query: Roald Dahl writes books.

pos: Roald Dahl Roald Dahl ( -LSB- langpronˈroʊ.əld _ ˈdɑːl -RSB- , -LSB- ˈɾuːɑl dɑl -RSB- ; 13 September 1916 -- 23 November 1990 ) was a British novelist , short story writer , poet , screenwriter , and fighter pilot . His books have sold more than 250 million copies worldwide .   Born in Wales to Norwegian parents , Dahl served in the Royal Air Force during the Second World War , in which he became a flying ace and intelligence officer , rising to the rank of acting wing commander . He rose to prominence in the 1940s with works for both children and adults and he became one of the world 's best selling authors . He has been referred to as `` one of the greatest storytellers for children of the 20th century '' . His awards for contribution to literature include the 1983 World Fantasy Award for Life Achievement , and the British Book Awards ' Children 's Author of the Year in 1990 . In 2008 , The Times placed Dahl 16th on its list of `` The 50 greatest British writers since 1945 '' .   Dahl 's short stories are known for their unexpected endings and his children 's books for their unsentimental , macabre , often darkly comic mood , featuring villainous adult enemies of the child characters . His books champion the kind-hearted , and feature an underlying warm sentiment . Dahl 's works for children include James and the Giant Peach , Charlie and the Chocolate Factory , Matilda , The Witches , Fantastic Mr Fox , The BFG , The Twits and George 's Marvellous Medicine . His adult works include Tales of the Unexpected .

neg: Roy Apps Roy Apps ( born 1951 ) is a British screenwriter , dramatist and children 's author .   In 2001 Roy Apps was awarded a personal BAFTA for outstanding contributions to children 's film and television .   For 10 years he wrote for the award-winning CBBC series Byker Grove where his first job was to write out the show 's leading characters ` PJ and Duncan ' played by Ant and Dec. . He co-devised and wrote for the award-winning series The Ghost Hunter and has contributed to many other TV series , including Chucklevision , Barmy Aunt Boomerang , Stacey Stone and Casper 's Scare School .   He has written over a hundred scripts for BBC radio , including Fungus the Bogeyman , which won a Sony Award . His most recent work includes The Master & Mrs Tucker , a play about the friendship between Noël Coward and E Nesbit and Life Begins at Crawley , a comedy drama featuring Penelope Keith . Both of these dramas were made for BBC Radio 4 by the award-winning independent production company Pier Productions .   He is the author of 78 children 's books . In 1991 , his novel The Secret Summer of Daniel Lyons won the Writers ' Guild Children 's Book Award and was shortlisted for the Whitbread Awards . The Fang Gang series is published by Bloomsbury . Charlie - Prince Of Wheels is published by the Oxford University Press . His popular How to Handle ... series has been relaunched as part of the Franklin Watts EDGE series . He has recently been commissioned to write four new titles for his sports series Dream to Win .   He regularly visits schools to help young writers create books , plays , films , poetry , musical theatre and opera . He has been Writer-in-Residence at The Museum of Canterbury , OperaHouse Music Projects , the Aspire Trust , the Palace Theatre , Westcliff-on-Sea and The National Gallery , London . He is Patron Of Reading at two schools : Oakley School , Tunbridge Wells and Paddington Academy , West London .

neg: Indian English literature Indian English Literature ( IEL ) refers to the body of work by writers in India who write in the English language and whose native or co-native language could be one of the numerous languages of India . Its early history began with the works of R. K. Narayan , Mulk Raj Anand and Raja Rao who contributed to Indian fiction in the 1930s . It is also associated with the works of members of the Indian diaspora , such as V. S. Naipaul , Kiran Desai , Jhumpa Lahiri , Kovid Gupta , Agha Shahid Ali , Rohinton Mistry and Salman Rushdie , who are of Indian descent .   It is frequently referred to as Indo-Anglian literature . ( Indo-Anglian is a specific term in the sole context of writing that should not be confused with Anglo-Indian ) . As a category , this production comes in the broader realm of postcolonial literature -- the production from previously colonised countries such as India .

neg: Spoilt Rotten Spoilt Rotten : The Toxic Cult of Sentimentality ( subtitle in US editions : How Britain is Ruined by Its Children ) is a non-fiction book by the British writer and retired doctor and psychiatrist Theodore Dalrymple , originally published in 2010 . Polemical in nature , the book contends that sentimentality has become culturally entrenched in British society , with harmful consequences . The author uses a range of cultural , educational , political , media and literary issues -- including falling standards in education , UK aid policies for African development , the death of Diana , Princess of Wales , the disappearance of Madeleine McCann , and the work and life of Sylvia Plath -- to illustrate what he sees as the danger of abandoning logic in favour of sentimentality , which he describes as `` the progenitor , the godparent , the midwife of brutality '' . Much of Dalrymple 's analysis is underpinned by his experience of working with criminals and the mentally ill .   Spoilt Rotten received a mostly favourable reception in the media . Dalrymple was praised for carrying out a thought-provoking and convincing analysis of a newly emerged cultural phenomenon which sees emotion substituted for reason . Some critics , however , accused the author of cynicism and misanthropic pessimism in his approach , and the historian Noel Malcolm claimed that Dalrymple had overreached in his analysis .

neg: BBC Books BBC Books ( also formerly known as BBC Publishing ) is an imprint majority owned and managed by Penguin Random House through its Ebury Publishing division . The minority shareholder is BBC Worldwide , the commercial subsidiary of the British Broadcasting Corporation . The imprint has been active since the 1980s .   BBC Books publishes a range of books connected to BBC radio and television programming , including cookery , natural history , lifestyle , and behind the scenes `` making-of '' books . There are also some non-programme related biographies and autobiographies of various well-known personalities in its list .   Amongst BBC Books ' best known titles are cookery books by former TV cook Delia Smith , wildlife titles by Sir David Attenborough and gardening titles by Alan Titchmarsh . In the BBC Publishing days , it turned down The Hitchhiker 's Guide to the Galaxy , a book which has now sold over 14,000,000 copies worldwide .

neg: Mr. Botibol `` Mr. Botibol '' is a short story by Roald Dahl , first collected in 1980 in the short story collection More Tales of the Unexpected by Penguin .

neg: Rudyard Kipling's Verse: Definitive Edition The Definitive Edition of the verse of Rudyard Kipling ( 1865 -- 1936 ) was published in 1940 in London by Hodder and Stoughton , Ltd and in Edinburgh by R. R. Clark . It is a one-volume collection and was printed on India paper .   The bibliographical information given on the verso of the title page ( the ` Edition notice ' ) of the 1958 reprint of the 1940 edition gives the following information ( years link to corresponding '' -LSB- year -RSB- in poetry '' article ) :  The first edition of Kipling 's Collected Verse ( 1885 -- 1912 ) was published in 1912 , with a reprint in the same year .  The second collected edition , the Inclusive Edition ( 1885 -- 1918 ) was first published in 3 volumes in December 1919 . A second impression came out in April 1920 .  This edition ( inclusive of his verse from 1885 to 1918 ) was issued as a single volume in October 1921 , and went through 18 further impressions by August 1926 .  The third collected edition ( Inclusive Edition , 1885 - 1926 ) appeared as a single volume in September 1927 . 11 more impressions came out by October 1931 .  The fourth Inclusive Edition of Rudyard Kipling 's Verse ( 1885 -- 1932 ) , in one volume , appeared in October 1933 , and was followed by six impressions up to November 1939 .  The Definitive Edition of Rudyard Kipling 's Verse appeared posthumously in 1940 . It was reprinted -- the edition notice of the 1958 reprint states -- in 1941 , 1949 and 1958 .   Many other versions of Kipling 's verse have been made . These include  Kipling , Rudyard ( 1913 ) Songs from Books , London , Macmillan .  Kipling , Rudyard ( 1925 ) A choice of songs from the verse of Rudyard Kipling , London , Methuem .  Kipling , Rudyard ( 1941 ) A Choice of Kipling 's Verse made by T.S.Eliot , with an essay on RUDYARD KIPLING , London , Faber and Faber .  Kipling , Rudyard ( 1986 ) Early verse by Rudyard Kipling , 1879-1889 : unpublished , uncollected , and rarely collected poems , Oxford , Clarendon Press .  Kipling , Rudyard ( 1992 ) Rudyard Kipling : selected poetry , London , Penguin .  Kipling , Rudyard ( 1994 ) The collected poems of Rudyard Kipling , introduction and notes by R. T. Jones , Ware , Wordsworth Editions .

neg: Places of interest in Buckinghamshire Buckinghamshire , England is most notable for its open countryside and natural features , including the Chiltern Hills Area of Outstanding Natural Beauty and the River Thames . The county is also home to many historic houses , some of which are open to the public through the National Trust , such as Waddesdon Manor , West Wycombe Park and Cliveden ; and others which still act as private houses such as the Prime Minister 's country retreat Chequers .   Buckinghamshire is also the home of various notable people from history in whose honour tourist attractions have been established . The most notable of these is the author Roald Dahl who included many local features and characters in his works .   There are various notable sports facilities in Buckinghamshire such as Adams Park , and the county is also home to the world-famous Pinewood Studios .   This is a list of places of interest in the county . See List of places in Buckinghamshire for a list of settlements .

neg: Profile Books Profile Books is a British independent book publishing firm founded in 1996 . It publishes non-fiction subjects including history , biography , memoir , politics , current affairs , travel and popular science .   Profile Books is distributed in the UK by Random House and sold by Faber & Faber , and is part of the Independent Alliance .

neg: Sally Ledger Sally Ledger ( 14 December 1961 - 21 January 2009 ) was a Professor of Victorian literature who made major contributions to the fields of nineteenth-century women 's writing , literary feminism , and the study of Charles Dickens .   Ledger took her undergraduate studies at Queen Mary University of London , where she won the George Smith Prize for the best English First in the University of London in 1985 . She completed her graduate studies at the University of Oxford , where she worked on the novels of Mark Rutherford under the supervision of Terry Eagleton at Wadham College . While at Oxford she was involved with the student pressure group Oxford English Limited , and wrote for its journal News from Nowhere : Journal of the Oxford English Faculty Opposition ; she also contributed to the journal Literature Teaching Politics , where her first published article appeared in 1987 . After her doctorate , Ledger had lectureships at Royal Holloway University of London , the University of Exeter and the University of the West of England before moving to Birkbeck University of London in 1995 as a Lecturer in English . She was promoted to Reader in 2001 and Professor in 2006 . Ledger moved to Royal Holloway University of London in 2008 to take up the Hildred Carlile Chair of English .   Professor Ledger 's major publications are The New Woman : Fiction and Feminism at the Fin de Siècle ( Manchester University Press , 1997 ) and Dickens and the Popular Radical Imagination ( Cambridge University Press , 2007 ) . She also wrote a study of Henrik Ibsen for Northcote House 's ` Writers and Their Work ' series ( 1999 ) , and co-edited a series of volumes : Political Gender : Texts and Contexts ( Routledge , 1994 ) , Cultural Politics at the Fin de Siècle ( Cambridge University Press , 1995 ) , The Fin de Siècle : A Reader in Cultural History ( Oxford University Press , 2000 ) and the posthumously published Charles Dickens in Context ( Cambridge University Press , 2013 ) . She also edited George Egerton 's Keynotes and Discords ( Bloomsbury Academic , 2000 ) . From 2005-2009 she was an integral part of the Dickens Project conference at the University of California , Santa Cruz and was planning a book on the origins of Victorian sentimentality at the time of her death . The British Association of Victorian Studies inaugurated the Sally Ledger Memorial Bursary fund for postgraduate students in her honour .

neg: The Famous Five (series) The Famous Five is the name of a series of children 's adventure novels written by English author Enid Blyton . The first book , Five on a Treasure Island , was published in 1942 . The novels feature the adventures of a group of young children -- Julian , Dick , Anne and Georgina ( George ) -- and their dog Timmy .   The stories take place in the children 's school holidays after they have returned from their respective boarding schools . Each time they meet they get caught up in an adventure , often involving criminals or lost treasure . Sometimes the scene is set close to George 's family home at Kirrin Cottage in Dorset , such as the picturesque Kirrin Island , owned by George and her family in Kirrin Bay . George 's own home and various other houses the children visit or stay in are hundreds of years old and often contain secret passages or smugglers ' tunnels .   In some books the children go camping in the countryside , on a hike or holiday together elsewhere . The settings , however , are almost always rural and enable the children to discover the simple joys of cottages , islands , the English and Welsh countryside and sea shores , as well as an outdoor life of picnics , lemonade , bicycle trips and swimming .   Blyton intended to write only six or eight books in the series , but owing to their high sales and immense commercial success she went on to write twenty-one full-length Famous Five novels , as well as a number of other series in similar style following groups of children discovering crime on holiday in the countryside . By the end of 1953 more than six million copies had been sold . Today , more than two million copies of the books are sold each year , making them one of the biggest-selling series for children ever written , with sales totalling over a hundred million . All the novels have been adapted for television , and several have been adapted as films in various countries .   Blyton 's publisher , Hodder & Stoughton , first used the term `` The Famous Five '' in 1951 , after nine books in the series had been published . Before this , the series was referred to as `` The ` Fives ' Books '' .

neg: The Railway Series The Railway Series is a set of story books about a railway system located on the fictional Island of Sodor . There are 42 books in the series , the first being published in 1945 . Twenty-six were written by the Rev. Wilbert Awdry , up to 1972 . A further 16 were written by his son , Christopher Awdry ; 14 between 1983 and 1996 , and two more in 2007 and 2011 .   Nearly all of The Railway Series stories were based upon real-life events . As a lifelong railway enthusiast , Awdry was keen that his stories should be as realistic as possible . The engine characters were almost all based upon real classes of locomotive , and some of the railways themselves were directly based upon real lines in the British Isles .   Characters and stories from the books formed the basis of the children 's television series Thomas and Friends .   Audio adaptations of The Railway Series have been recorded at various times under the title The Railway Stories .

neg: Waverley Novels The Waverley Novels is a long series of novels by Sir Walter Scott ( 1771 -- 1832 ) . For nearly a century , they were among the most popular and widely read novels in all of Europe .   Because Scott did not publicly acknowledge authorship until 1827 , the series takes its name from Waverley , the first novel of the series released in 1814 . The later books bore the words `` by the author of Waverley '' on their title pages .   The Tales of my Landlord sub-series was not advertised as `` by the author of Waverley '' and thus is not always included as part of the Waverley Novels series .

neg: Ophelia Dahl Ophelia Magdalena Dahl ( born 12 May 1964 ) is a British social justice and health care advocate .   As of January 2008 , Dahl is the president and executive director of Partners In Health ( PIH ) , a Boston , Massachusetts-based non-profit health care organization dedicated to providing a `` preferential option for the poor . '' She first encountered Paul Farmer , the future co-founder of PIH , as an eighteen-year-old volunteer in Haiti , and has since dedicated her life to advocating for social justice and healthcare equity .   As a co-founder and key member of the PIH team , Dahl was featured prominently in Mountains Beyond Mountains : The Quest of Dr. Paul Farmer , a Man Who Would Cure the World , Tracy Kidder 's book describing the work of the organization and the life of Dr. Farmer . In December 2006 , Ophelia Dahl and Paul Farmer received the Union Medal from Union Theological Seminary in New York . Dahl and the Partners in Health team is featured in the 2017 documentary film , Bending The Arc .   Dahl is the daughter of actress Patricia Neal and author Roald Dahl . Dahl contributed to the 2003 book The Roald Dahl Treasury , a collection of her father 's stories , memoirs , letters and poetry , and is currently writing a memoir of her father . She is a trustee of the Roald Dahl Museum and Story Centre , a registered charity with the mission of `` telling Roald Dahl 's life story , to care for his archive and to promote a love of creative writing in everyone . ''   Dahl graduated from Wellesley College as a Davis Scholar and delivered Wellesley 's 2006 commencement address .   In 2011 , she was named by the Boston Globe as one of the three Bostonians of the Year , along with her Partners in Health co-founder , Paul Farmer and a senior member of Partners in Health , Louise Ivers . This was mainly due to her and the charity 's response to the 2010 Haiti earthquake . She has also been selected by Social Capital Inc. ( SCI ) as a 2011 SCI Idealist Award recipient , to be given on 30 March 2011 .

neg: William Blake in popular culture William Blake 's body of work has influenced countless writers , poets and painters , and his legacy is often apparent in modern popular culture . His artistic endeavours , which included songwriting in addition to writing , etching and painting , often espoused a sexual and imaginative freedom that has made him a uniquely influential figure , especially since the 1960s . After Shakespeare , far more than any other canonical writer , his songs have been set and adapted by popular musicians including U2 , Jah Wobble , Tangerine Dream , Bruce Dickinson and Ulver . Folk musicians , such as M. Ward , have adapted or incorporated portions of his work in their music , and figures such as Bob Dylan , Alasdair Gray and Allen Ginsberg have been influenced by him . The genre of the graphic novel traces its origins to Blake 's etched songs and Prophetic Books , as does the genre of fantasy art .

neg: Dr. Seuss bibliography Theodor Seuss Geisel , better known as Dr. Seuss , published over 60 children 's books over the course of his long career . Though most were published under his well-known pseudonym , Dr. Seuss , he also authored over a dozen books as Theo . LeSieg and one as Rosetta Stone . As one of the most popular children 's authors of all time , Geisel 's books have topped many bestseller lists , sold over 222 million copies , and been translated into more than 15 languages . In 2000 , when Publishers Weekly compiled their list of the best-selling children 's books of all time ; 16 of the top 100 hardcover books were written by Geisel , including Green Eggs and Ham , at number 4 , The Cat in the Hat , at number 9 , and One Fish Two Fish Red Fish Blue Fish , at number 13 , and Dr. Seuss 's ABC . In the years following his death in 1991 , several additional books based on his sketches and notes were published , including Hooray for Diffendoofer Day ! and Daisy-Head Mayzie . Although they were all published under the name Dr. Seuss , only My Many Colored Days , originally written in 1973 , was entirely by Geisel .

neg: Welsh literature in English Anglo-Welsh literature and Welsh writing in English are terms used to describe works written in the English language by Welsh writers . It has been recognised as a distinctive entity only since the 20th century . The need for a separate identity for this kind of writing arose because of the parallel development of modern Welsh-language literature ; as such it is perhaps the youngest branch of English-language literature in the British Isles .   Welsh writers in English have traditionally favoured the short story form over the novel for two main reasons : in a society lacking sufficient wealth to support professional writers , the amateur writer was able to spare time only for short bursts of creativity ; and , like poetry , it concentrated linguistic delight and exuberance . However , the genre did not develop in these writers much beyond its origin in rural sketches . Satire was avoided , and , since the main market was London publishers , the short stories tended to focus on the eccentricities ( as seen from a metropolitan viewpoint ) of Welsh life .

neg: Penguin Celebrations Penguin Celebrations was a book series released by Penguin Books in 2008 , Penguin re-released 36 modern popular works using Penguin 's distinctive late 1940s style , rebranded ` Penguin Celebrations ' . Following the 1940s style ; Green is for ` mystery ' , Orange for ` fantastic fiction ' , Pink for ` distant lands ' , Dark Blue for ` real lives ' and Purple for ` viewpoints ' .   The ` Penguin Celebrations ' books are as follows :  Fiction  William Boyd - Any Human Heart  Jonathan Coe - What a Carve Up !  Jonathan Safran Foer - Everything Is Illuminated  Zoë Heller - Notes on a Scandal  Nick Hornby - How to Be Good  Marian Keyes - The Other Side of the Story  Matthew Kneale - English Passengers  Hari Kunzru - The Impressionist  Marina Lewycka - A Short History of Tractors in Ukrainian  Meg Rosoff - How I Live Now  Ali Smith - The Accidental  Zadie Smith - White Teeth  Sue Townsend - Adrian Mole and the Weapons of Mass Destruction  Pat Barker - Regeneration   Non-fiction  Noam Chomsky - Hegemony or Survival  Niall Ferguson - Empire  Robin Lane Fox - The Classical World  Malcolm Gladwell - Blink  Brian Greene - The Fabric of the Cosmos  Steven Levitt and Stephen J. Dubner - Freakonomics  James Lovelock - The Revenge of Gaia  Eric Schlosser - Fast Food Nation   Crime  Donna Tartt - The Secret History  P. D. James - A Certain Justice  John Mortimer - Rumpole and the Penge Bungalow Murders  Alex Garland - The Beach  Barbara Vine - The Chimney-sweeper 's Boy   Travel and adventure  Ryszard Kapuściński - The Shadow of the Sun  Redmond O'Hanlon - Congo Journey  Paul Theroux - Dark Star Safari   Biography  Charles Nicholl - Leonardo da Vinci : Flights of the Mind  Claire Tomalin - Jane Austen : A Life  Jeremy Paxman - The English   Essays  Alain de Botton - The Consolations of Philosophy  Jeremy Clarkson - The World According to Clarkson  Alistair Cooke - Letter from America

neg: Danny, the Champion of the World Danny , the Champion of the World is a 1975 children 's book by Roald Dahl . The plot centers on Danny , a  young English boy , and his father , William , who live in a Gypsy caravan fixing cars for a living and partake in poaching pheasants . It was first published in 1975 in the United States by Alfred A. Knopf , Inc. and in the United Kingdom by Jonathan Cape .   It was adapted into a made-for-TV movie in 1989 by Thames Television which starred Jeremy Irons . It is based on Dahl 's adult short story `` Champion of the World '' which first appeared in print in The New Yorker magazine , as did some of the other short stories that would later be reprinted as Kiss Kiss ( 1960 ) . Peter Serafinowicz provides the English language audiobook recording .

neg: Roald Mandelstam Roald Charlsovich Mandelstam ( Роа́льд Ча́рльсович Мандельшта́м September 16 , 1932 , Leningrad - February 26 , 1961 , Leningrad ) was a Russian poet .

neg: An Experiment in Criticism An Experiment in Criticism is a 1961 book by C. S. Lewis in which he proposes that the quality of books should be measured not by how they are written , but by how they are read . To do this , the author describes two kinds of readers . One is what he calls the `` unliterary '' , and the other the `` literary '' . He proceeds to outline some of the differences between these two types of readers . For example , one characterization of an unliterary reader is that the argument `` I 've read it before '' is a conclusive reason not to read a book . In contrast , literary readers reread books many times , savoring certain passages , and attempting to glean more from subsequent readings .   Lewis also argued that judging books by whether they are `` lowbrow '' or `` highbrow '' is not necessarily fruitful ; many `` lowbrow '' books prove to be valuable to a literary reader willing to approach without prejudgment . He noted that books classified as `` lowbrow '' , such as science fiction , are also capable of inducing a passion to re-read and imparting experience which changes reader 's worldview . Lewis suggests that books which are capable of doing this may prove to have enduring merit regardless of their genre of origin . He suggested that attempting to judge the literary merit of books based on traditional criteria may not prove fruitful .   Thus , Lewis suggests that a quality book is one that someone , anyone will re-read . A highbrow view that such a book is poor quality has failed to appreciate whatever qualities merit re-reading by someone .


query: Hypothyroidism can cause mood changes.

pos: Hypothyroidism Hypothyroidism , also called underactive thyroid or low thyroid , is a common disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone . It can cause a number of symptoms , such as poor ability to tolerate cold , a feeling of tiredness , constipation , depression , and weight gain . Occasionally there may be swelling of the front part of the neck due to goitre . Untreated hypothyroidism during pregnancy can lead to delays in growth and intellectual development in the baby , which is called cretinism .   Worldwide , too little iodine in the diet is the most common cause of hypothyroidism . In countries with enough iodine in the diet , the most common cause of hypothyroidism is the autoimmune condition Hashimoto 's thyroiditis . Less common causes include : previous treatment with radioactive iodine , injury to the hypothalamus or the anterior pituitary gland , certain medications , a lack of a functioning thyroid at birth , or previous thyroid surgery . The diagnosis of hypothyroidism , when suspected , can be confirmed with blood tests measuring thyroid-stimulating hormone ( TSH ) and thyroxine levels .   Prevention at the population level has been with the universal salt iodization . Hypothyroidism can be treated with levothyroxine . The dose is adjusted according to symptoms and normalization of the thyroxine and TSH levels . Thyroid medication is safe in pregnancy . While a certain amount of dietary iodine is important , excessive amounts can worsen certain types of hypothyroidism .   Worldwide about one billion people are estimated to be iodine deficient ; however , it is unknown how often this results in hypothyroidism . In the United States , hypothyroidism occurs in 0.3 -- 0.4 % of people . Subclinical hypothyroidism , a milder form of hypothyroidism characterized by normal thyroxine levels and an elevated TSH level , is thought to occur in 4.3 -- 8.5 % of people in the United States . Hypothyroidism is more common in women than men . People over the age of 60 are more commonly affected . Dogs are also known to develop hypothyroidism and in rare cases cats and horses can also have the disorder . The word `` hypothyroidism '' is from Greek hypo - meaning `` reduced '' , thyreos for `` shield '' , and eidos for `` form . ''

neg: Global perceptions of autism This article discusses diagnosis , treatment , and experiences of autism globally . Although the diagnosis of autism is rising in post-industrial nations , diagnosis rates are much lower in developing nations . Reasons given by researchers for this discrepancy include more awareness and better detection in developed nations and cultural differences such that symptoms associated with autism may be considered normal behavior in some cultures . However , many scientists theorize that other factors may also be responsible for the increasing rates in post-industrial countries . Some claim that about one third of ASD is due to immune dysregulation during pregnancy . That is , anything that causes an inflammatory response in the pregnant mother , such as infection or an immune disorder , may expose the fetal brain to inflammatory signals and disrupt development . For example , mothers with celiac disease have an increased chance of autism by 350 percent , while those with rheumatoid arthritis have an elevated risk of 80 percent .

neg: Endophenotype Endophenotype is a genetic epidemiology term which is used to separate behavioral symptoms into more stable phenotypes with a clear genetic connection . The concept was coined by Bernard John and Kenneth R. Lewis in a 1966 paper attempting to explain the geographic distribution of grasshoppers . They claimed that the particular geographic distribution could not be explained by the obvious and external `` exophenotype '' of the grasshoppers , but instead must be explained by their microscopic and internal `` endophenotype . ''   The next major use of the term was in psychiatric genetics , to bridge the gap between high-level symptom presentation and low-level genetic variability , such as single nucleotide polymorphisms . It is therefore more applicable to more heritable disorders , such as bipolar disorder and schizophrenia . Since then , the concept has expanded to many other fields , such as the study of ADHD , addiction , Alzheimer 's disease obesity and cystic fibrosis . Some other terms which have a similar meaning but do not stress the genetic connection as highly are `` intermediate phenotype '' , `` biological marker '' , `` subclinical trait '' , `` vulnerability marker '' , and `` cognitive marker '' . The strength of an endophenotype is its ability to differentiate between potential diagnoses that present with similar symptoms .

neg: Parathyroid gland Parathyroid glands are small endocrine glands in the neck of humans and other tetrapods that produce parathyroid hormone . Humans usually have four parathyroid glands , variably located on the back of the thyroid gland -- considerable variation exists . Parathyroid hormone and calcitonin ( one of the hormones made by the thyroid gland ) have key roles in regulating the amount of calcium in the blood and within the bones .   Parathyroid glands share a similar blood supply , venous drainage , and lymphatic drainage to the thyroid glands . Parathyroid glands are derived from the epithelial lining of the third and fourth branchial pouches , with the superior glands arising from the fourth pouch , and the inferior glands arising from the higher third pouch . The relative position of the inferior and superior glands , which are named according to their final location , changes because of the migration of embryological tissues .   Hyperparathyroidism and hypoparathyroidism , characterized by alterations in the blood calcium levels and bone metabolism , are states of surplus or insufficient parathyroid function .

neg: Sleep state misperception Sleep state misperception ( SSM ) is a term in the International Classification of Sleep Disorders ( ICSD ) most commonly used for people who mistakenly perceive their sleep as wakefulness , though it has been proposed that it be applied to those who severely overestimate their sleep time as well ( `` positive '' sleep state misperception ) . While most sleepers with this condition will report not having slept in the previous night at all or having slept very little , clinical recordings generally show normal sleep patterns . Though the sleep patterns found in those with SSM have long been considered indistinguishable from those without , some preliminary research suggest there may be subtle differences ( see Symptoms and diagnosis : Spectral analysis ) .   Patients are otherwise generally in good health , and any ills -- such as depression -- appear to be more associated with fear of negative consequences of insomnia ( `` insomnia phobia '' ) than from any actual loss of sleep .   Sleep state misperception was adopted by the ICSD to replace two previous diagnostic terminologies : `` subjective insomnia complaint without objective findings '' and `` subjective sleepiness complaint without objective findings . ''   Other synonyms of the term include : paradoxical insomnia , pseudo-insomnia , subjective insomnia , subjective sleepiness , and sleep hypochondriasis .

neg: Intermittent explosive disorder Intermittent explosive disorder ( sometimes abbreviated as IED ) is a behavioral disorder characterized by explosive outbursts of anger and violence , often to the point of rage , that are disproportionate to the situation at hand ( e.g. , impulsive screaming triggered by relatively inconsequential events ) . Impulsive aggression is unpremeditated , and is defined by a disproportionate reaction to any provocation , real or perceived . Some individuals have reported affective changes prior to an outburst ( e.g. , tension , mood changes , energy changes , etc. ) .   The disorder is currently categorized in the Diagnostic and Statistical Manual of Mental Disorders ( DSM-5 ) under the `` Disruptive , Impulse-Control , and Conduct Disorders '' category . The disorder itself is not easily characterized and often exhibits comorbidity with other mood disorders , particularly bipolar disorder . Individuals diagnosed with IED report their outbursts as being brief ( lasting less than an hour ) , with a variety of bodily symptoms ( sweating , stuttering , chest tightness , twitching , palpitations ) reported by a third of one sample . Aggressive acts are frequently reported accompanied by a sensation of relief and in some cases pleasure , but often followed by later remorse .

neg: Hypermetabolism Hypermetabolism is the physiological state of increased rate of metabolic activity and is characterized by an abnormal increase in the body 's basal metabolic rate . Hypermetabolism is accompanied by a variety of internal and external symptoms , most notably extreme weight loss , and can also be a symptom in itself . This state of increased metabolic activity can signal underlying issues , especially hyperthyroidism or fatal familial insomnia . The drastic impact of the hypermetabolic state on patient nutritional requirements is often understated or overlooked as well .   Hypermetabolism typically occurs after significant injury to the body . In hospitals and institutions , the most common causes are infections , sepsis , burns , multiple traumas , fever , long-bone fractures , hyperthyroidism , prolonged steroid therapy , surgery and bone marrow transplants . Hypermetabolism may occur in particular in the brain after traumatic brain injury . The cause and location of hypermetabolic symptoms within the body can be accurately detected by PET scan . Symptoms will usually subside once the underlying illness or injury is treated .

neg: Hyperthyroidism Hyperthyroidism is the condition that occurs due to excessive production of thyroid hormone by the thyroid gland . Thyrotoxicosis is the condition that occurs due to excessive thyroid hormone of any cause and therefore includes hyperthyroidism . Some , however , use the terms interchangeably . Signs and symptoms vary between people and may include irritability , muscle weakness , sleeping problems , a fast heartbeat , heat intolerance , diarrhea , enlargement of the thyroid , and weight loss . Symptoms are typically less in the old and during pregnancy . An uncommon complication is thyroid storm in which an event such as an infection results in worsening symptoms such as confusion and a high temperature and often results in death . The opposite is hypothyroidism , when the thyroid gland does not make enough thyroid hormone .   Graves ' disease is the cause of about 50 % to 80 % of the cases of hyperthyroidism in the United States . Other causes include multinodular goiter , toxic adenoma , inflammation of the thyroid , eating too much iodine , and too much synthetic thyroid hormone . A less common cause is a pituitary adenoma . The diagnosis may be suspected based on signs and symptoms and then confirmed with blood tests . Typically blood tests show a low thyroid stimulating hormone ( TSH ) and raised T3 or T4 . Radioiodine uptake by the thyroid , thyroid scan , and TSI antibodies may help determine the cause .   Treatment depends partly on the cause and severity of disease . There are three main treatment options : radioiodine therapy , medications , and thyroid surgery . Radioiodine therapy involves taking iodine-131 by mouth which is then concentrated in and destroys the thyroid over weeks to months . The resulting hypothyroidism is treated with synthetic thyroid hormone . Medications such as beta blockers may control the symptoms , and anti-thyroid medications such as methimazole may temporarily help people while other treatments are having effect . Surgery to remove the thyroid is another option . This may be used in those with very large thyroids or when cancer is a concern . In the United States hyperthyroidism affects about 1.2 % of the population . It occurs between two and ten times more often in women . Onset is commonly between 20 and 50 years of age . Overall the disease is more common in those over the age of 60 years .

neg: Parkinson's disease Parkinson 's disease ( PD ) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system . The symptoms generally come on slowly over time . Early in the disease , the most obvious are shaking , rigidity , slowness of movement , and difficulty with walking . Thinking and behavioral problems may also occur . Dementia becomes common in the advanced stages of the disease . Depression and anxiety are also common occurring in more than a third of people with PD . Other symptoms include sensory , sleep , and emotional problems . The main motor symptoms are collectively called `` parkinsonism '' , or a `` parkinsonian syndrome '' .   The cause of Parkinson 's disease is generally unknown , but believed to involve both genetic and environmental factors . Those with a family member affected are more likely to get the disease themselves . There is also an increased risk in people exposed to certain pesticides and among those who have had prior head injuries while there is a reduced risk in tobacco smokers and those who drink coffee or tea . The motor symptoms of the disease result from the death of cells in the substantia nigra , a region of the midbrain . This results in not enough dopamine in these areas . The reason for this cell death is poorly understood , but involves the build-up of proteins into Lewy bodies in the neurons . Diagnosis of typical cases is mainly based on symptoms , with tests such as neuroimaging being used to rule out other diseases .   There is no cure for Parkinson 's disease . Initial treatment is typically with the antiparkinson medication L-DOPA ( levodopa ) , with dopamine agonists being used once levodopa becomes less effective . As the disease progresses and neurons continue to be lost , these medications become less effective while at the same time they produce a complication marked by involuntary writhing movements . Diet and some forms of rehabilitation have shown some effectiveness at improving symptoms . Surgery to place microelectrodes for deep brain stimulation has been used to reduce motor symptoms in severe cases where drugs are ineffective . Evidence for treatments for the non-movement-related symptoms of PD , such as sleep disturbances and emotional problems , is less strong .   In 2015 , PD affected 6.2 million people and resulted in about 117,400 deaths globally . Parkinson 's disease typically occurs in people over the age of 60 , of which about one percent are affected . Males are more often affected than females . When it is seen in people before the age of 50 , it is called young-onset PD . The average life expectancy following diagnosis is between 7 and 14 years . The disease is named after the English doctor James Parkinson , who published the first detailed description in An Essay on the Shaking Palsy , in 1817 . Public awareness campaigns include World Parkinson 's Day ( on the birthday of James Parkinson , 11 April ) and the use of a red tulip as the symbol of the disease . People with parkinsonism who have increased the public 's awareness of the condition include actor Michael J. Fox , Olympic cyclist Davis Phinney , and late professional boxer Muhammad Ali .

neg: Immunosuppressive drug Immunosuppressive drugs or immunosuppressive agents or antirejection medications are drugs that inhibit or prevent activity of the immune system . They are used in immunosuppressive therapy to :  Prevent the rejection of transplanted organs and tissues ( e.g. , bone marrow , heart , kidney , liver )  Treat autoimmune diseases or diseases that are most likely of autoimmune origin ( e.g. , rheumatoid arthritis , multiple sclerosis , myasthenia gravis , psoriasis , vitiligo , systemic lupus erythematosus , sarcoidosis , focal segmental glomerulosclerosis , Crohn 's disease , Behcet 's Disease , pemphigus , and ulcerative colitis ) .  Treat some other non-autoimmune inflammatory diseases ( e.g. , long term allergic asthma control ) , ankylosing spondylitis .   A common side-effect of many immunosuppressive drugs is immunodeficiency , because the majority of them act non-selectively , resulting in increased susceptibility to infections and decreased cancer immunosurveillance . There are also other side-effects , such as hypertension , dyslipidemia , hyperglycemia , peptic ulcers , lipodystrophy , moon face , liver and kidney injury . The immunosuppressive drugs also interact with other medicines and affect their metabolism and action . Actual or suspected immunosuppressive agents can be evaluated in terms of their effects on lymphocyte subpopulations in tissues using immunohistochemistry .   Immunosuppressive drugs can be classified into five groups :  glucocorticoids  cytostatics  antibodies  drugs acting on immunophilins  other drugs .

neg: Comedown (drugs) Comedown or crashing is the deterioration in mood that happens as a psychoactive drug , typically a stimulant , is either decreasing or is cleared from the blood and thus the cerebral circulation . The improvement and deterioration of mood ( euphoria and dysphoria ) are represented in the cognitive schema #Noun as high and low elevations ; thus , after the drug has elevated the mood ( a state known as a high ) , there follows a period of coming back down , which often has a distinct character from withdrawal in stimulants . Generally , a comedown ( `` down , '' `` low , '' sometimes `` crash '' ) can happen to anyone as a transient symptom , but in people who are dependent on the drug ( especially those addicted to it ) , it is an early symptom of withdrawal and thus can be followed by others . Various drug classes , most especially stimulants and to a lesser degree opioids and sedatives , are subject to comedowns . A milder analogous mood cycle can happen even with blood sugar levels ( thus sugar highs and sugar lows ) , which is especially relevant to people with diabetes mellitus and to parents and teachers managing children 's behavior , as well as in adults with ADHD . Stimulant comedowns are unique in that they often appear very abruptly after a period of focus or high , and are typically the more intensely dysphoric phase of withdrawal than that following complete elimination from the bloodstream . Besides general dysphoria , this phase can be marked by frustration , anger , anhedonia , social withdrawal , and other symptoms characteristic to a milder mixed episode in Bipolar Disorder . Alertness and other general stimulant effects are still present .

neg: Hypochondriasis Hypochondriasis , also known as hypochondria , health anxiety or illness anxiety disorder , refers to worry about having a serious illness . This debilitating condition is the result of an inaccurate perception of the condition of body or mind despite the absence of an actual medical condition . An individual suffering from hypochondriasis is known as a hypochondriac . Hypochondriacs become unduly alarmed about any physical or psychological symptoms they detect , no matter how minor the symptom may be , and are convinced that they have , or are about to be diagnosed with , a serious illness .   Often , hypochondria persists even after a physician has evaluated a person and reassured them that their concerns about symptoms do not have an underlying medical basis or , if there is a medical illness , their concerns are far in excess of what is appropriate for the level of disease . Many hypochondriacs focus on a particular symptom as the catalyst of their worrying , such as gastro-intestinal problems , palpitations , or muscle fatigue . To qualify for the diagnosis of hypochondria the symptoms must have been experienced for at least 6 months .   The DSM-IV-TR defines this disorder , `` Hypochondriasis '' , as a somatoform disorder and one study has shown it to affect about 3 % of the visitors to primary care settings . The newly published DSM-5 replaces the diagnosis of hypochondriasis with the diagnoses of `` somatic symptom disorder '' and `` illness anxiety disorder '' .   Hypochondria is often characterized by fears that minor bodily or mental symptoms may indicate a serious illness , constant self-examination and self-diagnosis , and a preoccupation with one 's body . Many individuals with hypochondriasis express doubt and disbelief in the doctors ' diagnosis , and report that doctors ' reassurance about an absence of a serious medical condition is unconvincing , or short-lasting . Additionally , many hypochondriacs experience elevated blood pressure , stress , and anxiety in the presence of doctors or while occupying a medical facility , a condition known as `` white coat syndrome '' . Many hypochondriacs require constant reassurance , either from doctors , family , or friends , and the disorder can become a disabling torment for the individual with hypochondriasis , as well as his or her family and friends . Some hypochondriacal individuals completely avoid any reminder of illness , whereas others frequently visit medical facilities , sometimes obsessively . Some sufferers may never speak about it .

neg: Long-term effects of alcohol consumption The long-term effects of alcohol ( ethanol ) consumption range from cardioprotective health benefits for low to moderate alcohol consumption in industrialized societies with higher rates of cardiovascular disease to severe detrimental effects in cases of chronic alcohol abuse . Health effects associated with alcohol intake in large amounts include an increased risk of alcoholism , malnutrition , chronic pancreatitis , alcoholic liver disease , and cancer . In addition , damage to the central nervous system and peripheral nervous system can occur from chronic alcohol abuse . The long-term use of alcohol is capable of damaging nearly every organ and system in the body . The developing adolescent brain is particularly vulnerable to the toxic effects of alcohol . In addition , the developing fetal brain is also vulnerable , and fetal alcohol spectrum disorders ( FASDs ) may result if pregnant mothers consume alcohol .   The inverse relation in Western cultures between alcohol consumption and cardiovascular disease has been known for over 100 years . Many physicians do not promote alcohol consumption , however , given the many health concerns associated with it , some suggest that alcohol should be regarded as a recreational drug , and promote exercise and good nutrition to combat cardiovascular disease . Others have argued that the benefits of moderate alcohol consumption may be outweighed by other increased risks , including those of injuries , violence , fetal damage , liver disease , and certain forms of cancer .   Withdrawal effects and dependence are also almost identical . Alcohol at moderate levels has some positive and negative effects on health . The negative effects include increased risk of liver diseases , oropharyngeal cancer , esophageal cancer and pancreatitis . Conversely moderate intake of alcohol may have some beneficial effects on gastritis and cholelithiasis . Of the total number of deaths and diseases caused by alcohol , most happen to the majority of the population who are moderate drinkers , rather than the heavy drinker minority . Chronic alcohol misuse and abuse has serious effects on physical and mental health . Chronic excess alcohol intake , or alcohol dependence , can lead to a wide range of neuropsychiatric or neurological impairment , cardiovascular disease , liver disease , and malignant neoplasms . The psychiatric disorders which are associated with alcoholism include major depression , dysthymia , mania , hypomania , panic disorder , phobias , generalized anxiety disorder , personality disorders , schizophrenia , suicide , neurologic deficits ( e.g. impairments of working memory , emotions , executive functions , visuospatial abilities and gait and balance ) and brain damage . Alcohol dependence is associated with hypertension , coronary heart disease , and ischemic stroke , cancer of the respiratory system , and also cancers of the digestive system , liver , breast and ovaries . Heavy drinking is associated with liver disease , such as cirrhosis . Excessive alcohol consumption can have a negative impact on aging .   Recent studies have focused on understanding the mechanisms by which moderate alcohol consumption confers cardiovascular benefit .

neg: Zona fasciculata The zona fasciculata constitutes the middle and also the widest zone of the adrenal cortex , sitting directly beneath the zona glomerulosa . Constituent cells are organized into bundles or `` fascicles '' .   The zona fasciculata chiefly produces glucocorticoids ( mainly cortisol in the human ) , which regulates the metabolism of glucose , especially in times of stress ( e.g. , part of the fight-or-flight response ) , it is stimulated by the hormone Adrenocorticotropic Hormone ( ACTH ) which is released from the anterior portion of the pituitary and axised upon this adrenal gland . This tissue also generates a small amount of weak androgens ( e.g. , dehydroepiandrosterone ) . The main source of androgens will come from the zona reticularis region . In certain animals such as rodents , the lack of 17alpha-hydroxylase results in the synthesis of corticosterone instead of cortisol .   Steroid-producing adrenal tumours and hyperplasia of the zona fasciculata result in excess cortisol production and are the cause for adrenal Cushing 's syndrome . The genetic disorder McCune-Albright syndrome can also present Cushing 's syndrome in affected patients .

neg: Mood ring A mood ring is a ring that contains a thermochromic element , such as liquid crystal , that changes colors based upon the temperature of the finger of the wearer . Most new rings come with a color chart indicating the supposed mood of the wearer based upon the colors indicated on the ring .   The mood ring was created in 1975 by two New York inventors , Josh Reynolds and Maris Ambats , who bonded liquid crystals with quartz stones set into rings . They initially retailed for $ 45 for a `` silvery setting '' and $ 250 for gold , and first sold at Bonwit Teller , rapidly becoming a fad in the 1970s .

neg: Mental health care in the Philippines Mental health is defined as `` a state of well-being in which every individual realizes his or her own potential , can cope with the normal stresses of life , can work productively and fruitfully , and is able to make a contribution to her or his community '' . The World Health Organization emphasized the importance of mental health by including it in their definition of health as `` a state of complete physical , mental and social well-being and not merely the absence of disease or infirmity . ''   Mental health care is the status of providing and maintaining psychological , psychiatric , and emotional health by means of diagnosis , treatment , and prevention of mental illnesses .   This article will survey the status of psychological , psychiatric , and emotional health care in the Philippines from both past and present programs .

neg: Inverse Warburg effect The term inverse Warburg effect was introduced by Lloyd Demetrius and colleagues ( 1,2 ) to describe the metabolic reprogramming observed in cortical regions of the brain during the prodromal phase of Alzheimer 's disease ( 3,4 ) and Parkinson 's disease ( 5,6 ) . This reprogramming refers to the up regulation of oxidative phosphorylation ( OxPhos ) in mitochondria of certain neurons -- a process which induces a hypermetabolic state in these neurons in an age dependent manner . The aging process is driven , in part , by an increase in molecular disorder and a concomitant decrease in enzymatic activity ( 7 ) leading to an impairment in the capacity of cells to appropriate energy from the external environment and to convert this energy into biosynthetic work . Consequently , the capacity of neurons to convert food derived fuel sources into ATP and to use this energy to maintain neuronal viability is susceptible to decline with age . However , age-induced mitochondrial dysfunction will induce a compensatory increase in OxPhos in certain sub-populations of neurons to maintain adequate energy production , and thereby ensure synaptic function and cell survival ( 8 ) . Within neurons of the aging brain an increase in OxPhos activity in intact mitochondria , and a redistribution of these mitochondria to sites which require high energy production has been documented ( 9 ) . Lloyd Demetrius and colleagues ( 1,2 ) have proposed this compensatory change as the fundamental and initiating event in the progression towards neurodegenerative diseases .   The inverse Warburg effect is postulated as the primary event in a cascade of metabolic changes ( The Inverse Warburg Hypothesis ) which ultimately leads to neuronal loss . The main energy currency in living organisms is ATP which must be continually generated to maintain cell viability . The energy is derived from two types of processes -- OxPhos which provides ~ 80 % of the total energy , and glycolysis which contributes the remaining ~ 20 % ( 10 ) ( Figure 1 ) .    In oncology , most cancer cells predominantly produce energy by the up-regulation of glycolysis . Malignant , rapidly growing tumor cells have glycolytic rates higher than those of their normal tissue of origin ( Figure 2 ) . This mode of metabolic reprogramming is now called the Warburg effect , after the Nobel Laureate , Otto Warburg , who proposed that up-regulation of glycolysis is a primary initiating event in the progression towards cancer ( 11 ) . Elevated glycolysis fuels anabolic processes that contribute to the rapid growth and cellular division associated with cancer ( 12 ) .   Epidemilogical studies have shown that cancer is inversely comorbid with both Alzheimer 's disease ( AD ) and Parkinson 's disease ( PD ) ( 13,14 ) . The molecular and bioenergetic basis for this inverse relation can be explained by invoking the Warburg effect as the fundamental cause of cancer and the Inverse Warburg effect as the fundamental cause of AD and PD ( 15 ) . Elevated glycolysis in cancer cells leads to the heightened production of lactate , the end product of glycolysis . Lactate has emerged as a key cerebral energy source that can provide energy via OxPhos ( 16 ) . Therefore , neurons with elevated OxPhos become critically dependent on an oxidative substrate , such as lactate-derived pyruvate , a key feature of the inverse Warburg effect ( Figure 3 ) . Elevated lactate production , associated with cancer , may therefore fuel the heightened metabolic demands of neurons within the brains of elderly patients . A hypermetabolic state , as predicted by the inverse Warburg effect , has been detected in the brains of individuals during the presymptomatic phase of AD and PD ( 3 -- 6 ) . However , the inability to switch to the Warburg effect not only restricts the development of cancer , but also curtails a potential source of lactate for hypermetabolic neurons within the brain . Under this scenario , neurons are starved and neurodegeneration ensues . Thus the Inverse Warburg Effect provides a holistic model which defines the role of aging as a risk factor for AD and PD , and also provides an explanation for the inverse relationship between cancer and neurodegenerative disorders .

neg: Optimism Optimism is a mental attitude -- a happy belief that the outcome of some specific endeavor , or outcomes in general , will be good . A common idiom used to illustrate optimism versus pessimism is a glass with water at the halfway point , where the optimist is said to see the glass as half full and the pessimist sees the glass as half empty .   The term derives from the Latin optimum , meaning `` best '' . Being optimistic , in the typical sense of the word , is defined as expecting the best possible outcome from any given situation . This is usually referred to in psychology as dispositional optimism . It thus reflects a belief that future conditions will work out for the best .   Theories of optimism include dispositional models , and models of explanatory style . Methods to measure optimism have been developed within both theoretical systems , such as various forms of the Life Orientation Test , for the original definition of optimism , or the Attributional Style Questionnaire designed to test optimism in terms of explanatory style .   Variation in optimism and pessimism is somewhat heritable and reflects biological trait systems to some degree . It is also influenced by environmental factors , including family environment , with some suggesting it can be learned . Optimism may also be linked to health .

neg: Synactive Theory of Newborn Behavioral Organization and Development The Synactive Theory of Newborn Behavioral Organization and Development ( Synaction n. , or Synactive adj. -LSB- from the Greek syn `` together '' and the Latin actio `` action , '' resulting in : `` together in action '' -RSB- ) suggests that development of the human fetus , and later newborn , proceeds through the constant balancing of approach and avoidance behaviors , leading to : 1 ) a continuous interaction of the subsystems ( i.e. , Autonomic , Motor , State and Attention/Interaction , and Regulatory ) and their increasingly defined delineations within the organism , that is the infant , and 2 ) the organism 's interaction with the environment at large . This process is aimed at bringing about the increasingly well-defined species-unique developmental agenda .   Figure 1 ( below ) , provides a graphic representation of the Synactive Theory of development , as applied to both fetal and newborn stages . It focuses upon the infant 's within-organism , four subsystems of functioning , and their continuous interaction with each other and with the environment across time ( i.e. , `` together in action , '' or synaction ) . The four subsystems include the :   Autonomic Subsystem : Expressed in the pattern of respiration ( e.g. , fast , slow , pauses ) color changes ( e.g. , pink , pale , red ) , neurological indicators ( e.g. , seizures , tremulousness ) , and visceral or gut signals such as bowel movements , gagging , and hiccoughing ;   Motor Subsystem : Observable through the tone , posture and movement patterns of the infant ;   State and Attention/Interaction Subsystem : Expressed via : 1 ) the range of states available to the infant ( i.e. , deep sleep , light sleep , drowsy , alert , hyperalert , and cry ) , 2 ) how clearly it is to observably differentiate one state from the other , and 3 ) the patterns of transitions from one state to another ( e.g. , smooth well-differentiated state transitions versus abrupt unorganized state transitions ) .   The attention/interaction system is set within this state continuum ( i.e. , from deep sleep to cry ) and represented by the infant 's ability to adjust the robustness and increasing refinement of an alert , attentive state . The infant uses this state to take in cognitive and social information from the environment as well as to bring forth and modify inputs from the surrounding world ; and   Regulatory Subsystem : Behaviorally represented via the observable strategies the infant uses ( Self-Regulation ) in maintaining a balanced , relatively stable and relaxed state of subsystem of functioning or in returning to this a state of subsystem functioning if imbalance , or stress has occurred within the subsystems .   An additional component of the regulatory subsystem is observable in the kind and amount of support offered by the caregiver ( e.g. , supporting a soft , tucked , flexed position of the infant 's arms and legs ) or by the environment ( e.g. , dimming the lights in the nursery ) . This Co-Regulation may be necessary to help the infant 's return to balance in situations when his/her own self-regulatory capacities are exceeded .   Reproduced with permission from Als , H. Toward a synactive theory of development : Promise for the assessment of infant individuality . Infant Mental Health Journal . 1982 : ( 3 ) : 229-243 ; p. 234 .   The graphic representation of the Synactive Theory above depicts the developing organism , that is , the infant , in constant interaction with the environment from within the womb to the newborn intensive care unit ( NICU ) , and the caregiving family 's support in the NICU , to the family in their home . Newborn infants are actively striving for their next steps in development , while depending upon `` good enough '' environments and care to assure progress along their developmental agenda .   The Synactive Theory of Development continues to be instrumental in guiding clinicians ( e.g. , neonatologist , nurses , psychologists , developmental specialists , physical/occupational therapists , etc. ) and researchers in their understanding of the often very small steps in development that prematurely born and other high risk newborns attempt to accomplish ( which are major steps for their immature or injured brain ) . This theory gives professionals the framework and tools with which to identify the infant 's strengths , challenges and accomplishments . Such accomplishments may include breathing , sucking and swallowing in a coordinated sequence ; moving food down into and through the stomach and intestinal track instead of upwards , leading to reflux and vomiting ; looking at the caregiver and breathing at the same time , as well as many others .   The Synactive Theory is the foundation of both : 1 ) the Assessment of Preterm Infants ' Behavior ( APIB ) , a standardized comprehensive newborn test , and 2 ) the Newborn Individualized Developmental Care and Assessment Program ( NIDCAP ) , which is the care and intervention approach , that focuses on each infant 's behavioral cues ( e.g. , hand ( s ) to mouth , bracing with feet against a supporting surface ) in order to support the infant 's strengths and reduce the infant 's vulnerabilities . The infant 's family is viewed as the infant 's most important nurturer and is integrated in all care from the infant 's birth on throughout the infant 's hospitalization .

neg: Darwinian Happiness Darwinian Happiness : Evolution As a Guide for Living and Understanding Human Behavior , ISBN 0-87850-159-2 , is a 2002 book by the Norwegian biologist Bjørn Grinde from the Norwegian Institute of Public Health . He argues that human emotions find their cause in evolution and offers ways by which we can use this for our advantage .   More specifically , mammals are equipped with a nerve system that enables them to distinguish not only between pleasant and unpleasant sensations , but positive and negative experiences in general . While the biological term fitness refers to the capacity to create offspring , happiness ( or quality of life ) is , at least in a biological perspective , a question of the qualities of the experiences our nervous system offers us .   In order to improve these experiences there are two main principles to consider :   To utilize the rewarding sensations the brain has evolved to offer in a way that gives optimal long-term benefits ; and , similarly , to avoid punishing sensations .  To avoid stress and maladaptive ways of living in order to have a healthy mind with optimal potential for positive experiences .   As to the first principle , humans may actually have been equipped with more powerful positive and negative sensations , compared to other mammals , due to our capacity for free will . That is , evolution might tend to add stronger incentives for behavior benefiting the genes in an individual with a powerful free will ; as otherwise , the free will could easily result in maladaptive behavior .   As to the second principle , it may be added that , as a rule of thumb , we ought to adapt our way of living to how we are designed by evolution to live . Current ideas in evolutionary medicine and evolutionary psychology suggest that mismatches between the environment of evolutionary adaptation and the present way of living may cause somatic and mental health problems . Such adverse mismatches , referred to as discords , are obviously detrimental to quality of life . For example , unlike Europeans , Indigenous Australians have not had many generations exposed to alcohol , and so are prone to alcohol abuse and the social deprivation it causes .

neg: Disruptive mood dysregulation disorder Disruptive mood dysregulation disorder ( DMDD ) is a mental disorder in children and adolescents characterized by a persistently irritable or angry mood and frequent temper outbursts that are disproportionate to the situation and significantly more severe than the typical reaction of same-aged peers . The symptoms of DMDD resemble those of attention deficit hyperactivity disorder ( ADHD ) , oppositional defiant disorder ( ODD ) , anxiety disorders , and childhood bipolar disorder .   DMDD first appeared as a disorder in the Diagnostic and Statistical Manual of Mental Disorders , Fifth Edition ( DSM-5 ) in 2013 and is classified as a mood disorder . Treatments include medication to manage mood symptoms as well as individual and family therapy to address emotion-regulation skills . Children with DMDD are at risk for developing depression and anxiety later in life .


query: Jon Watts has only ever been a plumber.

pos: Jon Watts Jon Watts ( born June 28 , 1981 ) is an American film director , producer and screenwriter . Watts directed and co-wrote the upcoming Marvel Studios and Sony Pictures produced Spider-Man : Homecoming , slated for a July 7 , 2017 release .  He directed the films Clown and Cop Car and episodes of the Onion News Network .

neg: James Watts (Mayor of Manchester) James Watts was Mayor of Manchester ( 1855 -- 1857 ) also High Sheriff of Lancashire and owner of Abney Hall . He was the owner of S & J Watts Ltd , who built the Watts Warehouse on Portland Street .  Watts was born March 1804 , and baptised on 15 April 1804 at St Thomas Ardwick and started his life as a weaver in Didsbury . He became partners with his brothers Samuel and John and became an important figure among British industrialists , socialising with politicians and churchmen at his home , Abney Hall , in Cheadle . He was elected a councillor for St James 's Ward , became mayor in 1855 , was re-elected in 1856 , and at the same time an alderman . Prince Albert chose to stay with him when he visited Manchester to open the Art Treasures Exhibition in 1857 , the queen awarded him a knighthood . Sir James was a J.P. for Manchester . He died 6 April 1878 .

neg: Noel Howlett Noel Howlett ( 22 December 1902 -- 26 October 1984 ) was an English actor , principally remembered as the incompetent headmaster , Morris Cromwell , in the ITV 1970s cult television programme Please Sir ! . He was the subject of infatuation by Deputy Head Doris Ewell , played by Joan Sanderson .   Howlett was born in Maidstone , Kent , and began his career as Richard Greatham in Noël Coward 's Hay Fever . At Northampton Repertory Theatre in 1930 he played Sherlock Holmes . He also appeared as Mr Williams in the 1948 film The Winslow Boy , starring Robert Donat . At Stratford-on-Avon in 1953 , he played Old Gobbo ( father to Donald Pleasence 's Launcelot Gobbo ) in The Merchant of Venice , Edward IV ( brother to Marius Goring 's Richard III ) , Baptista in The Taming of the Shrew and Gloucester in King Lear .   An early TV role was portraying a vicar in the 1958/59 BBC series Quatermass and the Pit . He appeared as Professor Rushton in a one-off 1967 edition ( `` Mission Highly Improbable '' ) of The Avengers and as the Reverend Simon Blanding in a one-off 1967 edition ( `` Dead Man 's Shoes '' ) of Man in a Suitcase . Other screen appearances include the 1960s TV shows Softly , Softly and Danger Man . He also appeared in one 1976 episode ( `` I Talk to the Trees '' ) of the BBC situation comedy The Good Life as slightly eccentric allotment gardener Mr Wakeley .   He also frequently broadcast and did a spell for the BBC as a member of their Drama Repertory Company ( now the Radio Drama Company ) , one of his appearances being as Inspector Walter Neider in the 1965 Paul Temple radio episode , `` Paul Temple and the Geneva Mystery '' .

neg: Justin Watts Justin Lee Watts ( born July 1 , 1990 ) is an American professional basketball player who last played for New Heroes Den Bosch of the Dutch Basketball League . He played college basketball for the University of North Carolina , where he won an NCAA Championship as a freshman in 2009 . He turned pro in 2013 and won a QBL Championship with the Rockhampton Rockets . He went on to play in Mexico , Japan , Uruguay and the Netherlands .

neg: Adam Watts (footballer) Adam James Watts ( born 4 March 1988 ) is an English footballer who plays as a defender and most recently played for Eastbourne Borough .   He has previously played for Fulham , Milton Keynes Dons and Northampton Town , Lincoln City and Gainsborough Trinity .

neg: Ten Mile, Tennessee Ten Mile is an unincorporated community in northern Meigs and southeastern Roane counties in the U.S. state of Tennessee .   Ten Mile is primarily a summer cottage community on Watts Bar Lake . It includes summer cottages , small locally owned stores and restaurants , a bank , marinas , resorts , churches , and a Post Office ( ZIP code 37880 ) . The nearby TVA Watts Bar nuclear plant ( in bordering Rhea County ) , and Watts Bar Dam spanning the Tennessee River across the Meigs County and Rhea County lines have played , and continue to play , an important role in the local economy .   Ten Mile originated in a small community at the cross of Old Ten Mile and Ten Mile roads , which is next to Ten Mile Creek . The community consisted of a small school , a post office and two churches . The town has now moved closer to Watts Bar Lake . The only things that still exist in the old community are the two churches .   The Ten Mile community is named after the stream flowing through it , Ten Mile Creek . Although there are no definitive archives to specifically document who named the stream Ten Mile Creek or why , based on early maps of the area , the best educated guess is that the distance of the creek measures approximately 10 miles .   The Ten Mile zip code 37880 had a 2010 population of 3,477 .

neg: James Wilby James Jonathon Wilby ( born 20 February 1958 ) is an English film , television and theatre actor .

neg: Jack Dishel Jack Dishel ( born Yevgeny Leonidovich Dishel ) is an American musician , actor , writer , comic and producer . Born in the Soviet Union , he grew up in the US from the age of three . He releases and performs music under the band name Only Son and was previously the lead guitarist for The Moldy Peaches .   On December 17 , 2015 , Dishel launched his new web series , '' : DRYVRS '' starring Macaulay Culkin , which amassed over 6 million views on its first day of release and within its first week online had been viewed more than 20 million times .

neg: Gary Plumley Gary Plumley ( born 24 March 1956 in Birmingham ) is an English former professional footballer who played in the Football League for Newport County , Hereford United and Cardiff City , and in the Hong Kong First Division League for Happy Valley .   A goalkeeper , Plumley made 187 appearances for Newport County in four spells with the club between 1976 and 1987 . He was part of the team that won the Welsh Cup and were promoted to the Third Division in the 1979 -- 80 season , and in the subsequent season reached the quarter-final of the 1981 European Cup Winners Cup , holding eventual runners-up Carl Zeiss Jena to a draw in the away leg before losing 1 -- 0 at home .   Plumley also played for Hereford United , Cardiff City , Happy Valley and Ebbw Vale .   Plumley 's father Eddie was chief executive of Watford , a family connection which led to him making a one-off appearance in the 1987 FA Cup semi-final . Watford goalkeeper Tony Coton broke a finger two weeks before the game leaving manager Graham Taylor needing to find cover for Steve Sherwood after the transfer deadline . In desperation , Taylor suggested to Eddie Plumley that they sign his son , who had by then retired from football . Plumley signed , Sherwood dislocated a finger , so Plumley played ; Tottenham Hotspur won the match 4 -- 1 . No fee had been agreed at the time but Graham Taylor wanted to pay Plumley . A few weeks later he received a cheque and went straight out and bought a fridge with it . They called it the Watford fridge .   Plumley became an estate agent in Newport . He is married to Debbie Johnsey , who represented Great Britain at show jumping at the 1976 Montreal Olympics . Their daughter Gemma Plumley is also an accomplished show jumper .

neg: Temperatures Rising Temperatures Rising is an American television sitcom that aired on the ABC network from September 12 , 1972 to August 29 , 1974 . During its 46-episode run , it was presented in three different formats and cast line-ups . The series was developed for the network by William Asher and Harry Ackerman for Ashmont Productions and Screen Gems . Set in a fictional Washington , D.C. hospital , the series featured James Whitmore as a no-nonsense chief of staff , forced to deal with the outlandish antics of a young intern ( Cleavon Little ) and three nurses ( Joan Van Ark , Reva Rose , and Nancy Fox ) .   For the first season , 26 episodes were produced and broadcast . In the second season , Whitmore was replaced in the lead role by comedian Paul Lynde , and Asher was replaced as producer by Duke Vincent and Bruce Johnson . The series was re-titled The New Temperatures Rising Show , and featured a new supporting cast : Sudie Bond , Barbara Cason , Jennifer Darling , Jeff Morrow , and John Dehner . Cleavon Little was the only returning member of the original cast . In this season , Lynde was presented as the penny-pinching chief of staff , with Bond as his nagging mother and owner of the hospital .   The New Temperatures Rising Show ran for 13 episodes before being placed on hiatus in January 1974 due to poor ratings . It returned in July in yet another incarnation . Asher returned as producer and restored the series to its original format -- albeit with Lynde continuing in the lead . Reverting to the original title of Temperatures Rising , Little remained in the show 's cast , accompanied by a new line-up of supporting players : Alice Ghostley , Barbara Rucker and , returning from the first season 's cast , Nancy Fox . Offered as a summer replacement on Thursday nights , the third version of the sitcom ran for seven episodes , after which it was cancelled permanently .

neg: Gordon Lord Gordon John Lord ( born 25 April 1961 ) is a former cricketer : a left-handed batsman who played for Warwickshire and Worcestershire , but who despite a promising start in which he played three Youth Tests for England never fulfilled this promise and retired well short of 100 first-class games .   After his matches for Young England in the West Indies in 1979-80 , Lord had to wait more than three years before making his senior debut for Warwickshire , in a John Player League game against Nottinghamshire in late August 1983 . He made 40 , and was retained for the County Championship match against the same opponents which immediately followed : in this he hit 61 and 29 to keep himself in the team for two more September Championship matches .   Lord had another few outings in 1984 , and had a longer run in the first team the following year . However , the highlights -- 199 against Yorkshire ( he was run out one short of what would have been his only double century ) and his only List A century , 103 against Derbyshire -- were overshadowed by his poor form at other times ; his second-highest first-class score that season was a mere 18 . Another forgettable summer , with few opportunities , followed , and Lord departed for rivals Worcestershire for the 1987 season .   At New Road , Lord was given more chances in the first team , and when he hit 862 first-class runs in 1988 it seemed that his career might receive the kick-start it so badly needed , but a wretched 1989 followed in which he averaged under 19 and made only two fifties all year . In the batsmans ' - dream summer of 1990 , he averaged over 45 , including a score of 190 against Hampshire in August , and finally broke through the 1,000-run mark , being awarded the county cap that had eluded him at Warwickshire . But it was a false dawn , and after another mediocre season in 1991 Lord 's first-class career came to a quiet end at Kidderminster , being dismissed for 3 in his only innings . He did , however , play two minor games for Herefordshire in the 1992 Holt Cup .   His uncle , Charles Watts , played one first-class match for Leicestershire in 1924 .

neg: Joan Ruddock Dame Joan Mary Ruddock , DBE ( née Anthony ; born 28 December 1943 ) is a British Labour Party politician who served as the Member of Parliament ( MP ) for Lewisham Deptford from 1987 to 2015 . Ruddock was Minister of State for Energy at the Department of Energy and Climate Change until 11 May 2010 . She stood down at the 2015 General Election .

neg: Willy Clarkson William Berry `` Willy '' Clarkson ( 1861 - 12 October 1934 ) was a theatrical costume designer and wigmaker .   A 1900 article in the theatrical newspaper The Era stated that `` Not to know Willy Clarkson and his doings is to be out of the theatrical world , for Willy Clarkson , with the bright and easy ( though sometimes anxious ) manner is ever hovering `` before and behind . '' Scarcely any big production in London is undertaken without the aid of the owner of the Wellington-street wiggeries . ''   Clarkson 's father had been making wigs since 1833 and Willy Clarkson took over his father 's business in 1878 . In an 1898 court case Clarkson was fined for the offence of employing women in a factory on a Sunday . Author James Morton described Clarkson as `` the more notorious of Soho 's blackmailers of the interwar years '' in his 2012 book Gangland Soho . Morton describes a public lavatory in Soho 's Dansey Place as being known locally as Clarkson 's Cottage , and wrote that Clarkson was an accomplished insurance fraudster , with 11 of 12 premises Clarkson occupied having burnt down .   Willy Clarkson drafted his will himself and did not leave the residue of his estate to any particular person . This meant that upon his death his estate would have been forfeit to the crown . A solicitor 's clerk , William C. Hobbs , then forged Clarkson 's will in his favour with the help of lawyer Edmond O'Connor . Hobbes was later sentenced to five years in prison for this crime and O'Connor seven .   A London County Council blue plaque unveiled in 1966 commemorates Clarkson at 41-43 Wardour Street in Soho . The foundation stone of Clarkson 's Wardour Street premises ( then Wellington Street ) was laid by the actress Sarah Bernhardt and the coping stone by actor Henry Irving . Clarkson 's occupied the building from 1905 to 1940 .   On his death in 1934 Clarkson was buried in a modest grave in the Actors ' Acre in Brookwood Cemetery .   Harry J. Greenwall published The Strange Life of Willy Clarkson : An Experiment in Biography in 1936 .

neg: Worst Episode Ever `` Worst Episode Ever '' is the eleventh episode of The Simpsons ' twelfth season . It first aired on the Fox network in the United States on February 4 , 2001 . In the episode , Bart and Milhouse are banned from The Android 's Dungeon after stopping Comic Book Guy from buying a box of priceless Star Wars memorabilia for $ 5 . However , when Comic Book Guy suffers a massive heart attack after Tom Savini 's show , he hires Bart and Milhouse as his replacements while he leaves his job to make friends .   `` Worst Episode Ever '' was written by Larry Doyle and directed by Matthew Nastuk . The series ' staff found it hard to make Comic Book Guy seem likable , since he is usually portrayed as sarcastic and unfriendly . The episode features actor and makeup artist Tom Savini as himself . In its original broadcast , the episode was seen by approximately 10 million viewers , finishing in 27th place in the ratings the week it aired . Since its broadcast , the episode received positive reviews from critics , and Hank Azaria won a Primetime Emmy Award for Outstanding Voice-Over Performance for his performance as Comic Book Guy in the episode .

neg: Robert Watts Robert Watts ( born 23 May 1938 ) is a British film producer who is best known for his involvement with the Star Wars and Indiana Jones film series .

neg: Lou Watts Louise `` Lou '' Watts ( born 4 June 1962 ) is a British musician , perhaps best known for her vocal work with anarcho-punk and later folk band , Chumbawamba .   Born in Burnley , Watts was member of Chumbawamba from their formation in 1982 until their disbandment in 2012 , making her the second-longest serving band member behind Boff Whalley . She joined Whalley , Danbert Nobacon and Midge and Tomi in 1982 to form the original line-up , and the band made their live debut in January of that year .   The band gained a reputation for their anarchist views , and gained popularity for their opposition to homophobia and fascism and support of feminism and gay rights .   Watts provided lead vocals for the band 's hit song Tubthumping , which gained them international recognition , and topped charts in Australia , Canada , Ireland , Italy and New Zealand as well as Tubthumping 's follow-up song Amnesia , which reached number 1 on the UK Singles Chart . They were also nominated for a Brit Award for `` Best British Single '' at the 1998 Brit Awards , at which they also performed .

neg: Jon Savage Jon Savage ( born Jonathan Malcolm Sage ; 2 September 1953 in Paddington , London ) is an English writer , broadcaster and music journalist , best known for his award-winning history of the Sex Pistols and punk music , England 's Dreaming , published in 1991 .

neg: Thirty-Minute Theatre Thirty-Minute Theatre is an anthology drama series of short plays shown on BBC Television between 1965 and 1973 , which was used in part at least as a training ground for new writers , on account of its short running length , and which therefore attracted many writers who later became well known . It was initially produced by Graeme MacDonald .   Thirty-Minute Theatre began on BBC2 in 1965 with an adaptation of the black comedy Parson 's Pleasure ( author , Roald Dahl ) . Dennis Potter contributed Emergency -- Ward 9 ( 1966 ) , which he partially recycled in the much later The Singing Detective ( 1986 ) . In 1967 BBC2 launched the UK 's first colour service , with the consequence that Thirty-Minute Theatre became the first drama series in the country to be shown in colour .   As well as single plays , the series showed several linked collections of plays , including a group of four plays by John Mortimer named after areas of London in 1972 , two three-part Inspector Waugh series starring Clive Swift in the title role , and a trilogy of plays by Jean Benedetti , broadcast in 1969 , focusing on infamous historical figures such as Adolf Hitler and Joseph Stalin . Other plays were broadcast by writers like Charlotte and Denis Plimmer ( The Chequers Manoeuvre , 1968 ) , David Rudkin ( Bypass , 1972 , and Atrocity , 1973 ) and Jack Rosenthal ( And For my Next Trick , 1972 ) .   Thirty-Minute Theatre was cancelled in August 1973 . Second City Firsts , also of 30 minutes duration , fulfilled much the same role .

neg: Heating and Domestic Engineers' Union The Heating and Domestic Engineers ' Union was a trade union representing a wide range of workers , particularly those involved with domestic pipework , in the United Kingdom .   The union was founded in 1872 as the Amalgamated Stove , Grate and Kitchen Range Fitters ' Protection Society . It hoped to compete with the Amalgamated Society of Engineers by restricting its membership to those in a specific trade , but was also less selective in deciding the qualifications for membership .   The union survived , but remained very small for many years with only 360 by the end of the century . It changed its name to the Amalgamated Society of Kitchen Range , Hot Water , Art Metal and Other Fitters Concerned with the Above Trades in 1887 , then to the United Society of Fitters and Smiths in 1898 .   In 1908 , the Amalgamated Society of Whitesmiths , Domestic Engineers and General Pipe Fitters and the Birmingham Society of Hot Water and Steam Engineers merged into the union , which changed its name to the National Union of Operative Heating and Domestic Engineers , Whitesmiths and General Iron Workers . It relocated its head office to Birmingham , and was finally able to claim a membership of more than 1,000 workers .   The Society of Smiths , Fitters , Hot Water and Steam Engineers merged into the union in 1911 . In 1948 , it renamed itself as the National Union of Operative Heating and Domestic Engineers and General Iron Workers , then in 1956 it shortened this to the `` Heating and Domestic Engineers ' Union '' .   In 1967 , the union merged into the National Union of Sheet Metal Workers and Coppersmiths .

neg: Jon Thompson Jon Thompson ( 1936 -- February 2016 ) was an artist , curator and academic known for his involvement in the development of the YBA artist generation .   As the Head of Goldsmiths Department of Art in the 1980s , Thompson opened up specialisms and allowed students to move freely between the different modes of practice , such as painting , sculpture , photography and printing , etc. . Jon was a consummate tutor and teacher - he was able to find the best in the many young artists he taught - offering insight and kind words when needed based on his broad understanding of the sector . He cared about all of his students and was able to encourage new ways of thinking , directing students to follow emerging themes and content . In the past his own art had moved from painting to a conceptual photography and sculpture , but since his retirement from teaching Thompson concentrated on a kind of abstract painting . This separated Goldsmiths from the dominance of art schools like St Martins . His discovery of the derelict Surrey Docks in the north of Southwark , enabled to him live in the empty Dock Offices alongside the large empty docks and open spaces . Students such as Eileen Cooper and Tony Bevan completed their BA in these studios , their work thriving on the large open space and Jon 's support . In 1988 Jon was involved in the curation of the now legendary Freeze warehouse exhibition along with various art students and Damien Hirst whom Thompson had accepted on to the course and tutored since that time . After a break from Goldsmiths , Jon Thompson became Head of the MA Fine Art course at Middlesex University 's School of Art ( previously Hornsey College of Art ) and lectured on artists such as Marcel Duchamp and Piero Manzoni . He also curated shows at the Hayward Gallery in London including Gravity and Grace and Falls the Shadow with Barry Barker .   2011 saw the publication of The Collected Writings of Jon Thompson by Ridinghouse , which brought together the collected writings of the British artist , writer and professor . These writings are just brilliant .

neg: Plumbers and Gasfitters Employees Union Building The Plumbers and Gasfitters Employees ' Union Building ( PGEUB ) is an office building for the Plumbers and Gasfitters Union , located in Melbourne , Victoria . It was commissioned in 1969 with architect Graeme Gunn to design it , in creative collaboration with landscape designer Ellis Stones , and Merchant Builders . Construction was completed in 1971 . The design itself was architecturally intended to be up to date .