderate intake of alcohol may have some beneficial effects on gastritis and cholelithiasis . Of the total number of deaths and diseases caused by alcohol , most happen to the majority of the population who are moderate drinkers , rather than the heavy drinker minority . Chronic alcohol misuse and abuse has serious effects on physical and mental health . Chronic excess alcohol intake , or alcohol dependence , can lead to a wide range of neuropsychiatric or neurological impairment , cardiovascular disease , liver disease , and malignant neoplasms . The psychiatric disorders which are associated with alcoholism include major depression , dysthymia , mania , hypomania , panic disorder , phobias , generalized anxiety disorder , personality disorders , schizophrenia , suicide , neurologic deficits ( e.g. impairments of working memory , emotions , executive functions , visuospatial abilities and gait and balance ) and brain damage . Alcohol dependence is associated with hypertension , coronary heart disease , and ischemic stroke , cancer of the respiratory system , and also cancers of the digestive system , liver , breast and ovaries . Heavy drinking is associated with liver disease , such as cirrhosis . Excessive alcohol consumption can have a negative impact on aging .   Recent studies have focused on understanding the mechanisms by which moderate alcohol consumption confers cardiovascular benefit .

neg: Hormone replacement therapy Hormone replacement therapy ( HRT ) is any form of hormone therapy wherein the patient , in the course of medical treatment , receives hormones , either to supplement a lack of naturally occurring hormones or to substitute other hormones for naturally occurring hormones . Common forms of hormone replacement therapy include :   Hormone replacement therapy for menopause is based on the idea that the treatment may prevent discomfort caused by diminished circulating estrogen and progesterone hormones , or in the case of the surgically or prematurely menopausal , that it may prolong life and may reduce incidence of dementia . It involves the use of one or more of a group of medications designed to artificially boost hormone levels . The main types of hormones involved are estrogens , progesterone , or progestins , and sometimes , testosterone . It is often referred to as `` treatment '' rather than therapy .  Hormone replacement therapy for transgender people introduces hormones associated with the gender that the patient identifies with ( notably testosterone for trans men and estrogen for trans women ) . Some intersex people may also receive HRT . Cross-sex hormone treatment for transgender individuals is divided into two main types : hormone replacement therapy ( female-to-male ) and hormone replacement therapy ( male-to-female ) .  Androgen replacement therapy ( andropausal and ergogenic use ) is a hormone treatment often prescribed to counter the effects of male hypogonadism . It is also prescribed to lessen the effects or delay the onset of normal male aging . Additionally , androgen replacement therapy is used for men who have lost their testicular function to disease , cancer , or other causes .

neg: Hypnodermatology Hypnodermatology is an informal label for the use of hypnosis in treating the skin conditions that fall between conventional medical dermatology and the mental health disciplines .   The use of hypnosis to provide relief for some skin conditions is based on observations that the severity of the disease may correlate with emotional issues . In addition , hypnotherapy has been used to suggest improvement on dermatological symptoms , such as chronic psoriasis , eczema , ichthyosis , warts and alopecia areata .   Philip D. Shenefelt , a research dermatologist at the University of South Florida School of Medicine , has identified two dozen dermatologic conditions that have shown response to hypnosis in the literature , with varying degrees of evidence . These include successful results in controlled trials on verruca vulgaris , psoriasis , and atopic dermatitis . A 2005 review in the Mayo Clinic Proceedings stated that , `` A review of the use of hypnosis in dermatology supports its value for many skin conditions not believed to be under conscious control '' . The most comprehensively studied skin conditions in relation to hypnotherapy are psoriasis and warts . Hypnosis may have positive effects on dermatological conditions in both adults and children .   Hypnotherapy may contribute towards reducing itching and discomfort brought on by the presence of warts and improves and possibly decreasing lesions .

neg: 5-HT2C receptor agonist Serotonin 5-HT2 receptors are stimulated by monoamine neurotransmitters including serotonin , dopamine and norepinephrine . 5-HT2 receptor stimulation causes a buildup of intracellular inositol triphosphate and thereby an increase of cytosolic Ca2 + . 5-HT2C receptor agonists are attractive drug targets that have potential use in the treatment of a number of conditions including obesity , psychiatric disorders , sexual dysfunction and urinary incontinence .   The 5-HT2C receptors are one of three subtypes that belong to the serotonin 5-HT2 receptor subfamily along with 5-HT2A and 5-HT2B receptors . The development of 5-HT2C agonists has been a major obstacle , because of severe side effects due to a lack of selectivity over 5-HT2A and 5-HT2B receptors . Activation of 5-HT2A receptors can induce hallucinations , and the activation of 5-HT2B receptors has been implicated in cardiac valvular insufficiency and possibly in pulmonary hypertension .

neg: Parathyroid gland Parathyroid glands are small endocrine glands in the neck of humans and other tetrapods that produce parathyroid hormone . Humans usually have four parathyroid glands , variably located on the back of the thyroid gland -- considerable variation exists . Parathyroid hormone and calcitonin ( one of the hormones made by the thyroid gland ) have key roles in regulating the amount of calcium in the blood and within the bones .   Parathyroid glands share a similar blood supply , venous drainage , and lymphatic drainage to the thyroid glands . Parathyroid glands are derived from the epithelial lining of the third and fourth branchial pouches , with the superior glands arising from the fourth pouch , and the inferior glands arising from the higher third pouch . The relative position of the inferior and superior glands , which are named according to their final location , changes because of the migration of embryological tissues .   Hyperparathyroidism and hypoparathyroidism , characterized by alterations in the blood calcium levels and bone metabolism , are states of surplus or insufficient parathyroid function .

neg: Hypermetabolism Hypermetabolism is the physiological state of increased rate of metabolic activity and is characterized by an abnormal increase in the body 's basal metabolic rate . Hypermetabolism is accompanied by a variety of internal and external symptoms , most notably extreme weight loss , and can also be a symptom in itself . This state of increased metabolic activity can signal underlying issues , especially hyperthyroidism or fatal familial insomnia . The drastic impact of the hypermetabolic state on patient nutritional requirements is often understated or overlooked as well .   Hypermetabolism typically occurs after significant injury to the body . In hospitals and institutions , the most common causes are infections , sepsis , burns , multiple traumas , fever , long-bone fractures , hyperthyroidism , prolonged steroid therapy , surgery and bone marrow transplants . Hypermetabolism may occur in particular in the brain after traumatic brain injury . The cause and location of hypermetabolic symptoms within the body can be accurately detected by PET scan . Symptoms will usually subside once the underlying illness or injury is treated .

neg: Problem gambling Problem gambling ( or ludomania , but usually referred to as `` gambling addiction '' or `` compulsive gambling '' ) is an urge to gamble continuously despite harmful negative consequences or a desire to stop . Problem gambling is often defined by whether harm is experienced by the gambler or others , rather than by the gambler 's behaviour . Severe problem gambling may be diagnosed as clinical pathological gambling if the gambler meets certain criteria . Pathological gambling is a common disorder that is associated with both social and family costs .   The DSM-5 has re-classified the condition as an addictive disorder , with sufferers exhibiting many similarities to those who have substance addictions .  The term gambling addiction has long been used in the recovery movement . Pathological gambling was long considered by the American Psychiatric Association to be an impulse control disorder rather than an addiction . However , data suggest a closer relationship between pathological gambling and substance use disorders than exists between PG and obsessive-compulsive disorder , largely because the behaviors in problem gambling and most primary substance use disorders ( i.e. , those not resulting from a desire to `` self-medicate '' for another condition such as depression ) seek to activate the brain 's reward mechanisms while the behaviors characterizing obsessive-compulsive disorder are prompted by overactive and misplaced signals from the brain 's fear mechanisms .

neg: Diabetes mellitus Diabetes mellitus ( DM ) , commonly referred to as diabetes , is a group of metabolic diseases in which there are high blood sugar levels over a prolonged period . Symptoms of high blood sugar include frequent urination , increased thirst , and increased hunger . If left untreated , diabetes can cause many complications . Acute complications can include diabetic ketoacidosis , nonketotic hyperosmolar coma , or death . Serious long-term complications include heart disease , stroke , chronic kidney failure , foot ulcers , and damage to the eyes .   Diabetes is due to either the pancreas not producing enough insulin or the cells of the body not responding properly to the insulin produced . There are three main types of diabetes mellitus :  Type 1 DM results from the pancreas 's failure to produce enough insulin . This form was previously referred to as `` insulin-dependent diabetes mellitus '' ( IDDM ) or `` juvenile diabetes '' . The cause is unknown .  Type 2 DM begins with insulin resistance , a condition in which cells fail to respond to insulin properly . As the disease progresses a lack of insulin may also develop . This form was previously referred to as `` non insulin-dependent diabetes mellitus '' ( NIDDM ) or `` adult-onset diabetes '' . The most common cause is excessive body weight and not enough exercise .  Gestational diabetes is the third main form and occurs when pregnant women without a previous history of diabetes develop high blood sugar levels .   Prevention and treatment involve maintaining a healthy diet , regular physical exercise , a normal body weight , and avoiding use of tobacco . Control of blood pressure and maintaining proper foot care are important for people with the disease . Type 1 DM must be managed with insulin injections . Type 2 DM may be treated with medications with or without insulin . Insulin and some oral medications can cause low blood sugar . Weight loss surgery in those with obesity is sometimes an effective measure in those with type 2 DM . Gestational diabetes usually resolves after the birth of the baby .   , an estimated 415 million people had diabetes worldwide , with type 2 DM making up about 90 % of the cases . This represents 8.3 % of the adult population , with equal rates in both women and men . , trends suggested the rate would continue to rise . Diabetes at least doubles a person 's risk of early death . From 2012 to 2015 , approximately 1.5 to 5.0 million deaths each year resulted from diabetes . The global economic cost of diabetes in 2014 was estimated to be billion . In the United States , diabetes cost $ 245 billion in 2012 .

neg: Hypoplasia Hypoplasia ( from Ancient Greek ὑπo - hypo - , `` under '' + πλάσις plasis , `` formation '' ; adjective form hypoplastic ) is underdevelopment or incomplete development of a tissue or organ . Although the term is not always used precisely , it properly refers to an inadequate or below-normal number of cells . Hypoplasia is similar to aplasia , but less severe . It is technically not the opposite of hyperplasia ( too many cells ) . Hypoplasia is a congenital condition , while hyperplasia generally refers to excessive cell growth later in life . ( Atrophy , the wasting away of already existing cells , is technically the direct opposite of both hyperplasia and hypertrophy . )   Hypoplasia can be present in any tissue or organ . It is descriptive of many medical conditions , including underdevelopment of organs such as :   Breasts during puberty  Testes in Klinefelter 's syndrome  Ovaries in Fanconi anemia , gonadal dysgenesis , trisomy X  Thymus in DiGeorge syndrome  Labia majora in popliteal pterygium syndrome  Corpus callosum , connecting the two sides of the brain , in Agenesis of the corpus callosum  Cerebellum caused by mutation in the Reelin gene  Tooth caused by oral pathology , such as Turner 's hypoplasia  Chambers of the heart in hypoplastic left heart syndrome and hypoplastic right heart syndrome  Optic nerve in optic nerve hypoplasia  Sacrum in sacral agenesis  Facial muscle in asymmetric crying facies  Thumb from birth  Lungs , often as a result of oligohydramnios during gestation or the existence of congenital diaphragmatic hernia  Small bowel in coeliac disease  Fingers and ears in Harlequin type ichthyosis  Mandible in congenital hypothyroidism

neg: Adipomastia Adipomastia , or lipomastia , also known colloquially as fatty breasts , is a condition defined as an excess of skin and adipose tissue in the breasts without true breast glandular tissue . It is commonly present in men with obesity , and is particularly apparent in men who have undergone massive weight loss . A related/synonymous term is pseudogynecomastia . The condition is different and should be distinguished from gynecomastia ( `` women 's breasts '' ) , which involves true glandular breast development in a male . The two conditions can usually be distinguished easily by palpation to check for the presence of glandular tissue . Another difference between the conditions is that breast pain/tenderness does not occur in pseudogynecomastia . Sometimes , gynecomastia and pseudogynecomastia are present together ; this is related to the fact that fat tissue expresses aromatase , the enzyme responsible for the synthesis of estrogen , and estrogen is produced to a disproportionate extent in men with excessive amounts of fat , resulting in simultaneous glandular enlargement .

neg: Anabolic steroid Anabolic steroids , also known more properly as anabolic-androgenic steroids ( AAS ) , are steroidal androgens that include natural androgens like testosterone as well as synthetic substances that are structurally related and have similar effects to testosterone . They are anabolic and increase protein within cells , especially in skeletal muscles . AAS also have varying degrees of androgenic and virilizing effects , including induction of the development and maintenance of masculine secondary sexual characteristics such as the growth of the vocal cords and body hair . The word anabolic , referring to anabolism , comes from the Greek ἀναβολή anabole , `` that which is thrown up , mound . '' They are one of three types of sex hormone agonists , the others being estrogens like estradiol and progestogens like progesterone .   AAS were synthesized in the 1930s , and are now used therapeutically in medicine to stimulate muscle growth and appetite , induce male puberty and treat chronic wasting conditions , such as cancer and . The American College of Sports Medicine acknowledges that AAS , in the presence of adequate diet , can contribute to increases in body weight , often as lean mass increases and that the gains in muscular strength achieved through high-intensity exercise and proper diet can be additionally increased by the use of AAS in some individuals .   Health risks can be produced by long-term use or excessive doses of AAS . These effects include harmful changes in cholesterol levels ( increased low-density lipoprotein and decreased high-density lipoprotein ) , acne , high blood pressure , liver damage ( mainly with most oral AAS ) , and dangerous changes in the structure of the left ventricle of the heart . Conditions pertaining to hormonal imbalances such as gynecomastia and testicular size reduction may also be caused by AAS .   Ergogenic uses for AAS in sports , racing , and bodybuilding as performance-enhancing drugs are controversial because of their adverse effects and the potential to gain unfair advantage in competitive physical competitions . Their use is referred to as doping and banned by most major sporting bodies . For many years , AAS have been by far the most detected doping substances in IOC-accredited laboratories . In countries where AAS are controlled substances , there is often a black market in which smuggled , clandestinely manufactured or even counterfeit drugs are sold to users .


query: Terminator Salvation is a science fiction film.

pos: Terminator Salvation Terminator Salvation is a 2009 American post-apocalyptic science fiction war film directed by McG and starring Christian Bale and Sam Worthington . It is the fourth installment of the Terminator franchise . In a departure from the previous installments , which were set between 1984 and 2003 and used time travel as a key plot element , Salvation is a post-apocalyptic film set in the year 2018 , fifteen years after the events of Terminator 3 : Rise of the Machines . It focuses on the war between Skynet 's machine network and humanity ; the remnants of the world 's military have organized as the Resistance , fighting against Skynet 's killing machines . Bale portrays John Connor , Resistance fighter and central character to the franchise , while Worthington portrays cyborg Marcus Wright . Terminator Salvation also featured Anton Yelchin as a young Kyle Reese , a character first introduced in The Terminator , and the film depicts the origin of the T-800 ( Model 101 ) Terminator .   After a troubled pre-production , with The Halcyon Company acquiring the rights for the franchise from Andrew G. Vajna and Mario Kassar and several writers working on the screenplay , filming began in May 2008 in New Mexico and ran for 77 days . Terminator Salvation was released on May 21 , 2009 in the United States and Canada , followed by early June releases in the United Kingdom , Australia , New Zealand , and South Africa . Warner Bros. handled the North American release while Columbia Pictures handled the international release . The film grossed over $ 371 million worldwide and met with mixed reviews . A reboot of the film franchise occurred with the release of Terminator Genisys in 2015 .

neg: T2 3-D: Battle Across Time T2 3-D : Battle Across Time is an attraction at various Universal Studios parks around the world including those in Florida and Japan . The version of the show at Universal Studios Hollywood closed in 2012 .   The attraction is a mini-sequel to Terminator 2 : Judgment Day and reunites director James Cameron and the main cast from the movie , including Arnold Schwarzenegger as The Terminator , Linda Hamilton as Sarah Connor , Edward Furlong as John Connor , and Robert Patrick as the T-1000 . The show was presented in two parts ; a pre-show where a Cyberdyne Systems company hostess shows guests a brief video presentation about the company 's innovations , and the main show , where live performers interact with a 3-D film .

neg: A Taste of Armageddon `` A Taste of Armageddon '' ( season # 1 , episode # 23 , production # 23 ) is a first-season episode of the American science fiction television series , Star Trek . It was first broadcast on February 23 , 1967 , and repeated July 20 , 1967 . It was written by Robert Hamner and Gene L. Coon , and directed by Joseph Pevney .   In the episode , the crew of the USS Enterprise visits a planet whose people fight a computer-simulated war against a neighboring planet . Although the war is fought via computer simulation , the citizens of each planet have to submit to real executions inside `` disintegration booths '' to meet the casualty counts of the simulated attacks . The crew of the Enterprise is caught in the middle and are told to submit themselves voluntarily for execution after being `` killed '' in an `` enemy attack '' .

neg: Film series A film series ( also referred to as a film franchise ) is a collection of related films in succession that share the same fictional universe , or are marketed as a series .   Sometimes the work is conceived from the beginning as a multiple-film work , for example the Three Colours series , but in most cases the success of the original film inspires further films to be made . Individual sequels are relatively common , but are not always successful enough to spawn further installments .   The Marvel Cinematic Universe is the highest grossing film series in unadjusted US Dollar figures surpassing the Harry Potter , Star Wars , James Bond , and Peter Jackson 's The Lord of the Rings series . However , `` Star Wars '' has the highest when adjusted for inflation .

neg: The Salvation (film) Not to be confused with Salvation ! ( 1987 film )   The Salvation is a 2014 Danish western film directed by Kristian Levring and written by Anders Thomas Jensen and Levring . The film stars Mads Mikkelsen , Eva Green , Jeffrey Dean Morgan , Jonathan Pryce , Eric Cantona , Mikael Persbrandt , Douglas Henshall and Michael Raymond-James .

neg: System Shock System Shock is a 1994 first-person action role-playing video game developed by Looking Glass Technologies and published by Origin Systems . It was directed by Doug Church with Warren Spector serving as producer . The game is set aboard a space station in a cyberpunk vision of the year 2072 . Assuming the role of a nameless hacker , the player attempts to hinder the plans of a malevolent artificial intelligence called SHODAN .   System Shock 3D engine , physics simulation and complex gameplay have been cited as both innovative and influential . The developers sought to build on the emergent gameplay and immersive environments of their previous games , Ultima Underworld : The Stygian Abyss and Ultima Underworld II : Labyrinth of Worlds , by streamlining their mechanics into a more `` integrated whole '' .   Critics praised System Shock and hailed it as a major breakthrough in its genre . It was later placed on multiple hall of fame lists . The game was a moderate commercial success , with sales exceeding 170,000 copies , but Looking Glass ultimately lost money on the project . A sequel , System Shock 2 , was released by Looking Glass Studios and offshoot developer Irrational Games in 1999 . The 2000 game Deus Ex ( also produced by Spector ) and the 2007 game BioShock are spiritual successors to the two games . A remade version of the original game by Night Dive Studios is scheduled for release in 2018 .

neg: Cyberman The Cybermen are a fictional race of cyborgs who are among the most persistent enemies of the Doctor in the British science fiction television programme , Doctor Who . Within the context of the series , the Cybermen were originally a wholly organic species of humanoids originating on Earth 's twin planet Mondas that began to implant more and more artificial parts into their bodies as a means of self-preservation . This led to the race becoming coldly logical and calculating , with every emotion deleted from their minds .   They were created by Dr. Kit Pedler ( the unofficial scientific advisor to the show ) and story editor Gerry Davis in 1966 , first appearing in the serial The Tenth Planet . They were featured numerous times , up until the show 's cancellation .   Following the 2005 revival of the show , the Cybermen returned with a new origin story in a parallel universe , in the 2006 series ' two-parter `` Rise of the Cybermen '' and `` The Age of Steel '' , and have been recurring villains again ever since . A further redesign took place in the 2013 episode `` Nightmare in Silver '' , showing technologically advanced Cybermen , the result of a merge between the Mondasian and Parallel universe Cybermen , depicted as being able to instantly upgrade themselves to fix flaws and weaknesses .   The species also appeared in the Doctor Who spin-off Torchwood in its fourth episode , `` Cyberwoman '' ( 2006 ) . Cybermen have also appeared in installments of the 2010 Doctor Who video game series The Adventure Games .

neg: Discount theater Discount theaters , also known as dollar theatres , dollar movies , second-run theatres , and sub-run theatres , are movie theaters that show motion pictures for reduced prices after the films leave first-run theatres . Originally , they would receive 35mm films after they had been shown already at first run theaters ; therefore the film quality would be lower because the film was worn by dozens of showings , and the audience for the film would be reduced since it had been released weeks or months before .   At the time , VHS was just rising as an affordable home video technology . Consequently , budget-conscious film-goers might wait for a film to hit the local dollar house instead of paying more money to see the film first-run .   As the 21st century dawned , a pair of factors conspired to drive many discount theatres out of business : 1 ) an oversupply of American movie screens caused by ambitious overbuilding allowed films to stay longer in the first-run theatres , and 2 ) the delay between theatrical release and VHS or DVD release continued to shrink . This latter factor convinced many moviegoers that it was simply not worth the money , hassle , and possible encounters with noisy fellow patrons and sticky floors , meaning dollar theatres could be in the twilight of their existence .

neg: Journey to Silius Journey to Silius , known in Japan as , is a side-scrolling run and gun video game developed by Tokai Engineering and published by Sunsoft for the Nintendo Entertainment System in 1990 .   Journey to Silius was originally based on the 1984 film The Terminator , but the licensing rights to the film were lost during development . As a result , the graphics and storyline were altered to accommodate this change , but remnants of the earlier version still remain in the game . For example , the final boss has a striking resemblance to the titular Terminator in the film .

neg: Star Wars Holiday Special The Star Wars Holiday Special is a 1978 American musical science fiction television film set in the Star Wars galaxy . It stars the series ' first film 's main cast while introducing the character Boba Fett , who would appear in later films . It is one of the first official Star Wars spin-offs and was directed by Steve Binder .   In the storyline that ties the special together , Chewbacca and Han Solo visit Kashyyyk , Chewbacca 's home world , to celebrate Life Day . They are pursued by agents of the Galactic Empire , who are searching for members of the Rebel Alliance on the planet . The special introduces three members of Chewbacca 's family : his father Itchy , his wife Malla , and his son Lumpy , though these names were later explained to have been nicknames , their full names being Attichitcuk , Mallatobuck , and Lumpawarrump , respectively .   The program also features many other Star Wars characters , including Luke Skywalker , C-3PO , R2-D2 , Darth Vader and Princess Leia ( who sings the film 's `` theme song '' , set to the music of John Williams ' Star Wars theme , near the end ) , all of them portrayed by the original actors . The program includes stock footage from Star Wars , and also features a cartoon produced by Toronto-based Nelvana that officially introduces the bounty hunter Boba Fett . Scenes also take place in outer space and in spacecraft including the Millennium Falcon and an Imperial Star Destroyer . The variety-show segments and cartoon also take place in a few other locales , such as a Mos Eisley cantina on the desert planet of Tatooine and a newly introduced red ocean planet known as Panna .   The special is notorious for its extremely negative reception and has never been rebroadcast or officially released on home video . It has therefore become something of a cultural legend , because of the `` underground '' quality of its existence . It has been viewed and distributed in off-air recordings made from its original telecast by fans , which were later adapted to content-sharing websites via the Internet and bootleg copies .

neg: Prophets of Science Fiction Prophets of Science Fiction is an American documentary television series produced and hosted by Ridley Scott for the Science Channel . The program premiered on .   The series covers the life and work of leading science fiction authors of the last couple of centuries . It depicts how they predicted and , accordingly , influenced the development of scientific advancements by inspiring many readers to assist in transforming those futuristic visions into everyday reality . The stories are told through film clips , reenactments , illustrations and interviews .   The first episode received mixed reviews . Commentators appreciated the approach of combining coverage of contemporary scientific research and biographical exposition , but criticized the series as `` light on the substance and heavy on the exaggeration '' . The series ' attempts to link Mary Shelley 's Frankenstein to developments such as organ transplants , supercomputers and DNA research were described by one critic as far-fetched but by another as successful .

neg: Outpost 37 Outpost 37 ( also known as Alien Outpost ) is a 2014 science fiction action thriller film . The film follows a documentary crew sent to record the daily lives of the soldiers of Outpost 37 , 12 years after the initial alien invasion .

neg: Droid (robot) A droid is a fictional robot possessing some degree of artificial intelligence in the Star Wars science fiction franchise . Coined by special effects artist John Stears , the term is a clipped form of `` android '' , a word originally reserved for robots designed to look and act like a human . The word `` droid '' has been a registered trademark of Lucasfilm Ltd since 1977 .

neg: Commando (1985 film) Commando is a 1985 American action film directed by Mark L. Lester , and starring Arnold Schwarzenegger and Rae Dawn Chong . The film was released in the United States on October 4 , 1985 .   The film was nominated for a Saturn Award for Best Special Effects but lost to Back to the Future . The film 's score was provided by James Horner . A critical and commercial success , Commando was the 7th highest-grossing R-rated movie of 1985 worldwide , and the 25th highest-grossing overall .

neg: The Terminator: Rampage The Terminator : Rampage ( also known as just Terminator : Rampage ) is a first-person shooter video game released for the PC by Bethesda Softworks in 1993 . It is the third game based on the Terminator film series that was made by Bethesda , following The Terminator and The Terminator 2029 .

neg: Terminator: The Sarah Connor Chronicles Terminator : The Sarah Connor Chronicles ( sometimes abbreviated as Terminator : TSCC or simply TSCC ) is an American science fiction television series that aired on Fox . The show was produced by Warner Bros. . Television , and C2 Pictures ( C2 Pictures was replaced by The Halcyon Company in season two ) . It is a spin-off from the Terminator series of films . It revolves around the lives of the fictional characters Sarah and John Connor , following the events of Terminator 2 : Judgment Day , and ignoring the events of the 2003 sequel Terminator 3 : Rise of the Machines and the following films . The series premiered on Sunday , January 13 , 2008 , on the U.S. television network Fox . Production for the series was provided by the Judgment Day and Rise of the Machines producers and C2 Pictures , Sony Pictures Entertainment ( International ) co-presidents Mario Kassar and Andrew G. Vajna , C2 Senior Vice President James Middleton , David Nutter and Josh Friedman , who not only served as Executive Producer but also wrote the script for the first two episodes .   The show opened mid-season with a shortened run of nine episodes , January through March 2008 . It was the highest-rated new scripted series of the 2007 -- 08 television season  and was renewed for a second season ,  which began on September 8 , 2008 , and ended April 10 , 2009 ( The same year Warner Bros. and the Halcyon Company produced McG 's Terminator Salvation ) . On May 18 , 2009 , despite fan efforts ,  Fox Entertainment president Kevin Reilly announced Fox would not renew the show for a third season .

neg: Saw V Saw is a 2008 Canadian-American horror film directed by David Hackl and written by Patrick Melton and Marcus Dunstan and stars Tobin Bell , Costas Mandylor , Scott Patterson , Betsy Russell , Mark Rolston , Julie Benz , Carlo Rota , and Meagan Good . It is the fifth installment of the Saw franchise , and was released on October 23 , 2008 in Australia and October 24 , 2008 in North America .   David Hackl , who served as the production designer of Saw , Saw , and Saw IV , and second-unit director for Saw and Saw IV made his directorial debut with Saw . Patrick Melton and Marcus Dunstan , the writers of the previous film , returned to write the film . Charlie Clouser , who provided the score for all previous Saw films , also returned to compose the score for the film . Saw creators James Wan and Leigh Whannell served as executive producers .   The film focuses primarily on the events that led up to Detective Mark Hoffman becoming an apprentice of the Jigsaw Killer , as well as his efforts to prevent anyone else from learning his secret .

neg: Strategic Defense Initiative The Strategic Defense Initiative ( SDI ) was a proposed missile defense system intended to protect the United States from attack by ballistic strategic nuclear weapons ( intercontinental ballistic missiles and submarine-launched ballistic missiles ) . The system , which was to combine ground-based units and orbital deployment platforms , was first publicly announced by President Ronald Reagan on March 23 , 1983 . The initiative focused on strategic defense rather than the prior strategic offense doctrine of mutual assured destruction ( MAD ) . The Strategic Defense Initiative Organization ( SDIO ) was set up in 1984 within the United States Department of Defense to oversee the Strategic Defense Initiative .   Reagan was a vocal critic of MAD doctrine . SDI was an important part of his defense policy intended to end MAD as a nuclear deterrence strategy , as well as a strategic initiative to neutralize the military component of the Soviet Union 's nuclear defenses .   The ambitious initiative was criticized for allegedly threatening to destabilize the MAD-approach and to possibly re-ignite `` an offensive arms race '' . SDI was nicknamed largely in the mainstream media as `` Star Wars '' , after the popular 1977 film by George Lucas . In 1987 , the American Physical Society concluded that a global shield such as `` Star Wars '' was extremely ambitious and with existing technology not directly feasible for operational status , and that about ten more years of research was needed to learn about such a comprehensive and complex system to set up and make it fully operational .   Under the SDIO 's Innovative Sciences and Technology Office , headed by physicist and engineer Dr. James Ionson , the investment was predominantly made in basic research at national laboratories , universities , and in industry ; these programs have continued to be key sources of funding for top research scientists in the fields of high-energy physics , supercomputing/computation , advanced materials , and many other critical science and engineering disciplines -- funding which indirectly supports other research work by top scientists , and which was most politically viable to fund within the budget environment .   Laser research funded by the SDI office was disclosed at laser conferences that also included panel discussions on the subject with the participation of James Ionson , Edward Teller , and other prominent advocates of SDI .   During the administration of President Bill Clinton in 1993 , the SDIO 's name was changed to the Ballistic Missile Defense Organization ( BMDO ) and its focus shifted from national missile defense to theater missile defense ; and its scope from global to more regional coverage . It was never truly developed or deployed , though certain aspects of SDI research and technologies paved the way for some anti-ballistic missile systems of today . BMDO was renamed to the Missile Defense Agency in 2002 . This article covers defense efforts under the SDIO .   Today , the United States holds a significant advantage in the field of comprehensive advanced missile defense systems through years of extensive research and testing . The US and the UK also have both laser weapons and 360 degree laser shields in development , which are expected to be ready for military use as early as 2020 . Many of the obtained technological insights were transferred to subsequent programs and would find use in follow-up programs .

neg: B movie A B movie is a low-budget commercial movie , but one that is not an arthouse film . In its original usage , during the Golden Age of Hollywood , the term more precisely identified films intended for distribution as the less-publicized bottom half of a double feature . Although the U.S. production of movies intended as second features largely ceased by the end of the 1950s , the term B movie continues to be used in the broader sense it maintains today . In its post -- Golden Age usage , there is ambiguity on both sides of the definition : on the one hand , the primary interest of many inexpensive exploitation films is prurient ; on the other , many B movies display a high degree of craft and aesthetic ingenuity .   In either usage , most B movies represent a particular genre -- the Western was a Golden Age B movie staple , while low-budget science-fiction and horror films became more popular in the 1950s . Early B movies were often part of series in which the star repeatedly played the same character . Almost always shorter than the top-billed films they were paired with , many had running times of 70 minutes or less . The term connoted a general perception that B movies were inferior to the more handsomely budgeted headliners ; individual B films were often ignored by critics .   Latter-day B movies still sometimes inspire multiple sequels , but series are less common . As the average running time of top-of-the-line films increased , so did that of B pictures . In its current usage , the term has somewhat contradictory connotations : it may signal an opinion that a certain movie is ( a ) a genre film with minimal artistic ambitions or ( b ) a lively , energetic film uninhibited by the constraints imposed on more expensive projects and unburdened by the conventions of putatively `` serious '' independent film . The term is also now used loosely to refer to some higher-budgeted , mainstream films with exploitation-style content , usually in genres traditionally associated with the B movie .   From their beginnings to the present day , B movies have provided opportunities both for those coming up in the profession and others whose careers are waning . Celebrated filmmakers such as Anthony Mann and Jonathan Demme learned their craft in B movies . They are where actors such as John Wayne and Jack Nicholson first became established , and they have provided work for former A movie actors , such as Vincent Price and Karen Black . Some actors , such as Bela Lugosi , Eddie Constantine and Pam Grier , worked in B movies for most of their careers . The term B actor is sometimes used to refer to a performer who finds work primarily or exclusively in B pictures .

neg: List of accolades received by Star Wars: The Force Awakens Star Wars : The Force Awakens is a 2015 epic space opera film directed , co-produced , and co-written by J. J. Abrams . The seventh installment in the main Star Wars film series , and first of three in Star Wars sequel trilogy , it stars Harrison Ford , Mark Hamill , Carrie Fisher , Adam Driver , Daisy Ridley , John Boyega , Oscar Isaac , Lupita Nyong ` o , Andy Serkis , Domhnall Gleeson , Anthony Daniels , and Max von Sydow . The Force Awakens is set 30 years after Return of the Jedi ; it follows Rey , Finn , and Poe Dameron 's search for Luke Skywalker and their fight alongside the Resistance , led by veterans of the Rebel Alliance , against Kylo Ren and the First Order , a successor group to the Galactic Empire .   The Force Awakens was premiered by Walt Disney Studios Motion Pictures in Los Angeles on December 14 , and was released in United States and Canada on December 18 , 2015 . The Force Awakens opened across 14,300 theaters , breaking numerous box-office records and became the first film to earn more than $ 100 million worldwide in a single day . The film grossed a worldwide total of over $ 2 billion on a production budget of $ 306 million becoming the highest-grossing release of 2015 , and the fastest film to earn $ 1 billion worldwide , doing so in twelve-days . The Force Awakens became the third film in history to surpass $ 2 billion worldwide ( after Avatar ( 2009 ) and Titanic ( 1997 ) ) , doing so on its 53rd day of release .   Rotten Tomatoes , a review aggregator , surveyed 360 reviews and judged 92 percent to be positive . The Force Awakens garnered many awards and nominations in a variety of categories with particular praise for Abrams ' direction , its action sequences , visual effects , editing and Ridley 's and Boyega 's performances . Several awards held their nominations before the December release of The Force Awakens , making the film ineligible for the 73rd Golden Globe Awards and some other awards ceremonies . However , the film was added to the 21st Critics ' Choice Awards 's slate of best picture nominees after a special vote by the board of directors , and the announcement of the 2015 American Film Institute Awards was delayed until after the release of film , where it was named one of Top Ten Films of the year .   The Force Awakens received five nominations at the 88th Academy Awards as Best Original Score , Best Sound Editing , Best Sound Mixing , Best Film Editing and Best Visual Effects . The film garnered four nominations at 69th British Academy Film Awards , and won for Best Special Visual Effects and a special BAFTA Rising Star Award for John Boyega . At the 21st Empire Awards , the film received nine nominations and won five including Best Sci-Fi/Fantasy Film , and Best Director for J.J. Abrams . The Force Awakens became the most nominated film in Saturn Awards history with total of thirteen nominations at 42nd Saturn Awards and won eight including Best Science Fiction Film , Best Director and Best Special Effects . The film received seven nominations from the Visual Effects Society , winning four including Outstanding Visual Effects in an Effects Driven Feature Motion Picture . Star Wars : The Force Awakens received eleven nominations at MTV Movie Awards , the most for the ceremony and won three including Movie of the Year .

neg: Procedural drama A procedural drama is a genre of television programming which focuses on how crimes are solved or some other aspect of a law enforcement agency , legislative body , or court of law . Some dramas include a lab or conference room with high-tech or state-of-the-art equipment where the main characters meet to work out the problem . Shows usually have an episodic format that does not require the viewer to have seen previous episodes . Episodes typically have a self-contained , also referred to as stand-alone , plot that is introduced and resolved within the same episode .   The procedural format is popular around the world . In 2011 , the director of a TV consultancy said , `` The continuing trend is for procedurals because they use a predictable structure . '' Due to their stand-alone episodic nature , they are more accessible to new viewers than serials . Self-contained episodes also make it easier for viewers to return to a show if they have missed some episodes . In general , procedural dramas can usually be re-run with little concern for episode order .   Procedurals are often criticized for being formulaic . Procedurals are also generally less character-driven than serialized shows . However , some procedurals have more character emphasis than is typical of the format . Some may occasionally feature a storyline stretching over several episodes .   A popular variant is the police procedural .


query: Ilkhanate was ruled by Hulagu Khan.

pos: Ilkhanate The Ilkhanate , also spelled Il-khanate ( ایلخانان , Ilkhānān ; Хүлэгийн улс , Hulagu-yn Ulus ) , was established as a khanate that formed the southwestern sector of the Mongol Empire , ruled by the Mongol House of Hulagu . It was founded in the 13th century and was based primarily in Iran as well as neighboring territories , such as present-day Azerbaijan and the central and eastern parts of present-day Turkey . The Ilkhanate was originally based on the campaigns of Genghis Khan in the Khwarazmian Empire in 1219 -- 24 and was founded by Hulagu Khan , a grandson of Genghis Khan . With the fragmentation of the Mongol Empire after 1259 it became a functionally separate khanate . At its greatest extent , the state expanded into territories that today comprise most of Iran , Iraq , Armenia , Azerbaijan , Georgia , Turkmenistan , Turkey , western Afghanistan , and southwestern Pakistan . Later Ilkhanate rulers , beginning with Ghazan in 1295 , would convert to Islam .

neg: Chonos tribe Chonos , one of the Mongolian tribes , can be found in Kalmykia , Buryatia , and the Irkutskaya province in the Russian Federation , and also in Mongolia and the People 's Republic of China . The name of the tribe translates as `` wolves '' or `` wolf 's '' , and it is one of the most ancient Mongolian tribes . It is famous as a first tribe which joined Genghis Khan .   Other names of the tribe in the various Mongolian languages include `` Shono '' , `` Chono '' , `` Shonod '' , and `` Chinos '' .   According to Rashid-al-Din , the founders of the Chonos tribe were two sons of Charake-Lingum , named Gendu-Chino and Ulug-Chino , while the third son of Charake-Lingum , Surkuduku-Chino , was the father of Ambagay-Khan . Rashid-al-Din states that the male line of the Chonos tribe is Bodonchar - Habichi-Baatar - Dutum-Meneen - Haidu - Charake-Lingum - Gendu-Chino and Ulug-Chino . The name of Gendu-Chino is still found among the Chonos `` arvans '' in Kalmykia .   In Mongolia the Chonos tribe is found among the Darkhad .

neg: Mamluk dynasty (Delhi) The Mamluk Dynasty ( sometimes referred as Slave Dynasty or Ghulam Dynasty ) was directed into Northern India by Qutb ud-Din Aibak , a Turkic general from Central Asia . The Mamluk Dynasty ruled from 1206 to 1290 ; it was the first of five unrelated dynasties to rule as the Delhi Sultanate till 1526 . Aibak 's tenure as a Ghurid dynasty administrator lasted from 1192 to 1206 , a period during which he led invasions into the Gangetic heartland of India and established control over some of the new areas .

neg: Shaki Khanate Shaki khanate ( Şəki xanlığı , also spelled as Sheki khanate , Shekin khanate , Shakki khanate ) was a Caucasian khanate established in Afsharid Iran , on the territory of modern Azerbaijan , between 1743 and 1819 with its capital in the town of Shaki .

neg: Sogdia Sogdia or Sogdiana was an ancient Iranian civilization that at different times included territory located in present-day Tajikistan and Uzbekistan such as : Samarkand , Bukhara , Khujand , Panjikent and Shahrisabz . Sogdiana was also a province of the Achaemenid Empire , eighteenth in the list on the Behistun Inscription of Darius the Great ( i. 16 ) . In the Avesta , Sogdiana is listed as the second best land that the supreme deity Ahura Mazda had created . It comes second , after Airyanem Vaejah , `` homeland of the Aryans '' , in the Zoroastrian book of Vendidad , indicating the importance of this region from ancient times . Sogdiana was conquered by the Macedonian ruler Alexander the Great in 328 BC and later formed part of the Greco-Bactrian Kingdom and Sasanian Empire .   The Sogdian states , although never politically united , were centred on the main city of Samarkand . Sogdiana lay north of Bactria , east of Khwarezm , and southeast of Kangju between the Oxus ( Amu Darya ) and the Jaxartes ( Syr Darya ) , embracing the fertile valley of the Zeravshan ( ancient Polytimetus ) . Sogdian territory corresponds to the modern provinces of Samarkand and Bokhara in modern Uzbekistan as well as the Sughd province of modern Tajikistan . During the High Middle Ages , Sogdian cities included sites stretching towards Issyk Kul such as that at the archeological site of Suyab . Sogdian , an Eastern Iranian language , is no longer a spoken language , but its direct descendant , Yaghnobi , is still spoken by the Yaghnobis of Tajikistan . It was widely spoken in Central Asia as a lingua franca and even served as one of the Turkic Khaganate 's court languages for writing documents .   Sogdians also lived in Imperial China and rose to special prominence in the military and government of the Chinese Tang dynasty ( 618 -- 907 AD ) . Sogdian merchants and diplomats traveled as far west as the Byzantine Empire . They played an important part as middlemen in the trade route of the Silk Road . While originally following the faiths of Zoroastrianism and Manichaeism from Persia , Buddhism from India , and Nestorian Christianity from West Asia , the gradual conversion to Islam among the Sogdians and their descendants began with the Muslim conquest of Transoxiana in the 8th century . The Sogdian conversion to Islam was virtually complete by the end of the Samanid Empire in 999 , coinciding with the decline of the Sogdian language , as it was largely supplanted by Persian .

neg: Gvantsa Kakhaberidze Gvantsa ( გვანცა , or , archaically , Guantsa , გუანცა ; also transliterated as Gwantza , Gontza , Gontsa , or Gonc ` a ) ( died c. 1263 ) was a Queen Consort of Georgia as the third wife of King David VII `` Ulu '' ( r. : 1245-1270 ) .   She was the daughter of Kakhaber IV Kakhaberidze , Duke of Racha and Takveri , who married Gvantsa off to Prince Avag Mkhargrdzeli , Lord High Tutor and Lord High Constable of Georgia with whom she begot a daughter Khvashak . After Avag 's death in 1250 , Gvantsa remarried the Georgian king David VII in 1252 and gave birth to a son , the future king Demetre II of Georgia , in 1259 . In the meantime , Khvashak was reared by the king 's trustee Sumbat Orbeli or Sadun Mankaberdeli ( here the medieval sources diverge ) and later given in marriage to Shams ad-Din Juvayni , an influential minister at the Mongol Il-Khan 's court .   Unlike David VII 's first wife , the late Jigda-Khatun , Gvantsa was on extremely bad terms with the influential royal favorite Jikur , the Master of Ceremonies ( mestumre ) of Georgia . Jikur 's rivals exploited this enmity and accused him of treason before the king who had him executed by drowning in the Mtkvari River . When David staged a failed revolt from the Il-Khan hegemony in 1260 , Gvantsa was captured by the Mongol punitive forces and killed on the orders of the Il-Khan Hulagu through the intrigues of rival Georgian nobles .

neg: Babylonia Babylonia was an ancient Akkadian-speaking state and cultural area based in central-southern Mesopotamia ( present-day Iraq ) . A small Amorite-ruled state emerged in 1894 BC , which contained at this time the minor city of Babylon . Babylon greatly expanded during the reign of Hammurabi in the first half of the 18th century BC , becoming a major capital city . During the reign of Hammurabi and afterwards , Babylonia was called Māt Akkadī `` the country of Akkad '' in the Akkadian language .  It was often involved in rivalry with its older fellow Akkadian-speaking state of Assyria in northern Mesopotamia . Babylonia briefly became the major power in the region after Hammurabi ( fl . c. 1792 -- 1752 BC middle chronology , or c. 1696 -- 1654 BC , short chronology ) created a short-lived empire , succeeding the earlier Akkadian Empire , Third Dynasty of Ur , and Old Assyrian Empire ; however , the Babylonian empire rapidly fell apart after the death of Hammurabi .   The Babylonian state , like Assyria to the north , retained the written Akkadian language for official use ( the language of its native populace ) , despite its Northwest Semitic-speaking Amorite founders and Kassite successors , who spoke a language isolate . It retained the Sumerian language for religious use ( as did Assyria ) , but by the time Babylon was founded , this was no longer a spoken language , having been wholly subsumed by Akkadian . The earlier Akkadian and Sumerian traditions played a major role in Babylonian and Assyrian culture , and the region would remain an important cultural center , even under protracted periods of outside rule .   The earliest mention of the city of Babylon can be found in a clay tablet from the reign of Sargon of Akkad ( 2334 -- 2279 BC ) , dating back to the 23rd century BC . Babylon was merely a religious and cultural centre at this point and neither an independent state nor a large city ; like the rest of Mesopotamia , it was subject to the Akkadian Empire which united all the Akkadian and Sumerian speakers under one rule . After the collapse of the Akkadian empire , the south Mesopotamian region was dominated by the Gutian people for a few decades before the rise of the Third Dynasty of Ur , which , apart from northern Assyria , encompassed the whole of Mesopotamia , including the city of Babylon .

neg: Achaemenid Assyria Athura ( ð ð ° ð cents ð 1/4 ð Aθurā ) , also called Assyria Babylonia , was a geographical area within the Persian Achaemenid Empire held by the last nobility of Aššur ( Akkadian ) , known as Athura ( Neo-Aramaic ) or Atouria ( Greek ) , during the period of 539 BC to 330 BC as a military protectorate state of Persia under the rule of Cyrus the Great . Although sometimes regarded as a satrapy , Achaemenid royal inscriptions list it as a dahyu , a concept generally interpreted as meaning either a group of people or both a country and its people , without any administrati   It mostly incorporated the original Assyrian kingdom , corresponding with modern northern Iraq in the upper Tigris , the middle and upper Euphrates , modern-day north eastern Syria ( Eber-Nari ) and part of south-east Anatolia ( modern Turkey ) . The Neo-Assyrian Empire collapsed after a period of violent civil wars , followed by an invasion by a coalition of some of its former subject peoples , the Iranian peoples ( Medes , Persians and Scythians ) , Babylonians and Cimmerians in the late 7th century BC , culminating in the Battle of Nineveh , and Assyria had fallen completely by 605 BC . Between 605 and 559 BC , Assyria was divided between the Median Empire to the east and the Neo-Babylonian Empire to the west . Both parts were subsumed into the Achaemenid Empire in 539 BC , and it has been argued that they constituted the satrapies of Media and Athura , respectively . In Herodotus ' account the Ninth Tributary District comprised `` Babylonia and the rest of Assyria '' , and excluded Eber-Nari .   Despite a few rebellions , Assyria functioned as an important part of the Achaemenid Empire . The Assyrian people were given the right to govern themselves throughout Achaemenid rule , and the Assyrian ( Aramaic ) language was used diplomatically by the Persians . Known for their combat skills , Assyrian soldiers ( along with the Lydians ) constituted the main heavy infantry of the Achaemenid empire 's military . Due to the major destruction of Assyria during the fall of its empire , some early scholars described the area as an `` uninhabited wasteland . '' Other Assyriologists , however , such as John Curtis and Simo Parpola , have strongly disputed this claim , citing how Assyria would eventually become one of the wealthiest regions among the Achaemenid Empire . This wealth was due to the land 's great prosperity for agriculture that the Persians used effectively for almost 200 years . In contrast to the policy of the Assyrian Empire , the Achaemenid Persians did not intervene in the internal affairs of their ruling satrapies as long as they continued the flow of tribute and taxes back to Persia .

neg: Khanate of Kazan The Khanate of Kazan ( -LSB- Казан ханлыгы , Qazan xanlığı , قازان خانليغى -RSB- Russian : Казанское ханство , tr : Kazanskoye khanstvo ) was a medieval Bulgarian-Tatar Turkic state that occupied the territory of former Volga Bulgaria between 1438 and 1552 . Its khans were the patrilineal descendants of Tugh Temür , the thirteenth son of Jochi and grandson of Genghis Khan . The khanate covered contemporary Tatarstan , Mari El , Chuvashia , Mordovia , and parts of Udmurtia and Bashkortostan ; its capital was the city of Kazan . It was one of the successor states of the Golden Horde , and it came to an end when it was conquered by the Tsardom of Russia .

neg: Temüge Temüge ( 1168 -- 1246 ) was the youngest full-brother of Genghis Khan , fourth son of Yesugei and Oelun .  The Secret History of the Mongols tells that `` when Temujin was 9 years of age , Temuge was three years old . '' Being the youngest boy in the family , he received a prefix to the name `` otchigin '' ( diminutive form of '' отгон '' or `` otgon '' meaning `` junior '' ) , who in the family is always a `` guardian of the family and home '' ) , and therefore is often referred to as Temuge-otchigin or simply Otchigin . In childhood and adolescence was somewhat spoiled by his mother and older brothers , inclined to luxury , but was `` courageous , powerful and quick in battle '' that was recognized even by the family 's enemies . When the shaman Kokochu ( Teb-Tengri ) started dragging the power over the Mongols to his own family , Genghis khan sanctioned Temuge to kill Kokochu in a staged wrestling match .   As the youngest male sibling , Temüge and his mother , by Mongol traditions , were allotted the most land and people by Genghis Khan during his coronation . Although he seems to have been the least warlike of the brothers , and was criticized by Genghis himself for being lazy and shiftless , Temüge proved himself to be a skilled politician and capable ruler , who , alongside his mother Hoelun , ruled the Mongol heartland in his eldest brothers ' absence being engaged in war campaigns . He appears to have had intellectual leanings , first coming under the influence of the conquered Xia and Jin cultures and then taking an active interest in the other cultures encompassed in the vast Mongol empire .   Temuge attempted to enter the main political arena after the death of Ögedei Khan , his nephew and son of Genghis Khan , in 1241 . At that time , Ogedei 's son Güyük Khan was engaged in so-called `` Western campaign '' in Russia and Europe , so Temuge-otchigin tried to seize the throne , but he was intervened by Töregene , Ogedei 's widow and Güyük 's mother . After the 1246 kurultai elected Güyük as great khan , Temuge was executed .

neg: Hoysala Empire The Hoysala empire was a prominent Southern Indian Kannadiga empire that ruled most of the modern-day state of Karnataka between the 10th and the 14th centuries . The capital of the Hoysalas was initially located at Belur but was later moved to Halebidu .   The Hoysala rulers were originally from Malnad Karnataka , an elevated region in the Western Ghats range . In the 12th century , taking advantage of the internecine warfare between the then ruling Western Chalukya and Kalachuri kingdoms , they annexed areas of present-day Karnataka and the fertile areas north of the Kaveri River delta in present-day Tamil Nadu . By the 13th century , they governed most of present-day Karnataka , minor parts of Tamil Nadu and parts of western Andhra Pradesh and Telangana in Deccan India .   The Hoysala era was an important period in the development of art , architecture , and religion in South India . The empire is remembered today primarily for its temple architecture . Over a hundred surviving temples are scattered across Karnataka .   Well known temples `` which exhibit an amazing display of sculptural exuberance '' include the Chennakesava Temple at Belur , the Hoysaleswara Temple at Halebidu , and the Kesava Temple at Somanathapura . The Hoysala rulers also patronised the fine arts , encouraging literature to flourish in Kannada and Sanskrit .

neg: Dpon-chen The dpon-chen or pönchen , literally the `` great authority '' or `` great administrator '' , was the chief administrator or governor of Tibet located at Sakya Monastery during the Yuan administrative rule of Tibet in the 13th and 14th centuries . In the Mongol Empire the office of the dpon-chen was established in the 1260s and functioned for all practical purposes as the Tibetan government at the pleasure of the Mongol emperors of the Yuan dynasty , unlike the Sakya Imperial Preceptors ( Dishi ) who were active at the Yuan court .   The Mongols set up a government agency and top-level administrative department known as the Bureau of Buddhist and Tibetan Affairs in Khanbaliq ( modern Beijing ) that supervised Buddhist monks in addition to managing the territory of Tibet ; one of the department 's purposes was to select a dpon-chen to govern Tibet when the Sakya Lama ( e.g. Drogön Chögyal Phagpa ) was away . The dpon-chen was invariably a Tibetan nominated by the ruling Sakya Lama and approved by the reigning emperor . His function was , apart from being the chief executive head of the Sakya government , to appoint a tripön for each of the 13 myriarchies , and to act as liaison between the Yuan government and Tibet . Nevertheless , this system also led to conflicts between the Sakya leaders and the dpon-chens . While dpon-chens had a small army in Sakya itself , their major military support came from the Mongols or Yuan dynasty when an internal rebellion or external invasion occurred . As Yuan declined in the mid-14th century however , in Tibet , Tai Situ Changchub Gyaltsen toppled the Sakya and founded the Phagmodrupa Dynasty , marking the end of the dpon-chen system .

neg: Lydians The Lydians were an Anatolian people living in Lydia , a region in western Anatolia , who spoke the distinctive Lydian language , an Indo-European language of the Anatolian group .   Questions raised regarding their origins , as defined by the language and reaching well into the 2nd millennium BC , continue to be debated by language historians and archeologists . A distinct Lydian culture lasted , in all probability , until at least shortly before the Common Era , having been attested the last time among extant records by Strabo in Kibyra in south-west Anatolia around his time ( 1st century BC ) .   The Lydian capital was at Sfard or Sardis . Their recorded history of statehood , which covers three dynasties traceable to the Late Bronze Age , reached the height of its power and achievements during the 7th and 6th centuries BC , a time which coincided with the demise of the power of neighboring Phrygia which lay to the north-east of Lydia .   Lydian power came to an abrupt end with the fall of their capital in events subsequent to the Battle of Halys in 585 BC and defeat by Cyrus the Great in 546 BC .

neg: Permians The Permians are a branch of the Finno-Ugric peoples and include Komis and Udmurts , speakers of Permic languages . Formerly the name Bjarmians was also used to describe these peoples . The recent research on the Finno-Ugric substrate in northern Russian dialects , however , suggests that in Bjarmaland there also lived several other Finno-Ugric groups besides the Permians .   The ancestors of the Permians originally inhabited the land called Permia covering the middle and upper Kama River . Permians split into two groups , probably during the 9th century .   The Komis came under the rule of the Novgorod Republic in the 13th century and were converted to Orthodox Christianity in the 1360-1370s . In 1471-1478 , their lands were conquered by the Grand Duchy of Moscow that later became the Tsardom of Russia . In the 18th century the Russian authorities opened the southern parts of the land to colonization and the northern parts became a place to which criminal and political prisoners were exiled .   The Udmurts came under the rule of the Tatars , the Golden Horde and the Khanate of Kazan until their land was ceded to Russia , and the people were Christianized at the beginning of the 18th century .

neg: Alkhan-Kala operation The Alkhan-Kala operation was a week-long military `` cleansing '' operation ( zachistka , -LSB- : ru : зачистка , зачистка -RSB- ) by the Russian special forces in Chechnya starting on 25 June 2001 . Arbi Barayev , a Chechen insurgent commander and organized crime leader , was killed during the operation in the village of Alkhan-Kala near Grozny .   The battle lasted for days and resulted in massive destruction . House-to-house fighting left dozens of houses destroyed and about `` Barayev 's accomplices '' were killed , according to the Russian officials . Some 800 villagers were taken into the custody .   Barayev had been the most senior rebel leader to have been killed or captured by the Russians since the Second Chechen War began . According to some reports , Barayev was captured alive by his Chechen blood enemies in the GRU , and died at the Khankala military base `` after long torture '' .

neg: Tuvans The Tuvans or Tuvinians ( Тывалар , Тьvаlar / Tıvalar ; Тува , Tuwa ) are a Mongol people ethnic group living in southern Siberia . They are historically known as one of the Uriankhai , from the Mongolian designation .   Tuvans have historically been cattle-herding nomads , tending to their herds of goats , sheep , camels , reindeer , cattle and yaks for the past thousands of years . They have traditionally lived in yurts covered by felt or chums covered with birch bark or hide that they relocate seasonally as they move to newer pastures . Traditionally , the Tuvans were divided into nine regions called khoshuun , namely the Tozhu , Salchak , Oyunnar , Khemchik , Khaasuut , Shalyk , Nibazy , Daavan and Choodu , and Beezi . The first four were ruled by Uriankhai Mongol princes , while the rest were administered by Borjigin Mongol princes .

neg: Sajid dynasty The Sajid dynasty , was an Islamic dynasty that ruled from 889-890 until 929 . Sajids ruled Azerbaijan and parts Armenia first from Maragha and Barda and then from Ardabil . The Sajids originated from the Central Asian province of Ushrusana and were of Iranian ( Sogdians )  descent . Muhammad ibn Abi ` l-Saj Diwdad the son of Diwdad , the first Sajid ruler of Azerbaijan , was appointed as its ruler in 889 or 890 . Muhammad 's father Abi ` l-Saj Devdad had fought under the Ushrusanan prince Afshin Khaydar during the latter 's final campaign against the rebel Babak Khorramdin in Azerbaijan , and later served the caliphs . Toward the end of the 9th century , as the central authority of the Abbasid Caliphate weakened , Muhammad was able to form a virtually independent state . Much of the Sajids ' energies were spent in attempting to take control of neighboring Armenia . The dynasty ended with the death of Abu ` l-Musafir al-Fath in 929 .

neg: Mahalla (Uzbeks) A mahalla is an urban division in Uzbek communities which today exist in Uzbekistan , Kyrgyzstan , and Tajikistan . Historically , mahallas were autonomous social institutions built around familial ties and Islamic rituals . Before the establishment of the Soviet rule in Uzbekistan , Mahallas fulfilled local self-government functions connecting private sphere with public sphere . Religious rituals , life-cycle crisis ceremonies , resource management , conflict resolution , and many other community activities were performed at mahalla , or ( neighbourhood ) level . An informal council of elders ( oqsoqol , or aksakal ) provided leadership .   After the establishment of the Soviet Union , informal mahalla organizations were placed under the state control and served as local extensions of the Soviet government . Mahallas were thought to be `` eyes '' and `` ears '' of the Soviet government ; mahalla became a control mechanism of the state and the mahalla leaders were appointed by the government . However , mahalla level state-society relationships were more complex as mahalla leaders could serve as henchmen while also acting as buffers between the local community and the state . Due to intimate , face-to face relationships dominant at mahalla , mahalla organizations could shield the community from the incursions of the state .   Since 1993 , Uzbek government reorganized mahalla councils as bearers of `` Uzbek nationhood '' and `` morality , '' effectively reproducing Soviet style state domination over the society . Thus , they are formal structures run by committees ( headed by chairs called `` oqsoqols '' ) and regulated by the government . Human rights groups have accused Islam Karimov 's government of using mahallas to control the population , repress dissent , force resettlement , and persecute religious minorities .   Mahalla is a common unit not only in Uzbekistan , but in Tajikistani cities like Khujand and Kyrgyzstani cities like Osh .

neg: List of Crimean khans This is a list of khans of the Crimean Khanate , a state which existed in present-day southern Ukraine from 1441 until 1783 . Crimean Tatars , although not a part of the Ukrainian ethnos , are deeply interconnected , having ruled a large part of modern Ukraine over the span of 300 years .   The position of Khan in Crimea was electoral and was picked by beys from four of the most noble families ( also known as Qarachi beys : argyns , kipchaks , shirins , baryns ) at kurultai where the decision about a candidate was adopted . The newly elected Khan was raised on a white felt sheet and over him were read Islamic prayers , after that the Khan was triumphantly enthroned .   The following is the chronological table of reigns of Khans of the Crimean Khanate from the Giray dynasty :

neg: Tonyukuk Tonyukuk ( Old Turkic : Bilge Tuňuquq , born c. 646 , died c. 726 ) was the baga-tarkhan ( military leader ) of four Göktürk khagans , the best known of whom is Bilge Khan .   The name is spelled as t-o-ň-uq-uq in the Old Turkic script , variously interpreted as Tunuquq , Tonuquq , Tuj-uquq , Tony Yuguq , Tujun-oq , Tojuquq , with a number of suggestions for its etymology .   He played a major role in the politics of the Turkic tribes and the establishment and assertion of the Göktürk state against the Chinese Tang Dynasty .  Tonyukuk first served the Tang Empire , then joined the Göktürk rebellion against the empire . Tonyukuk was a `` guardian of Türk values '' and rejected Taoism and Buddhism as unsuitable to a people of warriors , advising the Turks to `` follow the water and the grass '' ( i.e. to adhere to their nomadic lifestyle ) to avoid annexation by the Chinese Empire , as they numbered `` less than a hundredth part of the Chinese '' .  He was one of the Turkic commanders during the battle on the Tola River and led the Göktürk campaigns against the Kirgiz Khanate in 708 -- 709 and against the Turgesh Khanate and Arab Qalifate in 711 -- 712 . After Qaghan Qapaghan 's death , he did not support Kultegin and Bilge in their struggle against the power of Qapaghan 's sons . When they emerged victorious , he was discharged from ruling the khanate . Subsequently , however , Bilge decided to rehabilitate him .   His biography , achievements and advices for state administration were carved in the so-called Orkhon-Turkic script on two stelae erected in 716 ( before his death ) at a site known as Bayn Tsokto , in Ulaanbataar 's Nalaikh district .

neg: Mongol invasion of Thrace The Mongol invasion of Thrace took place in the winter of 1264/1265 , under the leadership of Nogai Khan .