query: A mixtape is now recorded onto CDs or MP3 playlists.

pos: Mixtape A mixtape ( also mix-tape or mix tape ) is a home-made compilation of music ( typically copyrighted songs taken from other sources ) recorded in a specific order , traditionally onto a cassette tape , though later replaced by CD or MP3 playlist formats . The songs can be sequential , or by beatmatching the songs and creating overlaps and fades between the end of one song and the beginning of another the tape may become a seamless whole . Compilations may include a selection of favorite songs , or music linked by theme or mood , perhaps tailored to the tape 's intended recipient .   Writing in 2004 , essayist Geoffrey O'Brien called the personal mix tape `` perhaps the most widely practiced American art form '' .   `` Mixtape '' is also used in hip hop to describe certain types of recordings , typically self-produced and independently released albums that are issued free of charge to gain publicity and/or circumvent possible copyright infringement .

neg: Dub music Dub is a genre of music that grew out of reggae in the 1960s , and is commonly considered a subgenre , though it has developed to extend beyond the scope of reggae . Music in this genre consists predominantly of instrumental remixes of existing recordings and is achieved by significantly manipulating and reshaping the recordings , usually by removing the vocals from an existing music piece , and emphasizing the drum and bass parts ( this stripped-down track is sometimes referred to as a riddim ) . Other techniques include dynamically adding extensive echo , reverb , panoramic delay , and occasional dubbing of vocal or instrumental snippets from the original version or other works . It was an early form of popular electronic music .   Dub was pioneered by Osbourne `` King Tubby '' Ruddock , Lee `` Scratch '' Perry , Errol Thompson and others in the late 1960s . Augustus Pablo is credited with bringing the melodica to dub , and is also among the pioneers and creators of the genre . Similar experiments with recordings at the mixing desk outside of the dancehall environment were also done by producers Clive Chin and Herman Chin Loy . These producers , especially Ruddock and Perry , looked upon the mixing console as an instrument , manipulating tracks to come up with something new and different .  Dub has influenced many genres of music , including rock ( most significantly the subgenre of post-punk and other kinds of punk ) , pop , hip hop , disco , and later house , techno , ambient , electronic dance music , and trip hop . Dub has become a basis for the genres of jungle and drum and bass Traditional dub has survived , and some of the originators , such as Lee `` Scratch '' Perry and Mad Professor , continue to produce new material .

neg: The Lost Tape (mixtape) The Lost Tape is the tenth mixtape by American hip hop recording artist 50 Cent . The mixtape , hosted by DJ Drama , is 50 Cent 's first `` Gangsta Grillz '' mixtape . It was released as a free download on May 22 , 2012 .

neg: Demo (music) A demo ( from `` demonstration '' ) is a song or group of songs recorded for limited circulation or reference use rather than for general public release . A demo is a way for a musician to approximate their ideas in a fixed format , such as cassette tape , compact disc , or digital audio files , and to thereby pass along those ideas to record labels , record producers , or to other artists .   Musicians often use demos as quick sketches to share with bandmates or arrangers or simply for personal reference during the songwriting process ; in other cases a songwriter might make a demo to send to artists in hopes of having the song professionally recorded , or a music publisher may need a simple recording for publishing or copyright purposes .

neg: Cold (mixtape) Cold is a mixtape by American electronic musician James Ferraro , recorded in New York City and released in March 2013 on the Hippos in Tanks label . The press release stated that Cold is about `` human drama '' that is a part of a nihilistic period , as well as `` the repetition and consumption of hedonism that can not represent or replace one night of love . '' Described by one journalist as a pastiche of contemporary R&B and hip-hop , Cold contains elements of two-step , dubstep , techno and lounge music styles . Reviews of the mixtape were very favorable in general , common praises including its production and the use of Ferraro 's own vocals .

neg: Now That's What I Call Music! 64 (UK series) This article describes an album in the UK Now ! series . It should not be confused with similarly or identically-titled albums belonging to different `` Now ! '' series . For more information , see Now That 's What I Call Music ! discography .   Now That 's What I Call Music ! 64 or Now 64 was released on 24 July 2006 on digital MP3 download , audio cassette and Compact Disc . The album is the 64th edition of the original ( UK ) Now ! series .   Now 64 features six songs which reached number one on the UK Singles Chart : `` Crazy '' , `` Maneater '' , `` Do n't Stop Me Now '' , `` I Wish I Was a Punk Rocker ( With Flowers in My Hair ) '' , `` Smile '' and `` So Sick '' . The Robin Beck song `` First Time '' previously featured on Now 14 in its original form . There is the tiniest of overlaps between MP3 and cassette in the history of NOW - this was the last UK Now Album to be released on tape , and only a very limited number of copies were made available . Compact Disc remains the largest-selling format to this day .

neg: List of compact disc player manufacturers This is a list of compact disc player manufacturers . A CD player is an electronic device that plays audio compact discs . CD players are often a part of home stereo systems , car audio systems , and personal computers . They are also manufactured as portable devices . Modern units can play other formats in addition to PCM audio coding used in CDs , such as MP3 , AAC and WMA . DJs often use players with an adjustable playback speed to alter the pitch and tempo of the music . CD playback functionality is also available on CD-ROM/DVD-ROM drive equipped computers as well as on DVD players and CD-ROM/DVD-ROM based game consoles .

neg: A Coming into Existence A Coming Into Existence was recorded June 16 , 1998 .  It was the first music released by Origin .  It was released on tape & cd .

neg: Double album A double album ( or double record ) is an audio album which spans two units of the primary medium in which it is sold , typically records and compact discs . A double album is usually though not always released as such , because the recording is longer than the capacity of the medium . Recording artists often think of double albums as comprising a single piece artistically ; however , there are exceptions such as John Lennon 's Some Time in New York City and Pink Floyd 's Ummagumma ( both examples of one studio record and one live album packaged together ) and OutKast 's Speakerboxxx/The Love Below ( effectively two solo albums , one by each member of the duo ) . A classic example of this idea is Works ( Volume One ) by Emerson Lake and Palmer , where side one was Keith Emerson , two Greg Lake , three Carl Palmer while side four was by the entire group .   Since the advent of the compact disc , albums are sometimes released with a bonus disc featuring additional material as a supplement to the main album , with live tracks , studio out-takes , cut songs , or older unreleased material . One innovation is the accompaniment of a CD with a DVD of related material , such as video related to the album or DVD-Audio versions of the same recordings . These could be regarded as a new form of double album ; some such discs were also released on a two-sided format called DualDisc . Due to the limitations of the gramophone record , many albums primarily released on the format were under 40 minutes long . This has led to record labels re-releasing two of these albums on one CD , thus making a double album .   The same principles apply to the triple album , which comprises three units . Packages with more units than three are often packaged as a box set .

neg: Tape recorder An audio tape recorder , tape deck or tape machine is an analog audio storage device that records and plays back sounds , including articulated voices , usually using magnetic tape , either wound on a reel or in a cassette , for storage . In its present-day form , it records a fluctuating signal by moving the tape across a tape head that polarizes the magnetic domains in the tape in proportion to the audio signal . Tape-recording devices include reel-to-reel tape deck and the cassette deck .   The use of magnetic tape for sound recording originated around 1930 . Magnetizable tape revolutionized both the radio broadcast and music recording industries . It gave artists and producers the power to record and re-record audio with minimal loss in quality as well as edit and rearrange recordings with ease . The alternative recording technologies of the era , transcription discs and wire recorders , could not provide anywhere near this level of quality and functionality . Since some early refinements improved the fidelity of the reproduced sound , magnetic tape has been the highest quality analog sound recording medium available . As of the first decade of the 21st century , analog magnetic tape has been largely replaced by digital recording technologies for consumer purposes , although some still record audio by analog .   Prior to the development of magnetic tape , magnetic wire recorders had successfully demonstrated the concept of magnetic recording , but they never offered audio quality comparable to the other recording and broadcast standards of the time . Some individuals and organizations developed innovative uses for magnetic wire recorders while others investigated variations of the technology . One particularly important variation was the application of an oxide powder to a long strip of paper . This German invention was the start of a long string of innovations that have led to present day magnetic tape recordings .

neg: Music of Life Music of Life is a British independent dance music label formed in 1986 by two influential DJ remixers , Froggy and Simon Harris , managed by Chris France . Following several successful productions , one of which reached No. 3 in the UK pop music charts ( The Real Thing 's ` You to me are Everything ' ) Harris and Froggy decided to launch their own label , they were offered a label deal by Morgan Khan ( Streetwave ) and the first release was a remix by the duo of Cerrone 's ` Supernature ' ( his ` Music of Life song was the inspiration for the label name ) . Within a few months Froggy left the label and Streetwave went out of business . Harris being active in remixing and production for many other artists and labels financed the label with his remix income . After the demise of Streetwave Harris and France decided to re-launch as a British hip-hop ( usually UK Hip Hop , ) music label . Music of Life opened an office in London 's Soho at 22 Hanway Street , Chris France and his sister Michelle spent their days in the busy Soho office whilst Simon could usually be found in his home studio ` The Bunker ' producing many of the Music of Life releases .   At first the label licensed new rap music from US production company Powerplay for the first compilation album ` Def Beats 1 ' but as an addition to the US material Harris produced an extra track , under his own ` Music of Life Productions ' recorded in London by the label 's A&R man Derek Boland . ` Rock the Beat ' by Derek B created a demand for British hip-hop and the demo tapes started to arrive , Music of Life signed the best artists instead of licensing more US material and Harris would produce many new songs featuring artists including M.C Duke , The Demon Boyz ( Million Dan ) , Thrashpack , Asher D and Daddy Freddy , CJ Macintosh & Einstein , She Rockers ( Betty Boo ) , Hijack and many more .   Many of these recordings broke ground and are still considered to be highly innovative , the first reggae/hip-hop combination ( Asher D & Daddy Freddy 's ` Ragamuffin Hip Hop ) and Derek B 's album would be licensed to US label ` Profile ' ( Run DMC ) , Hijack would be signed to Ice-T 's Rhyme syndicate label and many more . Music Week wrote that Music of Life was `` the most successful hip hop label in the UK right now '' , in 1988 . Record Mirror identified Music of Life as one of the few hip hop labels `` to believe in home grown talent '' . In 1989 , Studio Week magazine called Music of Life `` the foremost rap label in this country at the moment . ''   So far the Music of Life catalog of recordings and copyrights under Music of Life Productions and released on many labels worldwide including Music of Life have exceeded 2000 titles and include music videos and documentary TV shows ( ` Kings of Rap ' - MTV ) .   Music of Life is one of the UK 's longest running independent dance music labels ( 1986 -- present day ) and the catalog has been licensed and released in over 70 countries with many chart hits including the UK , Germany , Japan , France and the USA ( Harris 's ` Bass ' how low can you go ? was a No. 1 Billboard US chart hit ) and many Grammy award winning artists ( Luthor Vandross , REM , Beastie Boys , Beck ) have licensed from the Music of Life catalog .   Sister label ` Living Beat ' was launched in 1989 and would release many dance music , house and pop recordings with chart success including ` Supermarioland ' reaching No. 6 in the UK pop charts with Harris 's AKA ` Ambassadors of Funk ' in association with Nintendo , Samantha Fox 's Song for Europe entry ` Go for the Heart ' and was instrumental in helping Prince achieve his first UK No1 pop single ` The Most Beautiful Girl in the World ' .   Harris also produced the world 's best selling series of ` Breakbeat ' albums used by DJs and producers , ` Beats Breaks and Scratches ' in 12 volumes and worked with top artists Norman Cook ( Fatboy Slim ) , Paul Oakenfold , Afrika Bambaataa and George Clinton to produce and release similar albums that are part of the Music of Life catalog . Music of Life is now a registered trademark .   The Music of Life catalog includes songs from :   M.C. Duke & D.J. Leader 1  Thrashpack  She Rockers ( featuring * Betty Boo )  Daddy Freddy  Asher D  Tenor Fly  Nitty Gritty  Derek B  Hijack  Hardnoise  3 Knights  DJ Daddy  Leslie Lyrics  Norman Cook  Paul Oakenfold  George Clinton  Simon Harris ( label founder )  Einstein  Ambassadors of Funk  Afrika Bambaataa  Demon Boyz  Professor Griff  Clyde Stubblefield  Killa Instinct  S.L. Troopers  First Frontal Assault  Kobalt 60  Overlord X

neg: DVD authoring DVD authoring is the process of creating a DVD video capable of playing on a DVD player . DVD authoring software must conform to the specifications set by the DVD Forum .   DVD authoring is the second step in the process of producing finished DVDs . The first step is the creation of the movie ( or programme ) and the second , the authoring , is the creation of artwork , user menus , insertion of chapter points , overdubs/commentaries , setting autoplay and/or repeat options , etc. . The final step is the manufacturing ( replication ) process to mass-produce finished DVDs .   Strictly speaking , DVD authoring differs from the process of MPEG encoding , but most DVD authoring software has a built-in encoder , although separate encoders are still used when better quality or finer control over compression settings are required .   Most DVD-authoring applications focus exclusively on video DVDs and do not support the authoring of DVD-Audio discs .   Stand-alone DVD recorder units generally have basic authoring functions , though the creator of the DVD has little or no control over the layout of the DVD menus , which generally differ between models and brands .

neg: Music for Robots (website) Music For Robots is a mp3 blog written and curated by a collective of friends who originally met at Bates College , who founded the website in April 2004 . The blog made history in 2004 when it hosted a song by the band The Secret Machines provided to them by Warner Bros. . Records , signaling the first time a major label had deliberately encouraged a blog to post an mp3 by one of its artists . The site gained greater notoriety later that year when MTV aired a news feature about the site and one of their discoveries , a band of teenagers from Brooklyn called Hysterics . In 2005 , the `` robots '' branched out , dipping their toes in concert promotion and releasing a compilation CD titled Music For Robots , Vol . 1 , which included music from Hysterics , Avenue D , Death from Above 1979 , Stratageme , and Daedelus . Music ( For Robots ) are well known for their diverse , comprehensive musical tastes and willingness to cooperate with the record industry , and only post music with permission of the artist and/or label .   Music ( For Robots ) has been featured by many publications and programs in the mainstream media including Wired magazine , The New York Times , Rolling Stone , Spin , NPR , the Fresno Bee , The Guardian , The Philadelphia Inquirer , Entertainment Weekly , and was the first MP3 Blog to be featured in primetime TV during MTV 's TRL program in early 2005 .

neg: 05 Fuck Em 05 Fuck Em is a mixtape by American rapper Lil B . It was independently released on December 24 , 2013 , through Lil B 's own record label , BasedWorld Records . Intended to be spread across six discs , the mixtape is one of the longest mixtape releases by Lil B after the 676-track Free Music : The Complete MySpace Collection ( 2011 ) and 855 Song Based Freestyle Mixtape ( 2012 ) , verging on nearly six hours with 101 tracks .

neg: Now That's What I Call Music! 25 (U.S. series) Now That 's What I Call Music ! 25 was released on July 17 , 2007 . The album is the 25th edition of the Now ! series in the United States . It debuted at number one on the Billboard 200 , selling approximately 223,000 copies in its first week , and remained at number one in its second week , selling another 149,000 copies .   Now ! 25 contains three Billboard Hot 100 number-one hits , `` Girlfriend '' , `` Glamorous '' and `` Buy U a Drank ( Shawty Snappin ' ) '' , and has been certified Platinum by the RIAA .

neg: Audio mixing (recorded music) In sound recording and reproduction , audio mixing is the process of combining multitrack recordings into a single track and these tracks that are blended together are done so by using various processes such as EQ , Compression and Reverb . The track may be mixed in mono , stereo , or surround sound . There are numerous approaches , methods and techniques involved in Audio mixing ; some of these practices include levels setting , equalization , stereo panning , and effects . Audio mixing techniques and approaches can vary widely , and these can greatly affect the qualities of the sound recording .   Audio mixing techniques largely depend on music genres and the quality of sound recordings involved . The process is generally carried out by a mixing engineer , though sometimes the musical producer or music artist may assist . After mixing , a mastering engineer prepares the final product for production .   Audio mixing may be transferred onto a mixing console or digital audio workstation .

neg: Now That's What I Call Music! 43 (U.S. series) Now That 's What I Call Music ! 43 was released on August 7 , 2012 . It is the 43rd edition of the Now ! series in the United States . It debuted at number one on the Billboard 200 albums chart with sales of 111,000 copies in its first week of release , becoming the 16th number-one album in the series ' franchise .   Now ! 43 features two number-one Billboard Hot 100 hits , `` Call Me Maybe '' and `` Part of Me '' .   Instead of the main version of `` Payphone '' , which featured Wiz Khalifa , the `` No-rap '' version was included on this album .

neg: MD Data MD Data stands for MiniDisc Data , and is a magneto-optical medium for storing computer data . Sony wanted MD Data to replace floppy disks , but the Zip drive from Iomega ended up filling that market need and , later on , the advent of affordable CD writers and very cheap blank CD media , coupled with the availability of memory sticks and cards proved the final straw for MD Data .   The technology provided 140 MB of data storage , but it was slow and expensive . Also , data drives can only read or write audio MDs when set in `` play '' mode , which , however , does not provide computer access to the data .   MD Data appeared in products such as an MD still camera and an MD document scanner . MD Data was also used in the late 1990s in 4 - and 8-track multitrack recording decks . Meant as a step up from the popular 4-track cassette-based studios , these recorders enjoyed a brief prominence before they were replaced by relatively affordable -- and far more flexible -- direct-to-hard drive recording on Windows and Macintosh based computers . The format has always been hampered by the lack of an affordable MD Data drive with which to manipulate and back up data using a PC .   In 1997 , Sony introduced the MD Data2 format , which could hold 650 MB of data ( as opposed to MD Data 's 140 MB ) . However this format was only used by Sony 's DCM-M1 camcorder ( capable of still images and MPEG-2 video ) , and a few multitrack `` portastudio '' - style audio recorders such as Sony 's MDM-X4 and Tascam 's 564 , among others .   The introduction of Hi-MD in 2004 allowed any type of data ( files , music , etc. ) to be stored on a Hi-MD formatted MiniDisc . This allows for storage capacity of around 340MB on a standard MiniDisc and approx . 1GB on a new , higher-density Hi-MD .

neg: International Documentation of Electroacoustic Music The International Documentation of Electroacoustic Music ( EMDoku ) is an extensive online database , which contains detailed information on over 33000 works , 7000 authors as well as media ( CD , DVD , tape , etc. ) , labels and studios . Electroacoustic music is understood as an umbrella term for tape music , acousmatic music , electronic music , musique concrète , field recordings , computer music , radio art , sound art , sound installations , live electronics etc. , and includes performances and venues such as concert hall , radio , film , installation , media and internet .   The EMDoku is available in three forms on the internet :  as a static HTML site ( German , English , French , Spanish , Russian )  as a relational database with web interface  as a relational database over a TCP/IP-based network sharing   In addition to music and media science research , the documentation is intended to enable historically informed performance practice and interpretation research . It is considered as an `` essential initiative '' for the preservation of electroacoustic music .

neg: VinylDisc The VinylDisc is a combination of a digital layer , either in CD or DVD format , and an analog layer , which is a vinyl record , developed by the German company Optimal Media Production .  It consists of a silver layer containing CD or DVD and a black polyvinyl chloride layer ( able to hold 3.5 minutes of audio on 33 1/3 rpm ) which can be played on a regular phonograph .   Examples of singles already released in the hybrid format are Paramore 's `` Misery Business '' , The Mars Volta 's cover of `` Candy and a Currant Bun '' by Pink Floyd , and Fightstar 's `` Deathcar '' which reportedly had a limited run of 3000 copies . A sample VinylDisc to promote this new format was given to visitors of the 2007 Popkomm , containing music by Jazzanova , where it was presented in September 2007 .

neg: Sheet music Sheet music is a handwritten or printed form of music notation that uses modern musical symbols to indicate the pitches ( melodies ) , rhythms and/or chords of a song or instrumental musical piece . Like its analogs -- printed books or pamphlets in English , Arabic or other languages -- the medium of sheet music typically is paper ( or , in earlier centuries , papyrus or parchment ) , although the access to musical notation since the 1980s has included the presentation of musical notation on computer screens and the development of scorewriter computer programs that can notate a song or piece electronically , and , in some cases , `` play back '' the notated music using a synthesizer or virtual instruments .   Use of the term `` sheet '' is intended to differentiate written or printed forms of music from sound recordings ( on vinyl record , cassette , CD ) , radio or TV broadcasts or recorded live performances , which may capture film or video footage of the performance as well as the audio component . In everyday use , `` sheet music '' ( or simply `` music '' ) can refer to the print publication of commercial sheet music in conjunction with the release of a new film , TV show , record album , or other special or popular event which involves music . The first printed sheet music made with a printing press was made in 1473 .   Sheet music is the basic form in which Western classical music is notated so that it can be learned and performed by solo singers or instrumentalists or musical ensembles . Many forms of traditional and popular Western music are commonly learned by singers and musicians `` by ear '' , rather than by using sheet music ( although in many cases , traditional and pop music may also be available in sheet music form ) .   `` Score '' is a common alternative ( and more generic ) term for sheet music , and there are several types of scores , as discussed below . The term `` score '' can also refer to theatre music , orchestral music or songs written for a play , musical , opera or ballet , or to music or songs written for a television programme or film ; for the last of these , see Film score .


query: Depression is a symptom of Hypothyroidism.

pos: Hypothyroidism Hypothyroidism , also called underactive thyroid or low thyroid , is a common disorder of the endocrine system in which the thyroid gland does not produce enough thyroid hormone . It can cause a number of symptoms , such as poor ability to tolerate cold , a feeling of tiredness , constipation , depression , and weight gain . Occasionally there may be swelling of the front part of the neck due to goitre . Untreated hypothyroidism during pregnancy can lead to delays in growth and intellectual development in the baby , which is called cretinism .   Worldwide , too little iodine in the diet is the most common cause of hypothyroidism . In countries with enough iodine in the diet , the most common cause of hypothyroidism is the autoimmune condition Hashimoto 's thyroiditis . Less common causes include : previous treatment with radioactive iodine , injury to the hypothalamus or the anterior pituitary gland , certain medications , a lack of a functioning thyroid at birth , or previous thyroid surgery . The diagnosis of hypothyroidism , when suspected , can be confirmed with blood tests measuring thyroid-stimulating hormone ( TSH ) and thyroxine levels .   Prevention at the population level has been with the universal salt iodization . Hypothyroidism can be treated with levothyroxine . The dose is adjusted according to symptoms and normalization of the thyroxine and TSH levels . Thyroid medication is safe in pregnancy . While a certain amount of dietary iodine is important , excessive amounts can worsen certain types of hypothyroidism .   Worldwide about one billion people are estimated to be iodine deficient ; however , it is unknown how often this results in hypothyroidism . In the United States , hypothyroidism occurs in 0.3 -- 0.4 % of people . Subclinical hypothyroidism , a milder form of hypothyroidism characterized by normal thyroxine levels and an elevated TSH level , is thought to occur in 4.3 -- 8.5 % of people in the United States . Hypothyroidism is more common in women than men . People over the age of 60 are more commonly affected . Dogs are also known to develop hypothyroidism and in rare cases cats and horses can also have the disorder . The word `` hypothyroidism '' is from Greek hypo - meaning `` reduced '' , thyreos for `` shield '' , and eidos for `` form . ''

neg: Mental health care in the Philippines Mental health is defined as `` a state of well-being in which every individual realizes his or her own potential , can cope with the normal stresses of life , can work productively and fruitfully , and is able to make a contribution to her or his community '' . The World Health Organization emphasized the importance of mental health by including it in their definition of health as `` a state of complete physical , mental and social well-being and not merely the absence of disease or infirmity . ''   Mental health care is the status of providing and maintaining psychological , psychiatric , and emotional health by means of diagnosis , treatment , and prevention of mental illnesses .   This article will survey the status of psychological , psychiatric , and emotional health care in the Philippines from both past and present programs .

neg: Problem gambling Problem gambling ( or ludomania , but usually referred to as `` gambling addiction '' or `` compulsive gambling '' ) is an urge to gamble continuously despite harmful negative consequences or a desire to stop . Problem gambling is often defined by whether harm is experienced by the gambler or others , rather than by the gambler 's behaviour . Severe problem gambling may be diagnosed as clinical pathological gambling if the gambler meets certain criteria . Pathological gambling is a common disorder that is associated with both social and family costs .   The DSM-5 has re-classified the condition as an addictive disorder , with sufferers exhibiting many similarities to those who have substance addictions .  The term gambling addiction has long been used in the recovery movement . Pathological gambling was long considered by the American Psychiatric Association to be an impulse control disorder rather than an addiction . However , data suggest a closer relationship between pathological gambling and substance use disorders than exists between PG and obsessive-compulsive disorder , largely because the behaviors in problem gambling and most primary substance use disorders ( i.e. , those not resulting from a desire to `` self-medicate '' for another condition such as depression ) seek to activate the brain 's reward mechanisms while the behaviors characterizing obsessive-compulsive disorder are prompted by overactive and misplaced signals from the brain 's fear mechanisms .

neg: Long-term effects of alcohol consumption The long-term effects of alcohol ( ethanol ) consumption range from cardioprotective health benefits for low to moderate alcohol consumption in industrialized societies with higher rates of cardiovascular disease to severe detrimental effects in cases of chronic alcohol abuse . Health effects associated with alcohol intake in large amounts include an increased risk of alcoholism , malnutrition , chronic pancreatitis , alcoholic liver disease , and cancer . In addition , damage to the central nervous system and peripheral nervous system can occur from chronic alcohol abuse . The long-term use of alcohol is capable of damaging nearly every organ and system in the body . The developing adolescent brain is particularly vulnerable to the toxic effects of alcohol . In addition , the developing fetal brain is also vulnerable , and fetal alcohol spectrum disorders ( FASDs ) may result if pregnant mothers consume alcohol .   The inverse relation in Western cultures between alcohol consumption and cardiovascular disease has been known for over 100 years . Many physicians do not promote alcohol consumption , however , given the many health concerns associated with it , some suggest that alcohol should be regarded as a recreational drug , and promote exercise and good nutrition to combat cardiovascular disease . Others have argued that the benefits of moderate alcohol consumption may be outweighed by other increased risks , including those of injuries , violence , fetal damage , liver disease , and certain forms of cancer .   Withdrawal effects and dependence are also almost identical . Alcohol at moderate levels has some positive and negative effects on health . The negative effects include increased risk of liver diseases , oropharyngeal cancer , esophageal cancer and pancreatitis . Conversely moderate intake of alcohol may have some beneficial effects on gastritis and cholelithiasis . Of the total number of deaths and diseases caused by alcohol , most happen to the majority of the population who are moderate drinkers , rather than the heavy drinker minority . Chronic alcohol misuse and abuse has serious effects on physical and mental health . Chronic excess alcohol intake , or alcohol dependence , can lead to a wide range of neuropsychiatric or neurological impairment , cardiovascular disease , liver disease , and malignant neoplasms . The psychiatric disorders which are associated with alcoholism include major depression , dysthymia , mania , hypomania , panic disorder , phobias , generalized anxiety disorder , personality disorders , schizophrenia , suicide , neurologic deficits ( e.g. impairments of working memory , emotions , executive functions , visuospatial abilities and gait and balance ) and brain damage . Alcohol dependence is associated with hypertension , coronary heart disease , and ischemic stroke , cancer of the respiratory system , and also cancers of the digestive system , liver , breast and ovaries . Heavy drinking is associated with liver disease , such as cirrhosis . Excessive alcohol consumption can have a negative impact on aging .   Recent studies have focused on understanding the mechanisms by which moderate alcohol consumption confers cardiovascular benefit .

neg: Parkinson's disease Parkinson 's disease ( PD ) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system . The symptoms generally come on slowly over time . Early in the disease , the most obvious are shaking , rigidity , slowness of movement , and difficulty with walking . Thinking and behavioral problems may also occur . Dementia becomes common in the advanced stages of the disease . Depression and anxiety are also common occurring in more than a third of people with PD . Other symptoms include sensory , sleep , and emotional problems . The main motor symptoms are collectively called `` parkinsonism '' , or a `` parkinsonian syndrome '' .   The cause of Parkinson 's disease is generally unknown , but believed to involve both genetic and environmental factors . Those with a family member affected are more likely to get the disease themselves . There is also an increased risk in people exposed to certain pesticides and among those who have had prior head injuries while there is a reduced risk in tobacco smokers and those who drink coffee or tea . The motor symptoms of the disease result from the death of cells in the substantia nigra , a region of the midbrain . This results in not enough dopamine in these areas . The reason for this cell death is poorly understood , but involves the build-up of proteins into Lewy bodies in the neurons . Diagnosis of typical cases is mainly based on symptoms , with tests such as neuroimaging being used to rule out other diseases .   There is no cure for Parkinson 's disease . Initial treatment is typically with the antiparkinson medication L-DOPA ( levodopa ) , with dopamine agonists being used once levodopa becomes less effective . As the disease progresses and neurons continue to be lost , these medications become less effective while at the same time they produce a complication marked by involuntary writhing movements . Diet and some forms of rehabilitation have shown some effectiveness at improving symptoms . Surgery to place microelectrodes for deep brain stimulation has been used to reduce motor symptoms in severe cases where drugs are ineffective . Evidence for treatments for the non-movement-related symptoms of PD , such as sleep disturbances and emotional problems , is less strong .   In 2015 , PD affected 6.2 million people and resulted in about 117,400 deaths globally . Parkinson 's disease typically occurs in people over the age of 60 , of which about one percent are affected . Males are more often affected than females . When it is seen in people before the age of 50 , it is called young-onset PD . The average life expectancy following diagnosis is between 7 and 14 years . The disease is named after the English doctor James Parkinson , who published the first detailed description in An Essay on the Shaking Palsy , in 1817 . Public awareness campaigns include World Parkinson 's Day ( on the birthday of James Parkinson , 11 April ) and the use of a red tulip as the symbol of the disease . People with parkinsonism who have increased the public 's awareness of the condition include actor Michael J. Fox , Olympic cyclist Davis Phinney , and late professional boxer Muhammad Ali .

neg: Synactive Theory of Newborn Behavioral Organization and Development The Synactive Theory of Newborn Behavioral Organization and Development ( Synaction n. , or Synactive adj. -LSB- from the Greek syn `` together '' and the Latin actio `` action , '' resulting in : `` together in action '' -RSB- ) suggests that development of the human fetus , and later newborn , proceeds through the constant balancing of approach and avoidance behaviors , leading to : 1 ) a continuous interaction of the subsystems ( i.e. , Autonomic , Motor , State and Attention/Interaction , and Regulatory ) and their increasingly defined delineations within the organism , that is the infant , and 2 ) the organism 's interaction with the environment at large . This process is aimed at bringing about the increasingly well-defined species-unique developmental agenda .   Figure 1 ( below ) , provides a graphic representation of the Synactive Theory of development , as applied to both fetal and newborn stages . It focuses upon the infant 's within-organism , four subsystems of functioning , and their continuous interaction with each other and with the environment across time ( i.e. , `` together in action , '' or synaction ) . The four subsystems include the :   Autonomic Subsystem : Expressed in the pattern of respiration ( e.g. , fast , slow , pauses ) color changes ( e.g. , pink , pale , red ) , neurological indicators ( e.g. , seizures , tremulousness ) , and visceral or gut signals such as bowel movements , gagging , and hiccoughing ;   Motor Subsystem : Observable through the tone , posture and movement patterns of the infant ;   State and Attention/Interaction Subsystem : Expressed via : 1 ) the range of states available to the infant ( i.e. , deep sleep , light sleep , drowsy , alert , hyperalert , and cry ) , 2 ) how clearly it is to observably differentiate one state from the other , and 3 ) the patterns of transitions from one state to another ( e.g. , smooth well-differentiated state transitions versus abrupt unorganized state transitions ) .   The attention/interaction system is set within this state continuum ( i.e. , from deep sleep to cry ) and represented by the infant 's ability to adjust the robustness and increasing refinement of an alert , attentive state . The infant uses this state to take in cognitive and social information from the environment as well as to bring forth and modify inputs from the surrounding world ; and   Regulatory Subsystem : Behaviorally represented via the observable strategies the infant uses ( Self-Regulation ) in maintaining a balanced , relatively stable and relaxed state of subsystem of functioning or in returning to this a state of subsystem functioning if imbalance , or stress has occurred within the subsystems .   An additional component of the regulatory subsystem is observable in the kind and amount of support offered by the caregiver ( e.g. , supporting a soft , tucked , flexed position of the infant 's arms and legs ) or by the environment ( e.g. , dimming the lights in the nursery ) . This Co-Regulation may be necessary to help the infant 's return to balance in situations when his/her own self-regulatory capacities are exceeded .   Reproduced with permission from Als , H. Toward a synactive theory of development : Promise for the assessment of infant individuality . Infant Mental Health Journal . 1982 : ( 3 ) : 229-243 ; p. 234 .   The graphic representation of the Synactive Theory above depicts the developing organism , that is , the infant , in constant interaction with the environment from within the womb to the newborn intensive care unit ( NICU ) , and the caregiving family 's support in the NICU , to the family in their home . Newborn infants are actively striving for their next steps in development , while depending upon `` good enough '' environments and care to assure progress along their developmental agenda .   The Synactive Theory of Development continues to be instrumental in guiding clinicians ( e.g. , neonatologist , nurses , psychologists , developmental specialists , physical/occupational therapists , etc. ) and researchers in their understanding of the often very small steps in development that prematurely born and other high risk newborns attempt to accomplish ( which are major steps for their immature or injured brain ) . This theory gives professionals the framework and tools with which to identify the infant 's strengths , challenges and accomplishments . Such accomplishments may include breathing , sucking and swallowing in a coordinated sequence ; moving food down into and through the stomach and intestinal track instead of upwards , leading to reflux and vomiting ; looking at the caregiver and breathing at the same time , as well as many others .   The Synactive Theory is the foundation of both : 1 ) the Assessment of Preterm Infants ' Behavior ( APIB ) , a standardized comprehensive newborn test , and 2 ) the Newborn Individualized Developmental Care and Assessment Program ( NIDCAP ) , which is the care and intervention approach , that focuses on each infant 's behavioral cues ( e.g. , hand ( s ) to mouth , bracing with feet against a supporting surface ) in order to support the infant 's strengths and reduce the infant 's vulnerabilities . The infant 's family is viewed as the infant 's most important nurturer and is integrated in all care from the infant 's birth on throughout the infant 's hospitalization .

neg: Substance dependence Substance dependence also known as drug dependence is an adaptive state that develops from repeated drug administration , and which results in withdrawal upon cessation of drug use . A drug addiction , a distinct concept from substance dependence , is defined as compulsive , out-of-control drug use , despite negative consequences . An addictive drug is a drug which is both rewarding and reinforcing . ΔFosB , a gene transcription factor , is now known to be a critical component and common factor in the development of virtually all forms of behavioral addiction and drug addictions , but not dependence .   Within the framework of the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders ( DSM-IV ) , substance dependence is redefined as a drug addiction , and can be diagnosed without the occurrence of a withdrawal syndrome . It is now described accordingly : `` When an individual persists in use of alcohol or other drugs despite problems related to use of the substance , substance dependence may be diagnosed . Compulsive and repetitive use may result in tolerance to the effect of the drug and withdrawal symptoms when use is reduced or stopped . This , along with Substance Abuse are considered Substance Use Disorders . ''

neg: X-linked recessive hypoparathyroidism X-linked recessive hypoparathyroidism is a rare , congenital form of hypoparathyroidism .

neg: Health psychology Health psychology is the study of psychological and behavioral processes in health , illness , and healthcare . It is concerned with understanding how psychological , behavioral , and cultural factors contribute to physical health and illness . Psychological factors can affect health directly . For example , chronically occurring environmental stressors affecting the hypothalamic -- pituitary -- adrenal axis , cumulatively , can harm health . Behavioral factors can also affect a person 's health . For example , certain behaviors can , over time , harm ( smoking , excessive alcohol consumption ) or enhance health ( exercise , diet low in saturated fat ) . Health psychologists take a biopsychosocial approach . In other words , health psychologists understand health to be the product not only of biological processes ( e.g. , a virus , tumor , etc. ) but also of psychological ( e.g. , thoughts and beliefs ) , behavioral ( e.g. , habits ) , and social processes ( e.g. , socioeconomic status and ethnicity ) .   By understanding psychological factors that influence health , and constructively applying that knowledge , health psychologists can improve health by working directly with individual patients or indirectly in large-scale public health programs . In addition , health psychologists can help train other healthcare professionals ( e.g. , physicians and nurses ) to take advantage of the knowledge the discipline has generated , when treating patients . Health psychologists work in a variety of settings : alongside other medical professionals in hospitals and clinics , in public health departments working on large-scale behavior change and health promotion programs , and in universities and medical schools where they teach and conduct research .   Although its early beginnings can be traced to the field of clinical psychology , four different divisions within health psychology and one related field , occupational health psychology ( OHP ) , have developed over time . The four divisions include clinical health psychology , public health psychology , community health psychology , and critical health psychology . Professional organizations for the field of health psychology include Division 38 of the American Psychological Association ( APA ) , the Division of Health Psychology of the British Psychological Society ( BPS ) , and the European Health Psychology Society . Advanced credentialing in the US as a clinical health psychologist is provided through the American Board of Professional Psychology .

neg: Comedown (drugs) Comedown or crashing is the deterioration in mood that happens as a psychoactive drug , typically a stimulant , is either decreasing or is cleared from the blood and thus the cerebral circulation . The improvement and deterioration of mood ( euphoria and dysphoria ) are represented in the cognitive schema #Noun as high and low elevations ; thus , after the drug has elevated the mood ( a state known as a high ) , there follows a period of coming back down , which often has a distinct character from withdrawal in stimulants . Generally , a comedown ( `` down , '' `` low , '' sometimes `` crash '' ) can happen to anyone as a transient symptom , but in people who are dependent on the drug ( especially those addicted to it ) , it is an early symptom of withdrawal and thus can be followed by others . Various drug classes , most especially stimulants and to a lesser degree opioids and sedatives , are subject to comedowns . A milder analogous mood cycle can happen even with blood sugar levels ( thus sugar highs and sugar lows ) , which is especially relevant to people with diabetes mellitus and to parents and teachers managing children 's behavior , as well as in adults with ADHD . Stimulant comedowns are unique in that they often appear very abruptly after a period of focus or high , and are typically the more intensely dysphoric phase of withdrawal than that following complete elimination from the bloodstream . Besides general dysphoria , this phase can be marked by frustration , anger , anhedonia , social withdrawal , and other symptoms characteristic to a milder mixed episode in Bipolar Disorder . Alertness and other general stimulant effects are still present .

neg: Endophenotype Endophenotype is a genetic epidemiology term which is used to separate behavioral symptoms into more stable phenotypes with a clear genetic connection . The concept was coined by Bernard John and Kenneth R. Lewis in a 1966 paper attempting to explain the geographic distribution of grasshoppers . They claimed that the particular geographic distribution could not be explained by the obvious and external `` exophenotype '' of the grasshoppers , but instead must be explained by their microscopic and internal `` endophenotype . ''   The next major use of the term was in psychiatric genetics , to bridge the gap between high-level symptom presentation and low-level genetic variability , such as single nucleotide polymorphisms . It is therefore more applicable to more heritable disorders , such as bipolar disorder and schizophrenia . Since then , the concept has expanded to many other fields , such as the study of ADHD , addiction , Alzheimer 's disease obesity and cystic fibrosis . Some other terms which have a similar meaning but do not stress the genetic connection as highly are `` intermediate phenotype '' , `` biological marker '' , `` subclinical trait '' , `` vulnerability marker '' , and `` cognitive marker '' . The strength of an endophenotype is its ability to differentiate between potential diagnoses that present with similar symptoms .

neg: Hypermetabolism Hypermetabolism is the physiological state of increased rate of metabolic activity and is characterized by an abnormal increase in the body 's basal metabolic rate . Hypermetabolism is accompanied by a variety of internal and external symptoms , most notably extreme weight loss , and can also be a symptom in itself . This state of increased metabolic activity can signal underlying issues , especially hyperthyroidism or fatal familial insomnia . The drastic impact of the hypermetabolic state on patient nutritional requirements is often understated or overlooked as well .   Hypermetabolism typically occurs after significant injury to the body . In hospitals and institutions , the most common causes are infections , sepsis , burns , multiple traumas , fever , long-bone fractures , hyperthyroidism , prolonged steroid therapy , surgery and bone marrow transplants . Hypermetabolism may occur in particular in the brain after traumatic brain injury . The cause and location of hypermetabolic symptoms within the body can be accurately detected by PET scan . Symptoms will usually subside once the underlying illness or injury is treated .

neg: Psychiatric epidemiology Psychiatric epidemiology is a field which studies the causes ( etiology ) of mental disorders in society , as well as conceptualization and prevalence of mental illness . It is a subfield of the more general epidemiology . It has roots in sociological studies of the early 20th century . However , while sociological exposures are still widely studied in psychiatric epidemiology , the field has since expanded to the study of a wide area of environmental risk factors , such as major life events , as well as genetic exposures . Increasingly neuroscientific techniques like MRI are used to explore the mechanisms behind how exposures to risk factors may impact psychological problems and explore the neuroanatomical substrate underlying psychiatric disorders .

neg: Zona fasciculata The zona fasciculata constitutes the middle and also the widest zone of the adrenal cortex , sitting directly beneath the zona glomerulosa . Constituent cells are organized into bundles or `` fascicles '' .   The zona fasciculata chiefly produces glucocorticoids ( mainly cortisol in the human ) , which regulates the metabolism of glucose , especially in times of stress ( e.g. , part of the fight-or-flight response ) , it is stimulated by the hormone Adrenocorticotropic Hormone ( ACTH ) which is released from the anterior portion of the pituitary and axised upon this adrenal gland . This tissue also generates a small amount of weak androgens ( e.g. , dehydroepiandrosterone ) . The main source of androgens will come from the zona reticularis region . In certain animals such as rodents , the lack of 17alpha-hydroxylase results in the synthesis of corticosterone instead of cortisol .   Steroid-producing adrenal tumours and hyperplasia of the zona fasciculata result in excess cortisol production and are the cause for adrenal Cushing 's syndrome . The genetic disorder McCune-Albright syndrome can also present Cushing 's syndrome in affected patients .

neg: Sleep state misperception Sleep state misperception ( SSM ) is a term in the International Classification of Sleep Disorders ( ICSD ) most commonly used for people who mistakenly perceive their sleep as wakefulness , though it has been proposed that it be applied to those who severely overestimate their sleep time as well ( `` positive '' sleep state misperception ) . While most sleepers with this condition will report not having slept in the previous night at all or having slept very little , clinical recordings generally show normal sleep patterns . Though the sleep patterns found in those with SSM have long been considered indistinguishable from those without , some preliminary research suggest there may be subtle differences ( see Symptoms and diagnosis : Spectral analysis ) .   Patients are otherwise generally in good health , and any ills -- such as depression -- appear to be more associated with fear of negative consequences of insomnia ( `` insomnia phobia '' ) than from any actual loss of sleep .   Sleep state misperception was adopted by the ICSD to replace two previous diagnostic terminologies : `` subjective insomnia complaint without objective findings '' and `` subjective sleepiness complaint without objective findings . ''   Other synonyms of the term include : paradoxical insomnia , pseudo-insomnia , subjective insomnia , subjective sleepiness , and sleep hypochondriasis .

neg: Hypoplasia Hypoplasia ( from Ancient Greek ὑπo - hypo - , `` under '' + πλάσις plasis , `` formation '' ; adjective form hypoplastic ) is underdevelopment or incomplete development of a tissue or organ . Although the term is not always used precisely , it properly refers to an inadequate or below-normal number of cells . Hypoplasia is similar to aplasia , but less severe . It is technically not the opposite of hyperplasia ( too many cells ) . Hypoplasia is a congenital condition , while hyperplasia generally refers to excessive cell growth later in life . ( Atrophy , the wasting away of already existing cells , is technically the direct opposite of both hyperplasia and hypertrophy . )   Hypoplasia can be present in any tissue or organ . It is descriptive of many medical conditions , including underdevelopment of organs such as :   Breasts during puberty  Testes in Klinefelter 's syndrome  Ovaries in Fanconi anemia , gonadal dysgenesis , trisomy X  Thymus in DiGeorge syndrome  Labia majora in popliteal pterygium syndrome  Corpus callosum , connecting the two sides of the brain , in Agenesis of the corpus callosum  Cerebellum caused by mutation in the Reelin gene  Tooth caused by oral pathology , such as Turner 's hypoplasia  Chambers of the heart in hypoplastic left heart syndrome and hypoplastic right heart syndrome  Optic nerve in optic nerve hypoplasia  Sacrum in sacral agenesis  Facial muscle in asymmetric crying facies  Thumb from birth  Lungs , often as a result of oligohydramnios during gestation or the existence of congenital diaphragmatic hernia  Small bowel in coeliac disease  Fingers and ears in Harlequin type ichthyosis  Mandible in congenital hypothyroidism

neg: Hypochondriasis Hypochondriasis , also known as hypochondria , health anxiety or illness anxiety disorder , refers to worry about having a serious illness . This debilitating condition is the result of an inaccurate perception of the condition of body or mind despite the absence of an actual medical condition . An individual suffering from hypochondriasis is known as a hypochondriac . Hypochondriacs become unduly alarmed about any physical or psychological symptoms they detect , no matter how minor the symptom may be , and are convinced that they have , or are about to be diagnosed with , a serious illness .   Often , hypochondria persists even after a physician has evaluated a person and reassured them that their concerns about symptoms do not have an underlying medical basis or , if there is a medical illness , their concerns are far in excess of what is appropriate for the level of disease . Many hypochondriacs focus on a particular symptom as the catalyst of their worrying , such as gastro-intestinal problems , palpitations , or muscle fatigue . To qualify for the diagnosis of hypochondria the symptoms must have been experienced for at least 6 months .   The DSM-IV-TR defines this disorder , `` Hypochondriasis '' , as a somatoform disorder and one study has shown it to affect about 3 % of the visitors to primary care settings . The newly published DSM-5 replaces the diagnosis of hypochondriasis with the diagnoses of `` somatic symptom disorder '' and `` illness anxiety disorder '' .   Hypochondria is often characterized by fears that minor bodily or mental symptoms may indicate a serious illness , constant self-examination and self-diagnosis , and a preoccupation with one 's body . Many individuals with hypochondriasis express doubt and disbelief in the doctors ' diagnosis , and report that doctors ' reassurance about an absence of a serious medical condition is unconvincing , or short-lasting . Additionally , many hypochondriacs experience elevated blood pressure , stress , and anxiety in the presence of doctors or while occupying a medical facility , a condition known as `` white coat syndrome '' . Many hypochondriacs require constant reassurance , either from doctors , family , or friends , and the disorder can become a disabling torment for the individual with hypochondriasis , as well as his or her family and friends . Some hypochondriacal individuals completely avoid any reminder of illness , whereas others frequently visit medical facilities , sometimes obsessively . Some sufferers may never speak about it .

neg: Parathyroid gland Parathyroid glands are small endocrine glands in the neck of humans and other tetrapods that produce parathyroid hormone . Humans usually have four parathyroid glands , variably located on the back of the thyroid gland -- considerable variation exists . Parathyroid hormone and calcitonin ( one of the hormones made by the thyroid gland ) have key roles in regulating the amount of calcium in the blood and within the bones .   Parathyroid glands share a similar blood supply , venous drainage , and lymphatic drainage to the thyroid glands . Parathyroid glands are derived from the epithelial lining of the third and fourth branchial pouches , with the superior glands arising from the fourth pouch , and the inferior glands arising from the higher third pouch . The relative position of the inferior and superior glands , which are named according to their final location , changes because of the migration of embryological tissues .   Hyperparathyroidism and hypoparathyroidism , characterized by alterations in the blood calcium levels and bone metabolism , are states of surplus or insufficient parathyroid function .

neg: Testosterone and the cardiovascular system The predominant androgen in men , testosterone , has shown to substantially decline throughout the aging process . The decline in both serum and total testosterone with age have been linked to several disease states in men . In particular , cardiac failure and ischemic heart disease have been linked to this natural biochemical decline in testosterone . Previously , the higher cardiovascular risk in men has been attributed in part to the negative effects of systemic testosterone , however , more recent research has highlighted the protective nature of testosterone against cardiovascular disease . The magnitude and mechanism of action by which low testosterone in men is influential in the pathogenesis of cardiovascular risk and the potential benefits of testosterone therapy has yet to be fully determined .

neg: Delayed- Maturation Theory of Obsessive Compulsive Disorder The Delayed-Maturation Theory of Obsessive Compulsive Disorder  suggests that Obsessive Compulsive Disorder ( OCD ) can be caused by delayed maturation of the frontal striatal circuitry or parts of the brain that make up the frontal cortex , striatum , or integrating circuits . Some researchers suspect that variations in the volume of specific brain structures can be observed in children that have OCD ( Lambert , K.G ; Kinsley , C.H. , 2011 ) . It has not been determined if delayed-maturation of this frontal circuitry contributes to the development of OCD or if OCD is the ailment that inhibits normal growth of structures in the frontal striatal , frontal cortex , or striatum . However , the use of neuroimaging has equipped researchers with evidence of some brain structures that are consistently less adequate and less matured in patients diagnosed with OCD in comparison to brains without OCD . More specifically , structures such as the caudate nucleus , volumes of gray matter , white matter , and the cingulate have been identified as being less developed in people with OCD in comparison to individuals that do not have OCD ( Lambert , K.G. ; Kinsley , C.H. ) . However , the cortex volume of the operculum ( brain ) is larger and OCD patients are also reported to have larger temporal lobe volumes ; which has been identified in some women patients with OCD ( Jenike , M. ; Breiter , H. ; at el , 1996 ) . Further research is needed to determine the effect of these structural size differences on the onset and degree of OCD and the maturation of specific brain structures .

neg: Melatonin treatments for major depressive disorder Melatonin is a hormone typically associated with the regulation of circadian rhythms , blood pressure , seasonal reproduction and ovarian and retinal physiologies . It is hypothesized that the use of melatonin to restore circadian rhythms can reduce depressive symptoms .


query: Back to the Future Part II is historical fiction.

pos: Back to the Future Part II Back to the Future Part II is a 1989 American science-fiction adventure comedy film directed by Robert Zemeckis and written by Bob Gale . It is the sequel to the 1985 film Back to the Future and the second installment in the Back to the Future trilogy . The film stars Michael J. Fox , Christopher Lloyd , Thomas F. Wilson , and Lea Thompson and continues immediately following the original film . After repairing the damage to history done by his previous time travel adventures , Marty McFly ( Fox ) and his friend Dr. Emmett `` Doc '' Brown ( Lloyd ) travel to 2015 to prevent McFly 's future son from ending up imprisoned . However , their presence allows Biff Tannen ( Wilson ) to steal Doc 's DeLorean time machine and travel to 1955 , where he alters history by making his younger self wealthy .   The film was produced on a $ 40-million budget and was filmed back-to-back with its sequel , Part III . Filming began in February 1989 after two years were spent building the sets and writing the scripts . Two actors from the first film , Crispin Glover and Claudia Wells , did not return for the final two . While Elisabeth Shue was recast in the role of Wells ' character , Jennifer , Glover 's character , George McFly , was not only minimized in the plot , but also was obscured and recreated with another actor . Glover successfully sued both Zemeckis and Gale , changing how producers can deal with the departure and replacement of actors in a role . Back to the Future Part II was also a ground-breaking project for effects studio Industrial Light & Magic ( ILM ) : In addition to digital compositing , ILM used the VistaGlide motion control camera system , which allowed an actor to portray multiple characters simultaneously on-screen without sacrificing camera movement .   Back to the Future Part II was released by Universal Pictures on November 22 , 1989 . The film received mixed reviews from critics and grossed over $ 331 million worldwide , making it the third-highest-grossing film of 1989 .

pos: Science fiction film Science fiction film ( or sci-fi ) is a genre that uses speculative , fictional science-based depictions of phenomena that are not fully accepted by mainstream science , such as extraterrestrial lifeforms , alien worlds , extrasensory perception and time travel , along with futuristic elements such as spacecraft , robots , cyborgs , interstellar travel or other technologies . Science fiction films have often been used to focus on political or social issues , and to explore philosophical issues like the human condition . In many cases , tropes derived from written science fiction may be used by filmmakers ignorant of or at best indifferent to the standards of scientific plausibility and plot logic to which written science fiction is traditionally held .   The genre has existed since the early years of silent cinema , when Georges Melies ' A Trip to the Moon ( 1902 ) employed trick photography effects . The next major example in the genre was the film Metropolis ( 1927 ) - being the first feature length science fiction movie . From the 1930s to the 1950s , the genre consisted mainly of low-budget B movies . After Stanley Kubrick 's landmark 2001 : A Space Odyssey ( 1968 ) , the science fiction film genre was taken more seriously . In the late 1970s , big-budget science fiction films filled with special effects became popular with audiences after the success of Star Wars and paved the way for the blockbuster hits of subsequent decades .

neg: Aristopia Aristopia : A Romance-History of the New World is an 1895 utopian novel by Castello Holford , considered the first novel-length alternate history in English ( and among the earliest alternate histories in general ) .   Though part of the major wave utopian and dystopian literature that distinguished the final decades of the nineteenth century , Holford 's book reverses the normal stance of utopian projection : instead of imagining a better society at a future time or in a far-off place , he supposes that the founding of the United States occurred under different conditions and follows its development forward to a superior society in his own day .   In Aristopia ( Greek for `` the best place '' ) , Ralph Morton , an early settler in Virginia , discovers a reef made of solid gold . He cannily uses his wealth to build a planned society , based on the Utopia of Sir Thomas More , with innovations and adaptations of his own . In Aristopia , all the land is owned by the government , and only leased to businesses and private citizens . Large-scale trade is also monoplized by the state , and inherited wealth is limited . Morton welcomes productive refugees from European conflicts -- Huguenots , Irish fugitives from Cromwell 's wars , and northern Italian and Swiss artisans .   The colony prospers , buys more land from the Indians , and spreads westward . Morton dies at the age of 100 ; his descendants and successors carry his policies forward .   The Aristopians support the American Revolution , and on their own initiative conquer Canada . Aristopia comes to dominate the new nation , eventually ruling all of North America north of Mexico .   Holford loads his description of Aristopia with satirical remedies for what he saw as contemporary problems and circumstances . In Aristopian jurisprudence , for example , the Court for Assessing the Value of Abstract Words and Phrases polices the language to prevent abuses ; it is the largest and busiest function in the Palace of Justice .   The English playwright Henry Arthur Jones was taken with the idea of Aristopia , and used it in his own polemical writings , as in his `` The Tax-Wise Men of Aristopia '' and his My Dear Wells .   Holford was not the first writer in English to employ the term `` Aristopia . '' The eighteenth-century freethinker John Fransham ( 1730 -- 1810 ) left a posthumous manuscript titled Memorablilia Classica , which contains a piece called `` The Code of Aristopia , or Scheme for a Perfect Government . ''

neg: Utopian and dystopian fiction The utopia and its derivative , the dystopia , are genres of literature that explore social and political structures . Utopian fiction portrays a setting that agrees with the author 's ethos , having various attributes of another reality intended to appeal to readers . Dystopian ( or dystopic ) fiction ( sometimes combined with , but distinct from apocalyptic literature ) is the opposite : the portrayal of a setting that completely disagrees with the author 's ethos . Many novels combine both , often as a metaphor for the different directions humanity can take , depending on its choices , ending up with one of two possible futures . Both utopias and dystopias are commonly found in science fiction and other speculative fiction genres , and arguably are by definition a type of speculative fiction .   More than 400 utopian works were published prior to the year 1900 in the English language alone , with more than a thousand others during the twentieth century .

neg: Paraspace The term ` paraspace ' comes from Samuel R. Delany , a ` space ' existing parallel to normal or ordinary space . According to Delany , the para-space is an alternate space that ` exists parallel to the normal space of the diegesis -- a rhetorically heightened  `` other realm ''' ( Bukatman 1993 : 157 ) . Bukatman ( 1993 : 157 ) says `` Cyberspace is clearly a '' paraspace ' . '   `` Delany connects cyberpunk to the mysterious lunar artifact of Algis Budrys ' Rogue Moon and early evocations of outer space , all of which use inflated rhetoric to differentiate `` paraspace '' from mundane dimensions '' Samuel Review Essay .   Paraspace is defined by Barry Malzberg as `` the condition of hyperspace -LSB- that -RSB- is itself insane '' ( as cited by Bukatman , 1993 : 157 ) .   Michael Fisch ( 2004 : 371 , citing Murakami , 2002 : 157 ) comments `` While the para-space is often inaugurated through cognition it is always a ` materially manifested ' and ` linguistically intensified ' space in which ` conflicts that begin in ordinary space are resolved ' ''  ( Murakami 2002 : 157 ) .   Implications   Walter Benjamin ( 1936/1968 ) declare the end of storytelling because of its incapacity to relate traumatic experiences , such as warfare , shell shock in World War I . As work lost its spaces to practice not just storytelling , but storylistening , the skills of interpretation of experience atrophied .   Paraspace is the hyperspace gone insane ( Malzberg , The worker flesh-body is displaced by the corporate ad-inventions , set on the global stage of `` technoorganic reconstructions of the flesh '' ( Bukatman , 1993 : 19 ) .   Walter Benjamin ( 1936 ) declared that the art of storytelling is coming to an end . We can no longer tell a tale of trauma properly . We can no longer exchange our experiences of trauma of war ( PTSD ) , economic collapse sending millions into homelessness , including veterans of the recent wars , the ubiquitousness of sweatshops , and so on . Of relevance to paraspace , the lost art of storytelling has an accumulated effect ( Fisch , 2004 : p. 365 ) ; it gets worth with cyber-real . / When the ` real ' pokes through the cyberspace , it gets quickly displaced by obfuscation . Our ` real ' in hyperspace is not closer to Lacanian Real ( FIsch , p. 372 ) .   Paraspace is invisible , yet has material consequences ( Bukatman , 1992 ) .   Benjamin , W. ( 1936/1968 ) Illuminations , New York : Harcourt Brace & World .   Bukatman , S. ( 1992 ) . Amidst These Fields of Data : Allegory , Rhetoric , and the Paraspace . Critique : Studies in Contemporary Fiction , 33 ( 3 ) , 199-219 .   Bukatman , S. ( 1993 ) Terminal Identity : The Virtual Subject in Postmodern Science Fiction , Durham ,  NC : Duke University Press .   Delany , Samuel R. ( 1988 ) . Some real mothers : An interview with Samuel R. Delany by Takayuki Tatsumi . '' Science Fiction Eye , 1 , # 3 : 5-11 .   Fisch , M. ( 2004 , October ) . In search of the real : technology , shock and language in Murakami Haruki 's Sputnik Sweetheart . In Japan Forum ( Vol . 16 , No. 3 , pp. 361 -- 383 ) . Taylor & Francis .   Murakami , H. ( 2002 ) Sputnik Sweetheart , trans . P. Gabriel , New York : Vintage International .

neg: The Dead Past `` The Dead Past '' is a science fiction short story by American writer Isaac Asimov , first published in the April 1956 issue of Astounding Science Fiction . It was later collected in Earth Is Room Enough ( 1957 ) and The Best of Isaac Asimov ( 1973 ) , and adapted into an episode of the science-fiction television series Out of the Unknown . Its pattern is that of dystopian fiction , but of a subtly nuanced flavor . It is considered by some people to be one of his best short stories .

neg: Speculative fiction Speculative fiction is an umbrella genre encompassing narrative fiction with supernatural or futuristic elements . This includes the genres science fiction , fantasy , horror and supernatural fiction , as well as their combinations . The broader usage of the term is attributed to Robert Heinlein , who referenced it in 1947 in an editorial essay , although there are prior mentions of speculative fiction or its variant `` speculative literature '' .

neg: The Iron Dream The Iron Dream is a metafictional 1972 alternate history novel by American author Norman Spinrad . The book has a nested narrative that tells a story within a story . On the surface , the novel presents an unexceptional pulp , post-apocalypse science fiction action tale entitled Lord of the Swastika . However , this is a pro-fascism narrative written by an alternate-history Adolf Hitler , who in this timeline emigrated from Germany to the United States in 1919 after the Great War , and used his modest artistic skills to become first a pulp -- science fiction illustrator and later a successful science fiction writer , telling lurid , purple-prosed adventure stories under a thin science fiction-veneer .   Spinrad was intent on demonstrating just how close Joseph Campbell 's hero with a thousand faces and much science fiction and fantasy literature can be to the racist ideology of Nazi Germany . The nested narrative is followed by a faux scholarly analysis by a fictional literary critic , Homer Whipple , of New York University , which is said to have been written in 1959 .

neg: The Hoax of the Twentieth Century The Hoax of the Twentieth Century : The Case Against the Presumed Extermination of European Jewry is a book by Northwestern University electrical engineering professor Arthur Butz . First published in 1976 by Historical Review Press , it attempts to refute the idea of the Holocaust that Nazi Germany tried to exterminate millions of Jews using homicidal gas chambers during World War 2 , and is influential in the Holocaust denial movement . The book has been banned in Canada and is X-rated in Germany where it can not be displayed or advertised . It has been described as anti-semitic with Alan Davies calling it an `` antisemitic classic '' .   After carrying it for almost 20 years , Amazon.com on March 7 , 2017 struck the listing of this book on its website , and those of Createspace and Kindle Direct Publishing . In this process , it also removed listings of all used copies for sale by others . The message to its publisher advised that this action was taken because of `` violation of content guidelines . ''

neg: Both Sides of Time Both Sides of Time ( 1995 ) is a fiction book and the first of the Time Travelers Quartet series by Caroline B. Cooney . It was first published on July 1 , 1995 . The hardcover book has 224 pages and was published on October 9 , 2001 by Delacorte Books for Young Readers . In Both Sides of Time , Caroline B. Cooney gives a realistic view of the struggles women had faced in the 19th century and how far they have come in the 20th century . The dialogue of this novel contains a mixture of the English language from the use of speech in the Victorian era to the terminologies and style of talk in modern English . The recommended age for this book is from ages 12 to 14 .

neg: 22nd century in fiction The 22nd century ( years 2101-2200 CE ) is a common setting for fiction .

neg: 11/22/63 11/22/63 is a novel by Stephen King about a time traveler who attempts to prevent the assassination of President John F. Kennedy , which occurred on November 22 , 1963 ( the novel 's titular date ) . The novel was announced on King 's official site on March 2 , 2011 . A short excerpt was released online on June 1 , 2011 , and another excerpt was published in the October 28 , 2011 , issue of Entertainment Weekly . The novel was published on November 8 , 2011 and quickly became a number-one bestseller . It stayed on The New York Times Best Seller list for 16 weeks . 11/22/63 won the 2011 Los Angeles Times Book Prize for Best Mystery/Thriller and the 2012 International Thriller Writers Award for Best Novel , and was nominated for the 2012 British Fantasy Award for Best Novel and the 2012 Locus Award for Best Science Fiction Novel .   The novel required considerable research to accurately portray the late 1950s and early 1960s . King commented on the amount of research it required , saying `` I 've never tried to write anything like this before . It was really strange at first , like breaking in a new pair of shoes . ''   The novel was adapted into a 2016 Hulu television series , 11.22.63 .

neg: Prophets of Science Fiction Prophets of Science Fiction is an American documentary television series produced and hosted by Ridley Scott for the Science Channel . The program premiered on .   The series covers the life and work of leading science fiction authors of the last couple of centuries . It depicts how they predicted and , accordingly , influenced the development of scientific advancements by inspiring many readers to assist in transforming those futuristic visions into everyday reality . The stories are told through film clips , reenactments , illustrations and interviews .   The first episode received mixed reviews . Commentators appreciated the approach of combining coverage of contemporary scientific research and biographical exposition , but criticized the series as `` light on the substance and heavy on the exaggeration '' . The series ' attempts to link Mary Shelley 's Frankenstein to developments such as organ transplants , supercomputers and DNA research were described by one critic as far-fetched but by another as successful .

neg: The Guns of the South The Guns of the South is an alternate history novel set during the American Civil War by Harry Turtledove . It was released in the United States on September 22 , 1992 .   The story deals with a group of time-travelling white supremacist members of the Afrikaner Weerstandsbeweging from an imagined 21st-century South Africa , who supply Robert E. Lee 's Army of Northern Virginia with AK-47s and small amounts of other supplies ( including nitroglycerine tablets for treating Lee 's heart condition ) . Their intervention and technologies results in a Confederate victory in the war . Afterwards , however , Lee and the racists from the future have a violent falling out with each other .

neg: Logic of Empire `` Logic of Empire '' is a science fiction novella by American writer Robert A. Heinlein . Part of his Future History series , it originally appeared in Astounding Science Fiction ( March 1941 ) , and was collected in The Green Hills of Earth ( and subsequently The Past Through Tomorrow ) .   Ostensibly a tale about a man in the wrong place at the wrong time , and his struggle to free himself from the oppressive circumstances in which he is plunged , this story also serves to explain how slavery develops in a new colony . Even in the future , the technology available to a new colony is always initially low . If a machine to do a necessary job is too expensive to import ( say a wheat harvester , a water pump , or even a washing machine ) , a human must do it instead . If too many jobs must be done by hand and there is a shortage of labor compared with independent resources that free labor could take up ( `` land '' , although this condition is not clear in the story ) , a market for slavery develops . Decades later , while there is still an abundance of land , this market remains because the colony itself has quotas to meet and debts to repay - they can not spare the resources to develop local industries to make the machines themselves and free labor does not have to bid its price down enough to out compete slave labor .   Throughout the story , Heinlein takes the view of the objective narrator when describing Venusian society . `` Logic of Empire '' places different rationales on the people who participate in slavery . There are no real villains ; everybody 's just doing their job , trying to maximize income in a capitalist system . Even the plantation owner who owns the hero is portrayed as a struggling -- and failing -- small businessman , whose main motivation is to secure a livelihood for his daughter .

neg: 58 Minutes 58 Minutes is a thriller novel by American novelist Walter Wager . The novel was the basis for the 1990 film Die Hard 2 .

neg: Episode II Episode II , Episode 2 or Episode Two may refer to :   Episode II ( album ) , an album by Safri Duo  Episode II ( EP ) , an EP by Eiffel 65  `` Episode 2 '' ( song ) , a song by Dragon Ash  `` Episode 2 '' ( Ashes to Ashes ) , an episode of Ashes to Ashes  `` Series 1 : Episode 2 '' ( Life on Mars ) , an episode of Life on Mars  `` Episode 2 '' ( Twin Peaks ) , an episode of Twin Peaks  Episode 2 ( The Casual Vacancy ) , ( 2015 ) , the second episode of the TV miniseries The Casual Vacancy  Half-Life 2 : Episode Two , a computer game sequel  Star Wars : Episode II -- Attack of the Clones , a 2002 film

neg: We Were There The We Were There books are a series of historical novels written for children . The series consists of 36 titles , first released between 1955 and 1963 by Grosset & Dunlap . Each book in the series is a fictional retelling of an historical event , featuring one or more children as primary characters . The books were written by a number of different authors , each writing from one to seven of the books ; the authors included Benjamin Appel , Jim Kjelgaard , Earl Schenck Miers , William O. Steele , and others . Each book 's byline also lists a separate `` historical consultant , '' who was a specialist in the historic topic covered by that particular book . The historical consultants were typically college professors or , in the case of war-related stories , retired military officers ; among the more noteworthy consultants for the series were the historians Bruce Catton , Walter Prescott Webb and A. B. Guthrie , Jr. . The books are illustrated with black-and-white line art , with color drawings on the dust jacket .   The dust jackets of the original printings of the books describe the series as follows :   We Were There books are easy to read and provide exciting , entertaining stories , based upon true historic events . Each story is checked for factual accuracy by an outstanding authority on this particular phase of our history . Though written simply enough for young readers , they make interesting reading for boys and girls well into their teens .  The original hardbound editions of the books were followed by several other printings , including editions for book clubs and libraries . The books were later reissued with hardbound picture covers ( using the original dust jacket artwork ) , and softcover editions of some books became available in the 1970s . Three of the books are available from Lamppost Publishers and American Home School Publishers . Most of the original books are available in varying used conditions from various sellers through Amazon , although selection will naturally vary at any given time .

neg: Space opera Space opera is a subgenre of science fiction that emphasizes space warfare , melodramatic adventure , interplanetary battles , as well as chivalric romance , and often risk-taking . Set mainly or entirely in outer space , it usually involves conflict between opponents possessing advanced abilities , futuristic weapons , and other sophisticated technology . The term has no relation to music but is instead a play on the terms `` soap opera '' and `` horse opera '' , the latter of which was coined during the 1930s to indicate clichéd and formulaic Western movies . Space operas emerged in the 1930s and they continue to be produced in literature , film , comics , and video games .   Notable space opera novels include the Foundation series ( 1942 -- 1999 ) by Isaac Asimov , the Lensman series ( 1948-1954 ) by E. E. Smith and the Ender 's Game series ( 1985 -- present ) by Orson Scott Card . An early notable space opera film was Flash Gordon ( 1936 -- present ) created by Alex Raymond . In the late 1970s , the Star Wars franchise ( 1977 -- present ) created by George Lucas brought a great deal of attention to the subgenre .

neg: Breakpoint (novel) Breakpoint is a cyberpunk science fiction novel by former United States intelligence and counterterrorism official Richard A. Clarke . It is his second novel . The book paints a dystopic prediction of the future .

neg: There Will Be Time There Will Be Time is a science fiction novel by American writer Poul Anderson . It was published in 1972 in a hardback edition by Doubleday and in 1973 in a paperback edition by New American Library .   The story is about a young man who has a genetic mutation that allows him to move through time . It was nominated for the Hugo Award for Best Novel in 1973 .

neg: The Great Abraham Lincoln Pocket Watch Conspiracy The Great Abraham Lincoln Pocket Watch Conspiracy is a historical fiction novel written by Jacopo della Quercia . The plot follows President William Howard Taft , scientist and son of a former president Robert Todd Lincoln , Secret Service Chief John Wilkie , Captain ( later Major ) Archibald Butt and others as they slowly unravel a worldwide conspiracy over a decade in the making .   The book , which was della Quercia 's debut novel , was published in 2014 by St. Martin 's Griffin , an imprint of publishing company St. Martin 's Press . The author described the book 's genre not as singular distinct genre , but as an `` equal parts cocktail '' of adventure , historical fiction , science fiction , thriller and comedy . In 2015 , della Quercia released a spiritual sequel , License to Quill , of a similar nature that concerns the lives of Christopher Marlowe and William Shakespeare in Reformation-era Europe .   The book has many references to actual events ; some , such as the sinking of the RMS Titanic , are important plot points , while others , such as the destruction of the zeppelin Erbslöh , are passively mentioned as news or memories . The author also includes excerpts from real newspaper articles , which were used to provide exposition in the storyline . Similarly , all of the main characters in the book were real , relevant figures in the 20th century . The characters profiles were fictionalized to fit in with the book 's plot and atmosphere , but their names , positions , occupations and personalities are kept largely intact .