query: The Land Before Time is a 1988 live-action film.

pos: The Land Before Time The Land Before Time is a 1988 American-Irish animated adventure drama film directed and produced by Don Bluth and executive produced by Steven Spielberg , George Lucas , Kathleen Kennedy , and Frank Marshall .   Produced by Sullivan Bluth Studios , Amblin Partners ' Amblin Entertainment and Lucasfilm ( despite not receiving an official credit nor the film 's marketing bearing the studio 's logo ) , it features dinosaurs living in the prehistoric times . The plot concerns a young Brontosaurus named Littlefoot who is orphaned when his mother is killed by a Tyrannosaurus . Littlefoot flees famine and upheaval to search for the Great Valley , an area spared from devastation . On his journey , he meets four young companions : Cera , Ducky , Petrie , and Spike , a Spike-tail .   The film explores issues of prejudice between the different species and the hardships they endure in their journey as they are guided by the spirit of Littlefoot 's mother and also forced to deal with the murderous T-Rex that killed her . This is the only Don Bluth film of the 1980s in which Dom DeLuise did not participate ( instead , he starred in Disney 's Oliver & Company that same year ) , and the only film in The Land Before Time series that is not a musical , as well as the only one to be released theatrically worldwide .   Released by Universal Pictures on November 18 , 1988 , the film was a critical and financial success , and spawned a multimillion-dollar franchise with thirteen direct-to-video sequels and a television series ( without involvement from Bluth , Spielberg , or Lucas ) as well as merchandise ( toys , video games , etc. ) and a television series .

neg: Sweet Hearts Dance Sweet Hearts Dance is a 1988 American comedy drama film directed by Robert Greenwald . The screenplay by Ernest Thompson centers on two small town couples , one married for several years and the other at the beginning of their relationship .   The film was shot on location in Hyde Park , Vermont at Brendan Mullins ' house . Mayor of Burlington , future Vermont Senator and 2016 presidential candidate Bernie Sanders makes a cameo appearance in the film .

neg: Barracuda (1988 film) Barracuda is a 1988 Australian TV film .

neg: Rapid Fire (1989 film) Rapid Fire is a 1989 American action film produced by Action International Pictures and directed by David A. Prior . It was filmed in Mobile , Alabama and it is the last film appearance of Joe Spinell , who died shortly after filming ended .

neg: Boulevard of Broken Dreams (film) Boulevard of Broken Dreams is a 1988 Australian film . It was the first movie from Boulevard Films .

neg: The Moderns The Moderns is a 1988 film by Alan Rudolph , which takes place in 1926 Paris during the period of the Lost Generation and at the height of modernist literature . The film stars Keith Carradine , Linda Fiorentino and John Lone among others .

neg: Donald Land is a Family Computer video game produced by Data East , in 1988 . It is a side-scrolling platforming game featuring Ronald McDonald and McDonald characters .   The game 's only background music is a derivative of the classic McDonald 's theme song as heard through Japanese televisions of the 1980s .

neg: Haunted Summer Haunted Summer is a 1988 drama film directed by Ivan Passer .

neg: 11/22/63 11/22/63 is a novel by Stephen King about a time traveler who attempts to prevent the assassination of President John F. Kennedy , which occurred on November 22 , 1963 ( the novel 's titular date ) . The novel was announced on King 's official site on March 2 , 2011 . A short excerpt was released online on June 1 , 2011 , and another excerpt was published in the October 28 , 2011 , issue of Entertainment Weekly . The novel was published on November 8 , 2011 and quickly became a number-one bestseller . It stayed on The New York Times Best Seller list for 16 weeks . 11/22/63 won the 2011 Los Angeles Times Book Prize for Best Mystery/Thriller and the 2012 International Thriller Writers Award for Best Novel , and was nominated for the 2012 British Fantasy Award for Best Novel and the 2012 Locus Award for Best Science Fiction Novel .   The novel required considerable research to accurately portray the late 1950s and early 1960s . King commented on the amount of research it required , saying `` I 've never tried to write anything like this before . It was really strange at first , like breaking in a new pair of shoes . ''   The novel was adapted into a 2016 Hulu television series , 11.22.63 .

neg: Blue Skies (1988 TV series) Blue Skies is an American drama that aired from June 13 until August 1 , 1988 .

neg: E.T. the Extra-Terrestrial E.T. the Extra-Terrestrial is a 1982 American science fiction fantasy film co-produced and directed by Steven Spielberg , and written by Melissa Mathison . It features special effects by Carlo Rambaldi and Dennis Muren , and stars Henry Thomas , Dee Wallace , Robert MacNaughton , Drew Barrymore , Peter Coyote and Pat Welsh . It tells the story of Elliott ( Thomas ) , a lonely boy who befriends an extraterrestrial , dubbed `` E.T. '' , who is stranded on Earth . He and his siblings help it return home while attempting to keep it hidden from their mother and the government .   The concept was based on an imaginary friend Spielberg created after his parents ' divorce in 1960 . In 1980 , Spielberg met Mathison and developed a new story from the stalled sci-fi horror film project Night Skies . It was shot from September to December 1981 in California on a budget of US$ 10.5 million . Unlike most films , it was shot in rough chronological order , to facilitate convincing emotional performances from the young cast .   Released on June 11 , 1982 by Universal Pictures , E.T was an immediate blockbuster , surpassing Star Wars to become the highest-grossing film of all time -- a record it held for eleven years until Jurassic Park , another Spielberg-directed film , surpassed it in 1993 . It is the highest-grossing film of the 1980s . Widely regarded as one of the greatest films of all time , critics acclaimed it as a timeless story of friendship , and it ranks as the greatest science fiction film ever made in a Rotten Tomatoes survey . In 1994 , it was selected for preservation in the United States National Film Registry as being `` culturally , historically , or aesthetically significant '' . It was re-released in 1985 , and then again in 2002 to celebrate its 20th anniversary , with altered shots and additional scenes .

neg: Above the Law (film) Above the Law ( also known as Nico ) is a 1988 American action film written , produced and directed by Andrew Davis , and also produced by and starring Steven Seagal in his film debut . The film co-stars Pam Grier , Sharon Stone , Daniel Faraldo and Henry Silva . This came about after a successful screen test , financed by Michael Ovitz , leading to Seagal being offered a contract by Warner Bros. . The film was set and filmed on location in Chicago . The film was released in the United States on April 8 , 1988 .

neg: Groundhog Day (film) Groundhog Day is a 1993 American fantasy-comedy film directed by Harold Ramis , starring Bill Murray , Andie MacDowell , and Chris Elliott . It was written by Ramis and Danny Rubin , based on a story by Rubin . Murray plays Phil Connors , an arrogant Pittsburgh TV weatherman who , during an assignment covering the annual Groundhog Day event in Punxsutawney , Pennsylvania , finds himself caught in a time loop , repeating the same day again and again . After indulging in hedonism and committing suicide numerous times , he begins to re-examine his life and priorities .   On its release , Groundhog Day was a modest success and garnered generally positive reviews . It gained stronger appreciation among critics and film historians over time , and is now often listed among the best comedy films ever . It further entered into the public consciousness , where the term `` Groundhog Day '' can represent a situation that seems to repeat over and over in government and military arenas , as well as influencing other entertainment . In 2006 , the film was added to the United States National Film Registry as being deemed `` culturally , historically , or aesthetically significant '' . A stage musical version of the film premiered in 2016 .

neg: Moving Target (1988 American film) Moving Target is a 1988 American television film directed by Chris Thomson .

neg: A Time of Destiny A Time of Destiny is a 1988 American drama film directed by Gregory Nava and written by Nava and Anna Thomas . The story is based on the opera La forza del destino by Giuseppe Verdi . The motion picture was executive produced by Shep Gordon and Carolyn Pfeiffer . It features original music by veteran composer Ennio Morricone .   Set during World War II in Italy and San Diego , the film tells of two friends who become enemies during the war .

neg: 1988 Academy Awards 1988 Academy Awards may refer to :   60th Academy Awards , the Academy Awards ceremony that took place in 1988  61st Academy Awards , the 1989 ceremony honoring the best in film for 1988

neg: Histoire(s) du cinéma Histoire ( s ) du cinéma ( -LSB- is.twaʁ dy si.ne.ma -RSB- ) is an 8-part video project begun by Jean-Luc Godard in the late 1980s and completed in 1998 . The longest , at 266 minutes , and one of the most complex of Godard 's films , Histoire ( s ) du cinéma is an examination of the history of the concept of cinema and how it relates to the 20th century ; in this sense , it can also be considered a critique of the 20th century and how it perceives itself . The project is considered by many the most important work of the late period of Godard 's career .   Histoire ( s ) du cinéma is always referred to by its French title , because of the word play it implies : histoire means both `` history '' and `` story , '' and the s in parentheses gives the possibility of a plural . Therefore , the phrase Histoire ( s ) du cinéma simultaneously means The History of Cinema , Histories of Cinema , The Story of Cinema and Stories of Cinema . Similar double or triple meanings , as well as puns , are a recurring motif throughout Histoire ( s ) and much of Godard 's work .   The film was screened out of competition at the 1988 Cannes Film Festival . Nine years later , it was screened in the Un Certain Regard section at the 1997 Festival .   The soundtrack was released as a 5-CD boxed set on the ECM record label .

neg: Tomorrowland (film) Tomorrowland ( subtitled A World Beyond in some regions ) is a 2015 American science-fiction mystery adventure film directed and co-written by Brad Bird . Bird co-wrote the film 's screenplay with Damon Lindelof , from an original story treatment by Bird , Lindelof and Jeff Jensen . The film stars George Clooney , Hugh Laurie , Britt Robertson , Raffey Cassidy , Tim McGraw , Kathryn Hahn and Keegan-Michael Key . In the film , a disillusioned genius inventor and a teenage science enthusiast embark to an ambiguous alternate dimension known as `` Tomorrowland '' where their actions directly affect the world and themselves .   Walt Disney Pictures originally announced the film in June 2011 under the working title 1952 , and later retitled it to Tomorrowland , after the futuristic themed land found at Disney theme parks . In drafting their story , Bird and Lindelof took inspiration from the progressive cultural movements of the Space Age , as well as Walt Disney 's optimistic philosophy of the future , notably his conceptual vision for the planned community known as EPCOT . Principal photography began in August 2013 , with footage shot in British Columbia , Alberta , Florida , and Spain with second unit filming in France , California and the Bahamas .   Tomorrowland was released in conventional and IMAX formats on May 22 , 2015 , and was the first theatrical film to be released in Dolby Vision and Dolby Cinema . Upon its release , the film received mixed reviews from critics ; earning praise for its original premise , musical score , action , visuals , and themes , but criticism in regards to the screenplay 's uneven writing and tone . The film grossed $ 209 million worldwide against a total production and marketing cost of $ 330 million , losing Disney $ 120 -- 140 million .

neg: The Blood of Heroes The Blood of Heroes is a 1989 post-apocalyptic film directed by David Webb Peoples and starring Rutger Hauer and Joan Chen . The film is also known by the names The Salute of the Jugger and Salute to the Jugger . The film has inspired the creation of the sport Jugger . It has also found its way into Amtgard , a live action role-playing game which has been playing the game for almost 20 years .

neg: Without a Clue Without a Clue is a 1988 British comedy film directed by Thom Eberhardt and starring Michael Caine and Ben Kingsley .

neg: Distant Thunder (1988 film) Distant Thunder is a 1988 American drama film directed by Rick Rosenthal and starring John Lithgow and Ralph Macchio .


query: Sarah Palin is Australian.

pos: Sarah Palin Sarah Louise Palin ( -LSB- ˈpeɪlᵻn -RSB- née Heath ; born February 11 , 1964 ) is an American politician , commentator , and author who served as the ninth Governor of Alaska from 2006 until her resignation in 2009 . As the Republican Party nominee for Vice President of the United States in the 2008 election alongside presidential nominee , Arizona Senator John McCain , she was the first Alaskan on the national ticket of a major political party and the first Republican woman selected as a vice presidential candidate . Also , her book Going Rogue has sold more than two million copies .   She was elected to the Wasilla city council in 1992 and became mayor of Wasilla in 1996 . In 2003 , after an unsuccessful run for lieutenant governor , she was appointed chair of the Alaska Oil and Gas Conservation Commission , responsible for overseeing the state 's oil and gas fields for safety and efficiency . She was the youngest person and the first woman to be elected Governor of Alaska .   Since her resignation as Governor , she has endorsed and campaigned for the Tea Party movement as well as several candidates in multiple election cycles , prominently including Donald Trump for President in 2016 . From 2010 to 2015 , she provided political commentary for Fox News . On April 3 , 2014 , Palin premiered her TV show , Amazing America with Sarah Palin , on the Sportsman Channel , which ran until February 12 , 2015 . On July 27 , 2014 , Palin launched the online news network called the Sarah Palin Channel , which was closed on July 4 , 2015 .

neg: Conservation in Australia Conservation in Australia is an issue of state and federal policy . Australia is one of the most biologically diverse countries in the world , with a large portion of species endemic to Australia . Preserving this wealth of biodiversity is important for future generations .   Animal habitats like reefs and forests must be preserved in order to preserve population and diversity of animal species . Conservation is vital for future study and for field research to be taken , and because biological richness is an unmeasurable aesthetic that may be developed into commercial recreational attractions .   According to Janine Benyus , the potential for advances in biomimicry in Australia are great because the extreme weather and conditions found here provide an excellent evolutionary incubator . Research on natural processes can only occur if habitat is preserved and organisms continue to thrive .   Federal and State governments manage protected areas and national parks ; a number of non-governmental organizations are also involved in conservation .

neg: Australian Transaction Reports and Analysis Centre Australian Transaction Reports and Analysis Centre ( AUSTRAC ) is an Australian government financial intelligence agency set up to monitor financial transactions to identify money laundering , organised crime , tax evasion , welfare fraud and terrorism . AUSTRAC was established in 1989 under the Financial Transaction Reports Act 1988 and continued in existence under the Anti-Money Laundering and Counter-Terrorism Financing Act 2006 ( AML/CTF Act ) . AUSTRAC 's head office is in Sydney , New South Wales .   The Anti-Money Laundering and Counter-Terrorism Financing Act 2006 ( Cth ) came into law on 12 December 2006 , and extended the existing monitoring regime to cover financing of terrorism and listed terrorist organisations . Under Division 103 of the Criminal Code Act 1995 ( Cth ) , it is illegal to finance terrorism . The Attorney-General 's Department maintains a list of outlawed terror organisations . In 2014 AUSTRAC released a report , Terrorism financing in Australia 2014 , which says , `` Terrorism financing poses a serious threat to Australians and Australian interests at home and abroad . ''   Australia is a member of the Egmont Group of Financial Intelligence Units and an observer in the Camden Assets Recovery Interagency Network and is a member of the Financial Action Task Force on Money Laundering ( FATF ) and the Global Forum on Transparency and Exchange of Information for Tax Purposes .   Certain classes of financial services are required to be reported to AUSTRAC , in particular bank cash transactions ( i.e. , notes and coins ) of A$ 10,000 or more , as well as suspicious transactions and all international transfers . The information that AUSTRAC collects is available for use by law enforcement , revenue , regulatory , security and other agencies .

neg: Internet television in Australia Internet television in Australia is the digital distribution of movies and television content via the Internet . In Australia , Internet television is provided by five major pay-per-view providers , in addition to several niche television streaming services . Australia 's five major free-to-air television networks all offer catch up TV of previously broadcast content to watch via the Internet or via podcasts - drawing on both domestic and foreign content . A feature of Internet television is that a user can view TV or video on demand . Some distributors provide content as downloads , whiles other streaming media ; the main difference being that with downloads the end-user must have storage capacity for the content on their device and must wait for the download to be completed before the content can be viewed , while streamed content can be viewed almost immediately , but is not stored for a later second viewing .   Whether downloaded or streamed , video files over the Internet are usually metered in Australia , with most ISPs setting download quotas which can limit the downloads that a subscriber can make without incurring additional costs . ISPs also provide plans with unlimited downloads . Some ISPs offer downloads on a quota-free basis for partnered television services , which is also known as `` unmetered '' content .

neg: Great Southern (Western Australia) __ NOTOC __   The Great Southern Region is one of the nine regions of Western Australia , as defined by the Regional Development Commissions Act 1993 , for the purposes of economic development . It is a section of the larger South Coast of Western Australia and neighbouring agricultural regions .   The region officially comprises the local government areas of Albany , Broomehill-Tambellup , Cranbrook , Denmark , Gnowangerup , Jerramungup , Katanning , Kent , Kojonup , Plantagenet and Woodanilling .   The Great Southern Region has an area of 39007 km2 and a population of about 54,000 . Its administrative centre is the historic port of Albany . It has a Mediterranean climate , with hot , dry summers and cool , wet winters .   The economy of the Great Southern Region is dominated by livestock farming and crop-growing . It has some of the most productive cereal grain and pastoral land in the state , and is a major producer of wool and lamb . Albany is a major fishing centre .   The coast of the Great Southern Region has milder summer weather than areas on the west coast proper and is also a popular destination for holidaymakers , tourists , anglers and surfers . Albany is home to the Kalgan River which is associated with riverboats , from 1918 to 1935 with the Silver Star which lowered its funnel to get under a bridge , and today with the Kalgan Queen which lowers its roof to pass beneath the same bridge .   Noongar people have inhabited the region for tens of thousands of years . European settlement began with the establishment of a temporary British military base , commanded by Major Edmund Lockyer , at King George Sound ( Albany ) on Christmas Day , 1826 . Albany is consequently regarded as the oldest European settlement in Western Australia .

neg: Australia Day 2012 protests The Australia Day Protests of 2012 began with a commemoration at the Aboriginal Tent Embassy in Canberra to mark its 40th Anniversary and culminated in a security scare which saw the Prime Minister and Opposition Leader of Australia escorted from a nearby Canberra venue amidst rowdy protesters . The protesters had been advised of the leaders ' whereabouts and misinformed of a statement by the opposition leader in relation to the Tent Embassy by a union official who had received information about Abbott 's statement and whereabouts from the prime minister 's office .   Gillard and Abbott were temporarily trapped when around 100 protesters surrounded the venue . The security scare made international headlines and saw Prime Minister Julia Gillard stumble and lose her shoe as she was carried by a body guard to her car .

neg: European Australians European Australians , or White Australians , are citizens or residents of Australia whose ancestry originates from the peoples of Europe and the Caucasus .   Since the early 19th century , people of European descent have formed the vast majority of the population in Australia . The majority of European Australians are of British Isles -- English , Irish , Scottish , Welsh or Cornish ( Anglo-Celtic ) -- ancestral origin . In 2010 , it was estimated that around 74 % of the Australian population were Anglo-Celtic Australians .   Other significant ancestries include Italian , German , Greek , Dutch , New Zealanders ( European New Zealanders ) , Polish , Maltese and Croatian . Today , Australians of British and other European ancestries are the dominant majority in Australia , estimated at 92 % of the total population .   Historically , European immigrants had great influence over Australian history and society , which resulted in the perception of Australia as a European country .

neg: Australian Aborigines' League The Australian Aborigines ' League was established in Melbourne , Australia , in 1934 by William Cooper and others , including Margaret Tucker , Eric Onus , Anna and Caleb Morgan , and Shadrach James .   In a Letter to the Editor of the West Australian , the Hon. Secretary of the Australian Aborigines League , William Cooper wrote that , `` The plea of our league is `` a fair deal for the dark race . ''   An early initiative by the League was to petition King George V for Indigenous Australians to be represented in the Australian Parliament , among other requests . 1,814 signatures were collected on the petition , although it was reported that William Cooper believed many Aboriginal people living on missions were too afraid to add their signature .   In 1938 it joined the New South Wales based Aborigines Progressive Association in staging a Day of Mourning on Australia Day ( 26 January ) in Sydney to draw attention to the treatment of Aborigines and to demand full citizenship and equal rights . Mr. W. Ferguson , organising secretary of the Aborigines ' Progressive Association of New South Wales , said of the planned national day of mourning : `` The aborigines do not want protection ... We have been protected for 150 years , and look what has become of us . Scientists have studied us and written books about us as though we were some strange curiosities , but they have not prevented us from contracting tuberculosis and other diseases , which have wiped us out in thousands . ''   On 6 December 1938 , following the Kristallnacht pogrom in Germany , a delegation of League members , led by Cooper , went to the German Consulate in Melbourne with a petition protesting against the `` cruel persecution of the Jewish people by the Nazi government of Germany '' .   The League was less active after Cooper 's death in 1941 but was revived after the Second World War by Douglas Nicholls and by Eric and Bill Onus . In the 1960s it became the Victorian branch of the Aborigines Advancement League .

neg: Federalism in Australia Federalism in Australia was formally adopted on 1 January 1901 when the six self-governing Australian colonies federated as the Commonwealth of Australia . To this day Australia remains a federation of those six `` original States '' under the Commonwealth Constitution . Australia is the seventh oldest federation in the world after the United States ( 1789 ) , Mexico ( 1824 ) , Switzerland ( 1848 ) , Canada ( 1867 ) , the German Empire ( 1871 ) and Brazil ( 1891 ) and the only one of those to have remained entirely unchanged in its composition . In formal constitutional terms , little has been altered since Australians made that decision over a century ago ; in practice , however , the way Australian federalism functions has changed enormously over the intervening years . The most significant respect in which it has changed is in the degree to which the Commonwealth government has assumed a position of dominance .

neg: Australian Senate The Australian Senate is the upper house of the bicameral Parliament of Australia , the lower house being the House of Representatives . The composition and powers of the Senate are established in Chapter I , Part II of the Australian Constitution . There are a total of 76 senators : 12 senators are elected from each of the six states ( regardless of population ) and two from each of the two autonomous internal territories ( the Australian Capital Territory and the Northern Territory ) . Senators are popularly elected under the single transferable vote system of proportional representation .   Unlike upper Houses in most Westminster parliamentary systems , the Senate is vested with significant power , including the capacity to block all legislation , including Budget and Appropriation Bills , initiated by the government in the House of Representatives , making it a distinctive hybrid of British Westminster bicameralism and US-style bicameralism . As a result of proportional representation , the chamber features a multitude of parties vying for power . The governing party or coalition , which has to maintain the confidence of the lower house , rarely has a majority in the Senate and usually needs to negotiate with other parties and Independents to get legislation passed .   Senators normally serve fixed six-year terms ( from 1 July to 30 June ) , unless the Senate is dissolved earlier in a double dissolution . Following a double dissolution half the state senators serve terms ending on the third 30 June following the election ( i.e. slightly less than three years ) with the rest serving three years longer . The term of the territory senators expires at the same time as there is an election for the House of Representatives . There is no constitutional requirement for the election of senators to take place at the same time as those for members of the House of Representatives , though the government usually synchronises election dates .

neg: Australian Olympic Committee The Australian Olympic Committee ( AOC ) is the National Olympic Committee responsible for developing , promoting and protecting the Olympic Movement in Australia . The AOC has the exclusive responsibility for the representation of Australia at the Olympic Games ( Summer and Winter ) , the Youth Olympic Games and at Regional Games patronised by the International Olympic Committee ( IOC ) . All National Olympic Committees ( currently 205 worldwide ) are constituents of the International Olympic Committee .

neg: Australian Capital Territory The Australian Capital Territory ( ACT ; formerly , `` The Territory for the Seat of Government '' and , later , the `` Federal Capital Territory '' ) is the federal district in the south east of Australia , enclaved within New South Wales . Its only city is Canberra , the capital city of Australia .   Geographically , the territory is bounded by the Goulburn-Cooma railway line in the east , the watershed of Naas Creek in the south , the watershed of the Cotter River in the west , and the watershed of the Molonglo River in the north-east . The ACT also has a small strip of territory around the southern end of the Beecroft Peninsula , which is the northern headland of Jervis Bay .   The need for a national territory was flagged by colonial delegates during the Federation conventions of the late 19th century . Section 125 of the Australian Constitution provided that , following Federation in 1901 , land would be ceded freely to the new Federal Government . The territory was transferred to the Commonwealth by the state of New South Wales in 1911 , two years prior to the naming of Canberra as the national capital in 1913 . The floral emblem of the ACT is the royal bluebell and the bird emblem is the gang-gang cockatoo .   The economic activity of the Australian Capital Territory is heavily concentrated around Canberra . A stable housing market , steady employment and rapid population growth in the 21st century have led to economic prosperity and in 2011 CommSec ranked the ACT as the second best performing economic region in the country . This trend continued into 2016 , when the territory was ranked the third best performing out of all of Australia 's states and territories . There is a higher proportion of young adults in the region compared with other Australian states or territories . Approximately one-fifth of ACT residents were born outside of Australia , mainly in the United Kingdom . Almost one-fifth speak a language other than English at home , the most common being Chinese .

neg: National Tally Room The National Tally Room was the Australian centre for national ( federal ) election results to be tallied ( totaled ) for electorates ( Divisions ) making up the Parliament of Australia , which consists of the Australian House of Representatives and the Australian Senate .   The tally room normally opened as results begin to flow in after voting ends at 6pm on the day of the election , always a Saturday , in the respective states and territories and polling places begin to count the votes ; however , some voting figures could come in as early as 5.20 pm . The room closed after the final results from polling places were announced to the tally room , often after midnight following the day of the election . ( Note : Polling centres that did not finish counting all votes recommenced counting on Sunday . )   The tally room was set up in the Budawang Building at Exhibition Park in Canberra ( EPIC ) in the northern suburbs of Canberra , the national capital city of Australia . A former venue , in the late 1970s , was the then newly built hall at Belconnen High School , a high school in the Canberra district of Belconnen . The building was fitted out by the Australian Electoral Commission ( AEC ) for the national elections , and was also used for live broadcasts by media outlets , normally led by the Australian television networks . Over 700 people worked in the tally room on the evening of the election .   Boards representing each electorate ( Division ) and Senate seat were set up on a `` tally wall '' . A box representing each Division was headed by the name of the Division and the number of registered electors ( shown in green lettering ) , then the names of the candidates prefaced by the acronym for their political party , and against their names the currently-recorded count of first preference votes ; at the bottom were two lines ( A and B ) for Two Candidate Preferred totals , estimating the result after a notional distribution of the preference votes . Staff at the rear of the tally wall changed the details by attaching numbers sheets to the rotating portion of the Division boxes . Media and the public followed the electoral results from the viewing gallery and the media/television sets on the floor of the tally room . Often , current , former or prospective members of the Parliament were seen on the floor , or at the media booths ( see picture above . )   For the 2013 federal election , no television networks chose to use the tally room as their backdrop , and subsequently , the AEC announced it would not operate the room for that election . The National Tally Room was replaced by an online `` Virtual '' Tally Room , and the tally board donated to the Museum of Australian Democracy .

neg: Theatre of Australia Theatre of Australia refers to the history of the performing arts in Australia , or produced by Australians . There are theatrical and dramatic aspects to a number of Indigenous Australian ceremonies such as the corroboree . During its colonial period , Australian theatrical arts were generally linked to the broader traditions of English literature and to British and Irish theatre . Australian literature and theatrical artists ( including Aboriginal as well as Anglo-Celtic and multicultural migrant Australians ) have over the last two centuries introduced the culture of Australia and the character of a new continent to the world stage .   Individuals who have contributed to theatre in Australia and internationally include Sir Robert Helpmann , Dame Joan Sutherland , Barry Humphries , David Williamson , Cate Blanchett , Geoffrey Rush , Judy Davis , Jim Sharman , Tim Minchin and Baz Luhrmann . Notable theatrical institutions include the Sydney Opera House , and the National Institute of Dramatic Art in Sydney .

neg: Racial violence in Australia Various examples of violence have been attributed to racial factors during the recorded history of Australia since white settlement , and a level of intertribal rivalry and violence among Indigenous Australians pre-dates the arrival of white settlers from Britain in 1788 .   During the period of British colonisation , various incidents of inter-racial tension and competition for land and resources between Europeans and Indigenous peoples involved violence , becoming a factor in the decline of indigenous populations during the 19th century . Incidents of racial violence between settler communities followed the large scale multi-ethnic immigration of the Australian goldrushes of the mid-19th century - notably white miners targeting Chinese miners - which contributed to the development of the White Australia Policy which preferenced British and `` white '' immigration to Australia for some decades . The policy resulted in a largely racially homogenous population by the mid-20th century .   Australia 's large scale , Post-World War Two , multi-ethnic immigration program has seen Australia develop into one of the most ethnically diverse nations , with relatively little racial violence , and in which incitement to racial violence is a crime . Nevertheless , incidents and examples of violence between the various ethnicities of modern Australia have continued to be attributed to racial motivations up to the present time .

neg: The Australian (1824 newspaper) The Australian ( Sydney , NSW : 1824 - 1848 ) was a weekly English language newspaper published in Sydney , New South Wales , Australia .

neg: Attorney-General for Australia The Attorney-General for AustraliaThe title is officially `` Attorney-General '' . For the purposes of distinguishing the office from other Attorneys-General , and in accordance with usual practice in the United Kingdom and other common law jurisdictions , the Australian Attorney-General currently refers to themselves as the `` Attorney-General for Australia '' or the `` Commonwealth Attorney-General '' : see Attorney-General website . Historically , `` Attorney-General of Australia '' was also used . is the first law officer of the Crown in right of the Commonwealth of Australia , chief law officer of the Commonwealth of Australia and a minister of the Crown . The Attorney-General is usually a member of the Federal Cabinet , but need not be . Under the Constitution they are appointed by the Governor-General on the advice of the Prime Minister , and serves at the Governor-General 's pleasure . In practice the Attorney-General is a party politician and their tenure is determined by political factors . By convention , but not constitutional requirement , the Attorney-General is a lawyer by training , either a barrister or solicitor .   Since 18 September 2013 , the Attorney-General for Australia has been Senator the Hon George Brandis , a Liberal Party of Australia member of the Australian Senate for the state of Queensland .

neg: Tony Abbott Anthony John `` Tony '' Abbott ( born 4 November 1957 ) is an Australian politician who was the 28th Prime Minister of Australia , from 18 September 2013 to 15 September 2015 . Abbott was leader of the Liberal Party of Australia from 2009 to 2015 , and has been a member of parliament for Warringah since 1994 .   Abbott was born in London , to an Australian mother and a British father , and emigrated to Sydney , Australia , with his parents in 1960 . Prior to entering Parliament , Abbott took the degrees of Bachelor of Economics and Bachelor of Laws at the University of Sydney , then attended The Queen 's College , Oxford , as a Rhodes Scholar , graduating as a Bachelor of Arts in Philosophy , Politics and Economics . He later proceeded by seniority to Master of Arts .   After graduating from Oxford , Abbott trained as a Roman Catholic seminarian , and later worked as a journalist , a manager , and a political adviser . In 1992 , he was appointed Director of Australians for Constitutional Monarchy , a position he held until his election to Parliament in 1994 . Abbott was first appointed to Cabinet following the 1998 election , as part of the Second Howard Ministry , becoming Minister for Employment , Workplace Relations and Small Business .   In 2003 , Abbott became Minister for Health and Ageing , retaining this position until the defeat of the Howard Government at the 2007 election . Initially serving in the Shadow Cabinets of Brendan Nelson and then Malcolm Turnbull , Abbott resigned from the front bench in November 2009 , in protest against Turnbull 's support for the Rudd Government 's proposed Emissions Trading Scheme ( ETS ) . Forcing a leadership ballot on the subject , Abbott defeated Turnbull by 42 votes to 41 , to become the Party 's leader and Leader of the Opposition .   Abbott led the Coalition at the 2010 election , which resulted in a hung parliament . Following negotiations , Labor formed a Government , with the support of one Greens MP and three Independent MPs . Abbott was re-elected as Liberal Leader unopposed . Abbott went on to lead the Coalition to victory in the 2013 election and was sworn in as the 28th Prime Minister of Australia on 18 September 2013 . On 14 September 2015 , Abbott was defeated in a vote for the Liberal leadership ( 54 votes to 44 ) by Malcolm Turnbull , who replaced Abbott as Prime Minister the following day .

neg: Prime Minister of Australia The Prime Minister of the Commonwealth of Australia is the head of government of Australia . The individual who holds the office is the most senior Minister of the Crown , the leader of the Cabinet and the chairperson of the National Security Committee . The Prime Minister also has the responsibility of administering the Department of the Prime Minister and Cabinet . The office is not mentioned in the Constitution of Australia and exists only through longstanding political convention and tradition . Despite this , in practice it is the most powerful parliamentary position in Australia . The individual who holds the office is commissioned by the Governor-General of Australia .   Almost always and according to convention , the Prime Minister is the leader of the majority party or largest party in a coalition of parties in the House of Representatives . However , there is no constitutional requirement that the Prime Minister sit in the House of Representatives , though by convention this is always the case . The only case where a member of the Senate was appointed Prime Minister was John Gorton , who subsequently resigned his Senate position and was elected as a member of the House of Representatives ( Senator George Pearce was acting Prime Minister for seven months in 1916 while Billy Hughes was overseas ) .   Malcolm Turnbull has held the office of Prime Minister since 15 September 2015 . He received his commission after replacing Tony Abbott as the leader of the Liberal Party , the dominant party in the Coalition government , following the outcome of the September 2015 Liberal leadership ballot .

neg: Jillian Broadbent Jillian Broadbent AO ( born 1948 ) is an Australian public figure and businesswoman .

neg: Australian English vocabulary Australian English is a major variety of the English language spoken throughout Australia . Most of the vocabulary of Australian English is shared with British English , though there are notable differences . The vocabulary of Australia is drawn from many sources , including various dialects of British English as well as Gaelic languages , some Indigenous Australian languages , and Polynesian languages .   One of the first dictionaries of Australian slang was Karl Lentzner 's Dictionary of the Slang-English of Australia and of Some Mixed Languages in 1892 . The first dictionary based on historical principles that covered Australian English was E. E. Morris 's Austral English : A Dictionary of Australasian Words , Phrases and Usages ( 1898 ) . In 1981 , the more comprehensive Macquarie Dictionary of Australian English was published . Oxford University Press published their own Australian Oxford Dictionary in 1999 , as a joint effort with the Australian National University . Oxford University Press also published The Australian National Dictionary .


query: Huntington's disease is not genetic.

pos: Huntington's disease Huntington 's disease ( HD ) , also known as Huntington 's chorea , is an inherited disorder that results in death of brain cells . The earliest symptoms are often subtle problems with mood or mental abilities . A general lack of coordination and an unsteady gait often follow . As the disease advances , uncoordinated , jerky body movements become more apparent . Physical abilities gradually worsen until coordinated movement becomes difficult and the person is unable to talk . Mental abilities generally decline into dementia . The specific symptoms vary somewhat between people . Symptoms usually begin between 30 and 50 years of age , but can start at any age . The disease may develop earlier in life in each successive generation . About 8 % of cases start before the age of 20 years and typically present with symptoms more similar to Parkinson 's disease . People with HD often underestimate the degree of their problems .   HD is typically inherited from a person 's parents , with 10 % of cases due to a new mutation . The disease is caused by an autosomal dominant mutation in either of an individual 's two copies of a gene called Huntingtin . This means a child of an affected person typically has a 50 % chance of inheriting the disease . The Huntingtin gene provides the genetic information for a protein that is also called `` huntingtin '' . Expansion of CAG ( cytosine-adenine-guanine ) triplet repeats in the gene coding for the Huntingtin protein results in an abnormal protein , which gradually damages cells in the brain , through mechanisms that are not fully understood . Diagnosis is by genetic testing , which can be carried out at any time , regardless of whether or not symptoms are present . This fact raises several ethical debates : the age at which an individual is considered mature enough to choose testing ; whether parents have the right to have their children tested ; and managing confidentiality and disclosure of test results .   There is no cure for HD . Full-time care is required in the later stages of the disease . Treatments can relieve some symptoms and in some improve quality of life . The best evidence for treatment of the movement problems is with tetrabenazine . HD affects about 4 to 15 in 100,000 people of European descent . It is rare among Japanese , while the occurrence rate in Africa is unknown . The disease affects men and women equally . Complications such as pneumonia , heart disease , and physical injury from falls reduce life expectancy . Suicide is the cause of death in about 9 % of cases . Death typically occurs fifteen to twenty years from when the disease was first detected .   The first likely description of the disease was in 1841 by Charles Oscar Waters . The condition was described in further detail in 1872 by George Huntington , after whom it is named . The genetic basis was discovered in 1993 by an international collaborative effort led by the Hereditary Disease Foundation . Research and support organizations began forming in the late 1960s to increase public awareness , to provide support for individuals and their families , and to promote research . Current research directions include determining the exact mechanism of the disease , improving animal models to aid with research , testing of medications to treat symptoms or slow the progression of the disease , and studying procedures such as stem cell therapy with the goal of repairing damage caused by the disease .

neg: Genome instability Genome instability ( also `` genetic instability '' or `` genomic instability '' ) refers to a high frequency of mutations within the genome of a cellular lineage . These mutations can include changes in nucleic acid sequences , chromosomal rearrangements or aneuploidy . Genome instability does occur in bacteria . In multicellular organisms genome instability is central to carcinogenesis , and in humans it is also a factor in some neurodegenerative diseases such as amyotrophic lateral sclerosis or the neuromuscular disease myotonic dystrophy .   The sources of genome instability have only recently begun to be elucidated . A high frequency of externally caused DNA damage can be one source of genome instability since DNA damages can cause inaccurate translesion synthesis past the damages or errors in repair , leading to mutation . Another source of genome instability may be epigenetic or mutational reductions in expression of DNA repair genes . Because endogenous ( metabolically-caused ) DNA damage is very frequent , occurring on average more than 60,000 times a day in the genomes of human cells , any reduced DNA repair is likely an important source of genome instability .

neg: History of Tourette syndrome Tourette syndrome is an inherited neurological disorder with onset in childhood , characterized by the presence of multiple physical ( motor ) tics and at least one vocal ( phonic ) tic .   The eponym was bestowed by Jean-Martin Charcot ( 1825 -- 93 ) on behalf of his resident , Georges Albert Édouard Brutus Gilles de la Tourette ( 1859 -- 1904 ) , a French physician and neurologist , who published an account of nine patients with Tourette 's in 1885 . The possibility that movement disorders , including Tourette syndrome , might have an organic origin was raised when an encephalitis epidemic from 1918 -- 1926 led to a subsequent epidemic of tic disorders . Research in 1972 advanced the argument that Tourette 's is a neurological , rather than psychological , disorder ; since the 1990s , a more neutral view of Tourette 's has emerged , in which biological vulnerability and adverse environmental events are seen to interact .   Findings since 1999 have advanced TS science in the areas of genetics , neuroimaging , neurophysiology , and neuropathology . Questions remain regarding how best to classify Tourette syndrome , and how closely Tourette 's is related to other movement disorders or psychiatric disorders . Good epidemiologic data is still lacking , and available treatments are not risk free and not always well tolerated .

neg: AntiMOG associated encephalomyelitis AntiMOG associated encephalomyelitis is an inflammatory demyelinating disease previously considered part of the multiple sclerosis spectrum , and currently considered an independent disease .   Antibodies against the Myelin oligodendrocyte glycoprotein have received much of its laboratory attention in studies dealing with multiple sclerosis ( MS ) . Several studies had pointed to a role for antibodies against MOG in the pathogenesis of MS , but most of them were written before the discovery of NMO-IgG and the NMO spectrum of diseases . MOG antibodies are currently considered mostly absent in multiple sclerosis .   Though some patients present brain lesions they do not have the ovoid shape perpendicular to the ventricle typical of MS.   Anti-MOG status is different depending whether it is measured by ELISA or by microarray ( CBA ) . The proper way to identify it is by microarray , reacting patient serum with living cells , and detecting the binding IgG via a fluorescent-labeled secondary antibody .

neg: The Gene Bomb The Gene Bomb is a 1996 book by David E. Comings , self-published by Hope Press , that puts forth the theory that higher education and advanced technology may unintentionally favor the selection of genes that increase the likelihood of ADHD , autism , drug addiction , learning disorders , and behavior problems . Comings claims that the prevalence of these disorders is rising and I.Q. is decreasing ; others argue that other factors may be responsible , including increased detection of these disorders . He claims that society is inadvertently creating delays for the highly educated that reduce their reproductivity and causes them to have children later in life , thus raising the odds of certain disorders like autism . On the other hand , he claims that those having learning disorders tend to drop out of school earlier and have more children , thus passing on learning disorders at a higher rate . Environmental and societal factors are usually accepted as the cause , but Comings argues the opposite .   According to a review of the book in the British Developmental Medicine and Child Neurology journal , `` The arguments are developed in this book with an alarming lack of scientific accuracy and satisfactory supporting evidence . '' The review concludes that the book `` is an apocalyptic , irrational , and emotional treatise which opens up scientifically unsound issues that have already been formally buried '' . A book review in the Journal of Medical Genetics said , `` This is the sort of book which gets geneticists a bad name '' , adding that some facts `` are simply wrong '' , while vital facts `` are simply missing '' . Comings replied , in a Letter to the Editor , that the review `` missed the  whole point of the book and presented to the readers of this journal a distorted view of the issues I attempted to raise '' .   Other Tourette syndrome ( TS ) researchers say of Comings ' Tourette 's research that his `` assertions fall outside of the mainstream of the very extensive TS literature that has developed over the past 2 decades '' .

neg: Neurodevelopmental disorder Neurodevelopmental disorders are impairments of the growth and development of the brain or central nervous system . A narrower use of the term refers to a disorder of brain function that affects emotion , learning ability , self-control and memory and that unfolds as the individual grows . The term is sometimes erroneously used as an exclusive synonym for autism spectrum disorders .   Disorders considered neurodevelopmental in origin , or that have neurodevelopmental consequences when they occur in infancy and childhood , include :  Intellectual disability ( ID ) or intellectual and developmental disability ( IDD )  Autism spectrum disorders , such as Asperger 's syndrome  Fetal alcohol spectrum disorder  Motor disorders including developmental coordination disorder and stereotypic movement disorder  Tic disorders including Tourette 's syndrome  Traumatic brain injury ( including congenital injuries such as those that cause cerebral palsy )  Communication , speech and language disorders  Genetic disorders , such as fragile-X syndrome  Down syndrome  Attention deficit hyperactivity disorder  Mendelsohnn 's syndrome  Schizophrenia  Schizotypal disorder  HIV  Malaria  Neurodevelopmental disorders are associated with widely varying degrees of difficulty which may have significant mental , emotional , physical , and economic consequences for individuals , and in turn their families and society in general .

neg: Stroke in China Recent epidemiologic studies confirm that stroke is the most frequent cause of death in the People 's Republic of China , with an incidence more than fivefold that of myocardial infarction . Intracerebral hemorrhage causes about one third of all strokes , nearly three times the frequency in North American stroke registries . A marked regional variation in stroke incidence exists , with a threefold higher stroke incidence in northern than in southern Chinese cities , suggesting important environmental or dietary influences . Stroke treatment often involves a combination of modern and traditional herbal medicine ; the latter may modify platelet aggregation and blood viscosity . Stroke , particularly intracerebral hemorrhage , is the most frequent and important vascular disorder in China .   China reports more patients with stroke than anywhere else in the world . While there is still a great deal of unknown information , stroke research has been making great progress in recent years , such as in the areas of clinical research , population and genetic epidemiology , brain ischemia/reperfusion exploring , leukoencephalopathy ( CADASIL ) , neural stem cell and stroke , neuroprotective treatment for stroke , clinical therapy test in stroke , rehabilitation and prevention .   Cities and towns in China have integrated systems for registering and investigating strokes . Chinese researchers have followed closely the international level of stroke treatment with a forward position in neural stem cell . Traditional Chinese drugs have featured effects on neuroprotective treatment for stroke which has also been investigated . Chinese scientists have suggested a new way of dividing neuroprotectors in stroke . The clinical therapy test with urokinase and defibrase for cerebral infarction in China is effective and relatively safe , yet the original papers published by Chinese researchers and clinical effects for patient treatment still need to be improved and updated .

neg: Distal hereditary motor neuropathy type V Distal hereditary motor neuropathy type V ( dHMN V ) is a particular type of neuropathic disorder . In general , distal hereditary motor neuropathies affect the axons of distal motor neurons and are characterized by progressive weakness and atrophy of muscles of the extremities . It is common for them to be called `` spinal forms of Charcot-Marie-Tooth disease ( CMT ) '' , because the diseases are closely related in symptoms and genetic cause . The diagnostic difference in these diseases is the presence of sensory loss in the extremities . There are seven classifications of dHMNs , each defined by patterns of inheritance , age of onset , severity , and muscle groups involved . Type V ( sometimes notated as Type 5 ) is a disorder characterized by autosomal dominance , weakness of the upper limbs that is progressive and symmetrical , and atrophy of the small muscles of the hands .

neg: Parkinson's disease Parkinson 's disease ( PD ) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system . The symptoms generally come on slowly over time . Early in the disease , the most obvious are shaking , rigidity , slowness of movement , and difficulty with walking . Thinking and behavioral problems may also occur . Dementia becomes common in the advanced stages of the disease . Depression and anxiety are also common occurring in more than a third of people with PD . Other symptoms include sensory , sleep , and emotional problems . The main motor symptoms are collectively called `` parkinsonism '' , or a `` parkinsonian syndrome '' .   The cause of Parkinson 's disease is generally unknown , but believed to involve both genetic and environmental factors . Those with a family member affected are more likely to get the disease themselves . There is also an increased risk in people exposed to certain pesticides and among those who have had prior head injuries while there is a reduced risk in tobacco smokers and those who drink coffee or tea . The motor symptoms of the disease result from the death of cells in the substantia nigra , a region of the midbrain . This results in not enough dopamine in these areas . The reason for this cell death is poorly understood , but involves the build-up of proteins into Lewy bodies in the neurons . Diagnosis of typical cases is mainly based on symptoms , with tests such as neuroimaging being used to rule out other diseases .   There is no cure for Parkinson 's disease . Initial treatment is typically with the antiparkinson medication L-DOPA ( levodopa ) , with dopamine agonists being used once levodopa becomes less effective . As the disease progresses and neurons continue to be lost , these medications become less effective while at the same time they produce a complication marked by involuntary writhing movements . Diet and some forms of rehabilitation have shown some effectiveness at improving symptoms . Surgery to place microelectrodes for deep brain stimulation has been used to reduce motor symptoms in severe cases where drugs are ineffective . Evidence for treatments for the non-movement-related symptoms of PD , such as sleep disturbances and emotional problems , is less strong .   In 2015 , PD affected 6.2 million people and resulted in about 117,400 deaths globally . Parkinson 's disease typically occurs in people over the age of 60 , of which about one percent are affected . Males are more often affected than females . When it is seen in people before the age of 50 , it is called young-onset PD . The average life expectancy following diagnosis is between 7 and 14 years . The disease is named after the English doctor James Parkinson , who published the first detailed description in An Essay on the Shaking Palsy , in 1817 . Public awareness campaigns include World Parkinson 's Day ( on the birthday of James Parkinson , 11 April ) and the use of a red tulip as the symbol of the disease . People with parkinsonism who have increased the public 's awareness of the condition include actor Michael J. Fox , Olympic cyclist Davis Phinney , and late professional boxer Muhammad Ali .

neg: Synactive Theory of Newborn Behavioral Organization and Development The Synactive Theory of Newborn Behavioral Organization and Development ( Synaction n. , or Synactive adj. -LSB- from the Greek syn `` together '' and the Latin actio `` action , '' resulting in : `` together in action '' -RSB- ) suggests that development of the human fetus , and later newborn , proceeds through the constant balancing of approach and avoidance behaviors , leading to : 1 ) a continuous interaction of the subsystems ( i.e. , Autonomic , Motor , State and Attention/Interaction , and Regulatory ) and their increasingly defined delineations within the organism , that is the infant , and 2 ) the organism 's interaction with the environment at large . This process is aimed at bringing about the increasingly well-defined species-unique developmental agenda .   Figure 1 ( below ) , provides a graphic representation of the Synactive Theory of development , as applied to both fetal and newborn stages . It focuses upon the infant 's within-organism , four subsystems of functioning , and their continuous interaction with each other and with the environment across time ( i.e. , `` together in action , '' or synaction ) . The four subsystems include the :   Autonomic Subsystem : Expressed in the pattern of respiration ( e.g. , fast , slow , pauses ) color changes ( e.g. , pink , pale , red ) , neurological indicators ( e.g. , seizures , tremulousness ) , and visceral or gut signals such as bowel movements , gagging , and hiccoughing ;   Motor Subsystem : Observable through the tone , posture and movement patterns of the infant ;   State and Attention/Interaction Subsystem : Expressed via : 1 ) the range of states available to the infant ( i.e. , deep sleep , light sleep , drowsy , alert , hyperalert , and cry ) , 2 ) how clearly it is to observably differentiate one state from the other , and 3 ) the patterns of transitions from one state to another ( e.g. , smooth well-differentiated state transitions versus abrupt unorganized state transitions ) .   The attention/interaction system is set within this state continuum ( i.e. , from deep sleep to cry ) and represented by the infant 's ability to adjust the robustness and increasing refinement of an alert , attentive state . The infant uses this state to take in cognitive and social information from the environment as well as to bring forth and modify inputs from the surrounding world ; and   Regulatory Subsystem : Behaviorally represented via the observable strategies the infant uses ( Self-Regulation ) in maintaining a balanced , relatively stable and relaxed state of subsystem of functioning or in returning to this a state of subsystem functioning if imbalance , or stress has occurred within the subsystems .   An additional component of the regulatory subsystem is observable in the kind and amount of support offered by the caregiver ( e.g. , supporting a soft , tucked , flexed position of the infant 's arms and legs ) or by the environment ( e.g. , dimming the lights in the nursery ) . This Co-Regulation may be necessary to help the infant 's return to balance in situations when his/her own self-regulatory capacities are exceeded .   Reproduced with permission from Als , H. Toward a synactive theory of development : Promise for the assessment of infant individuality . Infant Mental Health Journal . 1982 : ( 3 ) : 229-243 ; p. 234 .   The graphic representation of the Synactive Theory above depicts the developing organism , that is , the infant , in constant interaction with the environment from within the womb to the newborn intensive care unit ( NICU ) , and the caregiving family 's support in the NICU , to the family in their home . Newborn infants are actively striving for their next steps in development , while depending upon `` good enough '' environments and care to assure progress along their developmental agenda .   The Synactive Theory of Development continues to be instrumental in guiding clinicians ( e.g. , neonatologist , nurses , psychologists , developmental specialists , physical/occupational therapists , etc. ) and researchers in their understanding of the often very small steps in development that prematurely born and other high risk newborns attempt to accomplish ( which are major steps for their immature or injured brain ) . This theory gives professionals the framework and tools with which to identify the infant 's strengths , challenges and accomplishments . Such accomplishments may include breathing , sucking and swallowing in a coordinated sequence ; moving food down into and through the stomach and intestinal track instead of upwards , leading to reflux and vomiting ; looking at the caregiver and breathing at the same time , as well as many others .   The Synactive Theory is the foundation of both : 1 ) the Assessment of Preterm Infants ' Behavior ( APIB ) , a standardized comprehensive newborn test , and 2 ) the Newborn Individualized Developmental Care and Assessment Program ( NIDCAP ) , which is the care and intervention approach , that focuses on each infant 's behavioral cues ( e.g. , hand ( s ) to mouth , bracing with feet against a supporting surface ) in order to support the infant 's strengths and reduce the infant 's vulnerabilities . The infant 's family is viewed as the infant 's most important nurturer and is integrated in all care from the infant 's birth on throughout the infant 's hospitalization .

neg: List of questionable diseases This is a list of diseases and diagnoses that are considered questionable or rejected by many in the medical profession . Some are diagnosed using unvalidated or disputed diagnostic techniques such as applied kinesiology . Most purported symptoms are vague , generic , nonspecific , and generally categorised as `` symptoms of life '' .   Adrenal fatigue  Autistic enterocolitis  Chronic Lyme disease  Electromagnetic hypersensitivity  Fan death  Heavy legs  Leaky gut syndrome  Morgellons  Multiple chemical sensitivity  Non-coeliac gluten sensitivity  Oral galvanism  Wind turbine syndrome  Wilson 's temperature syndrome , also called Wilson 's thyroid syndrome . Not to be confused with Wilson 's disease .

neg: Microinfarct A microinfarct is a microscopic stroke less than 1 millimeter in size . Microinfarcts can be found in 25-50 % of all elderly deceased persons . Microinfarcts may be the second most important cause of dementia , after Alzheimer 's disease .   Microinfarcts are microscopic lesions , of cellular death or tissue necrosis , which are a result of pathologies involving small vessels . Such pathologies are arteriosclerosis or cerebral amyloid angiopathy . Microinfarcts take longer to affect neuronal death progress , at up to 28 days , rather than hours .   Microinfarcts can range in size from 0.2 to 2.9 mm . This ailment usually goes undetected in clinical-radiological , like structural MRI , studies and is known as a `` silent pathology '' . Depending on the size , large acute microinfarcts may be detected via a special imaging known as diffusion weighted imaging .   Microinfarcts tend to occur at a high frequency , without specific regionalized locations . They are common in aging brains . This high frequency is thought to directly disrupt cognitive networks that are imperative to brain operation . Even though microinfarcts are usually undetectable , there is a general assessment of the cognitive status measured on a scale called the Clinical Dementia Rating ( CDR ) . This scale measures different parts of the brain such as diffuse white matter , periventricular myelination and cortical microinfarcts . Assessments of cortical microinfarcts have had the highest rates with being associated with cognitive degeneration . This lower cognition specifically affects perceptual speed and memory ( semantic and episodic ) . People with high frequency of this ailment tend to have greater chances of developing dementia .   Although not many studies have been conducted and little is known between microinfarcts and other vascular or epidemiological risk factors , these brain lesions are thought to be masked by other pathologies . However , the common macroscopic infarct is not exhibited in 45 % of people tested for microinfarcts .

neg: Developmental cognitive neuroscience Developmental cognitive neuroscience is an interdisciplinary scientific field devoted to understanding psychological processes and their neurological bases in the developing organism . It examines how the mind changes as children grow up , interrelations between that and how the brain is changing , and environmental and biological influences on the developing mind and brain .   Developmental cognitive neuroscience is at the boundaries of neuroscience ( behavioral , systems , & cognitive neuroscience ) , psychology ( developmental , cognitive , & biobehavioral / physiological psychology ) , developmental science ( which includes sociology , anthropology , & biology in addition to psychology & neuroscience ) , cognitive science ( which includes computer science , philosophy , dynamical systems , & linguistics in addition to psychology ) , and even includes socio-emotional development and developmental aspects of social neuroscience and affective neuroscience .   The scientific interface between cognitive neuroscience and human development has evoked considerable interest in recent years , as technological advances make it possible to map in detail the changes in brain structure that take place during development . Developmental cognitive neuroscience overlaps somewhat with fields such as developmental psychology , developmental neuropsychology , developmental psychopathology , and developmental neuroscience , but is distinct from each of them as well . Developmental cognitive neuroscience is concerned with the brain bases of the phenomena that developmental psychologists study . Developmental neuropsychology and developmental psychopathology are both devoted primarily to studying patients , whereas developmental cognitive neuroscience is concerned with studying both typical and atypical development . Developmental neuroscience is devoted entirely to the study of developmental processes in the brain , and primarily during the prenatal period . Developmental cognitive neuroscience , on the other hand , is concerned with interrelations between psychological and biological development . Developmental cognitive neuroscientists study brain development and cognitive , social , and emotional development from the prenatal period through adulthood .   More recently , developmental cognitive neuroscience is interested in the role of genes in development and cognition . Thus , developmental cognitive neuroscience may shed light on nature versus nurture debates as well as constructivism and neuroconstructivism theories . Developmental cognitive neuroscience research provides data that alternately blends together , clarifies , challenges , and causes revisions in developmental , cognitive , and neuroscientific theories .

neg: Huntington's Disease Association The Huntington 's Disease Association ( HDA ) is a charity that supports people in England and Wales affected by the genetic neurodegenerative brain condition Huntington 's disease ( HD ) .   The HDA was founded in 1986 and is based in Liverpool . It supports a network of regional care advisors who offer care and support to people with and at risk of Huntington 's disease and their families . The HDA also has a research programme that supports scientific and social research into HD . It has worked to establish and support a network of multidisciplinary clinics for HD patients in the UK .   The charity was instrumental in the 2010 launch of an All-Party Parliamentary Group for Huntington 's disease in the UK Parliament , chaired by Lord Walton of Detchant , and 2010 research revealing that the prevalence of HD is much higher than previously thought .   The HDA won the 2005 UK Charity Award for healthcare and medical research and the 2005 National Health Service ( NHS ) Health and Social Care Award for long term conditions .   The HDA 's patrons are Patricia , Countess of Harewood , singer Tony Hadley and entertainer Shane Richie .   The HDA is part of the UK HD Alliance , along with the Scottish Huntington 's Association and HD Association Northern Ireland . It is also a member of the International Huntington Alliance .

neg: Molecular medicine Molecular medicine is a broad field , where physical , chemical , biological , bioinformatics and medical techniques are used to describe molecular structures and mechanisms , identify fundamental molecular and genetic errors of disease , and to develop molecular interventions to correct them . The concept of the distribution of medicine to each individual cell just as oxygen would be an example of the practice of molecular medicine ( via lung chemical reaction manipulation an idea coined by Saniab Jacob ) . The molecular medicine perspective emphasizes cellular and molecular phenomena and interventions rather than the previous conceptual and observational focus on patients and their organs .   In November 1949 , with the seminal paper , `` Sickle Cell Anemia , a Molecular Disease '' , in Science magazine , Linus Pauling , Harvey Itano and their collaborators laid the groundwork for establishing the field of molecular medicine . In 1956 , Roger J. Williams wrote Biochemical Individuality , a prescient book about genetics , prevention and treatment of disease on a molecular basis , and nutrition which is now variously referred to as individualized medicine and orthomolecular medicine . Another paper in Science by Pauling in 1968 , introduced and defined this view of molecular medicine that focuses on natural and nutritional substances used for treatment and prevention .   Published research and progress was slow until the 1970s ' `` biological revolution '' that introduced many new techniques and commercial applications .   Molecular medicine is a new scientific discipline in European universities . Combining contemporary medical studies with the field of biochemistry , it offers a bridge between the two subjects . At present only a handful of universities offer the course to undergraduates . With a degree in this discipline the graduate is able to pursue a career in medical sciences , scientific research , laboratory work and postgraduate medical degrees .

neg: Psychiatric epidemiology Psychiatric epidemiology is a field which studies the causes ( etiology ) of mental disorders in society , as well as conceptualization and prevalence of mental illness . It is a subfield of the more general epidemiology . It has roots in sociological studies of the early 20th century . However , while sociological exposures are still widely studied in psychiatric epidemiology , the field has since expanded to the study of a wide area of environmental risk factors , such as major life events , as well as genetic exposures . Increasingly neuroscientific techniques like MRI are used to explore the mechanisms behind how exposures to risk factors may impact psychological problems and explore the neuroanatomical substrate underlying psychiatric disorders .

neg: Endophenotype Endophenotype is a genetic epidemiology term which is used to separate behavioral symptoms into more stable phenotypes with a clear genetic connection . The concept was coined by Bernard John and Kenneth R. Lewis in a 1966 paper attempting to explain the geographic distribution of grasshoppers . They claimed that the particular geographic distribution could not be explained by the obvious and external `` exophenotype '' of the grasshoppers , but instead must be explained by their microscopic and internal `` endophenotype . ''   The next major use of the term was in psychiatric genetics , to bridge the gap between high-level symptom presentation and low-level genetic variability , such as single nucleotide polymorphisms . It is therefore more applicable to more heritable disorders , such as bipolar disorder and schizophrenia . Since then , the concept has expanded to many other fields , such as the study of ADHD , addiction , Alzheimer 's disease obesity and cystic fibrosis . Some other terms which have a similar meaning but do not stress the genetic connection as highly are `` intermediate phenotype '' , `` biological marker '' , `` subclinical trait '' , `` vulnerability marker '' , and `` cognitive marker '' . The strength of an endophenotype is its ability to differentiate between potential diagnoses that present with similar symptoms .

neg: Phenotype A phenotype is the composite of an organism 's observable characteristics or traits , such as its morphology , development , biochemical or physiological properties , behavior , and products of behavior ( such as a bird 's nest ) . A phenotype results from the expression of an organism 's genetic code , its genotype , as well as the influence of environmental factors and the interactions between the two . When two or more clearly different phenotypes exist in the same population of a species , the species is called polymorphic . A well-documented polymorphism is Labrador Retriever coloring ; while the coat color depends on many genes , it is clearly seen in the environment as yellow , black and brown .   This genotype-phenotype distinction was proposed by Wilhelm Johannsen in 1911 to make clear the difference between an organism 's heredity and what that heredity produces . The distinction is similar to that proposed by August Weismann , who distinguished between germ plasm ( heredity ) and somatic cells ( the body ) . The genotype-phenotype distinction should not be confused with Francis Crick 's central dogma of molecular biology , which is a statement about the directionality of molecular sequential information flowing from DNA to protein , and not the reverse .   Richard Dawkins in 1978 and then again in his 1982 book The Extended Phenotype suggested that bird nests and other built structures such as caddis fly larvae cases and beaver dams can be considered as `` extended phenotypes '' .

neg: Music-specific disorders Neuroscientists have learned a lot about the role of the brain in numerous cognitive mechanisms by understanding corresponding disorders . Similarly , neuroscientists have come to learn a lot about music cognition by studying music-specific disorders . Even though music is most often viewed from a `` historical perspective rather than a biological one '' music has significantly gained the attention of neuroscientists all around the world . For many centuries music has been strongly associated with art and culture . The reason for this increased interest in music is because it `` provides a tool to study numerous aspects of neuroscience , from motor skill learning to emotion '' .

neg: Huntington's disease in popular culture Huntington 's disease has been shown in numerous formats , more so as awareness of the condition has increased . Here is a list of references to it in popular culture ;

neg: Broca's area Broca 's area or the Broca area -LSB- broʊˈkɑː -RSB- or -LSB- ˈbroʊkə -RSB- is a region in the frontal lobe of the dominant hemisphere ( usually the left ) of the hominid brain with functions linked to speech production .   Language processing has been linked to Broca 's area since Pierre Paul Broca reported impairments in two patients . They had lost the ability to speak after injury to the posterior inferior frontal gyrus of the brain . Since then , the approximate region he identified has become known as Broca 's area , and the deficit in language production as Broca 's aphasia , also called expressive aphasia . Broca 's area is now typically defined in terms of the pars opercularis and pars triangularis of the inferior frontal gyrus , represented in Brodmann 's cytoarchitectonic map as areas 44 and 45 of the dominant hemisphere . Studies of chronic aphasia have implicated an essential role of Broca 's area in various speech and language functions . Further , fMRI studies have also identified activation patterns in Broca 's area associated with various language tasks . However , slow destruction of the Broca 's area by brain tumors can leave speech relatively intact suggesting its functions can shift to nearby areas in the brain .