query: Welcome Back (film) features only American actors.

pos: Welcome Back (film) Welcome Back is an Indian action comedy film directed by Anees Bazmee and produced by Firoz Nadiadwala , released in 2015 . It is a sequel to Welcome and features an ensemble cast that includes Anil Kapoor , Nana Patekar , John Abraham , Shruti Haasan , Paresh Rawal , Dimple Kapadia and Naseeruddin Shah . While Kapoor , Patekar and Rawal have reprised their roles from the 2007 film , Abraham and Hassan are new additions to the lead cast . Made on a budget of US$ 16 million , the film was largely shot in and around Dubai , United Arab Emirates . Welcome Back was released worldwide on 4 September 2015 .

pos: Anil Kapoor Anil Kapoor ( born 24 December 1956 ) is an Indian actor and producer who has appeared in many Bollywood films , as well as international films and television series . His career has spanned almost 40 years as an actor , and as a producer since 2005 . He has won many awards in his career , including two National Film Awards and six Filmfare Awards in different acting categories .   Kapoor made his Hindi film cameo appearance with Umesh Mehra 's Hamare Tumhare ( 1979 ) in a small role . He made his first debut film and then starred as a lead actor in the 1980 Telugu film , Vamsa Vruksham directed by Bapu . He then made his Kannada film debut with Mani Ratnam 's Pallavi Anu Pallavi ( 1983 ) . He received his first Filmfare Award , in the Best Supporting Actor category , for his role in Yash Chopra 's Mashaal ( 1984 ) . Kapoor earned his first Filmfare Best Actor Award for his performance in N. Chandra 's Tezaab ( 1988 ) and later again for his performance in Indra Kumar 's Beta ( 1992 ) .   He has also starred in many other critically and commercially successful films : Meri Jung ( 1985 ) ; Karma ( 1986 ) ; Mr. India ( 1987 ) ; Virasat ( 1997 ) , for which he won the Filmfare Critics Award for Best Actor ; Taal ( 1999 ) , for which he won his second Filmfare Best Supporting Actor Award ; Pukar ( 2000 ) , for which he won a National Film Award for Best Actor ; No Entry ( 2005 ) ; Dil Dhadakne Do ( 2015 ) for which he won his third Filmfare Best Supporting Actor Award .   Kapoor 's first role in an international film was in Danny Boyle 's Academy Award-winning film Slumdog Millionaire , for which he shared the Screen Actors Guild Award for Outstanding Performance by a Cast in a Motion Picture . His performance in the eighth season of the action series 24 generated rave reviews from the American press . Globally , Kapoor is one of the most recognised Indian actors .

neg: Ajay Naidu Ajay Kalahastri Naidu ( born February 12 , 1972 ) is an American actor . He is of Indian descent .

neg: Welcome to New York (2014 film) Welcome to New York is a 2014 French-American drama film co-written and directed by Abel Ferrara . Inspired by the Dominique Strauss-Kahn affair , the film was released on 17 May 2014 by VOD on the internet as the film failed to secure a place on the official selection at the 2014 Cannes Film Festival , nor was it picked up for theatrical distribution in France and is facing self-censorship by the French media , according to Vincent Maraval , one of the producers .

neg: Jaye Davidson Jaye Davidson ( born Alfred Amey ; March 21 , 1968 ) is an American-born British model and retired actor . He is best known for his role as the transgender character Dil in the 1992 suspense-drama thriller film The Crying Game ,  for which he received a nomination for the Academy Award for Best Supporting Actor , and for appearing in 1994 's Stargate as the god-like Ra .

neg: Into the West (miniseries) Into the West is a 2005 miniseries produced by Steven Spielberg and DreamWorks , with six two-hour episodes ( including commercials ) . The series was first broadcast in the U.S. on Turner Network Television ( TNT ) on six Fridays starting on June 10 , 2005 . It was also shown in the UK on BBC2 and BBC HD from November 4 , 2006 , and in Canada on CBC Television . The series also aired in the U.S. on AMC during the summer ( June/July ) and fall ( autumn , September/October ) of 2012 .   The miniseries begins in the 1820s and is told mainly through the third person narration of Jacob Wheeler ( Matthew Settle ) and Loved By the Buffalo ( Joseph M. Marshall III ) , although episodes outside the direct observation of both protagonists are also shown . The plot follows the story of two families , one white American , one Native American , as their lives become mingled through the momentous events of American expansion . The story intertwines real and fictional characters and events spanning the period of expansion of the United States in the American West , from 1825 to 1890 .   The show has a large cast , with about 250 speaking parts . The series features well known performers including Josh Brolin , Gary Busey , Michael Spears , Tonantzin Carmelo , Skeet Ulrich , Garrett Wang , Steve Reevis , Rachael Leigh Cook , Wes Studi , Irene Bedard , Alan Tudyk , Christian Kane , Russell Means , Jay Tavare , David Midthunder , Keri Russell , Graham Greene , Zahn McClarnon , Tom Berenger , Gil Birmingham , David Paymer , Raoul Trujillo , Eric Schweig , Lance Henriksen , Simon R. Baker , Tyler Christopher , Tatanka Means , Tokala Clifford , Gordon Tootoosis , Sheila Tousey , and Will Patton .   It was filmed in Drumheller , Alberta and Santa Fe , New Mexico .

neg: The American Side The American Side is a 2016 film starring Greg Stuhr and Matthew Broderick .

neg: Albert Daniels Albert Daniels ( born January 8 , 1983 in Bronx , New York ) , also known as Albe Back , often stylized ALBe . Back , is an actor , artist , producer , poet , and rapper .

neg: Lee Wallace (actor) Lee Wallace ( born July 15 , 1930 ) is an American actor of film , stage , and television .

neg: Welcome Home (Brian Littrell album) Welcome Home is the debut solo album by Backstreet Boys member Brian Littrell . The album was released on May 2 , 2006 on Sony BMG and Christian music label Reunion Records . The album peaked on the Billboard 200 at number 74 , and at number 3 on the Christian Albums chart . Four singles have been released from the album : `` Welcome Home ( You ) '' , which charted at number one on the Christian Songs chart , and won Best Video of the Year of Dove Award . The album has sold over 100,000 copies in U.S as of April 2007 .

neg: Sam Golzari Sam Golzari ( سام گلزاری born 12 July 1979 ) is a British actor of Iranian descent active in the United States . He is known for his debut role in American Dreamz .   Golzari was born in Hammersmith , London , England , to parents of Persian origin . He received his BA from UCLA in 2003 , where he worked in the Conservatory Acting Program .   Golzari got his start at the age of four as a Michael Jackson impersonator . Besides his work at UCLA , Golzari has also been a lab member of the Latino Theater Company under Jose Luis Valenzuela . Golzari 's plans were to stay in the theater , but while at college he started working on student films . It was there that he began to find a love for the craft of filmmaking . His short film The Break won an award for the `` best ensemble cast '' at the Method Fest film festival . After this , he got his TV debut when the Showtime network aired his film The Invisible Man , directed by UCLA film student Angela Mrema .   After college graduation , Golzari landed the first Hollywood film for which he auditioned , American Dreamz . In the film he stars alongside Hugh Grant , Mandy Moore and Dennis Quaid . Since that film , he plays the role of Kameron in the film 21 alongside Jim Sturgess and Kevin Spacey . He has also worked with Tony Shalhoub on the film AmericanEast , as well as an all-improv mockumentary , Juan Francis : Live , produced by Norman Lear .   Golzari is also a founding member of the LA-based band the Elevaters , who have released a self-titled EP as well as a full-length album entitled `` Rising . ''   He has also appeared in 2016 American film , Jimmy Vestvood : Amerikan Hero .

neg: Jay Pickett Jay Pickett ( born February 10 , 1961 ) is an American actor .

neg: Robert Hegyes Robert Hegyes ( pronounced Hedges ; May 7 , 1951 -- January 26 , 2012 ) was an American actor best known for his portrayal of high school student Juan Epstein on the 1970s American sitcom Welcome Back , Kotter and as detective Manny Esposito on the 1980s American crime drama Cagney & Lacey .

neg: American Gigolo American Gigolo is a 1980 American romantic crime film written and directed by Paul Schrader , and starring Richard Gere , Lauren Hutton , Hector Elizondo , Nina Van Pallandt and Bill Duke . It tells the story of Julian Kaye , a high-price male escort in Los Angeles who becomes romantically involved with a prominent politician 's wife while simultaneously becoming the prime suspect in a murder case .   The film is notable for establishing Gere as a leading man , and was one of the first mainstream Hollywood films to include frontal male nudity from its main star . It is also notable for its accompanying soundtrack , composed by Giorgio Moroder and featuring the number-one hit single `` Call Me '' by Blondie .   Schrader considers it one of four similar films , which he calls `` double bookends '' : Taxi Driver , bookended by Light Sleeper , and American Gigolo bookended by The Walker .

neg: The American Way (film) The American Way , also known as Riders of the Storm , is a 1986 American science fiction comedy film directed by Maurice Phillips and starring Dennis Hopper and Michael J. Pollard .

neg: Return (2010 film) Return ( Kotiinpaluu ) , also Homecoming , is a 2010 Finnish short film directed by Harri J. Rantala and starring Eerik Kantokoski , Reeta Annala , Kalevi Haapoja and Kauko Salo .

neg: Sam Rockwell Samuel Rockwell ( born November 5 , 1968 ) is an American actor known for independent and mainstream films .   He is known for his leading roles in Lawn Dogs ( 1997 ) , Confessions of a Dangerous Mind ( 2002 ) , Matchstick Men ( 2003 ) , The Hitchhiker 's Guide to the Galaxy ( 2005 ) , Choke ( 2008 ) , Moon ( 2009 ) , Seven Psychopaths ( 2012 ) , and Mr. Right ( 2015 ) , as well as for his supporting roles in The Green Mile ( 1999 ) , Galaxy Quest ( 1999 ) , The Assassination of Jesse James ( 2007 ) , Frost/Nixon ( 2008 ) , Conviction ( 2010 ) , Iron Man 2 ( 2010 ) , Cowboys & Aliens ( 2011 ) , The Way , Way Back ( 2013 ) , and Poltergeist ( 2015 ) .

neg: The Comedian (2016 film) The Comedian is a 2016 American comedy-drama film directed by Taylor Hackford and written by Lewis Friedman , Richard LaGravenese , Art Linson , and Jeff Ross . The film stars Robert De Niro , Leslie Mann , Danny DeVito , Edie Falco , Veronica Ferres , Charles Grodin , Cloris Leachman , Patti LuPone and Harvey Keitel .   The film had its world premiere at the AFI Fest on November 11 , 2016 and was released on December 9 , 2016 , by Sony Pictures Classics . The film opened to negative reviews from critics .

neg: Gary Cooper filmography The filmography of Gary Cooper chronicles the film appearances of American actor Gary Cooper . After starting his career in 1925 as a film extra and stuntman , Cooper made his official cinematic debut in 1926 in the Samuel Goldwyn production The Winning of Barbara Worth . He went on to become a contract player with Paramount Pictures where he established himself as a popular leading man prior to the end of the silent film era .   Cooper 's future in the sound era was assured with the release of The Virginian ( 1929 ) , his first all-talkie film . For the next 32 years , he would be one of cinema 's top money-making stars . From 1936 to 1957 , Cooper ranked 18 times among the top ten box office attractions -- a record when he died in 1961 , and later surpassed only by John Wayne , who ranked among the top ten 25 times , Clint Eastwood ( 21 times ) and Tom Cruise ( 20 times ) .   Cooper was nominated for the Best Actor Academy Award five times and won twice , for Sergeant York ( 1942 ) and High Noon ( 1952 ) . The latter film boosted his popularity , resulting in him being the number one box office attraction in 1953 . Cooper received a third Academy Award -- an honorary one -- just prior to his death in 1961 . His final film , The Naked Edge , was released shortly after his death .   As of February 2008 , more than half of Gary Cooper 's feature films are available on DVD , while others not yet on home video are available for television broadcast . Unfortunately , at least two of his silent films -- Beau Sabreur ( 1928 ) and The Legion of the Condemned ( 1928 ) -- are now considered lost films . Another of his silent films , Wolf Song ( 1929 ) , was originally released as a part talkie , but survives only as a silent film . One of Cooper 's earliest talkies , Paramount on Parade ( 1930 ) , survives incomplete . The prints that are available for television are missing all but one of the film 's Technicolor scenes -- a partial restoration of these scenes was done by the UCLA Film Archives .   This filmography contains sections for Cooper 's work as an extra in the earliest part of his film career , his feature film appearances , his occasional appearances in short films , and a section for a compilation film . Due to its length ( 92 films ) , the listing of his feature films is divided in four sections . Cooper 's film roles are listed , as well as the names of each film 's director and co-stars . Cooper 's awards and nominations are also listed . Except where noted , all of his films were shot in 35mm black and white . All films released prior to Lilac Time ( 1928 ) are silent films and all from The Virginian ( 1929 ) onward are sound films . The films made during the silent-to-sound transition are noted as being either silent or sound films . As an addendum , Cooper 's handful of television appearances are also listed .

neg: Silver Linings Playbook Silver Linings Playbook is a 2012 American romantic comedy-drama film written and directed by David O. Russell . It was adapted from the novel The Silver Linings Playbook , by Matthew Quick . The film stars Bradley Cooper and Jennifer Lawrence , with Robert De Niro , Jacki Weaver , Chris Tucker , Anupam Kher , and Julia Stiles in supporting roles .   Cooper plays Patrick `` Pat '' Solitano , Jr. , a man with bipolar disorder who is released from a psychiatric hospital and moves back in with his parents , played by Robert De Niro and Jacki Weaver . Determined to win back his estranged wife , Pat meets recently widowed Tiffany Maxwell , portrayed by Jennifer Lawrence , who offers to help him get his wife back if he enters a dance competition with her . The two become closer as they train and Pat , his father , and Tiffany examine their relationships with each other as they cope with their problems .   Silver Linings Playbook premiered at the 2012 Toronto International Film Festival on September 8 , 2012 , and was released in the United States on November 16 , 2012 . The film opened to major critical success and earned numerous accolades . It received eight Academy Award nominations , including Best Picture , Best Director , Best Adapted Screenplay . It became the first film since 1981 's Reds to be Oscar-nominated for the four acting categories and the first since 2004 's Million Dollar Baby to be nominated for the Big Five Oscars , with Lawrence winning the Academy Award for Best Actress . It also achieved four Golden Globe Award nominations , with Lawrence winning Best Actress ; three BAFTA nominations , with Russell winning for Best Adapted Screenplay ; four Screen Actors Guild nominations ; and five Independent Spirit Award nominations , winning in four categories , including Best Film . The film was a success at the box office , grossing over $ 236 million worldwide , more than eleven times its budget .

neg: Peter Greene Peter Greene ( born Peter Green ; October 8 , 1965 ) is an American character actor , generally known for playing villains .

neg: Bill Raymond William Joseph `` Bill '' Raymond ( born September 9 , 1938 ) is an American actor who has appeared in film , television and theatre since the 1960s .


query: Millie Bobby Brown is a model from the United Kingdom.

pos: Millie Bobby Brown Millie Bobby Brown ( born 19 February 2004 ) is an English actress and model known for her breakout role as Jane `` Eleven '' Ives in the Netflix science fiction drama series Stranger Things .

pos: England England is a country that is part of the United Kingdom . It shares land borders with Scotland to the north and Wales to the west . The Irish Sea lies northwest of England and the Celtic Sea lies to the southwest . England is separated from continental Europe by the North Sea to the east and the English Channel to the south . The country covers five-eighths of the island of Great Britain ( which lies in the North Atlantic ) in its centre and south ; and includes over 100 smaller islands such as the Isles of Scilly , and the Isle of Wight .   The area now called England was first inhabited by modern humans during the Upper Palaeolithic period , but takes its name from the Angles , one of the Germanic tribes who settled during the 5th and 6th centuries . England became a unified state in the 10th century , and since the Age of Discovery , which began during the 15th century , has had a significant cultural and legal impact on the wider world . The English language , the Anglican Church , and English law -- the basis for the common law legal systems of many other countries around the world -- developed in England , and the country 's parliamentary system of government has been widely adopted by other nations . The Industrial Revolution began in 18th-century England , transforming its society into the world 's first industrialised nation .   England 's terrain mostly comprises low hills and plains , especially in central and southern England . However , there are uplands in the north ( for example , the mountainous Lake District , and the Pennines ) and in the southwest ( for example , Dartmoor and the Cotswolds ) . The capital is London , which is the largest metropolitan area in both the United Kingdom and the European Union.According to the European Statistical Agency , London is the largest Larger Urban Zone in the EU , a measure of metropolitan area which comprises a city 's urban core as well as its surrounding commuting zone . London 's municipal population is also the largest in the EU . England 's population of over 53 million comprises 84 % of the population of the United Kingdom , largely concentrated around London , the South East , and conurbations in the Midlands , the North West , the North East , and Yorkshire , which each developed as major industrial regions during the 19th century .   The Kingdom of England -- which after 1535 included Wales -- ceased being a separate sovereign state on 1 May 1707 , when the Acts of Union put into effect the terms agreed in the Treaty of Union the previous year , resulting in a political union with the Kingdom of Scotland to create the Kingdom of Great Britain . In 1801 , Great Britain was united with the Kingdom of Ireland through another Act of Union to become the United Kingdom of Great Britain and Ireland . In 1922 the Irish Free State seceded from the United Kingdom , leading to the latter being renamed the United Kingdom of Great Britain and Northern Ireland .

neg: UK B-Boy Championships The UK B-Boy Championships is a hip-hop dance competition held annually in the United Kingdom . UK B-Boy Championships , alongside Battle of the Year and R-16 Korea , is regarded to be one of the main International B-Boy Championships held every year . There are national qualifiers worldwide where dancers compete for the opportunity to represent their country at the international final held in London . The event features solo breakers , poppers , hip-hop dancers and b-boy crews from across the globe . It also host DJs and graffiti artists from other countries .   The Championships brings together dancers from around the globe -- including the US , Japan , Korea , Russia , China , Holland and Scandinavia -- who 've won the preliminary tournaments . After a five-month search , staging eight international eliminations , the winners all converge at the Brixton Academy every year to take part in the international final . Since 2014 , UK B-boy Championships partnered up with the World BBoy Series and helped create Undisputed , an event to crown the solo world bboy champion . In 2015 , UK B-boy Championships was not held .

neg: Boogie Beebies Boogie Beebies is a United Kingdom children 's television programme , which is produced and broadcast by the BBC . It is aired on CBeebies ( both the separate channel and CBeebies on BBC One and BBC Two ) . It won the Best Pre School Live Action award , at the BAFTA Children 's Awards in 2005 .   Each programme is fifteen minutes long , and teaches children a dance ( to a short original song ) , a different one each week . It was originally presented by Nataylia Roni and Peter Hillier . Nataylia had previous been a member of the `` teen pop '' group B-Yond who attempted to win the 1997 Great British Song Contest with the song `` Lighten ' Up '' . However , from December 2006 , it was presented by Hillier alone . It also features clips of children ( at home , in schools or in front of bluescreen ) .   In earlier series , the same programme was shown throughout the week . In the later series , a slightly different programme was shown each day . The only variant being , the verses are taught , and the chorus is only run through once .   The dance is taught segment by segment by the instructor ( s ) . In earlier programmes , the two instructors took turns with each segment . The moves to each day 's dance , as well as the theme of the song , are drawn from nature or the world around us ( i.e. , `` The Ocean Motion '' features dance moves inspired by various sea creatures ) . The programme culminates with a complete performance of the song and dance , called `` Big Video Time '' .   The name of the programme comes from the informal verb to boogie ( dance ) and the Beebies part of CBeebies . The program was advertised using a child dancing `` travolta style '' to A Fifth of Beethoven by Walter Murphy .

neg: Freddie Lee Peterkin Freddie Lee Peterkin , also known as Freddie Lee , is a published author , singer -- songwriter , actor and ordained interdenominational Minister , born in Pahokee , Florida . He is known for his gritty power soul vocals reminiscent of Bobby Womack . He has become an artist of public note through his 2008 independent release of the Soul and Gospel album Beyond Comprehension under the recording name of Freddie Lee . He made his prime time acting debut as `` DJ Freddie Murphy '' on Channel 4 's T4 Stars & Strikes and as a character in BBC2 's Grumpy Guide to Work in 2011 . He was also the voice for Bewiser Owl in the Bewiser Insurance TV commercial in 2012 and 2013 . He established himself in the live entertainment industry with his choreographed costume Soul Tribute stage productions for theatres and resorts in 1991 . These critically acclaimed shows include The Sounds of the Four Tops , The Sounds of the Drifters and The Sounds of the Temptations .   Freddie Lee Peterkin is also a member of Alpha Phi Alpha Fraternity , Delta Psi Chapter a Fraternity known for members such as Martin Luther King . This historic organization was the first inter-collegiate Greek-letter organization established for Black college students founded on December 4 , 1906 . Peterkin was responsible for composing many Delta Psi Chapter fraternity anthems such as ' I Know I 've Been Changed ' written in 1985 while he was pledging . He was also a dancer and choreographer of the Delta Psi Chapter 's ` Step Shows ' . Stepping ( African-American ) or step-dancing is a form of percussive dance in which the participant 's entire body is used as an instrument to produce complex rhythms and sounds through a mixture of footsteps , spoken word , and hand claps and a strong part of Black Greek Letter Fraternities .   Peterkin is the son of migrant workers originally from Georgia who came to Florida to pick crops for a living . He is of African and Seminole Indian heritage . His stepfather , James Elijah Jr. , was the lead vocalist of the 1960s and 1970s gospel group , The Royal Lights . His sister Breyona Elijah is part of the gospel group James Smith & Nu Birth and they are both cousins of Gospel group Damali . His mother Bernice Bell is also a singer and as a child won a competition to write a song for Joe Tex , for which she was awarded concert tickets and a chance to meet her idol . Joe Tex went on to have a major hit with the song but Bernice remained uncredited . Bernice Bell has been more recently recognized for her charity work and ran youth programs in Pahokee 's Padgett Island Community Center for 17 years and donating hot meals to Pahokee 's underprivileged children . The community center was recently renamed `` The Bernice Bell Community Center '' .

neg: Melanie Appleby Melanie Susan `` Mel '' Appleby ( 11 July 1966 -- 18 January 1990 ) was one half of the 1980s English duo Mel and Kim .   Appleby was born to a Jamaican father and a white British mother . She initially worked as a glamour model ( she did a photo shoot for Mayfair in 1987 ) and then joined her sister Kim Appleby to form Mel and Kim , enjoying considerable chart success during the mid and late 1980s .

neg: The dress `` The dress '' is a photo that became a viral Internet picture on 26 February 2015 , when viewers disagreed over whether the item of clothing depicted was black and blue or white and gold . The phenomenon revealed differences in human colour perception which have been the subject of ongoing scientific investigation in neuroscience and vision science , with a number of papers published in peer-reviewed science journals .   The photo originated from a washed-out colour photograph of a dress posted on the social networking service Tumblr , and a dispute over whether the dress pictured was blue and black , or white and gold . In the first week after the surfacing of the image alone , more than 10 million tweets mentioned the dress , using hashtags such as #thedress , #whiteandgold and #blackandblue . Although the actual colour of the dress was eventually confirmed to be black and blue , the image prompted discussions surrounding the matter across various platforms , with users discussing their opinions on the colour and why they perceived the dress as being a certain colour . At the same time , members of the scientific community began to investigate the photo for fresh insights into human colour vision .   The dress itself , which was identified as a product of the retailer Roman Originals , experienced a major surge in sales as a result of the incident . The retailer also produced a one-off version of the dress actually coloured in white and gold as a charity campaign .

neg: Bobby Hashemi Bobby Hashemi is an investor at Union Ventures , a private investment vehicle that he founded in 2012 , focused on investing and supporting growth companies across the UK consumer / leisure sectors .   Bobby is a successful UK entrepreneur and investor with over 20 years ' experience in the consumer sector across three aspects - as an entrepreneur who has built a leisure business from scratch into a well-known national brand , as an investor partner in an established private equity investment fund , and as an advisor in a major US investment bank .

neg: Kelly Bell Kelly Bell ( born 21 February 1982 in Aldershot ) is an English former glamour model . She has been described as the United Kingdom 's `` number-one glamour model . ''   Bell has appeared in many young teen girl magazines , as a young teen model and has had many TV appearances over the last 15 years . She entered a competition to find Britain 's next top model in the Daily Sport at just 16 , placing first out of thousands of entrants .   Bell was voted the UK 's sexiest babe for 2007 by the readers of the Daily & Sunday Sport .   She recorded a single titled Down 'n Dirty in 2003 and performed a concert in Colchester in aid of the Army Benevolent Fund . She is a campaigner for the British Armed Forces and raises awareness for the military whenever she can .   Bell is a vegan who avoids the consumption or use of animal products . She is a supporter of the British vegetarian , vegan and animal rights group Viva ! .

neg: Alesha Dixon discography Alesha Dixon , a British R&B singer has released three studio albums , nine lead singles ( not including two singles on which she is featured and three promotional singles ) and thirteen music videos . Dixon was also a member of the popular music group Mis-Teeq , together with whom she released four albums and several successful singles .   Dixon 's discography as a solo artist began with the release of `` Lipstick '' under the mononym `` Alesha '' on 14 August 2006 in the United Kingdom , intended as the lead single from her album Fired Up . The song reached number fourteen on the UK Singles Chart , and was followed by `` Knockdown , '' the poor performance of which caused the album 's release to be cancelled and Alesha to be dropped by record label Polydor . However , Fired Up was released both physically and digitally in Japan , where it reached number 54 on the Japanese Oricon Albums Chart .   Following Dixon 's success on BBC reality television programme Strictly Come Dancing , she was signed to Asylum Records to release her second album The Alesha Show . The album yielded four singles , two of which reached the top ten of the UK Singles Chart . One , titled `` The Boy Does Nothing '' is Dixon 's best-selling single release to date , as it achieved worldwide chart success . The Alesha Show went on to be certified Platinum by the British Phonographic Industry , denoting shipments of 300,000 copies and allowing her to begin recording for her third studio album The Entertainer , which was preceded by the single `` Drummer Boy '' . Despite yielding four singles , the album peaked at just number 84 on the UK Albums Chart and was not certified , leading to Dixon parting with her record label .

neg: Gayle Williamson Gayle lady Williamson ( born c. 1980 , Dollingstown , Northern Ireland ) is a model and former Miss Northern Ireland and Miss United Kingdom winner . She was also a contestant in the 2002 Miss World beauty contest .

neg: Keeley Hazell Keeley Hazell ( born 18 September 1986 ) is an English glamour model , actress , . Hazell became one of Britain 's most successful glamour models , working with brands such as Page 3 , FHM , Loaded , Nuts and Zoo Weekly . She has also made numerous television appearances and has , more recently , focused on her acting career , appearing in films such as Horrible Bosses 2 .

neg: Millie Jackson (album) Millie Jackson is the self-titled debut album by singer-songwriter , Millie Jackson . This album is different from all her other album to follow in that this album features some Motown style songs . It includes the R&B hits `` A Child of God ( It 's Hard to Believe ) '' , `` My Man , A Sweet Man '' and `` Ask Me What You Want . '' The album was arranged by Tony Camillo and Bert de Coteaux .   In 2006 , Ace Records in the UK digitally remastered this album ( along with four other best-selling Millie Jackson albums ) and released it on CD with bonus tracks and extensive liner notes .

neg: Penelope Tree Penelope Tree ( born 2 December 1949 ) is an English former fashion model prominent in swinging sixties London .

neg: Bobby Noble (footballer, born 1945) Robert `` Bobby '' Noble ( born 18 December 1945 ) is an English former footballer who played as a full back in the Football League for Manchester United .   Born in Reddish , Stockport , Noble signed for Manchester United as a trainee in 1961 and turned professional the following year . He made his Football League debut on 9 April 1966 in a 2 -- 1 home defeat to Leicester City , and became a regular in the side that won the league title in 1967 . but he was seriously injured in a car crash just before United sealed the title . He recovered from the injuries which almost claimed his life , but his attempts to recover full fitness proved unsuccessful and he retired from playing three years later . He later worked as a printer .   Bobby has a sister named Jaqueline ( Jackie ) who has one son . Bobby also has his own children .

neg: So You Think You Can Dance (UK TV series) So You Think You Can Dance was a televised dance competition and reality show that launched in the United Kingdom in January 2010 with a format based on an American show by the same name . The show was broadcast on BBC One . The presentation of the show is similar to that of the Pop Idol series of singing competitions . The show focuses not only on the dancers ' talent , but also showcases new works by notable choreographers , crafted specifically for the dancers and the show .

neg: Ugly Models Ugly Models is a London-based alternative modelling agency that specialises in character modelling . Its owner Marc French says it is about `` celebrating everyone 's unique beauty '' . Its major clients include Calvin Klein , Levi 's , Diesel , Vogue , Elle , and Cosmopolitan . Its models have appeared in film series such as Harry Potter , Pirates of the Caribbean and James Bond . Ugly Models are in official partnership with Guinness World Records and represents the world 's tallest man , the world 's most pierced woman and the world 's most tattooed man .

neg: Katrina Kendall Katrina Kendall ( born 8 December 1989 ) is a Filipino-British environmental ambassador and beauty queen , best known for winning Miss Earth England 2015 which gives her the right to represent England in Miss Earth 2015 pageant .

neg: Brit Award for British Breakthrough Act The Brit Award for British Breakthrough Act is an award given by the British Phonographic Industry ( BPI ) , an organisation which represents record companies and artists in the United Kingdom . The accolade is presented at the Brit Awards , an annual celebration of British and international music . The winners and nominees are determined by the BRIT Awards voting academy with over 1,000 members , which comprise record labels , publishers , managers , agents , media , and previous winners and nominees .   The award was first presented in 1977 as two awards as `` British Male Newcomer '' and `` British Female Newcomer '' which were won by Graham Parker and Julie Covington . When the Brit Awards was held for the second time in 1982 , the awards `` British Male Newcomer '' and `` British Female Newcomer '' became joint as one award for both male and female acts as well introducing groups acts to award . The first award for the joint `` British Newcomer '' was won by The Human League . In 2003 the award was renamed to `` British Breakthrough Act '' .

neg: David Brown Automotive David Brown Automotive is a British manufacturer of limited edition automobiles in Coventry , England , belonging to British businessman David Brown .   The company announced the Speedback , its first model , in March 2014 in London . The vehicle 's public debut was at the Top Marques show in Monaco on 17 April 2014 . Despite sharing a similar background in engineering , and the same name as previous owner of Aston Martin , there is no family connection between the two companies .

neg: Susan Maughan Susan Maughan ( born Marian Maughan , 1 July 1938 , ) is an English singer who released successful singles in the 1960s . Her most famous and successful song , `` Bobby 's Girl '' ( a cover of the Marcie Blane single ) , reached number three in the UK Singles Chart at Christmas time in 1962 . It also reached number six in the Norwegian chart in that year .

neg: Dennis Brown Dennis Emmanuel Brown CD ( 1 February 1957 -- 1 July 1999 ) was a Jamaican reggae singer . During his prolific career , which began in the late 1960s when he was aged eleven , he recorded more than 75 albums and was one of the major stars of lovers rock , a subgenre of reggae . Bob Marley cited Brown as his favourite singer , dubbing him `` The Crown Prince of Reggae '' , and Brown would prove influential on future generations of reggae singers .


query: The exact mechanism of Huntington's disease is unknown.

pos: Huntington's disease Huntington 's disease ( HD ) , also known as Huntington 's chorea , is an inherited disorder that results in death of brain cells . The earliest symptoms are often subtle problems with mood or mental abilities . A general lack of coordination and an unsteady gait often follow . As the disease advances , uncoordinated , jerky body movements become more apparent . Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk . Mental abilities generally decline into dementia . The specific symptoms vary somewhat between people . Symptoms usually begin between 30 and 50 years of age , but can start at any age . The disease may develop earlier in life in each successive generation . About 8 % of cases start before the age of 20 years and typically present with symptoms more similar to Parkinson 's disease . People with HD often underestimate the degree of their problems .   HD is typically inherited from a person 's parents , with 10 % of cases due to a new mutation . The disease is caused by an autosomal dominant mutation in either of an individual 's two copies of a gene called Huntingtin . This means a child of an affected person typically has a 50 % chance of inheriting the disease . The Huntingtin gene provides the genetic information for a protein that is also called `` huntingtin '' . Expansion of CAG ( cytosine-adenine-guanine ) triplet repeats in the gene coding for the Huntingtin protein results in an abnormal protein , which gradually damages cells in the brain , through mechanisms that are not fully understood . Diagnosis is by genetic testing , which can be carried out at any time , regardless of whether or not symptoms are present . This fact raises several ethical debates : the age at which an individual is considered mature enough to choose testing ; whether parents have the right to have their children tested ; and managing confidentiality and disclosure of test results .   There is no cure for HD . Full-time care is required in the later stages of the disease . Treatments can relieve some symptoms and in some improve quality of life . The best evidence for treatment of the movement problems is with tetrabenazine . HD affects about 4 to 15 in 100,000 people of European descent . It is rare among Japanese , while the occurrence rate in Africa is unknown . The disease affects men and women equally . Complications such as pneumonia , heart disease , and physical injury from falls reduce life expectancy . Suicide is the cause of death in about 9 % of cases . Death typically occurs fifteen to twenty years from when the disease was first detected .   The first likely description of the disease was in 1841 by Charles Oscar Waters . The condition was described in further detail in 1872 by George Huntington , after whom it is named . The genetic basis was discovered in 1993 by an international collaborative effort led by the Hereditary Disease Foundation . Research and support organizations began forming in the late 1960s to increase public awareness , to provide support for individuals and their families , and to promote research . Current research directions include determining the exact mechanism of the disease , improving animal models to aid with research , testing of medications to treat symptoms or slow the progression of the disease , and studying procedures such as stem cell therapy with the goal of repairing damage caused by the disease .

neg: Endophenotype Endophenotype is a genetic epidemiology term which is used to separate behavioral symptoms into more stable phenotypes with a clear genetic connection . The concept was coined by Bernard John and Kenneth R. Lewis in a 1966 paper attempting to explain the geographic distribution of grasshoppers . They claimed that the particular geographic distribution could not be explained by the obvious and external `` exophenotype '' of the grasshoppers , but instead must be explained by their microscopic and internal `` endophenotype . ''   The next major use of the term was in psychiatric genetics , to bridge the gap between high-level symptom presentation and low-level genetic variability , such as single nucleotide polymorphisms . It is therefore more applicable to more heritable disorders , such as bipolar disorder and schizophrenia . Since then , the concept has expanded to many other fields , such as the study of ADHD , addiction , Alzheimer 's disease obesity and cystic fibrosis . Some other terms which have a similar meaning but do not stress the genetic connection as highly are `` intermediate phenotype '' , `` biological marker '' , `` subclinical trait '' , `` vulnerability marker '' , and `` cognitive marker '' . The strength of an endophenotype is its ability to differentiate between potential diagnoses that present with similar symptoms .

neg: Hypochondriasis Hypochondriasis , also known as hypochondria , health anxiety or illness anxiety disorder , refers to worry about having a serious illness . This debilitating condition is the result of an inaccurate perception of the condition of body or mind despite the absence of an actual medical condition . An individual suffering from hypochondriasis is known as a hypochondriac . Hypochondriacs become unduly alarmed about any physical or psychological symptoms they detect , no matter how minor the symptom may be , and are convinced that they have , or are about to be diagnosed with , a serious illness .   Often , hypochondria persists even after a physician has evaluated a person and reassured them that their concerns about symptoms do not have an underlying medical basis or , if there is a medical illness , their concerns are far in excess of what is appropriate for the level of disease . Many hypochondriacs focus on a particular symptom as the catalyst of their worrying , such as gastro-intestinal problems , palpitations , or muscle fatigue . To qualify for the diagnosis of hypochondria the symptoms must have been experienced for at least 6 months .   The DSM-IV-TR defines this disorder , `` Hypochondriasis '' , as a somatoform disorder and one study has shown it to affect about 3 % of the visitors to primary care settings . The newly published DSM-5 replaces the diagnosis of hypochondriasis with the diagnoses of `` somatic symptom disorder '' and `` illness anxiety disorder '' .   Hypochondria is often characterized by fears that minor bodily or mental symptoms may indicate a serious illness , constant self-examination and self-diagnosis , and a preoccupation with one 's body . Many individuals with hypochondriasis express doubt and disbelief in the doctors ' diagnosis , and report that doctors ' reassurance about an absence of a serious medical condition is unconvincing , or short-lasting . Additionally , many hypochondriacs experience elevated blood pressure , stress , and anxiety in the presence of doctors or while occupying a medical facility , a condition known as `` white coat syndrome '' . Many hypochondriacs require constant reassurance , either from doctors , family , or friends , and the disorder can become a disabling torment for the individual with hypochondriasis , as well as his or her family and friends . Some hypochondriacal individuals completely avoid any reminder of illness , whereas others frequently visit medical facilities , sometimes obsessively . Some sufferers may never speak about it .

neg: X-linked spinal muscular atrophy type 2 X-linked spinal muscular atrophy type 2 ( SMAX2 , XLSMA ) , also known as arthrogryposis multiplex congenita X-linked type 1 ( AMCX1 ) , is a rare neurological disorder involving death of motor neurons in the anterior horn of spinal cord resulting in generalised muscle wasting ( atrophy ) . The disease is caused by a mutation in UBA1 gene and is passed in a X-linked recessive manner by carrier mothers to affected sons .   Affected babies have general muscle weakness , weak cry and floppy limbs ; consequently , the condition is usually apparent at or even before birth . Symptoms resemble the more severe forms of the more common spinal muscular atrophy ( SMA ) ; however , SMAX2 is caused by a different genetic defect and only genetic testing can correctly identify the disease .   The disorder is usually fatal in infancy or early childhood due to progressive respiratory failure , although survival into teenage years have been reported . As with many genetic disorders , there is no known cure to SMAX2 . Appropriate palliative care may be able to increase quality of life and extend lifespan .

neg: Microinfarct A microinfarct is a microscopic stroke less than 1 millimeter in size . Microinfarcts can be found in 25-50 % of all elderly deceased persons . Microinfarcts may be the second most important cause of dementia , after Alzheimer 's disease .   Microinfarcts are microscopic lesions , of cellular death or tissue necrosis , which are a result of pathologies involving small vessels . Such pathologies are arteriosclerosis or cerebral amyloid angiopathy . Microinfarcts take longer to affect neuronal death progress , at up to 28 days , rather than hours .   Microinfarcts can range in size from 0.2 to 2.9 mm . This ailment usually goes undetected in clinical-radiological , like structural MRI , studies and is known as a `` silent pathology '' . Depending on the size , large acute microinfarcts may be detected via a special imaging known as diffusion weighted imaging .   Microinfarcts tend to occur at a high frequency , without specific regionalized locations . They are common in aging brains . This high frequency is thought to directly disrupt cognitive networks that are imperative to brain operation . Even though microinfarcts are usually undetectable , there is a general assessment of the cognitive status measured on a scale called the Clinical Dementia Rating ( CDR ) . This scale measures different parts of the brain such as diffuse white matter , periventricular myelination and cortical microinfarcts . Assessments of cortical microinfarcts have had the highest rates with being associated with cognitive degeneration . This lower cognition specifically affects perceptual speed and memory ( semantic and episodic ) . People with high frequency of this ailment tend to have greater chances of developing dementia .   Although not many studies have been conducted and little is known between microinfarcts and other vascular or epidemiological risk factors , these brain lesions are thought to be masked by other pathologies . However , the common macroscopic infarct is not exhibited in 45 % of people tested for microinfarcts .

neg: Dopamine transporter The dopamine transporter ( also dopamine active transporter , DAT , SLC6A3 ) is a membrane-spanning protein that pumps the neurotransmitter dopamine out of the synaptic cleft back into cytosol , from which other transporters sequester DA and NE into vesicles for storage and later release . Dopamine reuptake via DAT provides the primary mechanism through which dopamine is cleared from synapses , although there may be an exception in the prefrontal cortex , where evidence points to a possibly larger role of the norepinephrine transporter .   DAT is implicated in a number of dopamine-related disorders , including attention deficit hyperactivity disorder , bipolar disorder , clinical depression , and alcoholism . The gene that encodes the DAT protein is located on human chromosome 5 , consists of 15 coding exons , and is roughly 64 kbp long . Evidence for the associations between DAT and dopamine related disorders has come from a type of genetic polymorphism , known as a VNTR , in the DAT gene ( DAT1 ) , which influences the amount of protein expressed .

neg: Molecular and epigenetic mechanisms of alcoholism Alcoholism is a chronic disease characterized by trouble controlling the consumption of alcohol , dependence ( needing to consume more to achieve the same effects ) , and withdrawal upon rapid cessation of drinking . According to ARDI reports approximately 88,000 people had alcohol-related deaths in the United States between the years of 2006 and 2010 . Furthermore , chronic alcohol use is consistently the third leading cause of death in the United States . In consequence , research has sought to determine the factors responsible for the development and persistence of alcoholism . From this research , several molecular and epigenetic mechanisms have been discovered .

neg: Cholinergic In general , the word choline refers to the various quaternary ammonium salts containing the N,N,N-trimethylethanolammonium cation . Found in most animal tissues , choline is a primary component of the neurotransmitter acetylcholine and functions with inositol as a basic constituent of lecithin . It prevents fat deposits in the liver and facilitates the movement of fats into the cells . The richest sources of choline are liver , kidney , brain , wheat germ , brewer 's yeast , and egg yolk . Neurologically , cholinergic is the abbreviated term referring to acetylcholine , ( the suffix - ergic means stimulating ) . The parasympathetic nervous system , which uses acetylcholine almost exclusively to send its messages , is said to be almost entirely cholinergic . Neuromuscular junctions , preganglionic neurons of the sympathetic nervous system , the basal forebrain , and brain stem complexes are also cholinergic . In addition , the receptor for the merocrine sweat glands are also cholinergic , since acetylcholine is released from postganglionic sympathetic neurons .   In neuroscience and related fields , the term cholinergic is used in these related contexts :  A substance ( or ligand ) is cholinergic if it is capable of producing , altering , or releasing acetylcholine ( `` indirect-acting '' ) or mimicking its behaviour at one or more of the body 's acetylcholine receptor types ( `` direct-acting '' ) . Such mimics are called parasympathomimetic drugs or cholinomimetic drugs .  A receptor is cholinergic if it uses acetylcholine as its neurotransmitter .  A synapse is cholinergic if it uses acetylcholine as its neurotransmitter .

neg: Broca's area Broca 's area or the Broca area -LSB- broʊˈkɑː -RSB- or -LSB- ˈbroʊkə -RSB- is a region in the frontal lobe of the dominant hemisphere ( usually the left ) of the hominid brain with functions linked to speech production .   Language processing has been linked to Broca 's area since Pierre Paul Broca reported impairments in two patients . They had lost the ability to speak after injury to the posterior inferior frontal gyrus of the brain . Since then , the approximate region he identified has become known as Broca 's area , and the deficit in language production as Broca 's aphasia , also called expressive aphasia . Broca 's area is now typically defined in terms of the pars opercularis and pars triangularis of the inferior frontal gyrus , represented in Brodmann 's cytoarchitectonic map as areas 44 and 45 of the dominant hemisphere . Studies of chronic aphasia have implicated an essential role of Broca 's area in various speech and language functions . Further , fMRI studies have also identified activation patterns in Broca 's area associated with various language tasks . However , slow destruction of the Broca 's area by brain tumors can leave speech relatively intact suggesting its functions can shift to nearby areas in the brain .

neg: Inverse Warburg effect The term inverse Warburg effect was introduced by Lloyd Demetrius and colleagues ( 1,2 ) to describe the metabolic reprogramming observed in cortical regions of the brain during the prodromal phase of Alzheimer 's disease ( 3,4 ) and Parkinson 's disease ( 5,6 ) . This reprogramming refers to the up regulation of oxidative phosphorylation ( OxPhos ) in mitochondria of certain neurons -- a process which induces a hypermetabolic state in these neurons in an age dependent manner . The aging process is driven , in part , by an increase in molecular disorder and a concomitant decrease in enzymatic activity ( 7 ) leading to an impairment in the capacity of cells to appropriate energy from the external environment and to convert this energy into biosynthetic work . Consequently , the capacity of neurons to convert food derived fuel sources into ATP and to use this energy to maintain neuronal viability is susceptible to decline with age . However , age-induced mitochondrial dysfunction will induce a compensatory increase in OxPhos in certain sub-populations of neurons to maintain adequate energy production , and thereby ensure synaptic function and cell survival ( 8 ) . Within neurons of the aging brain an increase in OxPhos activity in intact mitochondria , and a redistribution of these mitochondria to sites which require high energy production has been documented ( 9 ) . Lloyd Demetrius and colleagues ( 1,2 ) have proposed this compensatory change as the fundamental and initiating event in the progression towards neurodegenerative diseases .   The inverse Warburg effect is postulated as the primary event in a cascade of metabolic changes ( The Inverse Warburg Hypothesis ) which ultimately leads to neuronal loss . The main energy currency in living organisms is ATP which must be continually generated to maintain cell viability . The energy is derived from two types of processes -- OxPhos which provides ~ 80 % of the total energy , and glycolysis which contributes the remaining ~ 20 % ( 10 ) ( Figure 1 ) .    In oncology , most cancer cells predominantly produce energy by the up-regulation of glycolysis . Malignant , rapidly growing tumor cells have glycolytic rates higher than those of their normal tissue of origin ( Figure 2 ) . This mode of metabolic reprogramming is now called the Warburg effect , after the Nobel Laureate , Otto Warburg , who proposed that up-regulation of glycolysis is a primary initiating event in the progression towards cancer ( 11 ) . Elevated glycolysis fuels anabolic processes that contribute to the rapid growth and cellular division associated with cancer ( 12 ) .   Epidemilogical studies have shown that cancer is inversely comorbid with both Alzheimer 's disease ( AD ) and Parkinson 's disease ( PD ) ( 13,14 ) . The molecular and bioenergetic basis for this inverse relation can be explained by invoking the Warburg effect as the fundamental cause of cancer and the Inverse Warburg effect as the fundamental cause of AD and PD ( 15 ) . Elevated glycolysis in cancer cells leads to the heightened production of lactate , the end product of glycolysis . Lactate has emerged as a key cerebral energy source that can provide energy via OxPhos ( 16 ) . Therefore , neurons with elevated OxPhos become critically dependent on an oxidative substrate , such as lactate-derived pyruvate , a key feature of the inverse Warburg effect ( Figure 3 ) . Elevated lactate production , associated with cancer , may therefore fuel the heightened metabolic demands of neurons within the brains of elderly patients . A hypermetabolic state , as predicted by the inverse Warburg effect , has been detected in the brains of individuals during the presymptomatic phase of AD and PD ( 3 -- 6 ) . However , the inability to switch to the Warburg effect not only restricts the development of cancer , but also curtails a potential source of lactate for hypermetabolic neurons within the brain . Under this scenario , neurons are starved and neurodegeneration ensues . Thus the Inverse Warburg Effect provides a holistic model which defines the role of aging as a risk factor for AD and PD , and also provides an explanation for the inverse relationship between cancer and neurodegenerative disorders .

neg: Genome instability Genome instability ( also `` genetic instability '' or `` genomic instability '' ) refers to a high frequency of mutations within the genome of a cellular lineage . These mutations can include changes in nucleic acid sequences , chromosomal rearrangements or aneuploidy . Genome instability does occur in bacteria . In multicellular organisms genome instability is central to carcinogenesis , and in humans it is also a factor in some neurodegenerative diseases such as amyotrophic lateral sclerosis or the neuromuscular disease myotonic dystrophy .   The sources of genome instability have only recently begun to be elucidated . A high frequency of externally caused DNA damage can be one source of genome instability since DNA damages can cause inaccurate translesion synthesis past the damages or errors in repair , leading to mutation . Another source of genome instability may be epigenetic or mutational reductions in expression of DNA repair genes . Because endogenous ( metabolically-caused ) DNA damage is very frequent , occurring on average more than 60,000 times a day in the genomes of human cells , any reduced DNA repair is likely an important source of genome instability .

neg: Synactive Theory of Newborn Behavioral Organization and Development The Synactive Theory of Newborn Behavioral Organization and Development ( Synaction n. , or Synactive adj. -LSB- from the Greek syn `` together '' and the Latin actio `` action , '' resulting in : `` together in action '' -RSB- ) suggests that development of the human fetus , and later newborn , proceeds through the constant balancing of approach and avoidance behaviors , leading to : 1 ) a continuous interaction of the subsystems ( i.e. , Autonomic , Motor , State and Attention/Interaction , and Regulatory ) and their increasingly defined delineations within the organism , that is the infant , and 2 ) the organism 's interaction with the environment at large . This process is aimed at bringing about the increasingly well-defined species-unique developmental agenda .   Figure 1 ( below ) , provides a graphic representation of the Synactive Theory of development , as applied to both fetal and newborn stages . It focuses upon the infant 's within-organism , four subsystems of functioning , and their continuous interaction with each other and with the environment across time ( i.e. , `` together in action , '' or synaction ) . The four subsystems include the :   Autonomic Subsystem : Expressed in the pattern of respiration ( e.g. , fast , slow , pauses ) color changes ( e.g. , pink , pale , red ) , neurological indicators ( e.g. , seizures , tremulousness ) , and visceral or gut signals such as bowel movements , gagging , and hiccoughing ;   Motor Subsystem : Observable through the tone , posture and movement patterns of the infant ;   State and Attention/Interaction Subsystem : Expressed via : 1 ) the range of states available to the infant ( i.e. , deep sleep , light sleep , drowsy , alert , hyperalert , and cry ) , 2 ) how clearly it is to observably differentiate one state from the other , and 3 ) the patterns of transitions from one state to another ( e.g. , smooth well-differentiated state transitions versus abrupt unorganized state transitions ) .   The attention/interaction system is set within this state continuum ( i.e. , from deep sleep to cry ) and represented by the infant 's ability to adjust the robustness and increasing refinement of an alert , attentive state . The infant uses this state to take in cognitive and social information from the environment as well as to bring forth and modify inputs from the surrounding world ; and   Regulatory Subsystem : Behaviorally represented via the observable strategies the infant uses ( Self-Regulation ) in maintaining a balanced , relatively stable and relaxed state of subsystem of functioning or in returning to this a state of subsystem functioning if imbalance , or stress has occurred within the subsystems .   An additional component of the regulatory subsystem is observable in the kind and amount of support offered by the caregiver ( e.g. , supporting a soft , tucked , flexed position of the infant 's arms and legs ) or by the environment ( e.g. , dimming the lights in the nursery ) . This Co-Regulation may be necessary to help the infant 's return to balance in situations when his/her own self-regulatory capacities are exceeded .   Reproduced with permission from Als , H. Toward a synactive theory of development : Promise for the assessment of infant individuality . Infant Mental Health Journal . 1982 : ( 3 ) : 229-243 ; p. 234 .   The graphic representation of the Synactive Theory above depicts the developing organism , that is , the infant , in constant interaction with the environment from within the womb to the newborn intensive care unit ( NICU ) , and the caregiving family 's support in the NICU , to the family in their home . Newborn infants are actively striving for their next steps in development , while depending upon `` good enough '' environments and care to assure progress along their developmental agenda .   The Synactive Theory of Development continues to be instrumental in guiding clinicians ( e.g. , neonatologist , nurses , psychologists , developmental specialists , physical/occupational therapists , etc. ) and researchers in their understanding of the often very small steps in development that prematurely born and other high risk newborns attempt to accomplish ( which are major steps for their immature or injured brain ) . This theory gives professionals the framework and tools with which to identify the infant 's strengths , challenges and accomplishments . Such accomplishments may include breathing , sucking and swallowing in a coordinated sequence ; moving food down into and through the stomach and intestinal track instead of upwards , leading to reflux and vomiting ; looking at the caregiver and breathing at the same time , as well as many others .   The Synactive Theory is the foundation of both : 1 ) the Assessment of Preterm Infants ' Behavior ( APIB ) , a standardized comprehensive newborn test , and 2 ) the Newborn Individualized Developmental Care and Assessment Program ( NIDCAP ) , which is the care and intervention approach , that focuses on each infant 's behavioral cues ( e.g. , hand ( s ) to mouth , bracing with feet against a supporting surface ) in order to support the infant 's strengths and reduce the infant 's vulnerabilities . The infant 's family is viewed as the infant 's most important nurturer and is integrated in all care from the infant 's birth on throughout the infant 's hospitalization .

neg: Parkinson's disease Parkinson 's disease ( PD ) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system . The symptoms generally come on slowly over time . Early in the disease , the most obvious are shaking , rigidity , slowness of movement , and difficulty with walking . Thinking and behavioral problems may also occur . Dementia becomes common in the advanced stages of the disease . Depression and anxiety are also common occurring in more than a third of people with PD . Other symptoms include sensory , sleep , and emotional problems . The main motor symptoms are collectively called `` parkinsonism '' , or a `` parkinsonian syndrome '' .   The cause of Parkinson 's disease is generally unknown , but believed to involve both genetic and environmental factors . Those with a family member affected are more likely to get the disease themselves . There is also an increased risk in people exposed to certain pesticides and among those who have had prior head injuries while there is a reduced risk in tobacco smokers and those who drink coffee or tea . The motor symptoms of the disease result from the death of cells in the substantia nigra , a region of the midbrain . This results in not enough dopamine in these areas . The reason for this cell death is poorly understood , but involves the build-up of proteins into Lewy bodies in the neurons . Diagnosis of typical cases is mainly based on symptoms , with tests such as neuroimaging being used to rule out other diseases .   There is no cure for Parkinson 's disease . Initial treatment is typically with the antiparkinson medication L-DOPA ( levodopa ) , with dopamine agonists being used once levodopa becomes less effective . As the disease progresses and neurons continue to be lost , these medications become less effective while at the same time they produce a complication marked by involuntary writhing movements . Diet and some forms of rehabilitation have shown some effectiveness at improving symptoms . Surgery to place microelectrodes for deep brain stimulation has been used to reduce motor symptoms in severe cases where drugs are ineffective . Evidence for treatments for the non-movement-related symptoms of PD , such as sleep disturbances and emotional problems , is less strong .   In 2015 , PD affected 6.2 million people and resulted in about 117,400 deaths globally . Parkinson 's disease typically occurs in people over the age of 60 , of which about one percent are affected . Males are more often affected than females . When it is seen in people before the age of 50 , it is called young-onset PD . The average life expectancy following diagnosis is between 7 and 14 years . The disease is named after the English doctor James Parkinson , who published the first detailed description in An Essay on the Shaking Palsy , in 1817 . Public awareness campaigns include World Parkinson 's Day ( on the birthday of James Parkinson , 11 April ) and the use of a red tulip as the symbol of the disease . People with parkinsonism who have increased the public 's awareness of the condition include actor Michael J. Fox , Olympic cyclist Davis Phinney , and late professional boxer Muhammad Ali .

neg: Neurophysiology Neurophysiology ( from Greek νεῦρον , neuron , `` nerve '' ; φύσις , physis , `` nature , origin '' ; and - λογία , - logia , `` knowledge '' ) is a branch of physiology and neuroscience that is concerned with the study of the functioning of the nervous system . The primary tools of basic neurophysiological research include electrophysiological recordings , such as patch clamp , voltage clamp , extracellular single-unit recording and recording of local field potentials , as well as some of the methods of calcium imaging , optogenetics , and molecular biology .   Neurophysiology is related to electrophysiology , neurobiology , psychology , neurology , clinical neurophysiology , neuroanatomy , cognitive science , biophysics , mathematical biology , and other sciences concerning the brain .

neg: Huntington's Disease Association The Huntington 's Disease Association ( HDA ) is a charity that supports people in England and Wales affected by the genetic neurodegenerative brain condition Huntington 's disease ( HD ) .   The HDA was founded in 1986 and is based in Liverpool . It supports a network of regional care advisors who offer care and support to people with and at risk of Huntington 's disease and their families . The HDA also has a research programme that supports scientific and social research into HD . It has worked to establish and support a network of multidisciplinary clinics for HD patients in the UK .   The charity was instrumental in the 2010 launch of an All-Party Parliamentary Group for Huntington 's disease in the UK Parliament , chaired by Lord Walton of Detchant , and 2010 research revealing that the prevalence of HD is much higher than previously thought .   The HDA won the 2005 UK Charity Award for healthcare and medical research and the 2005 National Health Service ( NHS ) Health and Social Care Award for long term conditions .   The HDA 's patrons are Patricia , Countess of Harewood , singer Tony Hadley and entertainer Shane Richie .   The HDA is part of the UK HD Alliance , along with the Scottish Huntington 's Association and HD Association Northern Ireland . It is also a member of the International Huntington Alliance .

neg: Neurodegeneration Neurodegeneration is the progressive loss of structure or function of neurons , including death of neurons . Many neurodegenerative diseases including amyotrophic lateral sclerosis , Parkinson 's , Alzheimer 's , and Huntington 's occur as a result of neurodegenerative processes . Such diseases are incurable , resulting in progressive degeneration and/or death of neuron cells . As research progresses , many similarities appear that relate these diseases to one another on a sub-cellular level . Discovering these similarities offers hope for therapeutic advances that could ameliorate many diseases simultaneously . There are many parallels between different neurodegenerative disorders including atypical protein assemblies as well as induced cell death . Neurodegeneration can be found in many different levels of neuronal circuitry ranging from molecular to systemic .

neg: Cortical column A cortical column , also called hypercolumn , macrocolumn , functional column or sometimes cortical module , is a group of neurons in the cortex of the brain that can be successively penetrated by a probe inserted perpendicularly to the cortical surface , and which have nearly identical receptive fields . Neurons within a minicolumn ( microcolumn ) encode similar features , whereas a hypercolumn `` denotes a unit containing a full set of values for any given set of receptive field parameters '' . A cortical module is defined as either synonymous with a hypercolumn ( Mountcastle ) or as a tissue block of multiple overlapping hypercolumns .   The columnar hypothesis states that the cortex is composed of discrete , modular columns of neurons , characterized by a consistent connectivity profile .   It is still unclear what precisely is meant by the term , and it does not correspond to any single structure within the cortex . It has been impossible to find a canonical microcircuit that corresponds to the cortical column , and no genetic mechanism has been deciphered that designates how to construct a column . However , the columnar organization hypothesis is currently the most widely adopted to explain the cortical processing of information .

neg: History of Tourette syndrome Tourette syndrome is an inherited neurological disorder with onset in childhood , characterized by the presence of multiple physical ( motor ) tics and at least one vocal ( phonic ) tic .   The eponym was bestowed by Jean-Martin Charcot ( 1825 -- 93 ) on behalf of his resident , Georges Albert Édouard Brutus Gilles de la Tourette ( 1859 -- 1904 ) , a French physician and neurologist , who published an account of nine patients with Tourette 's in 1885 . The possibility that movement disorders , including Tourette syndrome , might have an organic origin was raised when an encephalitis epidemic from 1918 -- 1926 led to a subsequent epidemic of tic disorders . Research in 1972 advanced the argument that Tourette 's is a neurological , rather than psychological , disorder ; since the 1990s , a more neutral view of Tourette 's has emerged , in which biological vulnerability and adverse environmental events are seen to interact .   Findings since 1999 have advanced TS science in the areas of genetics , neuroimaging , neurophysiology , and neuropathology . Questions remain regarding how best to classify Tourette syndrome , and how closely Tourette 's is related to other movement disorders or psychiatric disorders . Good epidemiologic data is still lacking , and available treatments are not risk free and not always well tolerated .

neg: Hypoplasia Hypoplasia ( from Ancient Greek ὑπo - hypo - , `` under '' + πλάσις plasis , `` formation '' ; adjective form hypoplastic ) is underdevelopment or incomplete development of a tissue or organ . Although the term is not always used precisely , it properly refers to an inadequate or below-normal number of cells . Hypoplasia is similar to aplasia , but less severe . It is technically not the opposite of hyperplasia ( too many cells ) . Hypoplasia is a congenital condition , while hyperplasia generally refers to excessive cell growth later in life . ( Atrophy , the wasting away of already existing cells , is technically the direct opposite of both hyperplasia and hypertrophy . )   Hypoplasia can be present in any tissue or organ . It is descriptive of many medical conditions , including underdevelopment of organs such as :   Breasts during puberty  Testes in Klinefelter 's syndrome  Ovaries in Fanconi anemia , gonadal dysgenesis , trisomy X  Thymus in DiGeorge syndrome  Labia majora in popliteal pterygium syndrome  Corpus callosum , connecting the two sides of the brain , in Agenesis of the corpus callosum  Cerebellum caused by mutation in the Reelin gene  Tooth caused by oral pathology , such as Turner 's hypoplasia  Chambers of the heart in hypoplastic left heart syndrome and hypoplastic right heart syndrome  Optic nerve in optic nerve hypoplasia  Sacrum in sacral agenesis  Facial muscle in asymmetric crying facies  Thumb from birth  Lungs , often as a result of oligohydramnios during gestation or the existence of congenital diaphragmatic hernia  Small bowel in coeliac disease  Fingers and ears in Harlequin type ichthyosis  Mandible in congenital hypothyroidism

neg: PBT2 PBT2 is an experimental drug candidate . It is a second-generation 8-hydroxyquinoline analog intended to be a successor to clioquinol and a potential treatment of Alzheimer 's disease and Huntington disease .

neg: Human pathogen A human pathogen is a pathogen ( microbe or microorganism such as a virus , bacterium , prion , or fungus ) that causes disease in humans .   The human physiological defense against common pathogens ( such as Pneumocystis ) is mainly the responsibility of the immune system with help by some of the body 's normal flora and fauna . However , if the immune system or `` good '' microbiota are damaged in any way ( such as by chemotherapy , human immunodeficiency virus ( HIV ) , or antibiotics being taken to kill other pathogens ) , pathogenic bacteria that were being held at bay can proliferate and cause harm to the host . Such cases are called opportunistic infections .   Some pathogens ( such as the bacterium Yersinia pestis , which may have caused the Black Plague , the Variola virus , and the malaria protozoa ) have been responsible for massive numbers of casualties and have had numerous effects on afflicted groups . Of particular note in modern times is HIV , which is known to have infected several million humans globally , along with the influenza virus . Today , while many medical advances have been made to safeguard against infection by pathogens , through the use of vaccination , antibiotics , and fungicide , pathogens continue to threaten human life . Social advances such as food safety , hygiene , and water treatment have reduced the threat from some pathogens .